-
1
-
-
0033964077
-
Neuronal nicotinic receptors in the human brain. Prog
-
Paterson, D.; Nordberg, A. Neuronal nicotinic receptors in the human brain. Prog. Neurobiol., 2000, 61, 75-111
-
(2000)
Neurobiol
, vol.61
, pp. 75-111
-
-
Paterson, D.1
Nordberg, A.2
-
2
-
-
0035899452
-
Selective dopamine filter of glutamate striatal afferents
-
Dani, J.A.; Ji, D.; Zhou, F.M. Selective dopamine filter of glutamate striatal afferents. Neuron, 2001, 31, 349-352
-
(2001)
Neuron
, vol.31
, pp. 349-352
-
-
Dani, J.A.1
Ji, D.2
Zhou, F.M.3
-
3
-
-
0242367566
-
Nicotinic acetylcholine receptors: From structure to brain function
-
Hogg, R.C.; Raggenbass, M.; Bertrand, D. Nicotinic acetylcholine receptors: from structure to brain function. Rev. Physiol. Biochem. Pharmacol., 2003, 147, 1-46
-
(2003)
Rev. Physiol. Biochem. Pharmacol
, vol.147
, pp. 1-46
-
-
Hogg, R.C.1
Raggenbass, M.2
Bertrand, D.3
-
4
-
-
2542486433
-
Nicotinic acetylcholine receptors and the regulation of neuronal signalling
-
Dajas-Bailador, F.; Wonnacott, S. Nicotinic acetylcholine receptors and the regulation of neuronal signalling. Trends Pharmacol. Sci., 2004, 25, 317-324
-
(2004)
Trends Pharmacol. Sci
, vol.25
, pp. 317-324
-
-
Dajas-Bailador, F.1
Wonnacott, S.2
-
5
-
-
0036499938
-
Nicotine addiction: The possible role of functional upregulation
-
Buisson, B.; Bertrand, D. Nicotine addiction: the possible role of functional upregulation. Trends Pharmacol. Sci., 2002, 23, 130-136
-
(2002)
Trends Pharmacol. Sci
, vol.23
, pp. 130-136
-
-
Buisson, B.1
Bertrand, D.2
-
6
-
-
0033626287
-
Role of 7 nicotinic receptors in nicotine dependence and implications for psychiatric illness
-
Nomikos, G.G.; Schilström, B.; Hildebrand, B.E.; Panagis, G.; Grenhoff, J.; Svensson, T.H. Role of 7 nicotinic receptors in nicotine dependence and implications for psychiatric illness. Behav. Brain Res., 2000, 113, 97-103
-
(2000)
Behav. Brain Res
, vol.113
, pp. 97-103
-
-
Nomikos, G.G.1
Schilström, B.2
Hildebrand, B.E.3
Panagis, G.4
Grenhoff, J.5
Svensson, T.H.6
-
7
-
-
0036019542
-
Nicotine addiction: Insights from recent animal studies
-
Mathieu-Kia, A.M.; Kellogg, S.H.; Butelman, E.R.; Kreek, M.J. Nicotine addiction: insights from recent animal studies. Psychopharmacology (Berl.), 2002, 162, 102-118
-
(2002)
Psychopharmacology (Berl.)
, vol.162
, pp. 102-118
-
-
Mathieu-Kia, A.M.1
Kellogg, S.H.2
Butelman, E.R.3
Kreek, M.J.4
-
8
-
-
0034017540
-
Nicotinic receptors in the brain. Links between molecular biology and behavior
-
Picciotto, M.R.; Caldarone, B.J.; King, S.L.; Zachariou, V. Nicotinic receptors in the brain. Links between molecular biology and behavior. Neuropsychopharmacology, 2000, 22, 451-465
-
(2000)
Neuropsychopharmacology
, vol.22
, pp. 451-465
-
-
Picciotto, M.R.1
Caldarone, B.J.2
King, S.L.3
Zachariou, V.4
-
9
-
-
0036582715
-
Neuronal systems underlying behaviors related to nicotine addiction: Neural circuits and molecular genetics
-
Picciotto, M.R.; Corrigall, W.A. Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. J. Neurosci., 2002, 22, 3338-3341
-
(2002)
J. Neurosci
, vol.22
, pp. 3338-3341
-
-
Picciotto, M.R.1
Corrigall, W.A.2
-
10
-
-
3142761435
-
Freedman, R. 7 nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia
-
Martin, L.F.; Kem, W.R.; Freedman, R. 7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology (Berl.), 2004, 174, 54-64
-
(2004)
Psychopharmacology (Berl.)
, vol.174
, pp. 54-64
-
-
Martin, L.F.1
Kem, W.R.2
-
11
-
-
0742288775
-
Effects of nicotinic stimulation on cognitive performance
-
Newhouse, P.A.; Potter, A.; Singh, A. Effects of nicotinic stimulation on cognitive performance. Curr. Opin. Pharmacol., 2004, 4, 36-46
-
(2004)
Curr. Opin. Pharmacol
, vol.4
, pp. 36-46
-
-
Newhouse, P.A.1
Potter, A.2
Singh, A.3
-
12
-
-
0029979162
-
Pharmacology of nicotine: Addiction and therapeutics
-
Benowitx, N.L. Pharmacology of nicotine: addiction and therapeutics. Ann. Rev. Pharmacol. Toxicol., 1996, 36, 597-613
-
(1996)
Ann. Rev. Pharmacol. Toxicol
, vol.36
, pp. 597-613
-
-
Benowitx, N.L.1
-
13
-
-
0031450275
-
Neuronal nicotinic acetylcholine receptors as targets for drug discovery
-
Holladay, M.W.; Dart, M.J.; Lynch, J.K. Neuronal nicotinic acetylcholine receptors as targets for drug discovery. J. Med. Chem., 1997, 40, 4169-4194
-
(1997)
J. Med. Chem
, vol.40
, pp. 4169-4194
-
-
Holladay, M.W.1
Dart, M.J.2
Lynch, J.K.3
-
14
-
-
0343131930
-
Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders
-
Léna, C.; Changeux, J.P. Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders. Curr. Opin. Neurobiol., 1997, 7, 674-682
-
(1997)
Curr. Opin. Neurobiol
, vol.7
, pp. 674-682
-
-
Léna, C.1
Changeux, J.P.2
-
15
-
-
0033780434
-
Multiple central nervous system targets for eliciting beneficial effects on memory and cognition
-
Buccafusco, J.J.; Terry, A.V. Multiple central nervous system targets for eliciting beneficial effects on memory and cognition. J. Pharmacol. Exp. Ther., 2000, 295, 438-446
-
(2000)
J. Pharmacol. Exp. Ther
, vol.295
, pp. 438-446
-
-
Buccafusco, J.J.1
Terry, A.V.2
-
16
-
-
0030769188
-
Human neuronal nicotinic receptors
-
Gotti, C.; Fornasari, D.; Clementi, F. Human neuronal nicotinic receptors. Prog. Neurobiol., 1997, 53, 199-237
-
(1997)
Prog. Neurobiol
, vol.53
, pp. 199-237
-
-
Gotti, C.1
Fornasari, D.2
Clementi, F.3
-
17
-
-
0033846304
-
Drugs selective for nicotinic receptor subtypes: A real possibility or a dream?
-
Gotti, C.; Carbonnelle, E.; Moretti, M.; Zwart, R.; Clementi, F. Drugs selective for nicotinic receptor subtypes: a real possibility or a dream? Behav. Brain Res., 2000, 113, 183-192
-
(2000)
Behav. Brain Res
, vol.113
, pp. 183-192
-
-
Gotti, C.1
Carbonnelle, E.2
Moretti, M.3
Zwart, R.4
Clementi, F.5
-
18
-
-
0033960085
-
Neuronal nicotinic acetylcholine receptors as novel drug targets
-
Lloyd, G.K.; Williams, M. Neuronal nicotinic acetylcholine receptors as novel drug targets. J. Pharmacol. Exp. Ther., 2000, 292, 461-467
-
(2000)
J. Pharmacol. Exp. Ther
, vol.292
, pp. 461-467
-
-
Lloyd, G.K.1
Williams, M.2
-
19
-
-
0034924993
-
Competitive neuronal nicotinic receptor antagonists: A new direction for drug discovery
-
Dwoskin, L.P.; Crooks, P.A. Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery. J. Pharmacol. Exp. Ther., 2001, 298, 395-402
-
(2001)
J. Pharmacol. Exp. Ther
, vol.298
, pp. 395-402
-
-
Dwoskin, L.P.1
Crooks, P.A.2
-
20
-
-
0033927801
-
Exploring the nature of molecular recognition in nicotinic acetylcholine receptors
-
Schmitt, J.D. Exploring the nature of molecular recognition in nicotinic acetylcholine receptors. Curr. Med. Chem., 2000, 7, 749-800
-
(2000)
Curr. Med. Chem
, vol.7
, pp. 749-800
-
-
Schmitt, J.D.1
-
21
-
-
0036890828
-
Nicotinic receptor subtypes and cognitive function
-
Levin, E.D. Nicotinic receptor subtypes and cognitive function. J. Neurobiol., 2002, 53, 633-640
-
(2002)
J. Neurobiol
, vol.53
, pp. 633-640
-
-
Levin, E.D.1
-
23
-
-
23844439286
-
7 Nicotinic receptor agonists as potential therapeutic drugs for schizophrenia
-
Hashimoto, K.; Koike, K.; Shimizu, E.; Iyo, M. 7 Nicotinic receptor agonists as potential therapeutic drugs for schizophrenia. Curr. Med. Chem. CNS Agents, 2005, 5, 171-184
-
(2005)
Curr. Med. Chem. CNS Agents
, vol.5
, pp. 171-184
-
-
Hashimoto, K.1
Koike, K.2
Shimizu, E.3
Iyo, M.4
-
24
-
-
0026593533
-
A subtype of nicotinic cholinergic receptor in rat brain is composed of 4 and 2 subunits and is up-regulated by chronic nicotine treatment
-
Flores, C.M.; Rogers, S.W.; Pabreza, L.A.; Wolfe, B.B.; Kellar, K.J. A subtype of nicotinic cholinergic receptor in rat brain is composed of 4 and 2 subunits and is up-regulated by chronic nicotine treatment. Mol. Pharmacol., 1992, 41, 31-37
-
(1992)
Mol. Pharmacol
, vol.41
, pp. 31-37
-
-
Flores, C.M.1
Rogers, S.W.2
Pabreza, L.A.3
Wolfe, B.B.4
Kellar, K.J.5
-
25
-
-
0020406964
-
Characterization of nicotine binding in mouse brain and comparison with the binding of -bungarotoxin and quinuclidinyl benzilate
-
Marks, M.J.; Collins, A.C. Characterization of nicotine binding in mouse brain and comparison with the binding of -bungarotoxin and quinuclidinyl benzilate. Mol. Pharmacol., 1982, 22, 554-564
-
(1982)
Mol. Pharmacol
, vol.22
, pp. 554-564
-
-
Marks, M.J.1
Collins, A.C.2
-
26
-
-
0032589578
-
The 7 nicotinic acetylcholine receptor in neuronal plasticity
-
Broide, R.S.; Leslie, F.M. The 7 nicotinic acetylcholine receptor in neuronal plasticity. Mol. Neurobiol., 1999, 20, 1-16
-
(1999)
Mol. Neurobiol
, vol.20
, pp. 1-16
-
-
Broide, R.S.1
Leslie, F.M.2
-
27
-
-
0033485390
-
Nicotinic receptors in the brain: Correlating physiology with function
-
Jones, S.; Sudweeks, S.; Yakel, J.L. Nicotinic receptors in the brain: correlating physiology with function. Trends Neurosci., 1999, 22, 555-561
-
(1999)
Trends Neurosci
, vol.22
, pp. 555-561
-
-
Jones, S.1
Sudweeks, S.2
Yakel, J.L.3
-
28
-
-
0034214261
-
Nicotinic receptor function: New perspectives from knockout mice
-
Cordero-Erausquin, M.; Marubio, L.M.; Klink, R.; Changeux, J.P. Nicotinic receptor function: new perspectives from knockout mice. Trends Pharamacol. Sci., 2000, 21, 211-217
-
(2000)
Trends Pharamacol. Sci
, vol.21
, pp. 211-217
-
-
Cordero-Erausquin, M.1
Marubio, L.M.2
Klink, R.3
Changeux, J.P.4
-
29
-
-
0035726679
-
Neuronal nicotinic acetylcholine receptor subunit knockout mice: Physiological and behavioral phenotypes and possible clinical implications
-
Picciotto, M.R.; Caldarone, B.J.; Brunzall, D.H.; Zachariou, V.; Stevens, T.R.; King, S.L. Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol. Ther., 2001, 92, 89-108
-
(2001)
Pharmacol. Ther
, vol.92
, pp. 89-108
-
-
Picciotto, M.R.1
Caldarone, B.J.2
Brunzall, D.H.3
Zachariou, V.4
Stevens, T.R.5
King, S.L.6
-
30
-
-
0344441256
-
Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system
-
Champtiaux, N.; Changeux, J.P. Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system. Prog. Brain Res., 2004, 145, 235-251
-
(2004)
Prog. Brain Res
, vol.145
, pp. 235-251
-
-
Champtiaux, N.1
Changeux, J.P.2
-
31
-
-
0030576581
-
An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the 7 subtype
-
Papke, R.L.; Bencherif, M.; Lippiello, P. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the 7 subtype. Neurosci. Lett., 1996, 213, 201-204
-
(1996)
Neurosci. Lett
, vol.213
, pp. 201-204
-
-
Papke, R.L.1
Bencherif, M.2
Lippiello, P.3
-
32
-
-
0031410384
-
Choline is a selective agonist of 7 nicotinic acetylcholine receptors in the rat brain neurons
-
Alkondon, M.; Pereira, E.F.R.; Cortes, W.S.; Maelicke, A.; Albuquerque, E.X. Choline is a selective agonist of 7 nicotinic acetylcholine receptors in the rat brain neurons. Eur. J. Neurosci., 1997, 9, 2734-2742
-
(1997)
Eur. J. Neurosci
, vol.9
, pp. 2734-2742
-
-
Alkondon, M.1
Pereira, E.F.R.2
Cortes, W.S.3
Maelicke, A.4
Albuquerque, E.X.5
-
33
-
-
0032105398
-
Contribution of nicotinic receptors to the function of synapses in the central nervous system: The action of choline as a selective agonist of 7 receptors
