Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors

Molecular Pharmacology

Volumn 63, Issue 2, 2003, Pages 332-341

  Nelson, Mark E ^a   Kuryatov, Alexander ^a   Choi, Catherine H ^a   Zhou, Yan ^a   Lindstrom, Jon ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; METHIONINE; NICOTINE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; CHOLINERGIC RECEPTOR STIMULATING AGENT; PROTEIN SUBUNIT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STOICHIOMETRY; XENOPUS LAEVIS; CELL CULTURE; DRUG EFFECT; GENETICS; METABOLISM; TEMPERATURE;

CELLS, CULTURED; CHOLINERGIC AGONISTS; DNA, COMPLEMENTARY; HUMANS; PROTEIN SUBUNITS; RECEPTORS, NICOTINIC; TEMPERATURE; TRANSFECTION;

EID: 0037289747     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.2.332     Document Type: Article

References (39)

1. Anand R, Conroy WG, Schoepfer R, Whiting P, and Lindstrom J (1991) Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. J Biol Chem 266:11192-11198.
2. 3H]nicotine binding sites in human brain. J Neurochem 50:1243-1247.
3. Buisson B and Bertrand D (2001) Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function. J Neurosci 21:1819-1829.
4. Buisson B, Vallejo YF, Green WN, and Bertrand D (2000) The unusual nature of epibatidine responses at the α4β2 nicotinic acetylcholine receptor. Neuropharmacol 39, 2561-2569.
5. Butt CM, Hutton SR, Marks MJ, and Collins AC (2002) Bovine serum albumin enhances nicotinic acetylcholine receptor function in mouse thalamic synaptosomes. J Neurochem 83:48-56.
6. Chavez-Noriega LE, Crona JH, Washburn MS, Urrutia A, Elliott KJ, and Johnson EC (1997) Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 expressed in Xenopus oocytes. J Pharmacol Exp Ther 280:346-356.
7. Chavez-Noriega LE, Gillespie A, Stauderman KA, Crona JH, Claeps BO, Elliott KJ, Reid RT, Rao TS, Velicelebi G, Harpold MM, et al. (2000) Characterization of the recombinant human neuronal nicotinic acetylcholine receptors α3β2 and α4β2 stably expressed in HEK293 cells. Neuropharmacol. 39:2543-2560.
8. Cooper E, Couturier S, and Ballivet M (1991) Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature (Lond) 350:235-238.
9. Cooper ST, Harkness PC, Baker ER, and Millar NS (1999) Up-regulation of cell-surface α4β2 neuronal nicotinic receptors by lower temperature and expression of chimeric subunits. J Biol Chem 274:27145-52.
10. Dani JA (2001) Overview of nicotinic receptors and their roles in the central nervous system. Biol Psychiatry 49:166-174.
11. Fenster CP, Beckman ML, Parker JC, Sheffield EB, Whitworth TL, Quick MW, and Lester RA (1999) Regulation of α4β2 nicotinic receptor desensitization by calcium and protein kinase C. Mol Pharmacol 55:432-443.
12. 2+ modulation of human neuronal α3 nicotinic receptors. J Pharmacol Exp Ther 286:311-320.
13. Gopalakrishnan M, Monteggia LM, Anderson DJ, Molinari EJ, Piattoni-Kaplan M, Donnelly-Roberts D, Arneric SP, and Sullivan JP (1996) Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine α4β2 receptor. J Pharmacol Exp Ther 276:289-297.
14. Huganir RL, Delcour AH, Greengard P, and Hess GP (1986) Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature (Lond) 321:774-776.
15. Karlin A and Akabas MH (1995) Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron 15:1231-1244.
16. 2+ permeability, conductance and gating of human α4β2 nicotinic acetylcholine receptors. J Neurosci 17:9035-9047.
17. Kuryatov A, Olale FA, Choi C, and Lindstrom J (2000) Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation. Eur J Pharmacol 393:11-21.
18. Margiotta JF, Berg DK, and Dionne VE (1987) Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons. Proc Natl Acad Sci USA 84:8155-8159.
