Parenteral iron formulations: A comparative toxicologic analysis and mechanisms of cell injury

American Journal of Kidney Diseases

Volumn 40, Issue 1, 2002, Pages 90-103

  Zager, Richard A ^a   Johnson, Ali C M ^a   Hanson, Sherry Y ^a   Wasse, Haimanot ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Human proximal tubule (HK 2) cells; Iron (Fe); Lipid peroxidation; Mitochondria; Proximal tubules

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; BENZOIC ACID; CATALASE; DIMETHYLTHIOUREA; FERRIC HYDROXIDE SUCROSE; FERROUS GLUCONATE; FREE RADICAL; GLUTATHIONE; GLYCINE; IRON DEXTRAN; IRON OLIGOSACCHARIDE; LACTATE DEHYDROGENASE; MALONALDEHYDE; OLIGOSACCHARIDE; SUCROSE; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; DRUG FORMULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IRON OVERLOAD; KIDNEY CORTEX; KIDNEY HOMOGENATE; KIDNEY PROXIMAL TUBULE; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN;

EID: 0036280354     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/ajkd.2002.33917     Document Type: Article

References (40)

1. DOQI Clinical Practice Guidelines for the Treatment of Anemia of Chronic Renal Failure
2. Enhanced oxidative stress in haemodialysis patients receiving intravenous iron therapy
3. Catalytically active iron and bacterial growth in serum of haemodialysis patients after IV ironsaccharate administration
4. Neutrophil impairment associated with iron therapy in hemodialysis patients with functional iron deficiency
5. Increase in plasma esterified F2-isoprostanes following intravenous iron infusion in patients on hemodialysis
6. Cellular and molecular studies of atherosclerosis
7. Atherosclerosis: An inflammatory disease
8. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin
9. Lipid peroxidation: Its mechanisms, measurement, and significance
10. Suspected iron dextran-related adverse drug events in hemodialysis patients
11. The comparative safety of intravenous iron dextran, iron saccharate, and sodium ferric gluconate
12. Comparative look at intravenous iron agents: Pharmacology, efficacy, and safety of iron dextran, iron saccharate, and ferric gluconate
13. Effects of inorganic iron and myoglobin on in vitro proximal tubular lipid peroxidation and cytotoxicity
14. Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat
15. Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo
16. Acquired resistance to acute oxidative stress. Possible role of heme oxygenase and ferritin
17. Deferoxamine confers striking protection against cold storage injury to isolated mouse proximal tubules
18. Iron, heme oxygenase, and glutathione: Effects on myohemoglobinuric proximal tubular injury
19. Re-emergence of sucrose nephropathy: Acute renal failure caused by high-dose intravenous immune globulin therapy
20. Acute renal failure in acquired haemophilia following the use of high dose intravenous immunoglobulin
21. Acute renal failure and intravenous immune globulin: Sucrose nephropathy in disguise?
22. Mitochondrial free radical production induces lipid peroxidation during myohemoglobinuria
23. HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney
24. Myoglobin inhibits proliferation of cultured human proximal tubular (HK-2) cells
25. Evidence suggesting a role for hydroxyl radical in glycerol induced acute renal failure
26. Hemoglobin- and myoglobin-induced acute renal failure in rats: Role of iron in nephrotoxicity
27. Cytoprotective effects of glycine and glutathione against hypoxic injury to renal tubules
28. Differential cytoprotection by glycine against oxidant damage to proximal tubule cells
29. Hyperthermia: Effects on renal ischemic/reperfusion injury in the rat
30. Body temperature: An important determinant of severity of ischemic renal injury
31. Differential expression of extracellular proteins is correlated with angiogenesis in vitro
32. Hematopoietic agents
33. 2, and terminal mitochondrial electron transport
34. Polyene antibiotics: Relative degrees of in vitro cytotoxicity and potential effects on tubule phospholipid and ceramide content
35. Reaction of human hemoglobin HbAO and two cross-linked derivatives with hydrogen peroxide: Differential behavior of the ferryl intermediate
36. Peroxidation of linoleate at physiological pH: Hemichrome formation by substrate binding protects against metmyoglobin activation by hydrogen peroxide
37. Plasma glutathione peroxidase activity is reduced in hemodialysis patients
38. Higher levels of antioxidant defenses in enalapril-treated versus non-enalapril-treated hemodialysis patients
39. Vitamin E, lipid profile, and peroxidation in hemodialysis patients
40. Secondary Prevention With Antioxidants of Cardiovascular Disease in End Stage Renal Disease (SPACE): Randomised placebo-controlled trial