ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPα and STAT-3

Biochemical and Biophysical Research Communications

Volumn 356, Issue 1, 2007, Pages 312-317

  Choi, Si On ^a   Cho, Young Suk ^a   Kim, Hye Lim ^a   Park, Jong Wan ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

C EBP ; Hepcidin; HIF 1; Reactive oxygen species; STAT 3

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; HEPCIDIN; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; MESSENGER RNA PRECURSOR; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HYPOXIA; LIVER; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONTENT;

ACETYLCYSTEINE; ANIMALS; ANOXIA; ANTIMICROBIAL CATIONIC PEPTIDES; BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL HYPOXIA; CELL LINE, TUMOR; DITHIOTHREITOL; DOWN-REGULATION; FREE RADICAL SCAVENGERS; GENE EXPRESSION; HUMANS; HYDROGEN PEROXIDE; HYPOXIA-INDUCIBLE FACTOR 1; MICE; MICE, INBRED BALB C; OXIDANTS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 33947095427     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.02.137     Document Type: Article

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