Human α6 AChR subtypes: Subunit composition, assembly, and pharmacological responses

Neuropharmacology

Volumn 39, Issue 13, 2000, Pages 2570-2590

  Kuryatov, A ^a   Olale, F ^a   Cooper, J ^a   Choi, C ^a   Lindstrom, J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

6 Subunits; Acetylcholine receptors; Nicotine; Nicotinic receptors

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; ACETYLCHOLINE; CHOLINERGIC RECEPTOR; CONOTOXIN; CYTISINE; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; DIAGNOSTIC AGENT; HYBRID PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY; NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA6; RADIOACTIVE IODINE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; HUMAN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; ELECTROPHYSIOLOGY; GENETICS; KINETICS; LEWIS RAT; METABOLISM; MOLECULAR CLONING; NERVE CELL; PATCH CLAMP; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CLONING, MOLECULAR; ELECTROPHYSIOLOGY; HUMANS; IODINE RADIOISOTOPES; KINETICS; NEURONS; NICOTINE; NICOTINIC AGONISTS; PATCH-CLAMP TECHNIQUES; RADIOIMMUNOASSAY; RATS; RATS, INBRED LEW; RECEPTORS, NICOTINIC; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0033626554     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00144-1     Document Type: Article

References (41)

1. Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure
2. Nucleotide sequence of the nicotinic acetylcholine receptor β2 subunit gene
3. Pharmacology of nicotine: addiction and therapeutics
4. Molecular and cellular aspects of nicotine abuse
5. Epitope mapping of antibodies to acetylcholine receptors
6. β3: A new member of nicotinic acetylcholine receptor gene family is expressed in brain
7. Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors
8. Formation of oligomers containing the β3 and β4 subunits of the rat nicotinic receptor
9. Asymmetric contribution to the conserved disulfide loop to subunit oligomerization and assembly of the nicotinic acetylcholine receptor
10. The neuronal α6 subunit forms functional heteromeric acetylcholine receptors in human transfected cells
11. 'Orphan' α6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor
12. ++ modulation of human neuronal α3 nicotinic receptors
13. Immunohisotochemical localization of the nicotinic acetylcholine receptor subunit α6 to dopaminergic neurons in the substantia nigra and ventral tegmental area
14. A reporter mutation approach shows incorporation of the 'orphan' subunit β3 into a functional nicotinic receptor
15. Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins
16. α-conotoxin MII blocks nicotine stimulated dopamine release in rat striatal synaptosomes
17. ++ permeability, conductance, and gating of human α4β2 nicotinic acetylcholine receptors
18. AChR extracellular domain determines sensitivity to nicotine-induced inactivation
19. Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons
20. Molecular evolution of the nicotinic acetylcholine receptor: an example of a multigene family in excitable cells
21. Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain
22. Involvement of α6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion
23. Neuronal nicotinic acetylcholine receptors
24. The structure of neuronal receptors
25. Acetylcholine receptors and myasthenia
26. Molecular and antigenic structure of nicotinic acetylcholine receptors
27. Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
28. Single channel properties of human α3 AChRs: impact of β2, β4, and α5 subunits
29. Chronic nicotine exposure differentially affects the function of human α3, α3, and α7 neuronal nicotinic receptor subtypes
30. Nicotine-induced upregulation of neuronal nicotinic receptors results from a decrease in the rate of turnover
31. Chronic nicotine treatment upregulates α3 and α7 acetylcholine receptor subtypes expressed by the human neuroblastoma cell line SH-SY5Y
32. Abnormal avoidance learning in mice lacking functional high affinity nicotine receptor in the brain
33. Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
34. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
35. Functional α6-containing nicotinic receptors are present in chick retina
36. β3 subunit is present in different nicotinic receptor subtypes in chick retina
37. Assembly of human neuronal nicotinic receptor α5 subunits with α3, β2, and β4 subunits
38. Assembly of the nicotinic acetylcholine receptor: the first transmembrane domains of truncated α and δ subunits are required for heterodimer formation in vivo
39. Chronic nicotine treatment upregulates human α3β2, but not α3β4 AChRs stably transfected in human embryonic kidney cells
40. Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies
41. Increased neurodegeneration during aging in mice lacking high-affinity nicotine receptors