Neuronal nicotinic receptors: From structure to function

Nicotine and Tobacco Research

Volumn 3, Issue 3, 2001, Pages 203-223

  Leonard, S ^a   Bertrand, D ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTRANSMITTER; NICOTINIC RECEPTOR; PROTEIN; RECEPTOR SUBUNIT;

AMINO ACID SEQUENCE; BEHAVIOR; BRAIN; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG TOLERANCE; GENE; HUMAN; MENTAL PATIENT; MULTIGENE FAMILY; NERVE CELL; NEUROLOGIC DISEASE; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR GENE; REGULATORY MECHANISM; REVIEW; SMOKING; TOBACCO DEPENDENCE;

EID: 0034846184     PISSN: 14622203     EISSN: None     Source Type: Journal    
DOI: 10.1080/14622200124004     Document Type: Review

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103. Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q
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108. Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration
109. Structural and functional characterization of the human alpha3 nicotinic subunit gene promoter
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111. Altered baroreflex responses in alpha 7 deficient mice
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173. Characterization of the neuroprotective and toxic effects of alpha7 nicotinic receptor activation in PC12 cells
174. Neuronal nicotinic acetylcholine receptors
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176. Five subunit genes of the human muscle nicotinic acetylcholine receptor are mapped to two linkage groups on chromosomes 2 and 17
177. Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes
178. Both α- and β-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors
179. Glycosylation within the cysteine loop and six residues near conserved Cys192/Cys193 are determinants of neuronal bungarotoxin sensitivity on the neuronal nicotinic receptor alpha3 subunit
180. Heterogeneity and regulation of nicotinic acetylcholine receptors
181. Interactions between tachykinins and diverse, human nicotinic acetylcholine receptor subtypes
182. Characterization of nicotinic acetylcholine receptors expressed by cells of the SH-SY5Y human neuroblastoma clonal line
183. Presynaptic ionotropic receptors and the control of transmitter release
184. Human vascular endothelial cells express functional nicotinic acetylcholine receptors
185. Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease
186. Long-term potentiation of excitatory inputs to brain reward areas by nicotine
187. Nicotinic autoreceptors mediating enhancement of acetylcholine release become operative in conditions of "impaired" cholinergic presynaptic function
188. A dose-response analysis of nicotine tolerance and receptor changes in two inbred mouse strains
189. Differential agonist inhibition identifies multiple epibatidine binding sites in mouse brain
190. Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
191. 3H]epibatidine
192. On the transcriptional regulation of neuronal nAChR genes
193. Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors
194. Beta43′: An enhancer displaying neural-restricted activity is located in the 3′-untranslated exon of the rat nicotinic acetylcholine receptor beta4 gene
195. Clozapine decreases smoking in patients with chronic schizophrenia
196. Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons
197. Presynaptic ionotropic receptors
198. Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes
199. Transdermal nicotine replacement and smoking cessation
200. Interactions between regulatory proteins that bind to the nicotinic receptor beta 4 subunit gene promoter
201. A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes
202. 3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner
203. Neuroprotective effects of 2,4-dimethoxybenzylidene anabaseine (DMXB) and tetrahydroaminoacridine (THA) in neocortices of nucleus basalis lesioned rats
204. Nicotine enhances sustained attention in the rat under specific task conditions
205. Review on the relationship between nicotinic acetylcholine receptors and dopaminergic neurotransmission in the central nervous system-dopa is an endogenous neuroactive substance
206. Nicotinic acetylcholine receptor at 4.6 A resolution: Transverse tunnels in the channel wall
207. On the nature of allosteric transitions: A plausible model
208. Cloning and transient expression of genes encoding the human alpha 4 and beta 2 neuronal nicotinic acetylcholine receptor (nAChR) subunits
209. Gating of auditory P50 in schizophrenics: Unique effects of clozapine
210. Single channel properties of human alpha 3 AChRs: Impact of beta 2, beta 4 and alpha 5 subunits
211. Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia
212. Differential effects of acute and chronic nicotine on dopamine output in the core and shell of the rat nucleus accumbens
213. Systemic nicotine-induced dopamine release in the rat nucleus-accumbens is regulated by nicotinic receptors in the ventral tegmental area
214. Presynaptic nicotinic acetylcholine receptors as a functional target of nefiracetam in inducing a long-lasting facilitation of hippocampal neurotransmission
215. Nefiracetam facilitates hippocampal neurotransmission by a mechanism independent of the piracetam and aniracetam action
216. Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit
217. Congenital myasthenic syndrome caused by decreased agonist binding affinity due to a mutation in the acetylcholine receptor epsilon subunit
218. Congenital myasthenic syndromes due to heteroallelic nonsense/missense mutations in the acetylcholine receptor epsilon subunit gene: Identification and functional characterization of six new mutations
219. Frameshifting and splice-site mutations in the acetylcholine receptor epsilon subunit gene in three Turkish kinships with congenital myasthenic syndromes
220. Cloning and mapping of the mouse alpha 7-neuronal nicotinic acetylcholine receptor
221. Mice deficient in the alpha 7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents
222. Mice homozygous for the L250T mutation in the α7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within one day of birth
223. Modulation of the neuronal nicotinic acetylcholine receptor-channel by the nootropic drug nefiracetam
224. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype
225. Steroid inhibition of rat neuronal nicotinic alpha 4 beta 2 receptors expressed in HEK 293 cells
226. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
227. Chronic corticosterone administration modulates nicotine sensitivity and brain nicotinic receptor binding in C3H mice
228. Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels
229. Human alpha 7 acetylcholine receptor: Cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes
230. Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover
231. Chronic nicotine treatment up-regulates alpha3 and alpha7 acetylcholine receptor subtypes expressed by the human neuroblastoma cell line SH-SY5Y
232. Increased nicotinic receptors in brains from smokers: Membrane binding and autoradiography studies
233. Alteration in nicotine binding-sites in Parkinsons disease, lewy body dementia and Alzheimers disease - Possible index of early neuropathology
234. Nicotine metabolism defect reduces smoking
235. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptors in the brain
236. Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine
237. Nicotine activates and desensitizes midbrain dopamine neurons
238. Nicotinic receptor of acetylcholine: Structure of an oligomeric integral membrane protein
239. Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease
240. A randomized trial of nortriptyline for smoking cessation
241. Functional expression of nicotinic acetylcholine receptors containing rat alpha 7 subunits in human SH-SY5Y neuroblastoma cells
242. Nicotinic receptors and Parkinson's disease
243. Similarity between rat brain nicotinic alpha-bungarotoxin receptors and stably expressed alpha-bungarotoxin binding sites
244. 2+ permeability of mouse and chick nicotinic acetylcholine receptors expressed in transiently transfected human cells
245. Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits
246. On the mechanism of desensitization at cholinergic receptors
247. Galantamine in AD - A 6-month randomized, placebo-controlled trial with a 6-month extension
248. The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)
249. Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
250. Analysis of the conserved glycosylation site in the nicotinic acetylcholine receptor: Potential roles in complex assembly
251. Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in Southern African Bantu families
252. Fast synaptic signaling by nicotinic acetylcholine and serotonin 5-HT3 receptors in developing visual cortex
253. Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels
254. Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels
255. The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF
256. Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels
257. Neuronal-type acetylcholine receptors and regulation of alpha 7 gene expression in vertebrate skeletal muscle
258. Nicotine-mecamylamine treatment for smoking cessation: The role of pre-cessation therapy
259. Phenotypic characterization of an α4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse
260. Distribution of neuronal nicotinic receptor subunits in human brain
261. Pharmacological characterization of SIB-1765F: A novel cholinergic ion channel agonist
262. Upregulation of nicotinic receptors following continuous infusion of nicotine is brain-region-specific
263. Barium permeability of neuronal nicotinic receptor alpha 7 expressed in Xenopus oocytes
264. Implication of a multisubunit Ets-related transcription factor in synaptic expression of the nicotinic acetylcholine receptor
265. Receptor-mediated mitogenic signals and lung cancer
266. Nicotine, acetylcholine and bombesin are trophic growth factors in neuroendocrine cell lines derived from experimental hamster lung tumors
267. D alpha3, a new functional alpha subunit of nicotinic acetylcholine receptors from Drosophila
268. Mutual occlusion of P2X ATP receptors and nicotinic receptors on sympathetic neurons of the guinea-pig
269. Molecular cloning, functional properties, and distribution of rat brain α7: A nicotinic cation channel highly permeable to calcium
270. Prenatal nicotine increases pulmonary alpha 7 nicotinic receptor expression and alters fetal lung development in monkeys
271. Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking
272. Inhibition of cytochrome P450 2A6 (CYP2A6) decreases smoking and activation of the procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
273. Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha-7 nicotinic receptor
274. UB-165: A novel nicotinic agonist with subtype selectivity implicates the alpha 4 beta 2 subtype in the modulation of dopamine release from rat striatal synaptosomes
275. The effect of bupropion on nicotine craving and withdrawal
276. Plasma nicotine and cotinine levels following intravenous nicotine self-administration in rats
277. Cytoskeletal links of neuronal acetylcholine receptors containing alpha 7 subunits
278. Transdermal nicotine for Tourette's syndrome
279. Mecamylamine in Tourette's syndrome: A two-year retrospective case study
280. Chemical modification of epibatidine causes a switch from agonist to antagonist and modifies its selectivity for neuronal nicotinic acetylcholine receptors
281. Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2)
282. The beta-subunit of neuronal nicotinic acetylcholine-receptors is a determinant of the affinity for substance-P inhibition
283. Two domains of the beta subunit of neuronal nicotinic acetylcholine receptors contribute to the affinity of substance P
284. Schizophrenia and smoking: Evidence for a common neurobiological basis
285. Exon-intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4)
286. An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy
287. A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy
288. Independent occurrence of the CHRNA4 Ser248Phe mutation in a Norwegian family with nocturnal frontal lobe epilepsy
289. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice
290. Nicotine in an animal model of attention
291. A microdialysis study of the effects of the nicotinic agonist RJR-2403 on cortical release of acetylcholine and biogenic amines
292. A 5-month, randomized, placebo-controlled trial of galantamine in AD
293. Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta
294. Pronounced cellular diversity and extrasynaptic location of nicotinic acetylcholine receptor subunit immunoreactivities in the chicken pretectum
295. Projection structure of the nicotinic acetylcholine receptor: Distinct conformations of the alpha subunits
296. Peptide modulation of ACh receptor desensitization controls neurotransmitter release from chicken sympathetic neurons
297. Progesterone modulates a neuronal nicotinic acetylcholine-receptor
298. GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue
299. Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes
300. Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors
301. Role of alpha 9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation
302. Nicotinic receptors that bind α-bungarotoxin on neurons raise intracellular free Ca++
303. Antibodies affecting ion channel function in acquired neuromyotonia, in seropositive and seronegative myasthenia gravis, and in antibody-mediated arthrogryposis multiplex congenita
304. Beta-amyloid(1-42) binds to alpha 7 nicotinic acetylcholine receptor with high affinity - Implications for Alzheimer's disease pathology
305. Amyloid peptide A beta(1-42) binds selectively and with picomolar affinity to alpha 7 nicotinic acetylcholine receptors
306. Neural mechanisms underlying nicotine addiction: Acute positive reinforcement and withdrawal
307. Neuronal nicotinic acetylcholine receptors: From the gene to the disease
308. The cholinergic 'pitfall': Acetylcholine, a universal cell molecule in biological systems, including humans
309. Cellular distribution of nicotinic acetylcholine receptor subunit mRNAs in the human cerebral cortex as revealed by non-isotopic in situ hybridization
310. Cellular distribution of the mRNA for the alpha 7 subunit of the nicotinic acetylcholine receptor in the human cerebral cortex
311. Four week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease
312. I-125-alpha-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain
313. Pharmacological and null mutation approaches reveal nicotinic receptor diversity
314. The paradox of nicotinic acetylcholine receptor upregulation by nicotine
315. Presynaptic nicotinic ACh receptors
316. Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA
317. Megacystis, mydriasis, and ion channel defect in mice lacking the alpha 3 neuronal nicotinic acetylcholine receptor
318. 3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line
319. Functional contribution of the alpha5 subunit to neuronal nicotinic channels expressed by chick sympathetic ganglion neurons
320. Functional contribution of the alpha7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurons
321. Presence of functional neuronal nicotinic acetylcholine receptors in brainstem motoneurons of the rat
322. Nicotine-mecamylamine interactions
323. Neuronal acetylcholine receptors that bind a-bungarotoxin with high affinity function as ligand-gated ion channels
324. Non-additive interaction between nicotinic cholinergic and P2X purine receptors in guinea-pig enteric neurons in culture
325. Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells
326. Identification of four classes of brain nicotinic receptors using beta2 mutant mice
327. Potentiation and inhibition of neuronal alpha 4 beta 4 nicotinic acetylcholine receptors by choline