19. Marks MJ, Pauly JR, Gross SD, Deneris ES, Hermans-Borgmeyer I, Heinemann SF, and Collins AC (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci 12:2765-2784.
20. Marks MJ, Whiteaker P, Caleaterra J, Stitzel JA, Bullock AE, Grady SR, Picciotto MR, Changeux JP, and Collins AC (1999) Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the β2 subunit. J Pharmacol Exp Ther 289:1090-1103.
21. Marubio LM, del Mar Arroyo-Jimenez M, Cordero-Erausquin M, Lena C, Le Novere N, de Kerchove d'Exaerde A, Huchet M, Damaj MI, and Changeux JP (1999) Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature (Lond) 398:805-810.
22. Merlie JP and Lindstrom J (1983) Assembly in vivo of mouse muscle acetylcholine receptor: identification of an alpha subunit species that may be an assembly intermediate. Cell 34:747-757.
23. Nelson ME and Lindstrom J (1999) Single channel properties of human α3 AChRs: impact of β2, β4 and α5 subunits. J Physiol (Lond) 516:657-678.
24. Nelson ME, Wang F, Kuryatov A, Choi CH, Gerzanich V, and Lindstrom J (2001) Functional properties of human nicotinic AChRs expressed by IMR-32 neuroblastoma cells resemble those of α3β4 AChRs expressed in permanently transfected HEK cells. J Gen Physiol 118:563-582.
25. Papke RL and Heinemann SF (1994) Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Mol Pharmacol 45:142-149.
26. Peng X, Gerzanich V, Anand R, Whiting PJ, and Lindstrom J (1994) Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol Pharmacol 46:523-530.
27. Picciotto MR, Caldarone BJ, Brunzell DH, Zachariou V, Stevens TR, and King SL (2001) Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol Ther 92:89-108.
28. Picciotto MR, Zoli M, Rimondini R, Lena C, Marubio LM, Pich EM, Fuxe K, and Changeux JP (1998) Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine. Nature (Lond) 391:173-177.
29. Rusted JM, Newhouse PA, and Levin ED (2000) Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease. Behav Brain Res 113:121-129.
30. Sabey K, Paradiso K, Zhang J, and Steinbach JH (1999) Ligand binding and activation of rat nicotinic α4β2 receptors stably expressed in HEK293 cells. Mol Pharmacol 55:58-66.
31. Sanes JR and Lichtman JW (2001) Induction, assembly, maturation and maintenance of a postsynaptic apparatus. Nat Rev Neurosci 2:791-805.
32. Wang F, Nelson ME, Kuryatov A, Olale F, Cooper J, Keyser K, and Lindstrom J (1998) Chronic nicotine treatment up-regulates human α3β2, but not α3β4 AChRs stably transfected in human embryonic kidney cells. J Biol Chem 273:28721-28732.
33. Weiland S, Bertrand D, and Leonard S (2000) Neuronal nicotinic acetylcholine receptors: from the gene to the disease. Behav Brain Res 113:43-56.
34. Whiteaker P, Sharples CG, and Wonnacott S (1998) Agonist-induced up-regulation of α4β2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition. Mol Pharmacol 53:950-962.
35. Whiting P, Schoepfer R, Lindstrom J, and Priestley T (1991) Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts. Mol Pharmacol 40:463-472.
36. Wonnacott S (1990) The paradox of nicotinic acetylcholine receptor upregulation by nicotine. Trends Pharmacol Sci 11:216-219.
37. Wonnacott S (1997) Presynaptic nicotinic ACh receptors. Trends Neurosci 20:92-98.
38. Zoli M, Jansson A, Sykova E, Agnati LF, and Fuxe K (1999) Volume transmission in the CNS and its relevance for neuropsychopharmacology. Trends Pharmacol Sci 20:142-150.
39. Zwart R and Vijverberg HP (1998) Four pharmacologically distinct subtypes of α4β2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes. Mol Pharmacol 54:1124-1131.