Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

Science

Volumn 306, Issue 5704, 2004, Pages 2090-2093

  Nemeth, Elizabeta ^a   Tuttle, Marie S ^b   Powelson, Julie ^b   Vaughn, Michael D ^b   Donovan, Adriana ^c   Ward, Diane McVey ^b   Ganz, Tomas ^a   Kaplan, Jerry ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; CELLS; IRON; TISSUE;

CELL SURFACE; HEPATOCYTES; INFLAMMATION; MACROPHAGES;

HORMONES;

FERROPORTIN 1; HEPCIDIN; IRON;

HORMONE;

ARTICLE; HELA CELL; HUMAN; HUMAN CELL; INTERNALIZATION; IRON BALANCE; IRON KINETICS; IRON TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; TRANSCRIPTION REGULATION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL TRANSPORT; CATION TRANSPORT PROTEINS; CELL LINE; CELL MEMBRANE; CYTOSOL; FERRITINS; HELA CELLS; HOMEOSTASIS; HUMANS; IRON; IRON REGULATORY PROTEIN 2; LYSOSOMES; MICE; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TRANSFECTION; TRANSFERRIN;

EID: 10844258104     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1104742     Document Type: Article

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