Nitric-oxide synthase: A cytochrome P450 family foster child

Biochimica et Biophysica Acta - General Subjects

Volumn 1770, Issue 3, 2007, Pages 432-445

  Gorren, Antonius C F ^a   Mayer, Bernd ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Nitric oxide synthase; Tetrahydrobiopterin; Uncoupling

Indexed keywords

CALMODULIN; CYTOCHROME P450; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN; UNCOUPLING PROTEIN; ZINC;

AMINO ACID SEQUENCE; AUTOOXIDATION; CATALYSIS; DIMERIZATION; ELECTRON TRANSPORT; ENZYME STRUCTURE; FOSTER CARE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTON TRANSPORT; REVIEW; STRUCTURAL HOMOLOGY; SYNTHESIS;

ANIMALS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATION-REDUCTION; PROTONS;

MAMMALIA;

EID: 33846389920     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2006.08.019     Document Type: Review

References (131)

1. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6 (1992) 3051-3064
2. Pfeiffer S., Mayer B., and Hemmens B. Nitric oxide: chemical puzzles posed by a biological messenger. Angew. Chem. Int. Ed. 38 (1999) 1714-1731
3. Grisham M.B., Jourd'heuil D., and Wink D.A. Nitric oxide I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation. Am. J. Physiol. 276 (1999) G315-G321
4. Schulz R., Rassaf T., Massion P.B., Kelm M., and Balligand J.-L. Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis. Pharmacol. Ther. 108 (2005) 225-256
5. Griffith O.W., and Stuehr D.J. Nitric oxide synthases: properties and catalytic mechanism. Annu. Rev. Physiol. 57 (1995) 707-736
6. Gorren A.C.F., and Mayer B. The versatile and complex enzymology of nitric oxide synthase. Biochemistry (Moscow) 63 (1998) 734-743
7. Stuehr D.J. Mammalian nitric oxide synthases. Biochim. Biophys. Acta 1411 (1999) 217-230
8. Andrew P.J., and Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc. Res. 43 (1999) 521-531
9. Alderton W.K., Cooper C.E., and Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357 (2001) 593-615
10. Roman L.J., Martásek P., and Masters B.S.S. Intrinsic and extrinsic modulation of nitric oxide synthase activity. Chem. Rev. 102 (2002) 1179-1189
11. Stuehr D.J., Santolini J., Wang Z.-Q., Wei C.-C., and Adak S. Update on mechanism and catalytic regulation in the NO synthases. J. Biol. Chem. 279 (2004) 36167-36170
12. Rousseau D.L., Li D., Couture M., and Yeh S.-R. Ligand-protein interactions in nitric oxide synthase. J. Inorg. Biochem. 99 (2005) 306-323
13. Förstermann U., Boissel J.-P., and Kleinert H. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J. 12 (1998) 773-790
14. Fulton D., Gratton J.-P., and Sessa W.C. Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?. J. Pharmacol. Exp. Ther. 299 (2001) 818-824
15. Kone B.C., Kuncewicz T., Zhang W., and Yu Z.-Y. Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. Am. J. Physiol. 285 (2003) F178-F190
16. Fleming I., and Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am. J. Physiol. 284 (2003) R1-R12
17. Fulton D., Church J.E., Ruan L., Li C., Sood S.G., Kemp B.E., Jennings I.G., and Venema R.C. Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83. J. Biol. Chem. 280 (2005) 35943-35952
18. Ravi K., Brennan L.A., Levic S., Ross P.A., and Black S.M. S-Nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 2619-2624
19. Erwin P.A., Lin A.J., Golan D.E., and Michel T. Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells. J. Biol. Chem. 280 (2005) 19888-19894
20. Mitchell D.A., Erwin P.A., Michel T., and Marletta M.A. S-Nitrosation and regulation of inducible nitric oxide synthase. Biochemistry 44 (2005) 4636-4647
21. Giulivi C. Characterization and function of mitochondrial nitric-oxide synthase. Free Radic. Biol. Med. 34 (2003) 397-408
22. Ghafourifar P., and Cadenas E. Mitochondrial nitric oxide synthase. Trends Pharmacol. Sci. 26 (2005) 190-195
