Iron overload alters innate and T helper cell responses to candida albicans in mice

Journal of Infectious Diseases

Volumn 175, Issue 6, 1997, Pages 1467-1476

  Mencacci, Antonella ^b   Cenci, Elio ^b   Boelaert, Johan R ^b   Bucci, Paola ^b   Mosci, Paolo ^b   D'Ostiani, Cristiana Fè ^b   Bistoni, Francesco ^b   Romani, Luigina ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; DEFEROXAMINE MESYLATE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; FEMALE; HELPER CELL; IMMUNOMODULATION; INFECTION SENSITIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; IRON OVERLOAD; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

EID: 0030946841     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/516481     Document Type: Article

References (17)

1. Romani L, Puccetti P, Bistoni F. Biological role of helper T-cell subsets in candidiasis. Chem Immunol 1995;63:115-37.
2. Puccetti P, Romani L, Bistoni F. A Th1-Th2-like switch in candidiasis: new perspectives for therapy. Trends Microbiol 1995;3:237-40.
3. + subset expression in murine candidiasis. Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance. J Immunol 1993;150:925-31.
4. Romani L, Mencacci A, Grohmann U, et al. Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J Exp Med 1992;176:19-25.
5. Romani L, Puccetti P, Mencacci A, et al. Neutralization of IL-10 upregulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J Immunol 1994;1532:3514-21.
6. Romani L, Mocci S, Bietta C, Lanfaloni L, Puccetti P, Bistoni F. Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance. Infect Immun 1991;59:4647-54.
7. Puccetti P, Mencacci A, Cenci E, et al. Cure of murine candidiasis by recombinant soluble interleukin-4 receptor. J Infect Dis 1994;169: 1325-31.
8. Romani L, Howard DH. Mechanisms of resistance to fungal infections. Curr Opin Immunol 1995;7:517-23.
9. Romani L, Bistoni F, Mencacci A, Cenci E, Spaccapelo R, Puccetti P. IL-12 in Candida albicans infections. Res Immunol 1996;146:532-8.
10. + Th1 development in IL-6-deficient mice infected with Candida albicans. J Exp Med 1996;183:1345-55.
11. Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science 1996;272:50-4.
12. Weinberg ED. Iron and infection. Microbiol Rev 1978;42:45-66.
13. Weinberg ED, Weinberg GA. The role of iron in infection. Curr Opin Infect Dis 1995;8:164-9.
14. Boelaert JR. Iron and infection [editorial]. Acta Clin Belg 1996;51:213-21.
15. Boelaert JR, Weinberg ED, Weinberg GA. Altered iron metabolism in HIV infection: mechanisms, possible consequences, and proposals for management. Infect Agents Dis 1996;5:36-46.
16. De Sousa M. Immune cell functions in iron overload. Clin Exp Immunol 1989;75:1-6.
17. Van Asbeck BS, Verburg HA, van Oost BA, Marx JM, Imhof HW, Verhoef J. Listeria monocytogenes meningitis and decreased phagocytosis associated with iron overload. Br Med J 1982;284:542-4.