Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

Hepatology

Volumn 53, Issue 4, 2011, Pages 1333-1341

  Ramos, Emilio ^a   Kautz, Léon ^b,c   Rodriguez, Richard ^a   Hansen, Michael ^a   Gabayan, Victoria ^a   Ginzburg, Yelena ^d   Roth, Marie Paule ^b,c   Nemeth, Elizabeta ^a   Ganz, Tomas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c France   (France)

^d NEW YORK BLOOD CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; HEMOJUVELIN; HEPCIDIN; HFE PROTEIN; HOLOTRANSFERRIN; IRON; MESSENGER RNA; TRANSFERRIN; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

ACUTE IRON LOADING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC IRON LOADING; CONTROLLED STUDY; FEMALE; IRON ABSORPTION; IRON DEPLETION; IRON INTAKE; IRON KINETICS; IRON METABOLISM; IRON OVERLOAD; LIVER LEVEL; LIVER METABOLISM; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; REGULATORY MECHANISM; WILD TYPE;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BONE MORPHOGENETIC PROTEIN 6; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; IRON; MEMBRANE PROTEINS; MICE; RECEPTORS, TRANSFERRIN; RNA, MESSENGER; TRANSFERRIN;

EID: 79953757053     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24178     Document Type: Article

References (27)

1. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004; 306: 2090-2093.
2. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood 2007; 110: 2182-2189.
3. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood 2008; 112: 4292-4297.
4. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004; 113: 1271-1276.
5. Flanagan JM, Truksa J, Peng H, Lee P, Beutler E. In vivo imaging of hepcidin promoter stimulation by iron and inflammation. Blood Cells Mol Dis 2007; 38: 253-257.
6. Ramey G, Deschemin JC, Vaulont S. Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. Haematologica 2009; 94: 765-772.
7. Kawabata H, Fleming RE, Gui D, Moon SY, Saitoh T, O'Kelly J, et al. Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 2005; 105: 376-381.
8. Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 2005; 115: 2180-2186.
9. Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, Roth MP. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet 2009; 41: 478-481.
10. Vujic SM, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, et al. Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab 2008; 7: 173-178.
11. Bondi A, Valentino P, Daraio F, Porporato P, Gramaglia E, Carturan S, et al. Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Haematologica 2005; 90: 1161-1167.
12. Li H, Rybicki AC, Suzuka SM, von BL, Breuer W, Hall CB, et al. Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med 2010; 16: 177-182.
13. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006; 108: 3730-3735.
14. Bachmanov AA, Reed DR, Beauchamp GK, Tordoff MG. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet 2002; 32: 435-443.
15. Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet 2009; 41: 482-487.
16. Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B Jr, Lin HY, et al. Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology 2009; 137: 1489-1497.
17. Kautz L, Meynard D, Besson-Fournier C, Darnaud V, Al ST, Coppin H, et al. BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression. Blood 2009; 114: 2515-2520.
18. Fleming RE, Sly WS. Mechanisms of iron accumulation in hereditary hemochromatosis. Annu Rev Physiol 2002; 64: 663-680.
19. Huang FW, Babitt JL, Wrighting DM, Samad TA, Xia Y, Sidis Y, et al. Hemojuvelin acts as a bone morphogenetic protein co-receptor to regulate hepcidin expression. ASH Annual Meeting Abstracts 2005; 106: 511.
20. Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. HEPATOLOGY 2009; 50: 1992-2000.
21. Pietrangelo A, Caleffi A, Henrion J, Ferrara F, Corradini E, Kulaksiz H, et al. Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes. Gastroenterology 2005; 128: 470-479.
22. Trombini P, Coliva T, Nemeth E, Mariani R, Ganz T, Biondi A, et al. Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia. Haematologica 2007; 92: 1407-1410.
23. Bartnikas TB, Andrews NC, Fleming MD. Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood 2010; doi:10.1182/blood-2010-05-287359.
24. Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 2008; 112: 1503-1509.
25. Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 2005; 106: 2884-2889.
26. Zhang AS, Anderson SA, Meyers KR, Hernandez C, Eisenstein RS, Enns CA. Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin. J Biol Chem 2007; 282: 12547-12556.
27. Silvestri L, Pagani A, Nai A, De D, I, Kaplan J, Camaschella C. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab 2008; 8: 502-511.