Amyloid peptide Aβ1-42 binds selectively and with picomolar affinity to α7 nicotinic acetylcholine receptors

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 1155-1161

  Wang, Hoau Yan ^a   Lee, Daniel H S ^a   Davis, Coralie B ^a   Shank, Richard P ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

7 Nicotinic receptors; Alzheimer plaques; Alzheimer's disease; Amyloid peptides

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CHOLINERGIC RECEPTOR; ACONITINE; ALKALOID; ALPHA-BUNGAROTOXIN RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); AZOCINE DERIVATIVE; BUNGAROTOXIN RECEPTOR; CYTISINE; DRUG DERIVATIVE; METHYLLYCACONITINE; MUSCARINIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINE; NICOTINIC RECEPTOR; PEPTIDE FRAGMENT; QUINOLIZINE DERIVATIVE; TRITIUM;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHOLINERGIC NERVE CELL; ENDOPLASMIC RETICULUM; GUINEA PIG; LIGAND BINDING; NERVE DEGENERATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SYNAPTIC MEMBRANE; SYNAPTIC TRANSMISSION; ANIMAL; BINDING COMPETITION; DRUG ANTAGONISM; HIPPOCAMPUS; KINETICS; LONG EVANS RAT; MALE; METABOLISM; RADIOASSAY;

ACONITINE; ALKALOIDS; AMYLOID BETA-PROTEIN; ANIMALS; AZOCINES; BINDING, COMPETITIVE; CEREBRAL CORTEX; GUINEA PIGS; HIPPOCAMPUS; KINETICS; MALE; NICOTINE; PEPTIDE FRAGMENTS; QUINOLIZINES; RADIOLIGAND ASSAY; RATS; RATS, LONG-EVANS; RECEPTORS, MUSCARINIC; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NICOTINIC; SYNAPTIC MEMBRANES; TRITIUM;

EID: 0033624509     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751155.x     Document Type: Article

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