-
Alkondon, M.; Pereira, E.F.R.; Braga, M.F.M.; Albuquerque, E.X. Contribution of nicotinic receptors to the function of synapses in the central nervous system: the action of choline as a selective agonist of 7 receptors. J. Physiol.(Paris), 1998, 92, 309-316
-
(1998)
J. Physiol.(Paris)
, vol.92
, pp. 309-316
-
-
Alkondon, M.1
Pereira, E.F.R.2
Braga, M.F.M.3
Albuquerque, E.X.4
-
34
-
-
0037387521
-
Regulation of neuronal function by choline and 4OH-GTS-21 through 7 nicotinic receptors
-
Uteshev, V.V.; Meyer, E.M.; Papke, R.L. Regulation of neuronal function by choline and 4OH-GTS-21 through 7 nicotinic receptors. J. Neurophysiol., 2003, 89, 1797-1806
-
(2003)
J. Neurophysiol
, vol.89
, pp. 1797-1806
-
-
Uteshev, V.V.1
Meyer, E.M.2
Papke, R.L.3
-
35
-
-
0036890808
-
Nicotinic 7 receptors: Synaptic options and downstream signaling in neurons
-
Berg, D.K.; Conroy, W.G. Nicotinic 7 receptors: synaptic options and downstream signaling in neurons. J. Neurobiol., 2002, 53, 512-523
-
(2002)
J. Neurobiol
, vol.53
, pp. 512-523
-
-
Berg, D.K.1
Conroy, W.G.2
-
36
-
-
0029805769
-
Hippocampal synaptic transmission enhanced by low concentrations of nicotine
-
Gray, R.; Rajan, A.S.; Radcliffe, K.A.; Yakehiro, M.; Dani, J.A. Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature, 1996, 383, 713-716
-
(1996)
Nature
, vol.383
, pp. 713-716
-
-
Gray, R.1
Rajan, A.S.2
Radcliffe, K.A.3
Yakehiro, M.4
Dani, J.A.5
-
37
-
-
21244442890
-
Dysfunction of glia-neuron communication in pathophysiology of schizophrenia
-
Hashimoto, K.; Shimizu, E.; Iyo, M. Dysfunction of glia-neuron communication in pathophysiology of schizophrenia. Curr. Psychiatry Rev., 2005, 1, 151-163
-
(2005)
Curr. Psychiatry Rev
, vol.1
, pp. 151-163
-
-
Hashimoto, K.1
Shimizu, E.2
Iyo, M.3
-
38
-
-
52449099589
-
Candidate Gene and Models. 4. Neurotransmission
-
Sawa, A., McInnis, M.G., Eds.; Informa Healthcare: New York
-
Hashimoto, K.; Hattori, E. Part II. Candidate Gene and Models. 4. Neurotransmission. In: Neurogenetics of Psychiatric Disorders. Sawa, A., McInnis, M.G., Eds.; Informa Healthcare: New York, 2007, pp. 81-100
-
(2007)
Neurogenetics of Psychiatric Disorders
, pp. 81-100
-
-
Hashimoto, K.1
Hattori, E.2
Part, I.I.3
-
39
-
-
0036197258
-
Amyloid cascade hypothesis of Alzheimer's disease and 7 nicotinic receptor
-
Hashimoto, K.; Iyo, M. Amyloid cascade hypothesis of Alzheimer's disease and 7 nicotinic receptor. Nihon Shinkei Seishin Yakurigaku Zasshi 2002, 22, 3-13
-
(2002)
Nihon Shinkei Seishin Yakurigaku Zasshi
, vol.22
, pp. 3-13
-
-
Hashimoto, K.1
Iyo, M.2
-
40
-
-
0038244830
-
Nicotinic receptors and Alzheimer's disease
-
Bourin, M.; Ripoll, N.; Dailly, E. Nicotinic receptors and Alzheimer's disease. Curr. Med. Res. Opin., 2003, 19, 169-177
-
(2003)
Curr. Med. Res. Opin
, vol.19
, pp. 169-177
-
-
Bourin, M.1
Ripoll, N.2
Dailly, E.3
-
41
-
-
33645319504
-
Targeting the 7 nicotinic acetylcholine receptor to reduce amyloid accumulation in Alzheimer's disease pyramidal neurons
-
D'Andrea, M.R.; Nagele, R.G. Targeting the 7 nicotinic acetylcholine receptor to reduce amyloid accumulation in Alzheimer's disease pyramidal neurons. Curr. Pharm. Des., 2006, 12, 677-684
-
(2006)
Curr. Pharm. Des
, vol.12
, pp. 677-684
-
-
D'andrea, M.R.1
Nagele, R.G.2
-
42
-
-
0023942243
-
125I]bungarotoxin and [3H]nicotine
-
125I]bungarotoxin and [3H]nicotine. Acta Physiol. Scand., 1988, 132, 1-14
-
(1988)
Acta Physiol. Scand
, vol.132
, pp. 1-14
-
-
Härfstrand, A.1
Adem, A.2
Fuxe, K.3
Agnati, L.4
Andersson, K.5
Nordberg, A.6
-
43
-
-
0027404595
-
Olson, L. -Bungarotoxin binding to hippocampal interneurons: Immunocytochemical characterization and effects on growth factor expression
-
Freedman, R.; Wetmore, C.; Strömberg, I.; Leonard, S.; Olson, L. -Bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression. J. Neurosci., 1993, 13, 1965-1975
-
(1993)
J. Neurosci
, vol.13
, pp. 1965-1975
-
-
Freedman, R.1
Wetmore, C.2
Strömberg, I.3
Leonard, S.4
-
44
-
-
0028029650
-
Schizophrenia and nicotinic receptors
-
Freedman, R.; Adler, L.E.; Bickford, P.; Byerley, W.; Coon, H.; Cullum, C.M.; Griffith, J.; Harris, J.G.; Leonard, S.; Miller, C.; Myles-Worsey, M.; Nagamoto, H.T.; Rose, G.; Waldo, M. Schizophrenia and nicotinic receptors. Harv. Rev. Psychiatry, 1994, 2, 179-192
-
(1994)
Harv. Rev. Psychiatry
, vol.2
, pp. 179-192
-
-
Freedman, R.1
Adler, L.E.2
Bickford, P.3
Byerley, W.4
Coon, H.5
Cullum, C.M.6
Griffith, J.7
Harris, J.G.8
Leonard, S.9
Miller, C.10
Myles-Worsey, M.11
Nagamoto, H.T.12
Rose, G.13
Waldo, M.14
-
45
-
-
0029085870
-
Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia
-
Freedman, R.; Hall, M.; Adler, L.E.; Leonard, S. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol. Psychiatry, 1995, 38, 22-33
-
(1995)
Biol. Psychiatry
, vol.38
, pp. 22-33
-
-
Freedman, R.1
Hall, M.2
Adler, L.E.3
Leonard, S.4
-
46
-
-
0032872325
-
Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: -bungarotoxin and nicotine binding in the thalamus
-
Court, J.; Spurden, D.; Lloyd, S.; McKeith, I.; Ballard, C.; Cairns, N.; Kerwin, R.; Perry, R.; Perry, E. Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: -bungarotoxin and nicotine binding in the thalamus. J. Neurochem., 1999, 73, 1590-1597
-
(1999)
J. Neurochem
, vol.73
, pp. 1590-1597
-
-
Court, J.1
Spurden, D.2
Lloyd, S.3
McKeith, I.4
Ballard, C.5
Cairns, N.6
Kerwin, R.7
Perry, R.8
Perry, E.9
-
47
-
-
0033519564
-
Decreased protein level of nicotinic receptor 7 subunit in the frontal cortex from schizophrenic brain
-
Guan, Z.Z.; Zhang, X.; Blennow, K.; Nordberg, A. Decreased protein level of nicotinic receptor 7 subunit in the frontal cortex from schizophrenic brain. Neuroreport, 1999, 10, 1779-1782
-
(1999)
Neuroreport
, vol.10
, pp. 1779-1782
-
-
Guan, Z.Z.1
Zhang, X.2
Blennow, K.3
Nordberg, A.4
-
48
-
-
0034945151
-
Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia
-
Marutle, A.; Zhang, X.; Court, J.; Piggott, M.; Johnson, M.; Perry, R.; Perry, E.; Nordberg, A. Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia. J. Chem. Neuroanat., 2001, 22, 115-126
-
(2001)
J. Chem. Neuroanat
, vol.22
, pp. 115-126
-
-
Marutle, A.1
Zhang, X.2
Court, J.3
Piggott, M.4
Johnson, M.5
Perry, R.6
Perry, E.7
Nordberg, A.8
-
49
-
-
0342596099
-
Nicotinic receptor function in schizophrenia
-
Leonard, S.; Adams, C.; Breese, C.R.; Adler, L.E.; Bickford, P.; Byerley, W.; Coon, H.; Griffith, J.M.; Miller, C.; Myles-Worsley, M.; Nagamoto, H.T.; Rollins, Y.; Stevens, K.E.; Waldo, M.; Freedman, R. Nicotinic receptor function in schizophrenia. Schizophr. Bull., 1996, 22, 431-445
-
(1996)
Schizophr. Bull
, vol.22
, pp. 431-445
-
-
Leonard, S.1
Adams, C.2
Breese, C.R.3
Adler, L.E.4
Bickford, P.5
Byerley, W.6
Coon, H.7
Griffith, J.M.8
Miller, C.9
Myles-Worsley, M.10
Nagamoto, H.T.11
Rollins, Y.12
Stevens, K.E.13
Waldo, M.14
Freedman, R.15
-
50
-
-
0034351614
-
The 7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia
-
Freedman, R.; Adams, C.E.; Leonard, S. The 7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia. J. Chem. Neuroanat., 2000, 20, 299-306
-
(2000)
J. Chem. Neuroanat
, vol.20
, pp. 299-306
-
-
Freedman, R.1
Adams, C.E.2
Leonard, S.3
-
51
-
-
1842799731
-
The 7 nicotinic acetylcholine receptor in schizophrenia: Decreased mRNA levels in peripheral blood lymphocytes
-
Perl, O.; Ilani, T.; Strous, R.D.; Lapidus, R.; Fuchs, S. The 7 nicotinic acetylcholine receptor in schizophrenia: decreased mRNA levels in peripheral blood lymphocytes. FASEB J., 2003, 17, 1948-1950
-
(2003)
FASEB J
, vol.17
, pp. 1948-1950
-
-
Perl, O.1
Ilani, T.2
Strous, R.D.3
Lapidus, R.4
Fuchs, S.5
-
52
-
-
0025190458
-
Sensorimotor gating and schizophrenia. Human and animal model studies. Arch. Gen
-
Braff, D.L.; Geyer, M.A. Sensorimotor gating and schizophrenia. Human and animal model studies. Arch. Gen. Psychiatry, 1990, 47, 181-188
-
(1990)
Psychiatry
, vol.47
, pp. 181-188
-
-
Braff, D.L.1
Geyer, M.A.2
-
53
-
-
0031751031
-
Schizophrenia, sensory gating, and nicotinic receptors
-
Adler, L.E.; Olincy, A.; Waldo, M.; Harris, J.G.; Giffith, J.; Stevens, K.; Flach, K.; Nagamoto, H.; Bickford, P.; Leonard, S.; Freedman, R. Schizophrenia, sensory gating, and nicotinic receptors. Schizophr. Bull., 1998, 24, 189-202
-
(1998)
Schizophr. Bull
, vol.24
, pp. 189-202
-
-
Adler, L.E.1
Olincy, A.2
Waldo, M.3
Harris, J.G.4
Giffith, J.5
Stevens, K.6
Flach, K.7
Nagamoto, H.8
Bickford, P.9
Leonard, S.10
Freedman, R.11
-
54
-
-
0002861128
-
Neuropsychopharmacology
-
In: , Davis. K.L., Charney, D., Coyle, J.T., Nemeroff, C.N., Eds., Philadelphia, PA
-
Braff, D.; Freedman, R. Neuropsychopharmacology, In: The Fifth Generation of Progress; Davis. K.L., Charney, D., Coyle, J.T., Nemeroff, C.N., Eds.; Lippincott Williams & Wilkins: Philadelphia, PA, 2003; pp. 703-716
-
(2003)
The Fifth Generation of Progress
, pp. 703-716
-
-
Braff, D.1
Freedman, R.2
-
55
-
-
0023551453
-
Neurobiological studies of sensory gating in schizophrenia
-
Freedman, R.; Adler, L.E.; Gerhardt, G.A.; Waldo, M.; Baker, N.; Rose, G.M.; Drebing, C.; Nagamoto, H.; Bickford-Wimer, P.; Franks, R. Neurobiological studies of sensory gating in schizophrenia. Schizophr. Bull., 1987, 13, 669-678
-
(1987)
Schizophr. Bull
, vol.13
, pp. 669-678
-
-
Freedman, R.1
Adler, L.E.2
Gerhardt, G.A.3
Waldo, M.4
Baker, N.5
Rose, G.M.6
Drebing, C.7
Nagamoto, H.8
Bickford-Wimer, P.9
Franks, R.10
-
56
-
-
0026472046
-
Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics
-
Adler, L.E.; Hoffer, L.J.; Griffith, J.; Waldo, M.C.; Freedman, R. Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics. Biol. Psychiatry, 1992, 32, 607-616
-
(1992)
Biol. Psychiatry
, vol.32
, pp. 607-616
-
-
Adler, L.E.1
Hoffer, L.J.2
Griffith, J.3
Waldo, M.C.4
Freedman, R.5
-
57
-
-
0027380988
-
Normalization of auditory physiology by cigarette smoking in schizophrenic patients
-
Adler, L.E.; Hoffer, L.J.; Wiser, A.; Freedman, R. Normalization of auditory physiology by cigarette smoking in schizophrenic patients. Am. J. Psychiatry, 1993, 150, 1856-1861
-
(1993)
Am. J. Psychiatry
, vol.150
, pp. 1856-1861
-
-
Adler, L.E.1
Hoffer, L.J.2
Wiser, A.3
Freedman, R.4
-
58
-
-
12644303225
-
Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
-
Freedman, R.; Coon, H.; Myles-Worsley, M.; Orr-Urtreger, A.; Olincy, A.; Davis, A.; Polymeropoulos, M.; Holik, J.; Hopkins, J.; Hoff, M.; Rosenthal, J.; Waldo, M.C.; Reimherr, F.; Wender, P.; Yaw, J.; Young, D.A.; Breese, C.R.; Adams, C.; Patterson, D.; Adler, L.E.; Kruglyak, L.; Leonard, S.; Byerley, W. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc. Natl. Acad. Sci. USA, 1997, 94, 587-592
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 587-592
-
-
Freedman, R.1
Coon, H.2
Myles-Worsley, M.3
Orr-Urtreger, A.4
Olincy, A.5
Davis, A.6
Polymeropoulos, M.7
Holik, J.8
Hopkins, J.9
Hoff, M.10
Rosenthal, J.11
Waldo, M.C.12
Reimherr, F.13
Wender, P.14
Yaw, J.15
Young, D.A.16
Breese, C.R.17
Adams, C.18
Patterson, D.19
Adler, L.E.20
Kruglyak, L.21
Leonard, S.22
Byerley, W.23
more..
