A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: In vitro and in vivo characterization

Journal of Neuroscience

Volumn 25, Issue 17, 2005, Pages 4396-4405

  Hurst, Raymond S ^a   Hajós, Mihaly ^a   Raggenbass, Mario ^b   Wall, Theron M ^a,c   Higdon, Nicole R ^a,c   Lawson, Judy A ^a   Rutherford Root, Karen L ^a   Berkenpas, Mitchell B ^a   Hoffmann, W E ^a   Piotrowski, David W ^a   Groppi, Vincent E ^a   Allaman, Geraldine ^b   Ogier, Roch ^b   Bertrand, Sonia ^b   Bertrand, Daniel ^b   Arneric, Stephen P ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c MPI RESEARCH   (United States)

Author keywords

7; Allosteric modulator; Auditory gating; Hippocampus; Nicotinic receptor; PNU 120596

Indexed keywords

1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 METHYLISOXAZOL 3 YL)UREA; ACETYLCHOLINE; ALPHA3BETA4 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR; ALPHA4BETA2 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR; ALPHA7 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR; ALPHA9ALPHA10 NEURONAL NICOTINIC ACETYCHOLINE RECEPTOR; CALCIUM; NICOTINIC AGENT; NICOTINIC RECEPTOR; PNU 120596; RECEPTOR SUBTYPE; TETRODOTOXIN; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ALLOSTERISM; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; BRAIN INJURY; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED AUDITORY RESPONSE; FEMALE; GABAERGIC SYSTEM; HIGH THROUGHPUT SCREENING; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNEURON; MALE; MEMBRANE CURRENT; MENTAL DISEASE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SCHIZOPHRENIA;

ACETYLCHOLINE; ACOUSTIC STIMULATION; ALLOSTERIC REGULATION; AMPHETAMINE; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CELL LINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CHOLINERGIC AGONISTS; CHOLINERGIC ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; EPITHELIAL CELLS; EVOKED POTENTIALS, AUDITORY; HIPPOCAMPUS; HUMANS; ISOXAZOLES; MALE; MEMBRANE POTENTIALS; MICROINJECTIONS; NEURONS; NICOTINE; OOCYTES; PATCH-CLAMP TECHNIQUES; PHENYLUREA COMPOUNDS; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; TETRODOTOXIN; TIME FACTORS; XENOPUS;

EID: 20944441082     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5269-04.2005     Document Type: Article

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