23. Lacza Z., Pankotai E., Csordás A., Geroö D., Kiss L., Horváth E.M., Kollai M., Busija D.W., and Szabó C. Mitochondrial NO and reactive nitrogen species production: does mtNOS exist?. Nitric Oxide 14 (2006) 162-168
24. Zemojtel T., Kolanczyk M., Kossler N., Stricker S., Lurz R., Mikula I., Duchniewicz M., Schuelke M., Ghafourifar P., Martasek P., Vingron M., and Mundlos S. Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate. FEBS Lett. 580 (2006) 455-462
25. Guo F.-Q., Okamoto M., and Crawford N.M. Identification of a plant nitric oxide synthase gene involved in hormonal signaling. Science 302 (2003) 100-103
26. Omura T. Heme-thiolate proteins. Biochem. Biophys. Res. Commun. 338 (2005) 404-409
27. Mansuy D., and Boucher J.-L. Alternative nitric oxide-producing substrates for NO synthases. Free Radic. Biol. Med. 37 (2004) 1105-1121
28. Sono M., Roach M.P., Coulter E.D., and Dawson J.H. Heme-containing oxygenases. Chem. Rev. 96 (1996) 2841-2887
29. Meunier B., de Visser S.P., and Shaik S. Mechanism of oxidation reactions catalyzed by cytochrome P450 enzymes. Chem. Rev. 104 (2004) 3947-3980
30. Jousserandot A., Boucher J.-L., Henry Y., Niklaus B., Clement B., and Mansuy D. Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C{double bond, long}N(OH) bond with formation of nitrogen oxides. Biochemistry 37 (1998) 17179-17191
31. Masters B.S.S. The journey from NADPH-cytochrome P450 oxidoreductase to nitric oxide synthases. Biochem. Biophys. Res. Commun. 338 (2005) 507-519
32. Daff S.N., Chapman S.K., Turner K.L., Holt R.A., Govindaraj S., Poulos T.L., and Munro A.W. Redox control of the catalytic cycle of flavocytochrome P-450 BM3. Biochemistry 36 (1997) 13816-13823
33. Munro A.W., Noble M.A., Robledo L., Daff S.N., and Chapman S.K. Determination of the redox properties of human NADPH-cytochrome P450 reductase. Biochemistry 40 (2001) 1956-1963
34. Noble M.A., Munro A.W., Rivers S.L., Robledo L., Daff S.N., Yellowlees L.J., Shimizu T., Sagami I., Guillemette J.G., and Chapman S.K. Potentiometric analysis of the flavin cofactors of neuronal nitric oxide synthase. Biochemistry 38 (1999) 16413-16418
35. Lane P., and Gross S.S. The autoinhibitory control element and calmodulin conspire to provide physiological modulation of endothelial and neuronal nitric oxide synthase activity. Acta Physiol. Scand. 168 (2000) 53-63
36. Jones R.J., Smith S.M.E., Gao Y.T., DeMay B.S., Mann K.J., Salerno K.M., and Salerno J.C. The function of the small insertion in the hinge subdomain in the control of constitutive mammalian nitric-oxide synthases. J. Biol. Chem. 279 (2004) 36876-36883
37. Garcin E.D., Bruns C.M., Lloyd S.J., Hosfield D.J., Tiso M., Gachhui R., Stuehr D.J., Tainer J.A., and Getzoff E.D. Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. J. Biol. Chem. 279 (2004) 37918-37927
38. Gorren A.C.F., and Mayer B. Tetrahydrobiopterin in nitric oxide synthesis: a novel biological role for pteridines. Curr. Drug Metab. 3 (2002) 133-157
39. Werner E.R., Gorren A.C.F., Heller R., Werner-Felmayer G., and Mayer B. Tetrahydrobiopterin and nitric oxide: mechanistic and pharmacological aspects. Exp. Biol. Med. 228 (2003) 1291-1302
40. Wei C.-C., Crane B.R., and Stuehr D.J. Tetrahydrobiopterin radical enzymology. Chem. Rev. 103 (2003) 2365-2383
41. Stuehr D.J., Wei C.-C., Wang Z., and Hille R. Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases. Dalton Trans. (2005) 3427-3435
42. White R.E., and Coon M.J. Oxygen activation by cytochrome P-450. Annu. Rev. Biochem. 49 (1980) 315-356
43. Dawson J.H., and Sono M. Cytochrome P-450 and chloroperoxidase: thiolate-ligated heme enzymes. Spectroscopic determination of their active site structures and mechanistic implications of thiolate ligation. Chem. Rev. 87 (1987) 1255-1276