-
59
-
-
0032503891
-
NIMH genetics initiative millenium schizophrenia consortium: Linkage analysis of African-American pedigrees
-
Kaufmann, C.A.; Suarez, B.; Malaspina, D.; Pepple, J.; Svrakic, D.; Markel, P.D.; Meyer, J.; Zambuto, C.T.; Schmitt, K.; Matise, T.C.; Harkavy Friedman, J.M.; Hampe, C.; Lee, H.; Shore, D.; Wynne, D.; Faraone, S.V.; Tsuang, M.T.; Cloninger, C.R. NIMH genetics initiative millenium schizophrenia consortium: linkage analysis of African-American pedigrees. Am. J. Med. Genet., 1998, 81, 282-289
-
(1998)
Am. J. Med. Genet
, vol.81
, pp. 282-289
-
-
Kaufmann, C.A.1
Suarez, B.2
Malaspina, D.3
Pepple, J.4
Svrakic, D.5
Markel, P.D.6
Meyer, J.7
Zambuto, C.T.8
Schmitt, K.9
Matise, T.C.10
Harkavy Friedman, J.M.11
Hampe, C.12
Lee, H.13
Shore, D.14
Wynne, D.15
Faraone, S.V.16
Tsuang, M.T.17
Cloninger, C.R.18
-
60
-
-
0032503911
-
Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH genetics initiative
-
Leonard, S.; Gault, J.; Moore, T.; Hopkins, J.; Robinson, M.; Olincy, A.; Adler, L.E.; Cloninger, C.R.; Kaufmann, C.A.; Tsuang, M.T.; Faraone, S.V.; Malaspina, D.; Svrakic, D.M.; Freedman, R. Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH genetics initiative. Am. J. Med. Genet., 1998, 81, 308-312
-
(1998)
Am. J. Med. Genet
, vol.81
, pp. 308-312
-
-
Leonard, S.1
Gault, J.2
Moore, T.3
Hopkins, J.4
Robinson, M.5
Olincy, A.6
Adler, L.E.7
Cloninger, C.R.8
Kaufmann, C.A.9
Tsuang, M.T.10
Faraone, S.V.11
Malaspina, D.12
Svrakic, D.M.13
Freedman, R.14
-
61
-
-
0032168029
-
Genomic organization and partial duplication of the human 7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)
-
Gault, J.; Robinson, M.; Berger, R.; Drebing, C.; Logel, J.; Hopkins, J.; Moore, T.; Jacobs, S.; Meriwether, J.; Choi, M.J.; Kim, E.J.; Walton, K.; Buiting, K.; Davis, A.; Breese, C.; Freedman, R.; Leonard, S. Genomic organization and partial duplication of the human 7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics, 1998, 52, 173-185
-
(1998)
Genomics
, vol.52
, pp. 173-185
-
-
Gault, J.1
Robinson, M.2
Berger, R.3
Drebing, C.4
Logel, J.5
Hopkins, J.6
Moore, T.7
Jacobs, S.8
Meriwether, J.9
Choi, M.J.10
Kim, E.J.11
Walton, K.12
Buiting, K.13
Davis, A.14
Breese, C.15
Freedman, R.16
Leonard, S.17
-
62
-
-
0036897309
-
Association of promoter variants in the 7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia
-
Leonard, S.; Gault, J.; Hopkins, J.; Logel, J.; Vianzon, R.; Short, M.; Drebing, C.; Berger, R.; Venn, D.; Sirota, P.; Zerbe, G.; Olincy, A.; Ross, R.G.; Adler, L.E.; Freedman, R. Association of promoter variants in the 7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch. Gen. Psychiatry, 2002, 59, 1085-1096
-
(2002)
Arch. Gen. Psychiatry
, vol.59
, pp. 1085-1096
-
-
Leonard, S.1
Gault, J.2
Hopkins, J.3
Logel, J.4
Vianzon, R.5
Short, M.6
Drebing, C.7
Berger, R.8
Venn, D.9
Sirota, P.10
Zerbe, G.11
Olincy, A.12
Ross, R.G.13
Adler, L.E.14
Freedman, R.15
-
63
-
-
3242813711
-
Evidence of association between smoking and 7 nicotinic receptor subunit gene in schizophrenia patients
-
De Luca, V.; Wong, A.H.C.; Muller, D.J.; Wong, G.W.H.; Tyndale, R.F.; Kennedy, J.L. Evidence of association between smoking and 7 nicotinic receptor subunit gene in schizophrenia patients. Neuropsychopharmacology, 2004, 29, 1522-1526
-
(2004)
Neuropsychopharmacology
, vol.29
, pp. 1522-1526
-
-
de Luca, V.1
Wong, A.H.C.2
Muller, D.J.3
Wong, G.W.H.4
Tyndale, R.F.5
Kennedy, J.L.6
-
64
-
-
33645344938
-
Nicotinic agonists and psychosis
-
Simosky, J.K.; Stevens, K.E.; Freedman, R. Nicotinic agonists and psychosis. Curr. Drug Targets CNS Neurol. Disord., 2002, 1, 433-442
-
(2002)
Curr. Drug Targets CNS Neurol. Disord
, vol.1
, pp. 433-442
-
-
Simosky, J.K.1
Stevens, K.E.2
Freedman, R.3
-
65
-
-
0141928543
-
Consequences of low levels of nicotinic acetylcholine receptors in schizophrenia for drug development
-
Leonard, S. Consequences of low levels of nicotinic acetylcholine receptors in schizophrenia for drug development. Drug Dev. Res., 2003, 60, 127-136
-
(2003)
Drug Dev. Res
, vol.60
, pp. 127-136
-
-
Leonard, S.1
-
66
-
-
33646187016
-
Characterization of allelic variants at chromosome 15q14 in schizophrenia
-
Freedman, R.; Leonard, S.; Waldo, M.; Gault, J.; Olincy, A.; Adler, L.E. Characterization of allelic variants at chromosome 15q14 in schizophrenia. Genes Brain Behav., 2006, 5 (Suppl 1), 14-22
-
(2006)
Genes Brain Behav
, vol.5
, Issue.SUPPL. 1
, pp. 14-22
-
-
Freedman, R.1
Leonard, S.2
Waldo, M.3
Gault, J.4
Olincy, A.5
Adler, L.E.6
-
67
-
-
35948986314
-
Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: Interactions with tobacco and cannabis use
-
Zammit, S.; Spurlock, G.; Williams, H.; Norton, N.; Williams, N.; O'Donovan, M.C.; Owen, M.J. Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. Br. J. Psychiatry, 2007, 191, 402-407
-
(2007)
Br. J. Psychiatry
, vol.191
, pp. 402-407
-
-
Zammit, S.1
Spurlock, G.2
Williams, H.3
Norton, N.4
Williams, N.5
O'Donovan, M.C.6
Owen, M.J.7
-
68
-
-
33749458682
-
Episodic memory performance predicted by the 2bp deletion in exon 6 of the alpha 7-like nicotinic receptor subunit gene
-
Dempster, E.L.; Toulopoulou, T.; McDonald, C.; Bramon, E.; Walshe, M.; Wickham, H.; Sham, P.C.; Murray, R.M.; Collier, D.A. Episodic memory performance predicted by the 2bp deletion in exon 6 of the alpha 7-like nicotinic receptor subunit gene. Am. J. Psychiatry, 2006, 163, 1832-1034
-
(2006)
Am. J. Psychiatry
, vol.163
, pp. 1832-1034
-
-
Dempster, E.L.1
Toulopoulou, T.2
McDonald, C.3
Bramon, E.4
Walshe, M.5
Wickham, H.6
Sham, P.C.7
Murray, R.M.8
Collier, D.A.9
-
69
-
-
34548684581
-
Treating schizophrenia symptoms with an 7 nicotinic agonist, from mice to men
-
Olincy, A.; Stevens, K.E. Treating schizophrenia symptoms with an 7 nicotinic agonist, from mice to men. Biochem. Pharmacol., 2007, 74, 1192-1201
-
(2007)
Biochem. Pharmacol
, vol.74
, pp. 1192-1201
-
-
Olincy, A.1
Stevens, K.E.2
-
70
-
-
34347232302
-
Evidence for a role of nicotinic acetylcholine receptor in schizophrenia
-
Adams, C.E.; Stevens, K.E. Evidence for a role of nicotinic acetylcholine receptor in schizophrenia. Front. Biosci., 2007, 12, 4755-4772
-
(2007)
Front. Biosci
, vol.12
, pp. 4755-4772
-
-
Adams, C.E.1
Stevens, K.E.2
-
71
-
-
0002791174
-
Biomedical assessment of neurotransmitter and metabolic dysfunction and cerebral atrophy in Alzheimer's disease
-
In: Biological Aspects of Alzheimer's Disease; Katzman, R., Ed., Cold Spring Harbor, NY
-
Bowen, D.M. Biomedical assessment of neurotransmitter and metabolic dysfunction and cerebral atrophy in Alzheimer's disease. In: Biological Aspects of Alzheimer's Disease; Katzman, R., Ed.; Cold Spring Harbor Laboratory: Cold Spring Harbor, NY, 1983; pp. 219-232
-
(1983)
Cold Spring Harbor Laboratory
, pp. 219-232
-
-
Bowen, D.M.1
-
72
-
-
0023475840
-
The role of the nucleus basalis of Meynert and dementia: Review and reconsideration
-
Cummings, J.L.; Benson, D.F. The role of the nucleus basalis of Meynert and dementia: Review and reconsideration. Alzheimer Dis. Assoc. Disord., 1987, 1, 128-145
-
(1987)
Alzheimer Dis. Assoc. Disord
, vol.1
, pp. 128-145
-
-
Cummings, J.L.1
Benson, D.F.2
-
73
-
-
0002933736
-
Cholinergic component of dementia and aging
-
In, Huppert, F.A.; Brayne, C.; O'Connor, D.W. Eds.; Cambridge University Press: New York
-
Perry, E.K.; Court, J.A.; Piggott, M.A.; Perry, R.H. Cholinergic component of dementia and aging. In: Dementia and Normal Aging; Huppert, F.A.; Brayne, C.; O'Connor, D.W. Eds.; Cambridge University Press: New York, 1994; pp. 437-469
-
(1994)
Dementia and Normal Aging
, pp. 437-469
-
-
Perry, E.K.1
Court, J.A.2
Piggott, M.A.3
Perry, R.H.4
-
74
-
-
0019521132
-
Postmortem stability of -bungarotoxin binding sites in mouse and human brain
-
Davies, P.; Feisullin, S. Postmortem stability of -bungarotoxin binding sites in mouse and human brain. Brain Res., 1981, 216, 449-454
-
(1981)
Brain Res
, vol.216
, pp. 449-454
-
-
Davies, P.1
Feisullin, S.2
-
75
-
-
0025607117
-
Nicotinic acetylcholine receptor subtypes in human frontal cortex: Changes in Alzheimer's disease
-
Sugaya, K.; Giacobini, E.; Chiappinelli, V.A. Nicotinic acetylcholine receptor subtypes in human frontal cortex: changes in Alzheimer's disease. J. Neurosci. Res., 1990, 27, 349-359
-
(1990)
J. Neurosci. Res
, vol.27
, pp. 349-359
-
-
Sugaya, K.1
Giacobini, E.2
Chiappinelli, V.A.3
-
76
-
-
0345434817
-
Regional distribution of nicotinic receptor subunit mRNAs in human brain: Comparison between Alzheimer and normal brain
-
Hellström-Lindhal, E.; Mousavi, M.; Zhang, X.; Ravid, R.; Nordberg, A. Regional distribution of nicotinic receptor subunit mRNAs in human brain: Comparison between Alzheimer and normal brain. Brain Res. Mol. Brain Res., 1999, 66, 94-103
-
(1999)
Brain Res. Mol. Brain Res
, vol.66
, pp. 94-103
-
-
Hellström-Lindhal, E.1
Mousavi, M.2
Zhang, X.3
Ravid, R.4
Nordberg, A.5
-
77
-
-
0033983966
-
Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease
-
Guan, Z.-Z.; Zhang, X.; Ravid, R.; Nordberg, A. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J. Neurochem., 2000, 74, 237-243
-
(2000)
J. Neurochem
, vol.74
, pp. 237-243
-
-
Guan, Z.-Z.1
Zhang, X.2
Ravid, R.3
Nordberg, A.4
-
78
-
-
0032589299
-
