Central role of transcription factor NF-IL6 for cytokine and iron- mediated regulation of murine inducible nitric oxide synthase expression

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 6171-6177

  Dlaska, Margit ^a   Weiss, Günter ^a,b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IRON; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; GENE STRUCTURE; GENETIC TRANSCRIPTION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REGULATOR GENE;

ANIMALS; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; CONSENSUS SEQUENCE; CYTOKINES; DNA FOOTPRINTING; DNA-BINDING PROTEINS; ENZYME INDUCTION; FIBROBLASTS; GENES, REPORTER; INTERFERON TYPE II; IRON; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NUCLEAR PROTEINS; PROTEIN BINDING; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0033563095     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Marletta, M. A. 1994. Nitric oxide synthase: aspects concerning structure and catalysis. Cell 78:927.
2. Xie, Q.-w., and C. Nathan. 1994. The high-output nitric oxide pathway: role and regulation. J. Leukocyte Biol. 56:576.
3. Bredt, D. S., P. M. Hwang, C. E. Glatt, C. Lowenstein, R. R. Reed, and S. H. Snyder. 1991. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351:714.
4. Hobbs, A. J., and L. J. Ignarro. 1996. Nitric oxide-cyclic GMP signal transduction system. Methods Enzymol. 269:134.
5. Xie, Q.-w., H. J. Cho, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, A. Ding, T. Troso, and C. Nathan. 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256:225.
6. Moncada, S., and A. Higgs. 1993. Mechanisms of disease: the L-arginine-nitric oxide pathway. N. Engl. J. Med. 329:2002.
7. MacMicking, J. D., Q.-w. Xie, and C. Nathan. 1997. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15:323.
8. Lepoivre, M., F. Fieschi, J. Coves, L. Thelander, and M. Fontecave. 1991. Inactivation of ribonucleotide reductase by nitric oxide. Biochem. Biophys. Res. Commun. 179:442.
9. Drapier, J. C., and J. B. Hibbs. 1988. Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells. J. Immunol. 140:2829.
10. Weiss, G., B. Goossen, W. Doppler, D. Fuchs, K. Pantopoulos, G. Werner-Felmayer, H. Wachter, and M. W. Hentze. 1993. Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway. EMBO J. 12:3651.
11. Drapier, J. C., H. Hirling, J. Wietzerbin, P. Kaldy, and L. C. Kuhn. 1993. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. EMBO J. 12:3643.
12. Weiss, G., G. Werner-Felmayer, E. R. Werner, K. Gruenewald, H. Wachter, and M. Hentze. 1994. Iron regulates nitric oxide synthase activity by controlling nuclear transcription. J. Exp. Med. 180:969.
13. Weiss, G., H. Wachter, and D. Fuchs. 1995. Linkage of cell-mediated immunity to iron metabolism. Immunol. Today 16:495.
14. Melillo, G., L. S. Taylor, A. Brooks, T. Musso, G. W. Cox, and L. Varesio. 1997. Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine. J. Biol. Chem. 272:12236.
15. Lowenstein, C. J., E. W. Alley, P. Raval, A. M. Snowman, S. H. Snyder, S. W. Russell, and W. Murphy. 1993. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90:9730.
16. Xie, Q.-w., R. Whisnant, and C. Nathan. 1993. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J. Exp. Med. 177:1779.
17. Martin, E., C. Nathan, and Q.-w. Xie. 1994. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:977.
18. Kimura, T., K. Nakayama, J. Penninger, M. Kitagawa, H. Harada, T. Matsuyama, N. Tanaka, R. Kamijo, J. Vilcek, and T. W. Mak. 1994. Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264:1921.
19. Gao, J., D. C. Morrison, T. J. Parmely, S. W. Russell, and W. J. Murphy. 1997. An interferon-γ-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-γ and lipopolysaccharide. J. Biol. Chem. 272:1226.
20. Goldring, C. E. P., S. Reveneau, M. Algarté, and J. F. Jeannin. 1996. In vivo footprinting of the mouse inducible nitric oxide synthase gene: inducible protein occupation of numerous sites including Oct and NF-IL6. Nucleic Acids Res. 24:1682.
21. Schreiber, E., P. Matthias, M. M. Müller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with "mini-extracts" prepared from a small number of cells. Nucleic Acids Res. 17:6419.
22. Schreiber, E., P. Matthias, M. M. Müller, and W. Schaffner. 1988. Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). EMBO J. 7:4221.
23. Ho, S. N , H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51.
24. Leblanc, B., and T. Moss. 1994. DNase I footprinting. In Methods in Molecular Biology, Vol. 30: DNA-Protein Interactions: Principles and Protocols. G. G. Kneale, ed. Humana Press, Totowa, NJ, p. 1.
25. Maxam, A. M., and W. Gilbert. 1980. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65:499.