44. Denisov I.G., Makris T.M., Sligar S.G., and Schlichting I. Structure and chemistry of cytochrome P450. Chem. Rev. 105 (2005) 2253-2277
45. Abu-Soud H.M., Gachhui R., Raushel F.M., and Stuehr D.J. The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of l-arginine and tetrahydrobiopterin on its stability. J. Biol. Chem. 272 (1997) 17349-17353
46. Bec N., Gorren A.C.F., Voelker C., Mayer B., and Lange R. Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin. J. Biol. Chem. 273 (1998) 13502-13508
47. Ledbetter A.P., McMillan K., Roman L.J., Masters B.S.S., Dawson J.H., and Sono M. Low-temperature stabilization and spectroscopic characterization of the dioxygen complex of the ferrous neuronal nitric oxide synthase oxygenase domain. Biochemistry 38 (1999) 8014-8021
48. Gorren A.C.F., Bec N., Schrammel A., Werner E.R., Lange R., and Mayer B. Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis. Biochemistry 39 (2000) 11763-11770
49. Couture M., Stuehr D.J., and Rousseau D.L. The ferrous dioxygen complex of the oxygenase domain of neuronal nitric-oxide synthase. J. Biol. Chem. 275 (2000) 3201-3205
50. Wei C.-C., Wang Z.-Q., Wang Q., Meade A.L., Hemann C., Hille R., and Stuehr D.J. Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase. J. Biol. Chem. 276 (2001) 315-319
51. Sørlie M., Gorren A.C.F., Marchal S., Shimizu T., Lange R., Andersson K.K., and Mayer B. Single-turnover of nitric-oxide synthase in the presence of 4-amino-tetrahydrobiopterin. Proposed role for tetrahydrobiopterin as a proton donor. J. Biol. Chem. 278 (2003) 48602-48610
52. Marchal S., Gorren A.C.F., Sørlie M., Andersson K.K., Mayer B., and Lange R. Evidence of two distinct oxygen complexes of reduced endothelial nitric oxide synthase. J. Biol. Chem. 279 (2004) 19824-19831
53. Chartier F.J.M., Blais S.P., and Couture M. A weak Fe-O bond in the oxygenated complex of the nitric-oxide synthase of Staphylococcus aureus. J. Biol. Chem. 281 (2006) 9953-9962
54. Sudhamsu J., and Crane B.R. Structure and reactivity of a thermostable prokaryotic nitric-oxide synthase that forms a long-lived oxy-heme complex. J. Biol. Chem. 281 (2006) 9623-9632
55. Marchal S., Lange R., Sørlie M., Andersson K.K., Gorren A.C.F., and Mayer B. CO exchange of the oxyferrous complexes of endothelial nitric-oxide synthase oxygenase domain in the presence of 4-amino-tetrahydrobiopterin. J. Inorg. Biochem. 98 (2004) 1217-1222
56. Shaik S., Kumar D., de Visser S.P., Altun A., and Thiel W. Theoretical perspective on the structure and mechanism of cytochrome P450 enzymes. Chem. Rev. 105 (2005) 2279-2328
57. Gorren A.C.F., Schrammel A., Riethmüller C., Schmidt K., Koesling D., Werner E.R., and Mayer B. Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyltetrahydrobiopterin. Biochem. J. 347 (2000) 475-484
58. cam research. Mechanistic insights into oxygenase catalysis. In: Ortiz de Montellano P.R. (Ed). Cytochrome P450: Structure, Mechanism, and Biochemistry. Second edition (1995), Plenum Press, New York 83-124
59. Presta A., Weber-Main A.M., Stankovich M.T., and Stuehr D.J. Comparative effects of substrates and pterin cofactor on the heme midpoint potential in inducible and neuronal nitric oxide synthases. J. Am. Chem. Soc. 120 (1998) 9460-9465
60. Abu-Soud H.M., Feldman P.L., Clark P., and Stuehr D.J. Electron transfer in the nitric-oxide synthases. Characterization of l-arginine analogs that block heme iron reduction. J. Biol. Chem. 269 (1994) 32318-32326
61. Hurshman A.M., Krebs C., Edmondson D.E., Huynh B.H., and Marletta M.A. Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen. Biochemistry 38 (1999) 15689-15696
62. Schmidt P.P., Lange R., Gorren A.C.F., Werner E.R., Mayer B., and Andersson K.K. Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy. J. Biol. Inorg. Chem. 6 (2001) 151-158
63. ω-hydroxyarginine oxidation by nitric-oxide synthase. J. Biol. Chem. 278 (2003) 46668-46673