4 but not 3 and 7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease
-
Martin-Ruiz, C.M.; Court, J.A.; Molnar, E.; Lee, M.; Gott, C.; Mamalki, A.; Tsouloufis, T.; Tzartos, S.; Ballard, C.; Perry, R.H.; Perry, E.K. 4 but not 3 and 7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease. J. Neurochem., 1999, 73, 1635-1640
-
(1999)
J. Neurochem
, vol.73
, pp. 1635-1640
-
-
Martin-Ruiz, C.M.1
Court, J.A.2
Molnar, E.3
Lee, M.4
Gott, C.5
Mamalki, A.6
Tsouloufis, T.7
Tzartos, S.8
Ballard, C.9
Perry, R.H.10
Perry, E.K.11
-
79
-
-
0034728596
-
Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimar's patients
-
Burghaus, L.; Schütz, U.; Krempel, U.; de Vos, R.A.; Jansen Steur, E.N.; Wevers, A.; Lindstrom, J.; Schröder, H. Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimar's patients. Brain Res. Mol. Brain Rev., 2000, 76, 385-388
-
(2000)
Brain Res. Mol. Brain Rev
, vol.76
, pp. 385-388
-
-
Burghaus, L.1
Schütz, U.2
Krempel, U.3
de Vos, R.A.4
Jansen, S.E.N.5
Wevers, A.6
Lindstrom, J.7
Schröder, H.8
-
80
-
-
0032971370
-
Albuquerque. E.X.; Schröder, H. Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease-histotopographical correlation with amyloid plaques and hyperphosphorylated tauprotein
-
Wevers, A.; Monteggia, L.; Nowacki, S.; Bloch, W.; Schütz, U.; Lindstrom, J.; Pereira, E.F.; Eisenberg, H.; Giacobini, E.; de Vos, R.A.; Steur, E.N.; Maelicke, A.; Albuquerque. E.X.; Schröder, H. Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease-histotopographical correlation with amyloid plaques and hyperphosphorylated tauprotein. Eur. J. Neurosci., 1999, 11, 2551-2565
-
(1999)
Eur. J. Neurosci
, vol.11
, pp. 2551-2565
-
-
Wevers, A.1
Monteggia, L.2
Nowacki, S.3
Bloch, W.4
Schütz, U.5
Lindstrom, J.6
Pereira, E.F.7
Eisenberg, H.8
Giacobini, E.9
de Vos, R.A.10
Steur, E.N.11
Maelicke, A.12
-
81
-
-
0035251750
-
Nicotinic receptor abnormalities in Alzheimer's disease
-
Court, J.; Martin-Ruiz, C.; Piggott, M.; Spurden, D.; Griffiths, M.; Perry, E. Nicotinic receptor abnormalities in Alzheimer's disease. Biol. Psychiatry, 2001, 49, 175-184
-
(2001)
Biol. Psychiatry
, vol.49
, pp. 175-184
-
-
Court, J.1
Martin-Ruiz, C.2
Piggott, M.3
Spurden, D.4
Griffiths, M.5
Perry, E.6
-
82
-
-
37149055806
-
7 Nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease
-
Counts, S.E.; He, B.; Che, S.; Iknomovic, M.D.; DeKosky, S.T.; Ginsberg, S.D.; Mufson, E.J. 7 Nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease. Arch. Neurol., 2007, 64, 1771-1776
-
(2007)
Arch. Neurol
, vol.64
, pp. 1771-1776
-
-
Counts, S.E.1
He, B.2
Che, S.3
Iknomovic, M.D.4
Dekosky, S.T.5
Ginsberg, S.D.6
Mufson, E.J.7
-
83
-
-
66249133352
-
Cortical 7 nicotinic acetylcholine receptor and -amyloid levels in early Alzheimer's disease
-
Ikonomovic, M.D.; Wecker, L.; Abrahamson, E.E.; Wuu, J.; Counts, S.E.; Ginsberg, S.D.; Mufson, E.J.; Dekosky, S.T. Cortical 7 nicotinic acetylcholine receptor and -amyloid levels in early Alzheimer's disease. Arch. Neurol., 2009, 66, 646-651
-
(2009)
Arch. Neurol
, vol.66
, pp. 646-651
-
-
Ikonomovic, M.D.1
Wecker, L.2
Abrahamson, E.E.3
Wuu, J.4
Counts, S.E.5
Ginsberg, S.D.6
Mufson, E.J.7
Dekosky, S.T.8
-
84
-
-
65249151342
-
Genetic variation in the 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease
-
Carson, R.; Craig, D.; Hart, D.; Todd, S.; McGuinness, B.; Johnston, J.A.; O'Neill, F.A.; Ritchie, C.W.; Passmore, A.P. Genetic variation in the 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease. Neuromol. Med., 2008, 10, 377-384
-
(2008)
Neuromol. Med
, vol.10
, pp. 377-384
-
-
Carson, R.1
Craig, D.2
Hart, D.3
Todd, S.4
McGuinness, B.5
Johnston, J.A.6
O'Neill, F.A.7
Ritchie, C.W.8
Passmore, A.P.9
-
85
-
-
0034893545
-
Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease
-
Jessen, F.; Kucharski, C.; Fries, T.; Papassotiropoulos, A.; Hoenig, K.; Maier, W.; Heun, R. Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease. Am. J. Psychiatry, 2001, 158, 1319-1321
-
(2001)
Am. J. Psychiatry
, vol.158
, pp. 1319-1321
-
-
Jessen, F.1
Kucharski, C.2
Fries, T.3
Papassotiropoulos, A.4
Hoenig, K.5
Maier, W.6
Heun, R.7
-
86
-
-
0034006944
-
Amyloid1-42 binds to 7 nicotinic acetylcholine receptor with high affinity: Implications for Alzheimer's disease pathology
-
Wang, H.Y.; Lee, D.H.; D'Andrea, M.R.; Peterson, P.A.; Shank, R.P.; Reitz, A.B. Amyloid1-42 binds to 7 nicotinic acetylcholine receptor with high affinity: implications for Alzheimer's disease pathology. J. Biol. Chem., 2000, 275, 5626-5632
-
(2000)
J. Biol. Chem
, vol.275
, pp. 5626-5632
-
-
Wang, H.Y.1
Lee, D.H.2
D'andrea, M.R.3
Peterson, P.A.4
Shank, R.P.5
Reitz, A.B.6
-
87
-
-
0033624509
-
Amyloid petide A 1-42 binds selectively and with pico-molar affinity to 7 nicotinic acetylcholine receptors
-
Wang, H.Y.; Lee, D.H.; Davis, C.B.; Shank, R.P. Amyloid petide A 1-42 binds selectively and with pico-molar affinity to 7 nicotinic acetylcholine receptors. J. Neurochem., 2000, 75, 1155-1161
-
(2000)
J. Neurochem
, vol.75
, pp. 1155-1161
-
-
Wang, H.Y.1
Lee, D.H.2
Davis, C.B.3
Shank, R.P.4
-
88
-
-
0037066072
-
Intracellular accumulation of -amyloid1-42 in neurons is facilitated by the 7 nicotinic acetylcholine receptor in Alzheimer's disease
-
Nagele, R.G.; D'Andrea, M.R.; Anderson, W.J.; Wang, H.-Y. Intracellular accumulation of -amyloid1-42 in neurons is facilitated by the 7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience, 2002, 110, 199-211
-
(2002)
Neuroscience
, vol.110
, pp. 199-211
-
-
Nagele, R.G.1
D'andrea, M.R.2
Anderson, W.J.3
Wang, H.-Y.4
-
89
-
-
0042357192
-
7 Nicotinic acetylcholine receptors mediate -amyloid peptides induced tau protein pshophorylation
-
Wang, H.Y.; Li, W.; Benedetti, N.J.; Lee, D.H. 7 Nicotinic acetylcholine receptors mediate -amyloid peptides induced tau protein pshophorylation. J. Biol. Chem., 2003, 278, 31547-31553
-
(2003)
J. Biol. Chem
, vol.278
, pp. 31547-31553
-
-
Wang, H.Y.1
Li, W.2
Benedetti, N.J.3
Lee, D.H.4
-
90
-
-
0035836747
-
Amyloid peptide blocks the response of 7-containing nicotinic receptors on hippocampal neurons
-
Liu, Q.S.; Kawai, H.; Berg, D.K. Amyloid peptide blocks the response of 7-containing nicotinic receptors on hippocampal neurons. Proc. Natl. Acad. Sci., USA, 2001, 48, 4734-4739
-
(2001)
Proc. Natl. Acad. Sci., USA
, vol.48
, pp. 4734-4739
-
-
Liu, Q.S.1
Kawai, H.2
Berg, D.K.3
-
91
-
-
0002006427
-
Amyloid1-42 peptide directly modulates nicotinic receptors in the rat hippocampal slice
-
Pettit, D.L.; Shao, Z.; Yakel, J.L. -Amyloid1-42 peptide directly modulates nicotinic receptors in the rat hippocampal slice. J. Neurosci., 2001, 21(RC120), 1-5
-
(2001)
J. Neurosci
, vol.21
, Issue.RC120
, pp. 1-5
-
-
Pettit, D.L.1
Shao, Z.2
Yakel, J.L.3
-
92
-
-
0037381479
-
Differential physiologic responses of 7 nicotinic acetylcholine receptors to -amyloid1-40 and -amyloid1-42
-
Lee, D.H.; Wang, H.Y. Differential physiologic responses of 7 nicotinic acetylcholine receptors to -amyloid1-40 and -amyloid1-42. J. Neurobiol., 2003, 55, 25-30
-
(2003)
J. Neurobiol
, vol.55
, pp. 25-30
-
-
Lee, D.H.1
Wang, H.Y.2
-
93
-
-
67650484613
-
Deletion of the 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease
-
Dziewczapolski, G.; Glogowski, C.M.; Masliah, E.; Heinemann, S.F. Deletion of the 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. J. Neurosci., 2009, 29, 8805-8815
-
(2009)
J. Neurosci
, vol.29
, pp. 8805-8815
-
-
Dziewczapolski, G.1
Glogowski, C.M.2
Masliah, E.3
Heinemann, S.F.4
-
94
-
-
69749119522
-
Dissociating -amyloid from 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain
-
Wang, H.Y.; Stucky, A.; Liu, J.; Shen, C.; Trocme-Thibierge, C.; Morain, P. Dissociating -amyloid from 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. J. Neurosci., 2009, 29, 10961-10973
-
(2009)
J. Neurosci
, vol.29
, pp. 10961-10973
-
-
Wang, H.Y.1
Stucky, A.2
Liu, J.3
Shen, C.4
Trocme-Thibierge, C.5
Morain, P.6
-
95
-
-
0031371159
-
Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist
-
Kem, W.R. Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist. Invert. Neurosci., 1997, 3, 251-259
-
(1997)
Invert. Neurosci
, vol.3
, pp. 251-259
-
-
Kem, W.R.1
-
96
-
-
0028883258
-
125I--bungarotoxin receptor subtypes
-
125I--bungarotoxin receptor subtypes. Mol. Pharmacol., 1995, 47, 164-171
-
(1995)
Mol. Pharmacol
, vol.47
, pp. 164-171
-
-
de Fiebre, C.M.1
Meyer, E.D.2
Henry, J.C.3
Muraskin, S.I.4
Kem, W.R.5
Papke, R.L.6
-
97
-
-
0031003185
-
Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo
-
Briggs, C.A.; Anderson, D.J.; Brioni, J.D.; Buccafusco, J.J.; Buckley, M.J.; Campbell, J.E.; Decker, M.W.; Donnelly-Roberts, D.; Elliott, R.L.; Gopalakrishnan, M.; Holladay, M.W.; Hui, Y.H.; Jackson, W.J.; Kim, D.J.; Marsh, K.C.; O'Neill, A.; Prendergast, M.A.; Ryther, K.B.; Sullivan, J.P.; Arneric, S.P. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol. Biochem. Behav., 1997, 57, 231-241
-
(1997)
Pharmacol. Biochem. Behav
, vol.57
, pp. 231-241
-
-
Briggs, C.A.1
Anderson, D.J.2
Brioni, J.D.3
Buccafusco, J.J.4
Buckley, M.J.5
Campbell, J.E.6
Decker, M.W.7
Donnelly-Roberts, D.8
Elliott, R.L.9
Gopalakrishnan, M.10
Holladay, M.W.11
Hui, Y.H.12
Jackson, W.J.13
Kim, D.J.14
Marsh, K.C.15
O'Neill, A.16
Prendergast, M.A.17
Ryther, K.B.18
Sullivan, J.P.19
Arneric, S.P.20
more..
