Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist

Pharmaceutica Acta Helvetiae

Volumn 74, Issue 2-3, 2000, Pages 125-130

  Cosford, Nicholas D P ^a   Bleicher, Leo ^a   Vernier, Jean Michel ^a   Chavez Noriega, Laura ^a   Rao, Tadimeti S ^a   Siegel, Robert S ^a   Suto, Carla ^a   Washburn, Mark ^a   Lloyd, G Kenneth ^a   McDonald, Ian A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Altinicline; Ca2+ flux; Cognitive deficits; Functional assays; nAChR subtypes; Nicotine; Nicotinic acetylcholine receptors; Parkinson's disease; Recombinant human receptors; SIB 1765F

Indexed keywords

3 ETHYNYL 5 (1 METHYL 2 PYRROLIDINYL)PYRIDINE; ALTINICLINE; EPIBATIDINE; ION CHANNEL; NICOTINE; NICOTINE DERIVATIVE; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; SIB 1663; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ANIMAL MODEL; ANIMAL TISSUE; BRAIN REGION; CALCIUM TRANSPORT; CELL LINE; CONFERENCE PAPER; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG DEVELOPMENT; DRUG RECEPTOR BINDING; IN VITRO STUDY; LOCOMOTION; MOLECULAR CLONING; MONKEY; MOUSE; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; RAT;

CALCIUM; DOPAMINE; HUMANS; ION CHANNEL GATING; ION CHANNELS; NICOTINIC AGONISTS; PYRIDINES; PYRROLIDINES; RECEPTORS, CHOLINERGIC; RECOMBINANT PROTEINS;

EID: 19244377299     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(99)00024-2     Document Type: Article

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