64. Bach R.D., and Dmitrenko O. The "somersault" mechanism for the P-450 hydroxylation of hydrocarbons. The intervention of transient inverted metastable hydroperoxides. J. Am. Chem. Soc. 128 (2006) 1474-1488
65. Haines D.C., Tomchick D.R., Machius M., and Peterson J.A. Pivotal role of water in the mechanism of P450BM-3. Biochemistry 40 (2001) 13456-13465
66. Davydov R., Makris T.M., Kofman V., Werst D.E., Sligar S.G., and Hoffman B.M. Hydroxylation of camphor by reduced oxy-cytochrome P450cam: mechanistic implications of EPR and ENDOR studies of catalytic intermediates in native and mutant enzymes. J. Am. Chem. Soc. 123 (2001) 1403-1415
67. G-hydroxyarginine. Biochemistry 41 (2002) 10375-10381
68. Hlavica P. Models and mechanisms of O-O bond activation by cytochrome P450. A critical assessment of the potential role of multiple active intermediates in oxidative catalysis. Eur. J. Biochem. 271 (2004) 4335-4360
69. Newcomb M., and Chandrasena R.E.P. Highly reactive electrophilic oxidants in cytochrome P450 catalysis. Biochem. Biophys. Res. Commun. 338 (2005) 394-403
70. Jung C., Schünemann V., and Lendzian F. Freeze-quenched iron-oxo intermediates in cytochromes P450. Biochem. Biophys. Res. Commun. 338 (2005) 355-364
71. Groves J.T., and Wang C.C.-Y. Nitric oxide synthase: models and mechanisms. Curr. Opin. Chem. Biol. 4 (2000) 687-695
72. Poulos T.L. Structural and functional diversity in heme monooxygenases. Drug Metab. Dispos. 33 (2005) 10-18
73. Gorren A.C.F., Sørlie M., Andersson K.K., Marchal S., Lange R., and Mayer B. Tetrahydrobiopterin as combined electron/proton donor in nitric oxide biosynthesis: cryogenic UV-Vis and EPR detection of reaction intermediates. Methods Enzymol. 396 (2005) 456-466
74. Jung C., Lendzian F., Schünemann V., Richter M., Böttger L.H., Trautwein A.X., Contzen J., Galander M., Ghosh D.K., and Barra A.-L. Multi-frequency EPR and Mössbauer spectroscopic studies on freeze-quenched reaction intermediates of nitric oxide synthase. Magn. Reson. Chem. 43 (2005) S84-S95
75. Poulos T.L., Li H., and Raman C.S. Heme-mediated oxygen activation in biology: cytochrome c oxidase and nitric oxide synthase. Curr. Opin. Chem. Biol. 3 (1999) 131-137
76. Guengerich F.P., Krauser J.A., and Johnson W.W. Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2. Biochemistry 43 (2004) 10775-10788
77. Mayer B., John M., Heinzel B., Werner E.R., Wachter H., Schultz G., and Böhme E. Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase. FEBS Lett. 288 (1991) 187-191
78. ω-Hydroxy-l-arginine is an intermediate in the biosynthesis of nitric oxide from l-arginine. J. Biol. Chem. 266 (1991) 6259-6263
79. Gorren A.C.F., Schrammel A., Schmidt K., and Mayer B. Effects of pH on the structure and function of neuronal nitric oxide synthase. Biochem. J. 331 (1998) 801-807
80. 2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase. Biochem. J. 281 (1992) 627-630
81. Pou S., Pou W.S., Bredt D.S., Snyder S.H., and Rosen G.M. Generation of superoxide by purified brain nitric oxide synthase. J. Biol. Chem. 267 (1992) 24173-24176
82. Vásquez-Vivar J., Hogg N., Martásek P., Karoui H., Pritchard Jr. K.A., and Kalyanaraman B. Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. J. Biol. Chem. 274 (1999) 26736-26742
83. Pignitte M., Gorren A.C.F., Nedeianu S., Schmidt K., and Mayer B. Inefficient spin trapping of superoxide in the presence of nitric oxide: Implications for studies on nitric oxide synthase uncoupling. Free Radic. Biol. Med. 41 (2006) 455-463
84. 2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J. Biol. Chem. 273 (1998) 25804-25808
85. List B.M., Klösch B., Völker C., Gorren A.C.F., Sessa W.C., Werner E.R., Kukovetz W.R., Schmidt K., and Mayer B. Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization. Biochem. J. 323 (1997) 159-165