-
98
-
-
0032254325
-
Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat 7 nicotinic receptors
-
Meyer, E.M.; Kuryatov, A.; Gerzanich, V.; Lindstrom, J.; Papke, R.L. Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat 7 nicotinic receptors. J. Pharmacol. Exp. Ther., 1998, 287, 918-925
-
(1998)
J. Pharmacol. Exp. Ther
, vol.287
, pp. 918-925
-
-
Meyer, E.M.1
Kuryatov, A.2
Gerzanich, V.3
Lindstrom, J.4
Papke, R.L.5
-
99
-
-
9144251593
-
Hydroxy metabolites of the Alzheimer's drug candidate 3- [(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS- 21): Their molecular properties, interactions with brain nicotinic receptors, and brain penetration
-
Kem, W.R.; Mahnir, V.; Prokai, L.; Papke, R.L.; Cao, X.; LeFrancois, S.; Wildeboer, K.; Prokai-Tatrai, K.; Porter-Papke, J.; Soti, F. Hydroxy metabolites of the Alzheimer's drug candidate 3- [(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS- 21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Mol. Pharmacol., 2004, 65, 56-67
-
(2004)
Mol. Pharmacol
, vol.65
, pp. 56-67
-
-
Kem, W.R.1
Mahnir, V.2
Prokai, L.3
Papke, R.L.4
Cao, X.5
Lefrancois, S.6
Wildeboer, K.7
Prokai-Tatrai, K.8
Porter-Papke, J.9
Soti, F.10
-
100
-
-
0033626286
-
The brain 7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: Studies with DMXBA (GTS-21)
-
Kem, W.R. The brain 7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21). Behav. Brain Res., 2000, 113, 169-181
-
(2000)
Behav. Brain Res
, vol.113
, pp. 169-181
-
-
Kem, W.R.1
-
101
-
-
0038690569
-
Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers
-
Kitagawa, H.; Takenouchi, T.; Azuma, R.; Wesnes, K.A.; Kramer, W.G.; Clody, D.E.; Burnett, A.L. Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers. Neuropsychopharmacology, 2003, 28, 542-551
-
(2003)
Neuropsychopharmacology
, vol.28
, pp. 542-551
-
-
Kitagawa, H.1
Takenouchi, T.2
Azuma, R.3
Wesnes, K.A.4
Kramer, W.G.5
Clody, D.E.6
Burnett, A.L.7
-
102
-
-
33744911665
-
Proof-of-concept trial of an 7 nicotinic agonist in schizophrenia
-
Olincy, A.; Harris, J.G.; Johnson, L.L.; Pender, V.; Kongs, S.; Allensworth, D.; Ellis, J.; Zerbe, G.O.; Leonard, S.; Stevens, K.E.; Stevens, J.O.; Martin, L.; Adler, L.E.; Soti, F.; Kem, W.R.; Freedman, R. Proof-of-concept trial of an 7 nicotinic agonist in schizophrenia. Arch. Gen. Psychiatry, 2006, 63, 630-638
-
(2006)
Arch. Gen. Psychiatry
, vol.63
, pp. 630-638
-
-
Olincy, A.1
Harris, J.G.2
Johnson, L.L.3
Pender, V.4
Kongs, S.5
Allensworth, D.6
Ellis, J.7
Zerbe, G.O.8
Leonard, S.9
Stevens, K.E.10
Stevens, J.O.11
Martin, L.12
Adler, L.E.13
Soti, F.14
Kem, W.R.15
Freedman, R.16
-
103
-
-
48949099564
-
Initial phase 2 trial of a nicotinic agonist in schizophrenia
-
Freedman, R.; Olincy, A.; Buchanan, R.W.; Harris, J.G.; Gold, J.M.; Johnson, L.; Allensworth, D.; Guzman-Bonilla, A.; Clement, B.; Ball, M.P.; Kutnick, J.; Pender, V.; Martin, L.F.; Stevens, K.E.; Wagner, B.D.; Zerbe, G.O.; Soti, F.; Kem, W.R. Initial phase 2 trial of a nicotinic agonist in schizophrenia. Am. J. Psychiatry, 2008, 165, 1040-1047
-
(2008)
Am. J. Psychiatry
, vol.165
, pp. 1040-1047
-
-
Freedman, R.1
Olincy, A.2
Buchanan, R.W.3
Harris, J.G.4
Gold, J.M.5
Johnson, L.6
Allensworth, D.7
Guzman-Bonilla, A.8
Clement, B.9
Ball, M.P.10
Kutnick, J.11
Pender, V.12
Martin, L.F.13
Stevens, K.E.14
Wagner, B.D.15
Zerbe, G.O.16
Soti, F.17
Kem, W.R.18
-
104
-
-
62649085127
-
Nausea associated with a nicotinic agonist therapy in schizophrenia
-
Hashimoto, K. Nausea associated with a nicotinic agonist therapy in schizophrenia. Clin. Psychopharmacol. Neurosci., 2009; 7, 26-27
-
(2009)
Clin. Psychopharmacol. Neurosci
, vol.7
, pp. 26-27
-
-
Hashimoto, K.1
-
105
-
-
0034597576
-
(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5 -oxazolidin-2 - one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the 7 nicotinic acetylcholine receptor
-
Mullen, G.; Napier, J.; Balestra, M.; DeCory, T.; Hale, G.; Macor, J.; Mack, R.; Loch, J. II., Wu, E.; Kover, A.; Verhoest, P.; Sampognaro, A.; Phillips, E.; Zhu, Y.; Murray, R.; Griffith, R.; Blosser, J.; Gurley, D.; Machulskis, A.; Zongrone, J.; Rosen, A.; Gordon, J. (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5 -oxazolidin-2 - one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the 7 nicotinic acetylcholine receptor. J. Med. Chem., 2000, 43, 4045-4050
-
(2000)
J. Med. Chem
, vol.43
, pp. 4045-4050
-
-
Mullen, G.1
Napier, J.2
Balestra, M.3
Decory, T.4
Hale, G.5
Macor, J.6
Mack, R.7
Loch II, J.8
Wu, E.9
Kover, A.10
Verhoest, P.11
Sampognaro, A.12
Phillips, E.13
Zhu, Y.14
Murray, R.15
Griffith, R.16
Blosser, J.17
Gurley, D.18
Machulskis, A.19
Zongrone, J.20
Rosen, A.21
Gordon, J.22
more..
-
106
-
-
0033847409
-
Evidence that nicotinic 7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine
-
Grottick, A.J.; Trube, G.; Corrigall, W.A.; Huwyler, J.; Malherbe, P.; Wyler, R.; Higgins, G.A. Evidence that nicotinic 7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine. J. Pharmacol. Exp. Ther., 2000, 294, 1112-1119
-
(2000)
J. Pharmacol. Exp. Ther
, vol.294
, pp. 1112-1119
-
-
Grottick, A.J.1
Trube, G.2
Corrigall, W.A.3
Huwyler, J.4
Malherbe, P.5
Wyler, R.6
Higgins, G.A.7
-
107
-
-
0033623950
-
The 4 2 agonist SIB 1765F, but not the 7 agonist AR-R 17779, cross-sensitises to the psychostimulant effects of nicotine
-
Grottick, A.J.; Wyler, R.; Higgins, G.A. The 4 2 agonist SIB 1765F, but not the 7 agonist AR-R 17779, cross-sensitises to the psychostimulant effects of nicotine. Psychopharmacology, (Berl.), 2000, 150, 233-236
-
(2000)
Psychopharmacology, (Berl.)
, vol.150
, pp. 233-236
-
-
Grottick, A.J.1
Wyler, R.2
Higgins, G.A.3
-
108
-
-
0033237390
-
AR-R17779, and 7 nicotinic agonist, improves learning and memory in rats. Behav
-
Levin, E.D.; Bettegowda, C.; Blosser, J.; Gordon, J. AR-R17779, and 7 nicotinic agonist, improves learning and memory in rats. Behav. Pharmacol., 1999, 10, 675-680
-
(1999)
Pharmacol
, vol.10
, pp. 675-680
-
-
Levin, E.D.1
Bettegowda, C.2
Blosser, J.3
Gordon, J.4
-
109
-
-
68349141525
-
Selective 7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes
-
Sydserff, S.; Sutton, E.J.; Song, D.; Quirk, M.C.; Maciag, C.; Li, C.; Jonak, G.; Gurley, D.; Gordon, J.C.; Christian, E.P.; Doherty, J.J.; Hudzik, T.; Johnson, E.; Mrzljak, L.; Piser, T.; Smagin, G.N.; Wang, Y.; Widzowski, D.; Smith, J.S. Selective 7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochem. Pharmacol., 2009, 78, 880-888
-
(2009)
Biochem. Pharmacol
, vol.78
, pp. 880-888
-
-
Sydserff, S.1
Sutton, E.J.2
Song, D.3
Quirk, M.C.4
Maciag, C.5
Li, C.6
Jonak, G.7
Gurley, D.8
Gordon, J.C.9
Christian, E.P.10
Doherty, J.J.11
Hudzik, T.12
Johnson, E.13
Mrzljak, L.14
Piser, T.15
Smagin, G.N.16
Wang, Y.17
Widzowski, D.18
Smith, J.S.19
-
110
-
-
77957983611
-
-
Macor, International Application No.: PCT/SE1997/000294, WO 97/30998, Aug
-
Macor, J.E.; Wu, E. Azabicyclic esters of carbamic acids useful in therapy. International Application No.: PCT/SE1997/000294, WO 97/30998, Aug. 28, 1997
-
(1997)
J.E.; Wu, E. Azabicyclic Esters of Carbamic Acids Useful In Therapy
, pp. 28
-
-
-
111
-
-
2942620549
-
(+)-3-[2-(Benzo[b]thiophen-2-yl)-2- oxoethyl]-1- azabicyclo[2.2.2]octane as potent agonists for the 7 nicotinic acetylcholine receptor
-
Tatsumi, R.; Seio, K.; Fujio, M.; Katayama, J.; Horikawa, T.; Hashimoto, K.; Tanaka, H. (+)-3-[2-(Benzo[b]thiophen-2-yl)-2- oxoethyl]-1- azabicyclo[2.2.2]octane as potent agonists for the 7 nicotinic acetylcholine receptor. Bioorg. Med. Chem., 2004, 14, 3781-3784
-
(2004)
Bioorg. Med. Chem
, vol.14
, pp. 3781-3784
-
-
Tatsumi, R.1
Seio, K.2
Fujio, M.3
Katayama, J.4
Horikawa, T.5
Hashimoto, K.6
Tanaka, H.7
-
112
-
-
17144370948
-
Discovery of the 7 nicotinic acetylcholine receptor agonists. (R)-3 -(5-Chlorothiophen-2- yl)spiro-1-azabicyclo[2.2.2]octane-3,5 -[1,3]oxazolidin-2 -one as a novel, potent, selective, and orally bioavailable ligand
-
Tatsumi, R.; Fujio, M.; Satoh, H.; Katayama, J.; Takanashi, S.; Hashimoto, K.; Tanaka, H. Discovery of the 7 nicotinic acetylcholine receptor agonists. (R)-3 -(5-Chlorothiophen-2- yl)spiro-1-azabicyclo[2.2.2]octane-3,5 -[1,3]oxazolidin-2 -one as a novel, potent, selective, and orally bioavailable ligand. J. Med. Chem., 2005, 48, 2678-2686
-
(2005)
J. Med. Chem
, vol.48
, pp. 2678-2686
-
-
Tatsumi, R.1
Fujio, M.2
Satoh, H.3
Katayama, J.4
Takanashi, S.5
Hashimoto, K.6
Tanaka, H.7
-
113
-
-
33745872934
-
(R)-3 -(3- methylbenzo[b]thiophen-5-yl)spiro[1- azabicyclo[2,2,2]octane- 3,5 -oxazolidin]-2 -one, a novel and potent 7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties
-
Tatsumi, R.; Fujio, M.; Takanashi, S.; Numata, A.; Katayama, J.; Satoh, H.; Shiigi, Y.; Maeda, J.; Kuriyama, M.; Horikawa, T.; Murozono, T.; Hashimoto, K.; Tanaka, H. (R)-3 -(3- methylbenzo[b]thiophen-5-yl)spiro[1- azabicyclo[2,2,2]octane- 3,5 -oxazolidin]-2 -one, a novel and potent 7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties. J. Med. Chem., 2006, 49, 4374-4383
-
(2006)
J. Med. Chem
, vol.49
, pp. 4374-4383
-
-
Tatsumi, R.1
Fujio, M.2
Takanashi, S.3
Numata, A.4
Katayama, J.5
Satoh, H.6
Shiigi, Y.7
Maeda, J.8
Kuriyama, M.9
Horikawa, T.10
Murozono, T.11
Hashimoto, K.12
Tanaka, H.13
-
114
-
-
1642343387
-
The neuroprotective effect of 2-(3-pyridyl)-1- azabicyclo[3.2.2]nonane (TC-1698), a novel 7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase
-
Marrero, M.B.; Papke, R.L.; Bhatti, B.S.; Shaw, S.; Bencherif, M. The neuroprotective effect of 2-(3-pyridyl)-1- azabicyclo[3.2.2]nonane (TC-1698), a novel 7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J. Pharmacol. Exp. Ther., 2003, 309, 16-27
-
(2003)
J. Pharmacol. Exp. Ther
, vol.309
, pp. 16-27
-
-
Marrero, M.B.1
Papke, R.L.2
Bhatti, B.S.3
Shaw, S.4
Bencherif, M.5
-
115
-
-
16244422671
-
2- (Arylmethyl)-3-substituted quinuclidines as selective 7 nicotinic receptor ligands
-
Marzurov, A.; Klucil, J.; Miao, L.; Philips, T.Y.; Seamans, A.; Schmitt, J.D.; Hauser T.A.; Johnson Jr., R.T.; Miller, C. 2- (Arylmethyl)-3-substituted quinuclidines as selective 7 nicotinic receptor ligands. Bioorg. Med. Chem. Lett., 2005, 15, 2073-2077
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 2073-2077
-
-
Marzurov, A.1
Klucil, J.2
Miao, L.3
Philips, T.Y.4
Seamans, A.5
Schmitt, J.D.6
Hauser, T.A.7
Johnson, R.T.8
Miller, C.9
-
116
-
-
68349148342
-
TC-5619: An 7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia
-
Hauser, T.A.; Kucinski, A.; Jordan, K.G.; Gatto, G.J.; Wetsinger, S.R.; Hesse, R.A.; Stachowiak, E.K.; Stachowiak, M.K.; Papke, R.L.; Lippiello, P.M.; Bencherif, M. TC-5619: an 7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia. Biochem. Pharmacol., 2009, 78, 803-812
-
(2009)
Biochem. Pharmacol
, vol.78
, pp. 803-812
-
-
Hauser, T.A.1
Kucinski, A.2
Jordan, K.G.3
Gatto, G.J.4
Wetsinger, S.R.5
Hesse, R.A.6
Stachowiak, E.K.7
Stachowiak, M.K.8
Papke, R.L.9
Lippiello, P.M.10
Bencherif, M.11
-
117
-
-
13944267447
-
Discovery and structure-activity relationship of quinuclidine benzamides as agonists of 7 nicotinic acetylcholine receptors
-
Bodnar, A.L.; Cortes-Burgos, L.A.; Cook, K.K.; Dinh, D.M.; Groppi, V.E.; Hajos, M.; Higdon, N.R.; Hoffmann, W.E.; Hurst, R.S.; Myers, J.K.; Rogers, B.N.; Wall, T.M.; Wolfe, M.L.; Wong, E. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of 7 nicotinic acetylcholine receptors. J. Med. Chem., 2005, 48, 905-908
-
(2005)
J. Med. Chem
, vol.48
, pp. 905-908
-
-
Bodnar, A.L.1
Cortes-Burgos, L.A.2
Cook, K.K.3
Dinh, D.M.4
Groppi, V.E.5
Hajos, M.6
Higdon, N.R.7
Hoffmann, W.E.8
Hurst, R.S.9
Myers, J.K.10
Rogers, B.N.11
Wall, T.M.12
Wolfe, M.L.13
Wong, E.14
-
118
-
-
14344251489
-
The selective 7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1- Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats
-
Hajós, M.; Hurst, R.S.; Hoffmann, W.E.; Krause, M.; Wall, T.M.; Higdon, N.R.; Groppi, V.E. The selective 7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1- Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J. Pharmacol. Exp. Ther., 2005, 312, 1213-1222
-
(2005)
J. Pharmacol. Exp. Ther
, vol.312
, pp. 1213-1222
-
-
Hajós, M.1
Hurst, R.S.2
Hoffmann, W.E.3
Krause, M.4
Wall, T.M.5
Higdon, N.R.6
Groppi, V.E.7
-
119
-
-
33745808357
-
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide, an agonist of the 7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: Synthesis and structure activity relationship
-
Wishka, D.G.; Walker, D.P.; Yates, K.M.; Reitz, S.C.; Jia, S.; Myers, J.K.; Olson, K.L.; Jacobsen, E.J.; Wolfe, M.L.; Groppi, V.E.; Hanchar, A.J.; Thornburgh, B.A.; Cortes-Burgons, L.A.; Wong, E.H.F.; Staton, B.A.; Raub, T.J.; Higdon, N.R.; Wall, T.M.; Hurst, R.S.; Walters, R.R.; Hoffmann, W.E.; Hajos, M.; Franklin, S.; Carey, G.; Gold, L.H.; Cook, K.K.; Sands, S.B.; Zhao, S.X.; Soglia, J.R.; Kalgutkar, A.S.; Arneric, A.P.; Rogers, B.N. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide, an agonist of the 7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure activity relationship. J. Med. Chem., 2006, 49, 4425-4436
-
(2006)
J. Med. Chem
, vol.49
, pp. 4425-4436
-
-
Wishka, D.G.1
Walker, D.P.2
Yates, K.M.3
Reitz, S.C.4
Jia, S.5
Myers, J.K.6
Olson, K.L.7
Jacobsen, E.J.8
Wolfe, M.L.9
Groppi, V.E.10
Hanchar, A.J.11
Thornburgh, B.A.12
Cortes-Burgons, L.A.13
Wong, E.H.F.14
Staton, B.A.15
Raub, T.J.16
Higdon, N.R.17
Wall, T.M.18
Hurst, R.S.19
Walters, R.R.20
Hoffmann, W.E.21
Hajos, M.22
Franklin, S.23
Carey, G.24
Gold, L.H.25
Cook, K.K.26
Sands, S.B.27
Zhao, S.X.28
Soglia, J.R.29
Kalgutkar, A.S.30
Arneric, A.P.31
Rogers, B.N.32
more..
-
120
-
-
33750532078
-
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as 7 nicotinic acetylcholine receptor agonists
-
Walker, D.P.; Wishka, D.G.; Piotrowski, D.W.; Jia, S.; Reitz, S.C.; Yates, K.M.; Myers, J.K.; Vetman, T.N.; Margolis, B.J.; Jacobsen, E.J.; Acker, B.A.; Groppi, V.E.; Wolfe, M.L.; Thornburgh, B.A.; Tinholt, P.M.; Cortes-Burgos, L.A.; Walters, R.R.; Hester, M.R.; Seest, E.P.; Dolak, L.A.; Han, F.; Olson, B.A.; Fitzgerald, L.; Staton, B.A.; Raub, T.J.; Hajos, M.; Hoffmann, W.E.; Li, K.S.; Higdon, N.R.; Wall, T.M.; Hurst, R.S.; Wong, E.H.F.; Rogers, B.N. Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as 7 nicotinic acetylcholine receptor agonists. Bioorg. Med. Chem., 2006, 14, 8219-8248
-
(2006)
Bioorg. Med. Chem
, vol.14
, pp. 8219-8248
-
-
Walker, D.P.1
Wishka, D.G.2
Piotrowski, D.W.3
Jia, S.4
Reitz, S.C.5
Yates, K.M.6
Myers, J.K.7
Vetman, T.N.8
Margolis, B.J.9
Jacobsen, E.J.10
Acker, B.A.11
Groppi, V.E.12
Wolfe, M.L.13
Thornburgh, B.A.14
Tinholt, P.M.15
Cortes-Burgos, L.A.16
Walters, R.R.17
Hester, M.R.18
Seest, E.P.19
Dolak, L.A.20
Han, F.21
Olson, B.A.22
Fitzgerald, L.23
Staton, B.A.24
Raub, T.J.25
Hajos, M.26
Hoffmann, W.E.27
Li, K.S.28
Higdon, N.R.29
Wall, T.M.30
Hurst, R.S.31
Wong, E.H.F.32
Rogers, B.N.33
more..
-
121
-
-
44649098133
-
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo-[2,3-c]pyridine-5- carboxamide as an agonist of the 7 nicotinic acetylcholine receptor: In vitro and in vivo activity
-
Acker, B.A.; Jacobsen, E.J.; Rogers, B.N.; Wishka, D.G.; Reitz, S.C.; Piotrowski, D.W.; Myers, J.K.; Wolfe, M.L.; Groppi, V.E.; Thornburgh, B.A.; Tinholt, P.M.; Walters, R.R.; Olson, B.A.; Fitzgerald, L.; Staton, B.A.; Raub, T.J.; Krause, M.; Li, K.S.; Hoffmann, W.E.; Hajos, M.; Hurst, R.S.; Walker, D.P. Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo-[2,3-c]pyridine-5- carboxamide as an agonist of the 7 nicotinic acetylcholine receptor: in vitro and in vivo activity. Bioorg. Med. Chem. Lett., 2008, 18, 3611-3615
-
(2008)
Bioorg. Med. Chem. Lett
, vol.18
, pp. 3611-3615
-
-
Acker, B.A.1
Jacobsen, E.J.2
Rogers, B.N.3
Wishka, D.G.4
Reitz, S.C.5
Piotrowski, D.W.6
Myers, J.K.7
Wolfe, M.L.8
Groppi, V.E.9
Thornburgh, B.A.10
Tinholt, P.M.11
Walters, R.R.12
Olson, B.A.13
Fitzgerald, L.14
Staton, B.A.15
Raub, T.J.16
Krause, M.17
Li, K.S.18
Hoffmann, W.E.19
Hajos, M.20
Hurst, R.S.21
Walker, D.P.22
more..
-
122
-
-
33845698922
-
SSR180711, a novel selective 7 nicotinic receptor partial agonist: (I) binding and functional profile
-
Biton, B.; Bergis, O.E.; Galli, F.; Nedelec, A.; Lochead, A.W.; Jegham, S.; Godet, D.; Lanneau, C.; Santamaria, R.; Chesney, F.; Léonardon, J.; Granger, P.; Debono, M.W.; Bohme, G.A.; Sgard, F.; Besnard, F.; Graham, D.; Coste, A.; Oblin, A.; Curet, O.; Vigé, X.; Voltz, C.; Rouquier, L.; Souihac, J.; Santucci, V.; Gueudet, C.; Françon, D.; Steinberg, R.; Griebel, G.; Oury-Donat, F.; George, P.; Avenet, P.; Scatton, B. SSR180711, a novel selective 7 nicotinic receptor partial agonist: (I) binding and functional profile. Neuropsychopharmacology, 2007, 32, 1-16
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 1-16
-
-
Biton, B.1
Bergis, O.E.2
Galli, F.3
Nedelec, A.4
Lochead, A.W.5
Jegham, S.6
Godet, D.7
Lanneau, C.8
Santamaria, R.9
Chesney, F.10
Léonardon, J.11
Granger, P.12
Debono, M.W.13
Bohme, G.A.14
Sgard, F.15
Besnard, F.16
Graham, D.17
Coste, A.18
Oblin, A.19
Curet, O.20
Vigé, X.21
Voltz, C.22
Rouquier, L.23
Souihac, J.24
Santucci, V.25
Gueudet, C.26
Françon, D.27
Steinberg, R.28
Griebel, G.29
Oury-Donat, F.30
George, P.31
Avenet, P.32
Scatton, B.33
more..
