Nicotinic acetylcholine receptors: From basic science to therapeutics

Pharmacology and Therapeutics

Volumn 137, Issue 1, 2013, Pages 22-54

  Hurst, Raymond ^a   Rollema, Hans ^b   Bertrand, Daniel ^c  

^a PFIZER INC   (United States)

^b Rollema Biomedical Consulting   (United States)

^c HiQScreen   (Switzerland)

Author keywords

Distribution; Function; Nicotinic acetylcholine receptors; Pharmacology; Structure; Therapeutics

Indexed keywords

1,4 DIAZABICYCLO[3.2.2]NONANE 4 CARBOXYLIC ACID 4 BROMOPHENYL ESTER; 3 (2 AZETIDINYLMETHOXY)PYRIDINE; 3 METHYL 5 (1 METHYL 2 PYRROLIDINYL)ISOXAZOLE; ACETYLCHOLINE; ALPHA BUNGAROTOXIN; AMFEBUTAMONE; AMYLOID BETA PROTEIN; BUNGAROTOXIN RECEPTOR; CYTISINE; EPIBATIDINE; FLUORODEOXYGLUCOSE F 18; GLUTAMATE SENSITIVE CHLORIDE CHANNEL; GLUTAMIC ACID; MECAMYLAMINE; METHYLLYCACONITINE; MUSCARINE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA 1; NICOTINIC RECEPTOR ALPHA 10; NICOTINIC RECEPTOR ALPHA 3; NICOTINIC RECEPTOR ALPHA 4; NICOTINIC RECEPTOR ALPHA 5; NICOTINIC RECEPTOR ALPHA 9; NICOTINIC RECEPTOR BETA 1; NICOTINIC RECEPTOR BLOCKING AGENT; POZANICLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARENICLINE;

ADDICTION; ALCOHOL USE DISORDER; ALZHEIMER DISEASE; ARTICLE; ATTENTION DEFICIT DISORDER; BASAL GANGLION; BINDING AFFINITY; BINDING SITE; BRAIN ELECTROPHYSIOLOGY; BRAIN FUNCTION; CALCIUM CELL LEVEL; CAUDATE NUCLEUS; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CHEMICAL STRUCTURE; CHOLINERGIC NERVE CELL; CHROMOSOME 8P; CIRCADIAN RHYTHM; COGNITIVE DEFECT; DEPRESSION; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; ELECTROSTIMULATION; ENDOPLASMIC RETICULUM; ENTORHINAL CORTEX; FRONTAL CORTEX; GENE CLUSTER; GENE FUNCTION; GENE LOCATION; GENE STRUCTURE; GENETICS; GLOBUS PALLIDUS; HABENULA; HIPPOCAMPUS; HUMAN; HYDROPHOBICITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTERPEDUNCULAR NUCLEUS; LIGAND BINDING; MEDULLA OBLONGATA; MESENCEPHALON; NEUROMUSCULAR SYNAPSE; NEUROTRANSMISSION; NICOTINE REPLACEMENT THERAPY; NOCTURNAL SEIZURE; NONHUMAN; OCCIPITAL CORTEX; PAIN; PARIETAL CORTEX; PHARMACODYNAMICS; PHARMACOKINETICS; PHARMACOLOGY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PONS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PUTAMEN; RECEPTOR DOWN REGULATION; SCHIZOPHRENIA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMOKING; SMOKING CESSATION; SUBICULUM; SUPRACHIASMATIC NUCLEUS; SYNAPTIC TRANSMISSION; TEMPORAL CORTEX; THALAMUS; TOBACCO DEPENDENCE; UPREGULATION; WHITE MATTER;

EID: 84872295116     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.08.012     Document Type: Review

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