86. Xia Y., Roman L.J., Masters B.S.S., and Zweier J.L. Inducible nitric-oxide synthase generates superoxide from the reductase domain. J. Biol. Chem. 273 (1998) 22635-22639
87. John S., and Schmieder R.E. Impaired endothelial function in arterial hypertension and hypercholesterolemia: potential mechanisms and differences. J. Hypertens. 18 (2000) 363-374
88. Suschek C.V., Schnorr O., and Kolb-Bachofen V. The role of iNOS in chronic inflammatory processes in vivo: is it damage-promoting, protective, or active at all?. Curr. Mol. Med. 4 (2004) 763-775
89. Förstermann U., and Münzel T. Endothelial nitric oxide synthase in vascular disease. From marvel to menace. Circulation 113 (2006) 1708-1714
90. Rabelink T.J., and Luscher T.F. Endothelial nitric oxide synthase. Host defense enzyme of the endothelium?. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 267-271
91. Chen K., Thomas S.R., and Keaney Jr. J.F. Beyond LDL oxidation: ROS in vascular signal transduction. Free Radic. Biol. Med. 35 (2003) 117-132
92. Stocker R., and Keaney Jr. J.F. Role of oxidative modifications in atherosclerosis. Physiol. Rev. 84 (2004) 1381-1478
93. Touyz R.M., and Schiffrin E.L. Reactive oxygen species in vascular biology: implications in hypertension. Histochem. Cell Biol. 122 (2004) 339-352
94. Gorren A.C.F., List B.M., Schrammel A., Pitters E., Hemmens B., Werner E.R., Schmidt K., and Mayer B. Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites. Biochemistry 35 (1996) 16735-16745
95. Gorren A.C.F., Schrammel A., Schmidt K., and Mayer B. Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition, and enzyme stabilization. Biochemistry 36 (1997) 4360-4366
96. Alderton W.K., Boyhan A., and Lowe P.N. Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay. Biochem. J. 332 (1998) 195-201
97. Mayer B., Pfeiffer S., Schrammel A., Koesling D., Schmidt K., and Brunner F. A new pathway of nitric oxide/cyclic GMP signaling involving S-nitrosoglutathione. J. Biol. Chem. 273 (1998) 3264-3270
98. Schrammel A., Pfeiffer S., Schmidt K., Koesling D., and Mayer B. Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol. Pharmacol. 54 (1998) 207-212
99. 2•-. Free Radic. Biol. Med. 34 (2003) 1078-1088
100. Broillet M.-C. S-Nitrosylation of proteins. Cell. Mol. Life Sci. 55 (1999) 1036-1042
101. Mannick J.B., and Schonhoff C.M. Nitrosylation: the next phosphorylation?. Arch. Biochem. Biophys. 408 (2002) 1-6
102. Miersch S., and Mutus B. Protein S-nitrosation: biochemistry and characterization of protein thiol-NO interactions as cellular signals. Clin. Biochem. 38 (2005) 777-791
103. Foster M.W., and Stamler J.S. New insights into protein S-nitrosylation. Mitochondria as a model system. J. Biol. Chem. 279 (2004) 25891-25897
104. Yang Y., and Loscalzo J. S-Nitrosoprotein formation and localization in endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 117-122
105. Greco T.M., Hodara R., Parastatidis I., Heijnen H.F.G., Dennehy M.K., Liebler D.C., and Ischiropoulos H. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 7420-7425
106. Kim S.F., Huri D.A., and Snyder S.H. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310 (2005) 1966-1970
107. Torreilles J. Nitric oxide: one of the more conserved and widespread signaling molecules. Front. Biosci. 6 (2001) D1161-D1172
108. Scheinker V., Fiore G., Di Cristo C., Di Cosmo A., d'Ischia M., Enikolopov G., and Palumbo A. Nitric oxide synthase in the nervous system and ink gland of the cuttlefish Sepia officinalis: molecular cloning and expression. Biochem. Biophys. Res. Commun. 338 (2005) 1204-1215
109. Golderer G., Werner E.R., Leitner S., Gröbner P., and Werner-Felmayer G. Nitric oxide synthase is induced in sporulation of Physarum polycephalum. Genes Dev. 15 (2001) 1299-1309
110. Cutruzzolà F. Bacterial nitric oxide synthesis. Biochim. Biophys. Acta 1411 (1999) 231-249