-
123
-
-
33845719612
-
SSR180711, a novel selective 7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia
-
Pichat, P.; Bergis, O.E.; Terranova, J.-P.; Urani, A.; Duarte, C.; Santucci, V.; Gueudet, C.; Voltz, C.; Steinberg, R.; Stemmelin, J.; Oury-Donat, F.; Avenet, P.; Griebel, G.; Scatton, B. SSR180711, a novel selective 7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology, 2007, 32, 17-34
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 17-34
-
-
Pichat, P.1
Bergis, O.E.2
Terranova, J.-P.3
Urani, A.4
Duarte, C.5
Santucci, V.6
Gueudet, C.7
Voltz, C.8
Steinberg, R.9
Stemmelin, J.10
Oury-Donat, F.11
Avenet, P.12
Griebel, G.13
Scatton, B.14
-
124
-
-
36849055179
-
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective 7 nicotinic receptor agonist SSR180711. Biol
-
Hashimoto, K.; Ishima, T.; Fujita, Y.; Matsuo, M.; Kobashi, T.; Takahagi, M.; Tsukada, H.; Iyo, M. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective 7 nicotinic receptor agonist SSR180711. Biol. Psychiatry, 2008, 63, 92-97
-
(2008)
Psychiatry
, vol.63
, pp. 92-97
-
-
Hashimoto, K.1
Ishima, T.2
Fujita, Y.3
Matsuo, M.4
Kobashi, T.5
Takahagi, M.6
Tsukada, H.7
Iyo, M.8
-
125
-
-
67349085106
-
7 Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment
-
Thomsen, M.S.; Christensen, D.Z.; Hansen, H.H.; Redrobe, J.P.; Mikkelsen, J.D. 7 Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment. Neuropharmacology, 2009, 56, 1001-1009
-
(2009)
Neuropharmacology
, vol.56
, pp. 1001-1009
-
-
Thomsen, M.S.1
Christensen, D.Z.2
Hansen, H.H.3
Redrobe, J.P.4
Mikkelsen, J.D.5
-
126
-
-
67349167960
-
Pro-cognitive and antipsychotic efficacy of the 7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia
-
Barak, S.; Arad, M.; De Levie, A.; Black, M.D.; Griebel, G.; Weiner, I. Pro-cognitive and antipsychotic efficacy of the 7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia. Neuropsychopharmacology, 2009, 34, 1753-1763
-
(2009)
Neuropsychopharmacology
, vol.34
, pp. 1753-1763
-
-
Barak, S.1
Arad, M.2
de Levie, A.3
Black, M.D.4
Griebel, G.5
Weiner, I.6
-
127
-
-
0033813572
-
The pharmacology of latent inhibition as an animal model of schizophrenia
-
Moser, P.C.; Hitchcock, J.M.; Lister, S.; Moran, P.M. The pharmacology of latent inhibition as an animal model of schizophrenia. Brain Res. Brain Res. Rev., 2000, 33, 275-307
-
(2000)
Brain Res. Brain Res. Rev
, vol.33
, pp. 275-307
-
-
Moser, P.C.1
Hitchcock, J.M.2
Lister, S.3
Moran, P.M.4
-
128
-
-
0038624724
-
The "two-headed" latent inhibition model of schizophrenia: Modeling positive and negative symptoms and their treatment
-
Weiner, I. The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment. Psychopharmacology (Berl.), 2003, 169, 257-297
-
(2003)
Psychopharmacology (Berl.)
, vol.169
, pp. 257-297
-
-
Weiner, I.1
-
129
-
-
34249804470
-
7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: An effect similar to antipsychotics
-
Hansen, H.H.; Timmermann, D.B.; Peters, D.; Walters, C.; Damaj, M.I.; Mikkelsen, J.D. 7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: an effect similar to antipsychotics. J. Neurosci. Res., 2007, 85, 1810-1818
-
(2007)
J. Neurosci. Res
, vol.85
, pp. 1810-1818
-
-
Hansen, H.H.1
Timmermann, D.B.2
Peters, D.3
Walters, C.4
Damaj, M.I.5
Mikkelsen, J.D.6
-
130
-
-
34247332734
-
The 7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of rat
-
Kristensen, S.E.; Thomsen, M.S.; Hansen, H.H.; Timmermann, D.B.; Hay-Schmidt, A.; Mikkelsen, J.D. The 7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of rat. Neurosci. Lett., 2007, 418, 154-158
-
(2007)
Neurosci. Lett
, vol.418
, pp. 154-158
-
-
Kristensen, S.E.1
Thomsen, M.S.2
Hansen, H.H.3
Timmermann, D.B.4
Hay-Schmidt, A.5
Mikkelsen, J.D.6
-
131
-
-
49149103195
-
The nicotinic 7 acetylcholine receptor agonist SSR180711 is unable to activate limbic neurons in mice overexpressing human amyloid- 1-42
-
Søderman, A.; Thomsen, M.S.; Hansen, H.H.; Nielsen, E.Ø.; Jensen, M.S.; West, M.J.; Mikkelsen, J.D. The nicotinic 7 acetylcholine receptor agonist SSR180711 is unable to activate limbic neurons in mice overexpressing human amyloid- 1-42. Brain Res., 2008, 1227, 240-247
-
(2008)
Brain Res
, vol.1227
, pp. 240-247
-
-
Søderman, A.1
Thomsen, M.S.2
Hansen, H.H.3
Nielsen, E.O.4
Jensen, M.S.5
West, M.J.6
Mikkelsen, J.D.7
-
132
-
-
67650046812
-
SAR and biological evaluation of SEN12333/WAY-317538: Novel 7 nicotinic acetylcholine receptor agonist
-
Haydar, S.N.; Ghiron, C.; Bettinetti, L.; Bothmann, H.; Comery, T.A.; Dunlop, J.; LaRosa, S.; Micco, I.; Pollastrini, M.; Quinn, J.; Roncarati, R.; Scali, C.; Valacchi, M.; Varrone, M.; Zanaletti, R. SAR and biological evaluation of SEN12333/WAY-317538: novel 7 nicotinic acetylcholine receptor agonist. Bioorg. Med. Chem., 2009, 17, 5247-5258
-
(2009)
Bioorg. Med. Chem
, vol.17
, pp. 5247-5258
-
-
Haydar, S.N.1
Ghiron, C.2
Bettinetti, L.3
Bothmann, H.4
Comery, T.A.5
Dunlop, J.6
Larosa, S.7
Micco, I.8
Pollastrini, M.9
Quinn, J.10
Roncarati, R.11
Scali, C.12
Valacchi, M.13
Varrone, M.14
Zanaletti, R.15
-
133
-
-
65649092520
-
Procognitive and neuroprotective activity of a novel 7 nicotinic acetyl choline receptor agonist for treatment of neurodegenerative and cognitive disorders
-
Roncarati, R.; Scali, C.; Comery, T.A.; Grauer, S.M.; Aschmi, A.; Bothmann, H.; Jow, B.; Kowai, D.; Gianfriddo, M.; Kelley, C.; Zanelli, U.; Ghiron, C.; Haydar, S.; Duniop, J.; Terstappen, G.C. Procognitive and neuroprotective activity of a novel 7 nicotinic acetyl choline receptor agonist for treatment of neurodegenerative and cognitive disorders. J. Pharmacol. Exp. Ther., 2009, 329, 459-468
-
(2009)
J. Pharmacol. Exp. Ther
, vol.329
, pp. 459-468
-
-
Roncarati, R.1
Scali, C.2
Comery, T.A.3
Grauer, S.M.4
Aschmi, A.5
Bothmann, H.6
Jow, B.7
Kowai, D.8
Gianfriddo, M.9
Kelley, C.10
Zanelli, U.11
Ghiron, C.12
Haydar, S.13
Duniop, J.14
Terstappen, G.C.15
-
134
-
-
34247184782
-
The novel 7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3- yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents
-
Boess, F.G.; Vry, J.D.; Erb, C.; Flessner, T.; Hendrix, M.; Luithle, J.; Methfessel, C.; Riedl, B.; Schnizler, K.; van der Staay, F.-J.; van Kampen, M.; Wiese, W.B.; Koenig, G. The novel 7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3- yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents. J. Pharmacol. Exp. Ther., 2007, 321, 716-725
-
(2007)
J. Pharmacol. Exp. Ther
, vol.321
, pp. 716-725
-
-
Boess, F.G.1
Vry, J.D.2
Erb, C.3
Flessner, T.4
Hendrix, M.5
Luithle, J.6
Methfessel, C.7
Riedl, B.8
Schnizler, K.9
van der Staay, F.-J.10
van Kampen, M.11
Wiese, W.B.12
Koenig, G.13
-
135
-
-
40149091555
-
7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues
-
Briggs, C.A.; Schrimpf, M.R.; Anderson, D.J.; Gubbins, E.J.; Grønlien, J.H.; Håkerud, M.; Ween, H.; Thorin-Hagene, K.; Malysz, J.; Li, J.; Bunnelle, W.H.; Gopalakrishnan, M.; Meyer, M.D. 7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br. J. Pharmacol., 2008, 153, 1054-1061
-
(2008)
Br. J. Pharmacol
, vol.153
, pp. 1054-1061
-
-
Briggs, C.A.1
Schrimpf, M.R.2
Anderson, D.J.3
Gubbins, E.J.4
Grønlien, J.H.5
Håkerud, M.6
Ween, H.7
Thorin-Hagene, K.8
Malysz, J.9
Li, J.10
Bunnelle, W.H.11
Gopalakrishnan, M.12
Meyer, M.D.13
-
136
-
-
37349119162
-
Gopalakrishnan, M [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5- aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity 7 neuronal nicotinic receptor agonist: Radioligand binding characterization to rat and human brain
-
Anderson, D.J.; Bunnelle, W.; Suber, B.; Du, J.; Surowy, C.; Tribollet, E.; Marguerat, A.; Bertrand, D.; Gopalakrishnan, M [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5- aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity 7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain. J. Pharmacol. Exp. Ther., 2008, 324, 179-187
-
(2008)
J. Pharmacol. Exp. Ther
, vol.324
, pp. 179-187
-
-
Anderson, D.J.1
Bunnelle, W.2
Suber, B.3
Du, J.4
Surowy, C.5
Tribollet, E.6
Marguerat, A.7
Bertrand, D.8
-
137
-
-
34848925196
-
Broad- spectrum efficacy across cognitive domains by 7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways
-
Bitner, R.S.; Bunnelle, W.H.; Anderson, D.J.; Briggs, C.A.; Buccafusco, J.; Curzon, P.; Decker, M.W.; Frost, J.M.; Gronlien, J.H.; Gubbins, E.; Li, J.; Malysz, J.; Markosyan, S.; Marsh, K.; Meyer, M.D.; Nikkel, A.L.; Radek, R.J.; Robb, H.M.; Timmermann, D.; Sullivan, J.P.; Gopalakrishnan, M. Broad- spectrum efficacy across cognitive domains by 7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J. Neurosci., 2007, 27, 10578-10587
-
(2007)
J. Neurosci
, vol.27
, pp. 10578-10587
-
-
Bitner, R.S.1
Bunnelle, W.H.2
Anderson, D.J.3
Briggs, C.A.4
Buccafusco, J.5
Curzon, P.6
Decker, M.W.7
Frost, J.M.8
Gronlien, J.H.9
Gubbins, E.10
Li, J.11
Malysz, J.12
Markosyan, S.13
Marsh, K.14
Meyer, M.D.15
Nikkel, A.L.16
Radek, R.J.17
Robb, H.M.18
Timmermann, D.19
Sullivan, J.P.20
Gopalakrishnan, M.21
more..
-
138
-
-
47149106256
-
Preclinical characterization of A-582941: A novel 7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
-
Tietje, K.R.; Anderson, D.J.; Bitner, R.S.; Blomme, E.A.; Brackemeyer, P.J.; Briggs, C.A.; Browman, K.E.; Bury, D.; Curzon, P.; Drescher, K.U.; Frost, J.M.; Fryer, R.M.; Fox, G.B.; Gronlien, J.H.; Håkerud, M.; Gubbins, E.J.; Halm, S.; Harris, R.; Helfrich, R.J.; Kohlhaas, K.L.; Law, D.; Malysz, J.; Marsh, K.C.; Martin, R.L.; Meyer, M.D.; Molesky, A.L.; Nikkel, A.L.; Otte, S.; Pan, L.; Puttfarcken, P.S.; Radek, R.J.; Robb, H.M.; Spies, E.; Thorin-Hagene, K.; Waring, J.F.; Ween, H.; Xu, H.; Gopalakrishnan, M.; Bunnelle, W.H. Preclinical characterization of A-582941: a novel 7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. CNS Neurosci. Ther., 2008, 14, 65-82
-
(2008)
CNS Neurosci. Ther
, vol.14
, pp. 65-82
-
-
Tietje, K.R.1
Anderson, D.J.2
Bitner, R.S.3
Blomme, E.A.4
Brackemeyer, P.J.5
Briggs, C.A.6
Browman, K.E.7
Bury, D.8
Curzon, P.9
Drescher, K.U.10
Frost, J.M.11
Fryer, R.M.12
Fox, G.B.13
Gronlien, J.H.14
Håkerud, M.15
Gubbins, E.J.16
Halm, S.17
Harris, R.18
Helfrich, R.J.19
Kohlhaas, K.L.20
Law, D.21
Malysz, J.22
Marsh, K.C.23
Martin, R.L.24
Meyer, M.D.25
Molesky, A.L.26
Nikkel, A.L.27
Otte, S.28
Pan, L.29
Puttfarcken, P.S.30
Radek, R.J.31
Robb, H.M.32
Spies, E.33
Thorin-Hagene, K.34
Waring, J.F.35
Ween, H.36
Xu, H.37
Gopalakrishnan, M.38
Bunnelle, W.H.39
more..
