Intracellular labile iron

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 3, 2008, Pages 350-354

  Breuer, William ^a   Shvartsman, Maya ^a   Cabantchik, Z Ioav ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Chelators; Fluorescence; Iron; Sensors

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; FERRITIN; FERROPORTIN; HYDRAZONE DERIVATIVE; IRON; IRON CHELATING AGENT; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; TRANSFERRIN RECEPTOR;

ANTIOXIDANT ACTIVITY; CELL COMPARTMENTALIZATION; CELL LEVEL; CELL NUCLEUS; CYTOSOL; HOMEOSTASIS; HUMAN; INTRACELLULAR TRANSPORT; IRON TRANSPORT; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSPORT KINETICS;

ANIMALS; CYTOPLASM; FERRITINS; HUMANS; IRON; IRON-REGULATORY PROTEINS; METABOLIC NETWORKS AND PATHWAYS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; RECEPTORS, TRANSFERRIN; TRANSFERRIN;

EID: 39049114182     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2007.03.010     Document Type: Short Survey

References (20)

1. Breuer W., Epsztejn S., and Cabantchik Z.I. Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II). J. Biol. Chem. 270 (1995) 24209-24215
2. De Domenico I., Vaughn M.B., Li L., Bagley D., Musci G., Ward D.M., et al. Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome. EMBO J. 25 (2006) 5396-5404
3. Esposito B.P., Epsztejn S., Breuer W., and Cabantchik Z.I. A review of fluorescence methods for assessing labile iron in cells and biological fluids. Anal. Biochem. 304 (2002) 1-18
4. Garrick L.M., Gniecko K., Hoke J.E., al-Nakeeb A., Ponka P., and Garrick M.D. Ferric-salicylaldehyde isonicotinoyl hydrazone, a synthetic iron chelate, alleviates defective iron utilization by reticulocytes of the Belgrade rat. J. Cell. Physiol. 146 (1991) 460-465
5. Glickstein H., Ben-El R.B., Link G., Breuer W., Konijn A.M., Hershko C., et al. Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences. Blood 108 (2006) 3195-3203
6. Glickstein H., Ben-El R.B., Shvartsman M., and Cabantchik Z.I. Intracellular labile iron pools as direct targets of iron chelators: A fluorescence study of chelator action in living cells. Blood 106 (2005) 3242-3250
7. Kakhlon O., and Cabantchik Z.I. The labile iron pool: Characterization, measurement, and participation in cellular processes. Free Radic. Biol. Med. 33 (2002) 1037-1046
8. Kruszewski M. Labile iron pool: The main determinant of cellular response to oxidative stress. Mutat. Res. 29 (2003) 81-92
9. Lange H., Kispal G., and Lill R. Mechanism of iron transport to the site of heme synthesis inside yeast mitochondria. J. Biol. Chem. 274 (1999) 18989-18996
10. Ma Y., DeGroot H., Liu Z., Hider R., and Petrat F. Chelation and determination of labile iron in primary hepatocytes by pyridinone fluorescent probes. Biochem. J. 395 (2006) 49-55
11. Napier I., Ponka P., and Richardson D.R. Iron trafficking in the mitochondrion: Novel pathways revealed by disease. Blood 105 (2005) 1867-1874
12. Petrat F., de Groot H., Sustmann R., and Rauen U. The chelatable iron pool in living cells: A methodically defined quantity. Biol. Chem. 383 (2002) 489-502
13. Rauen U., Springer A., Weisheit D., Petrat F., Korth H.G., de Groot H., et al. Assessment of chelatable mitochondrial iron by using mitochondrion-selective fluorescent iron indicators with different iron-binding affinities. Chembiochem 8 (2007) 341-352
14. Richardson D.R., Ponka P., and Vyoral D. Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: Examination of the intermediates involved in iron metabolism. Blood 87 (1996) 3477-3488
15. Rouault T.A. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat. Chem. Biol. 8 (2006) 406-414
16. Shaw G.C., Cope J.J., Li L., Corson K., Hersey C., Ackermann G.E., et al. Mitoferrin is essential for erythroid iron assimilation. Nature 440 (2006) 96-100
17. Shvartsman M., Kikkeri R., Shanzer A., and Cabantchik Z.I. Non-transferrin bound iron reaches mitochondria by a chelator-inaccessible mechanism. Biological and clinical implications. Am. J. Physiol. 293 (2007) 1383-1394
18. Wallander M.L., Leibold E.A., and Eisenstein R.S. Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim. Biophys. Acta 1763 (2006) 668-689
19. Whitnall M., and Richardson D.R. Iron: A new target for pharmacological intervention in neurodegenerative diseases. Semin. Pediatr. Neurol. 13 (2006) 186-197
20. Zhang A.S., Sheftel A.D., and Ponka P. Intracellular kinetics of iron in reticulocytes: Evidence for endosome involvement in iron targeting to mitochondria. Blood 105 (2005) 368-375