111. Chen Y.J., and Rosazza J.P.N. A bacterial nitric oxide synthase from a Nocardia species. Biochem. Biophys. Res. Commun. 203 (1994) 1251-1258
112. Noc) from a Nocardia species. J. Bacteriol. 177 (1995) 5122-5128
113. Sari M.-A., Moali C., Boucher J.-L., Jaouen M., and Mansuy D. Detection of a nitric oxide synthase possibly involved in the regulation of the Rhodococcus sp R312 nitrile hydratase. Biochem. Biophys. Res. Commun. 250 (1998) 364-368
114. Choi D.W., Oh H.Y., Hong S.Y., Han J.W., and Lee H.W. Identification and characterization of nitric oxide synthase in Salmonella typhimurium. Arch. Pharm. Res. 23 (2000) 407-412
115. Hong I., Kim Y.K., Choi W.S., Seo D.W., Yoon J.W., Han J.-W., Lee H.Y., and Lee H.W. Purification and characterization of nitric oxide synthase from Staphylococcus aureus. FEMS Microbiol. Lett. 222 (2003) 177-182
116. Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., and Oesterhelt D. Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis. Genome Res. 15 (2005) 1336-1343
117. Adak S., Aulak K.S., and Stuehr D.J. Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis. J. Biol. Chem. 277 (2002) 16167-16171
118. Adak S., Bilwes A.M., Panda K., Hosfield D., Aulak K.S., McDonald J.F., Tainer J.A., Getzoff E.D., Crane B.R., and Stuehr D.J. Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 107-112
119. Bird L.E., Ren J., Zhang J., Foxwell N., Hawkins A.R., Charles I.G., and Stammers D.K. Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus. Structure 10 (2002) 1687-1696
120. Chartier F.J.M., and Couture M. Stability of the heme environment of the nitric oxide synthase from Staphylococcus aureus in the absence of pterin cofactor. Biophys. J. 87 (2004) 1939-1950
121. Wang Z.-Q., Wei C.-C., Sharma M., Pant K., Crane B.R., and Stuehr D.J. A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles. J. Biol. Chem. 279 (2004) 19018-19025
122. Kers J.A., Wach M.J., Krasnoff S.B., Widom J., Cameron K.D., Bukhalid R.A., Gibson D.M., Crane B.R., and Loria R. Nitration of a peptide phytotoxin by bacterial nitric oxide synthase. Nature 429 (2004) 79-82
123. Midha S., Mishra R., Aziz M.A., Sharma M., Mishra A., Khandelwal P., and Bhatnagar R. Cloning, expression, and characterization of recombinant nitric oxide synthase-like protein from Bacillus anthracis. Biochem. Biophys. Res. Commun. 336 (2005) 346-356
124. Pant K., Bilwes A.M., Adak S., Stuehr D.J., and Crane B.R. Structure of a nitric oxide synthase heme protein from Bacillus subtilis. Biochemistry 41 (2002) 11071-11079
125. Santolini J., Roman M., Stuehr D.J., and Mattioli T.A. Resonance Raman study of Bacillus subtilis NO synthase-like protein: similarities and differences with mammalian NO synthases. Biochemistry 45 (2006) 1480-1489
126. Pant K., and Crane B.R. Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation. Biochemistry 45 (2006) 2537-2544
127. Zemojtel T., Wade R.C., and Dandekar T. In search of the prototype of nitric oxide synthase. FEBS Lett. 554 (2003) 1-5
128. Buddha M.R., Tao T., Parry R.J., and Crane B.R. Regioselective nitration of tryptophan by a complex between bacterial nitric-oxide synthase and tryptophanyl-tRNA synthetase. J. Biol. Chem. 279 (2004) 49567-49570
129. Raman C.S., Li H., Martásek P., Southan G., Masters B.S.S., and Poulos T.L. Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism. Biochemistry 40 (2001) 13448-13455
130. Rosenfeld R.J., Garcin E.D., Panda K., Andersson G., Åberg A., Wallace A.V., Morris G.M., Olson A.J., Stuehr D.J., Tainer J.A., and Getzoff E.D. Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. Biochemistry 41 (2002) 13915-13925
131. Gorren A.C.F., Kungl A.J., Schmidt K., Werner E.R., and Mayer B. Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase. Nitric Oxide 5 (2001) 176-186