26. Spink, J., and T. Evans. 1997. Binding of the transcription factor interferon regulatory factor-1 to the inducible nitric-oxide synthase promoter. J. Biol. Chem. 272:24417.
27. Cao, Z., R. M. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1538.
28. Lamb, P., and S. L. McKnight. 1991 Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization. Trends Biochem. Sci. 16:417.
29. Poli, V., F. P. Mancini, and R. Cortese. 1990. IL-6-DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 63:643.
30. Akira, S. 1992. NF-IL6 and gene regulation. Res. Immunol. 143:734.
31. Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL-6) is a member of a C/EBP family. EMBO J. 9:1897.
32. Nishizawa, M., and S. Nagata. 1990. Regulatory elements responsible for inducible gene expression of the granulocyte colony-stimulation factor gene in macrophages. Mol. Cell. Biol. 10:2002.
33. Natsuka, S., S. Akira, Y. Nishio, S. Hashimoto, T. Sugita, H. Isshiki, and T. Kishimoto 1992. Macrophage differentiation specific expression of NF-IL-6, a transcription factor for IL-6. Blood 79:460.
34. Mukaida, N., Y. Mahe, and K. Matsushima. 1990. Cooperative interaction of NF-κB-and C/EBP-like factor binding elements in activating the interleukin-8 gene by proinflammatory cytokines. J. Biol. Chem. 265:21128.
35. Stuehr, D. J., and M. A. Marletta. 1987. Synthesis of nitrite and nitrate in murine macrophage cell lines. Cancer Res. 47:5590.
36. Xie, Q.-w. 1997. A novel lipopolysaccharide-response element contributes to induction of nitric oxide synthase. J. Biol. Chem. 272:14867.
37. Xie, Q.-w., Y. Kashiwabara, and C. Nathan. 1994. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:4705.
38. Ding, A., S. Hwang, H. M. Lander, and Q.-w. Xie. 1995. Macrophages derived from C3H/HeJ (Lpsd) mice respond to bacterial lipopolysaccharide by activating NF-κB. J. Leukocyte Biol. 57:174.
39. Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
40. Stein, B., and A. S. Baldwin, Jr. 1993. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB. Mol. Cell. Biol. 13:7191.
41. Matsuka, T., K. Fujikawa, Y. Nishio, N. Mukaida, K. Matsushima, T. Kishimoto, and S. Akira. 1993. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin-6 and interleukin-8. Proc. Natl. Acad. Sci. USA 90:10193.
42. Kunsch, C., R. K. Lang, C.A. Rosen, and M. F. Shannon. 1994. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65(RelA) and NF-IL6. J. Immunol. 153:153.
43. Stein, B., P. C. Cogswell, and A. S. Baldwin, Jr. 1993. Functional and physical associations between NF-κB and C/EBP family members: a rel domain-bZIP interaction. Mol. Cell. Biol. 13:3964.
44. Schmitz, M. L., G. Stelzer, H. Altmann, M. Meisterernst, and P. A. Baeuerle. 1995. Interaction of the COOH-terminal transactivation domain of p65 NF-κB with TATA-binding protein, transcription factor IIB, and coactivators. J. Biol. Chem. 270:7219.
45. Nerlov, C., and E. B. Ziff. 1995. CCAAT/enhancer binding protein-α amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cell. EMBO J. 14:4318.
46. Plevy, S. E., J. H. M. Gemerling, S. Hsu, A. J. Dorner, and S. T. Smale. 1997. Multiple control elements mediate activation of the murine and human interleukin-12p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17:4572.
47. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405.
48. Sawada, T., L. A. Falk, R. Rao, W. J. Murphy, and D. H. Pluznik. 1997. IL-6 induction of protein-DNA complexes via a novel regulatory region of the inducible nitric oxide synthase gene promoter. J. Immunol. 158:5267.
49. Alonzi, T., B. Gorgoni, I. Screpanti, A. Gulino, and V. Poli. 1997. Interleukin-6 and CCAAT/enhancer binding protein β-deficient mice act as tools to dissect the IL-6 signalling pathway and IL-6 regulation. Immunobiology 198:144.
50. Lorsbach, R. B., W. J. Murphy, C. J. Lowenstein, S. H. Snyder, and S. W. Russell. 1993. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing: molecular basis for the synergy between interferon-γ and lipopolysaccharide. J. Biol. Chem. 268:1908.
51. Tanaka, T., S. Akira, K. Yoshida, M. Umemoto, Y. Yoneda, N. Shirafuji, H. Fujiwara, S. Suematsu, N. Yoshida, and T. Kishimoto. 1995. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353.
52. Akira, S., K. Yoshida, T. Tanaka, T. Taga, and T. Kishimoto. 1995 Targeted disruption of the IL-6 related genes: gp130 and NF-IL-6. Immunol. Rev. 148:221.
53. Rosen, G., M. S. Pou, C. Ramos, M. S. Cohen, and B. E. Britigan. 1995. Free radicals and phagocytic cells. FASEB J. 9:200.
54. Schreck, R., P. Rieber, and P. A. Baeuerle. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J. 10:2247.