-
139
-
-
62949084265
-
Selective 7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3 and decreases tau phosphorylation in vivo
-
Bitner, R.S.; Nikkel, A.L.; Markosyan, S.; Otte, S.; Puttfarcken, P.; Gopalakrishnan, M. Selective 7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3 and decreases tau phosphorylation in vivo. Brain Res., 2009, 1265, 65-74
-
(2009)
Brain Res
, vol.1265
, pp. 65-74
-
-
Bitner, R.S.1
Nikkel, A.L.2
Markosyan, S.3
Otte, S.4
Puttfarcken, P.5
Gopalakrishnan, M.6
-
140
-
-
67650729927
-
Octahydropyrrolo[3,4-c]pyrrole: A diamine scaffold for construction of either 4 2 or 7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity
-
Bunnelle, W.H.; Tietje, K.R.; Frost, J.M.; Peters, D.; Ji, J.; Li, T.; Scanio, M.J.C.; Shi, L.; Anderson, D.J.; Dyhring, T.; Grønlien, J.H.; Ween, H.; Thorin-Hagene, K.; Meyer, M.D. Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either 4 2 or 7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity. J. Med. Chem., 2009, 52, 4126-4141
-
(2009)
J. Med. Chem
, vol.52
, pp. 4126-4141
-
-
Bunnelle, W.H.1
Tietje, K.R.2
Frost, J.M.3
Peters, D.4
Ji, J.5
Li, T.6
Scanio, M.J.C.7
Shi, L.8
Anderson, D.J.9
Dyhring, T.10
Grønlien, J.H.11
Ween, H.12
Thorin-Hagene, K.13
Meyer, M.D.14
-
141
-
-
33947272663
-
JN403, in vitro characterization of a novel nicotinic acetylcholine receptor 7 selective agonist
-
Feuerbach, D.; Nozulak, J.; Lingenhoehl, K.; McAllister, K.; Hoyer, D. JN403, in vitro characterization of a novel nicotinic acetylcholine receptor 7 selective agonist. Neurosci. Lett., 2007, 416, 61-65
-
(2007)
Neurosci. Lett
, vol.416
, pp. 61-65
-
-
Feuerbach, D.1
Nozulak, J.2
Lingenhoehl, K.3
McAllister, K.4
Hoyer, D.5
-
142
-
-
58049109125
-
The selective nicotinic acetylcholine receptor 7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain
-
Feuerbach, D.; Lingenhoehl, K.; Olpe, H.-R.; Vassout, A.; Gentsch, C.; Chaperon, F.; Nozulak, J.; Enz, A.; Bilbe, G.; McAllister, K.; Hoyer, D. The selective nicotinic acetylcholine receptor 7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain. Neuropharmacology, 2008, 56, 254-263
-
(2008)
Neuropharmacology
, vol.56
, pp. 254-263
-
-
Feuerbach, D.1
Lingenhoehl, K.2
Olpe, H.-R.3
Vassout, A.4
Gentsch, C.5
Chaperon, F.6
Nozulak, J.7
Enz, A.8
Bilbe, G.9
McAllister, K.10
Hoyer, D.11
-
143
-
-
60749100712
-
Gamma-lactams - A novel scaffold for highly potent and selective 7 nicotinic acetylcholine receptor agonists
-
Enz, A.; Feuerbach, D.; Frederiksen, M.U.; Gentsch, C.; Hurth, K.; Müller, W.; Nozulak, J.; Roy, B.L. Gamma-lactams - A novel scaffold for highly potent and selective 7 nicotinic acetylcholine receptor agonists. Bioorg. Med. Chem. Lett., 2009, 19, 1287-1291
-
(2009)
Bioorg. Med. Chem. Lett
, vol.19
, pp. 1287-1291
-
-
Enz, A.1
Feuerbach, D.2
Frederiksen, M.U.3
Gentsch, C.4
Hurth, K.5
Müller, W.6
Nozulak, J.7
Roy, B.L.8
-
144
-
-
25444474951
-
3 receptor
-
Baker, S.R.; Boot, J.; Brunavs, M.; Dobson, D.; Green, R.; Hayhurst, L.; Keenan, M.; Wallace, L. High affinity ligands for the 7 nicotinic receptor that show no cross-reactivity with 5-HT3 receptor. Bioorg. Med. Chem. Lett., 2005, 15, 4727-4730
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 4727-4730
-
-
Baker, S.R.1
Boot, J.2
Brunavs, M.3
Dobson, D.4
Green, R.5
Hayhurst, L.6
Keenan, M.7
Wallace, L.8
-
145
-
-
60049101441
-
3 antagonist on sustained attention in rats
-
Rezvani, A.H.; Kholdebarin, E.; Brucato, F.H.; Callahan, P.M.; Lowe, D.A.; Levin, E.D. Effect of R3487/MEM3454, a novel nicotinic 7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2009, 33, 269-275
-
(2009)
Prog. Neuropsychopharmacol. Biol. Psychiatry
, vol.33
, pp. 269-275
-
-
Rezvani, A.H.1
Kholdebarin, E.2
Brucato, F.H.3
Callahan, P.M.4
Lowe, D.A.5
Levin, E.D.6
-
146
-
-
67650473070
-
Drug development for Alzheimer's disease: Where are we now and where are weheaded
-
Sabbagh, M.N. Drug development for Alzheimer's disease: where are we now and where are weheaded? Am. J. Geriatr. Pharmacother., 2009, 7, 167-185
-
(2009)
Am. J. Geriatr. Pharmacother
, vol.7
, pp. 167-185
-
-
Sabbagh, M.N.1
-
147
-
-
34547186153
-
Partial agonist and neuromodulatory activity of S 24795 for 7 nAChR responses of hippocampal interneurons
-
Lopez-Hernandez, G.; Placzek, A.N.; Thinschmidt, J.S.; Lestage, P.; Trocme-Thibierge, C.; Morain, P.; Papke, R.L. Partial agonist and neuromodulatory activity of S 24795 for 7 nAChR responses of hippocampal interneurons. Neuropharmacology, 2007, 53, 134-144
-
(2007)
Neuropharmacology
, vol.53
, pp. 134-144
-
-
Lopez-Hernandez, G.1
Placzek, A.N.2
Thinschmidt, J.S.3
Lestage, P.4
Trocme-Thibierge, C.5
Morain, P.6
Papke, R.L.7
-
148
-
-
38749132964
-
The partial 7 nicotinic acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus
-
Lagostena, L.; Trocme-Thibierge, C.; Morain, P.; Cherubini, E. The partial 7 nicotinic acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology, 2008, 54, 676-685
-
(2008)
Neuropharmacology
, vol.54
, pp. 676-685
-
-
Lagostena, L.1
Trocme-Thibierge, C.2
Morain, P.3
Cherubini, E.4
-
149
-
-
43049114949
-
Improvement of contextual memory by S 24795 in aged mice: Comparison with memantine
-
Beracochea, D.; Boucard, A.; Trocme-Thibierge, C.; Morain, P. Improvement of contextual memory by S 24795 in aged mice: comparison with memantine. Psychopharmacology (Berl), 2008, 196, 555-564
-
(2008)
Psychopharmacology (Berl)
, vol.196
, pp. 555-564
-
-
Beracochea, D.1
Boucard, A.2
Trocme-Thibierge, C.3
Morain, P.4
-
150
-
-
43149119474
-
Comparative effects of the 7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against age-related deficits in declarative and working memory in mice
-
Marighetto, A.; Valerio, S.; Desmedt, A.; Philippin, J.N.; Trocmé- Thibierge, C.; Morain, P. Comparative effects of the 7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against age-related deficits in declarative and working memory in mice. Psychopharmacology (Berl), 2008, 197, 499-508
-
(2008)
Psychopharmacology (Berl)
, vol.197
, pp. 499-508
-
-
Marighetto, A.1
Valerio, S.2
Desmedt, A.3
Philippin, J.N.4
Trocmé-Thibierge, C.5
Morain, P.6
-
151
-
-
0025997336
-
3 receptor, a serotonin-gated ion channel
-
Maricq, A.V.; Peterson, A.S.; Brake, A.J.; Myers, R.M.; Julius, D. Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science, 1991, 254, 432-437
-
(1991)
Science
, vol.254
, pp. 432-437
-
-
Maricq, A.V.1
Peterson, A.S.2
Brake, A.J.3
Myers, R.M.4
Julius, D.5
-
152
-
-
0035847383
-
3 antagonist tropisetron (ICS 205-930) is a potent and selective 7 nicotinic receptor partial agonist
-
Macor, J.E.; Gurley, D.; Lanthorn, T.; Loch, J.; Mack, R.A.; Mullen, G.; Tran, O.; Wright, N.; Gordon, J.C. The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective 7 nicotinic receptor partial agonist. Bioorg. Med. Chem. Lett., 2001, 11, 319-321
-
(2001)
Bioorg. Med. Chem. Lett
, vol.11
, pp. 319-321
-
-
Macor, J.E.1
Gurley, D.2
Lanthorn, T.3
Loch, J.4
Mack, R.A.5
Mullen, G.6
Tran, O.7
Wright, N.8
Gordon, J.C.9
-
153
-
-
1642588156
-
Activity of 7- selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes
-
Papke, R.L.; Porter Papke, J.K.; Rose, G.M. Activity of 7- selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. Bioorg. Med. Chem. Lett., 2004, 14, 1849-1853
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 1849-1853
-
-
Papke, R.L.1
Porter Papke, J.K.2
Rose, G.M.3
-
154
-
-
26944434787
-
Tropisetron improves deficient inhibitory auditory processing in DBA/2 mice: Role of 7 nicotinic acetylcholine receptors
-
Hashimoto, K.; Iyo, M.; Freedman, R.; Stevens, K.E. Tropisetron improves deficient inhibitory auditory processing in DBA/2 mice: role of 7 nicotinic acetylcholine receptors. Psychopharmacology (Berl), 2005, 183, 13-19
-
(2005)
Psychopharmacology (Berl)
, vol.183
, pp. 13-19
-
-
Hashimoto, K.1
Iyo, M.2
Freedman, R.3
Stevens, K.E.4
-
155
-
-
33751184167
-
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron: Role of 7 nicotinic receptors
-
Hashimoto, K.; Fujita, Y.; Ishima, T.; Hagiwara, H.; Iyo, M. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron: Role of 7 nicotinic receptors. Eur. J. Pharmacol., 2006, 553, 191-195
-
(2006)
Eur. J. Pharmacol
, vol.553
, pp. 191-195
-
-
Hashimoto, K.1
Fujita, Y.2
Ishima, T.3
Hagiwara, H.4
Iyo, M.5
-
156
-
-
20444483610
-
Tropisetron improves deficits in auditory P50 suppression in schizophrenia
-
Koike, K.; Hashimoto, K.; Takai, N.; Shimizu, E.; Komatsu, N.; Watanabe, H.; Nakazato, M.; Okamura, N.; Stevens, K.E.; Freedman, R.; Iyo, M. Tropisetron improves deficits in auditory P50 suppression in schizophrenia. Schizophr Res., 2005, 76, 67-72
-
(2005)
Schizophr Res
, vol.76
, pp. 67-72
-
-
Koike, K.1
Hashimoto, K.2
Takai, N.3
Shimizu, E.4
Komatsu, N.5
Watanabe, H.6
Nakazato, M.7
Okamura, N.8
Stevens, K.E.9
Freedman, R.10
Iyo, M.11
-
157
-
-
77955717770
-
Recent development of radioligands for imaging 7 nicotinic acetylcholine receptors in the brain
-
(in press)
-
Toyohara, J.; Wu, J.; Hashimoto, K. Recent development of radioligands for imaging 7 nicotinic acetylcholine receptors in the brain. Curr. Top. Med. Chem., 2010, (in press)
-
(2010)
Curr. Top. Med. Chem
-
-
Toyohara, J.1
Wu, J.2
Hashimoto, K.3
-
158
-
-
52449083063
-
11C]CHIBA- 1001 as a novel PET ligand for 7 nicotinic receptors in the brain: A PET study in conscious monkeys
-
11C]CHIBA- 1001 as a novel PET ligand for 7 nicotinic receptors in the brain: A PET study in conscious monkeys. PLoS One, 2008, 3, e3231
-
(2008)
PLoS One
, vol.e3231
, pp. 3
-
-
Hashimoto, K.1
Nishiyama, S.2
Ohba, H.3
Matsuo, M.4
Kobashi, T.5
Takahagi, M.6
Iyo, M.7
Kitashoji, T.8
Tsukada, H.9
-
159
-
-
67349282369
-
11C]CHIBA-1001 for mapping 7 nicotinic receptors by positron emission tomography
-
11C]CHIBA-1001 for mapping 7 nicotinic receptors by positron emission tomography. Ann. Nucl. Med., 2009, 23, 301-309.
-
(2009)
Ann. Nucl. Med
, vol.23
, pp. 301-309
-
-
Toyohara, J.1
Sakata, M.2
Wu, J.3
Ishikawa, M.4
Oda, K.5
Ishii, K.6
Iyo, M.7
Hashimoto, K.8
Ishiwata, K.9
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