Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells

British Journal of Pharmacology

Volumn 146, Issue 8, 2005, Pages 1096-1109

  Riganti, Loredana ^a   Matteoni, Cosetta ^b   Di Angelantonio, Silvia ^b   Nistri, Andrea ^a   Gaimarri, Annalisa ^a   Sparatore, Fabio ^c   Canu Boido, Caterina ^c   Clementi, Francesco ^a   Gotti, Cecilia ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SISSA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

bungarotoxin; Acetylcholine; Cytisine; Epibatidine; Nicotine; Upregulation

Indexed keywords

1,2 BIS N CYTISINYLETHANE; ALPHA BUNGAROTOXIN I 125; ALPHA CONOTOXIN MII; CARBACHOL; CYTISINE; DIHYDRO BETA ERYTHROIDINE; EPIBATIDINE; MESSENGER RNA; METHYLLYCACONITINE; MUSCARINIC RECEPTOR; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; SEROTONIN RECEPTOR; TRITIUM; TUBOCURARINE CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; IMMUNOPRECIPITATION; LONG TERM EXPOSURE; NEUROBLASTOMA CELL; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURIFICATION; RECEPTOR UPREGULATION; RNA TRANSCRIPTION; WHOLE CELL;

ALKALOIDS; AZOCINES; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BUNGAROTOXINS; CELL LINE, TUMOR; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIALS; NERVE TISSUE PROTEINS; NEUROBLASTOMA; NEURONS; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT; PYRIDINES; QUINOLIZINES; RECEPTORS, NICOTINIC; SUBCELLULAR FRACTIONS; TIME FACTORS; UP-REGULATION;

EID: 28944443905     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706434     Document Type: Article

References (52)

1. BALESTRA, B., MORETTI, M., LONGHI, R., MANTEGAZZA, R., CLEMENTI, F. & GOTTI, C. (2000). Antibodies against neuronal nicotinic receptor subtypes in neurological disorders. J. Neuroimmunol., 102, 89-97.
2. BENWELL, M.E., BALFOUR, D.J. & ANDERSON, J.M. (1988). Evidence that tobacco smoking increases the density of (-)-[3H]nicotine binding sites in human brain. J. Neurochem., 50, 1243-1247.
3. BOIDO, C.C., TASSO, B., BOIDO, V. & SPARATORE, F. (2003). Cytisine derivatives as ligands for neuronal nicotine receptors and with various pharmacological activities. Farmaco, 58, 265-277.
4. BUISSON, B. & BERTRAND, D. (2001). Chronic exposure to nicotine upregulates the human (alpha)4(beta)2 nicotinic acetylcholine receptor function. J. Neurosci., 21, 1819-1829.
5. CANU BOIDO, C. & SPARATORE, F. (1999). Synthesis and preliminary pharmacological evaluation of some cytisine derivatives. Farmaco, 54, 438-451.
6. CARBONNELLE, E., SPARATORE, F., CANU-BOIDO, C., SALVAGNO, C., BALDANI-GUERRA, B., TERSTAPPEN, G., ZWART, R., VIJVERBERG, H., CLEMENTI, F. & GOTTI, C. (2003). Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes. Eur. J. Pharmacol., 471, 85-96.
7. CARDENAS, A.M., KUIJPERS, G.A. & POLLARD, H.B. (1995). Effect of protein synthesis inhibitors on synexin levels and secretory response in bovine adrenal medullary chromaffin cells. Biochim. Biophys. Acta, 1234, 255-260.
8. CARTIER, G.E., YOSHIKAMI, D., GRAY, W.R., LUO, S., OLIVERA, B.M. & MCINTOSH, J.M. (1996). A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors. J. Biol. Chem., 271, 7522-7528.
9. CHAVEZ-NORIEGA, L.E., CRONA, J.H., WASHBURN, M.S., URRUTIA, A., ELLIOTT, K.J. & JOHNSON, E.C. (1997). Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther., 280, 346-356.
10. COVERNTON, P.J., KOJIMA, H., SIVILOTTI, L.G., GIBB, A.J. & COLQUHOUN, D. (1994). Comparison of neuronal nicotinic receptors in rat sympathetic neurones with subunit pairs expressed in Xenopus oocytes. J. Physiol., 481 (Part 1), 27-34.
11. DAMAJ, M.I., CARROLL, F.I., EATON, J.B., NAVARRO, H.A., BLOUGH, B.E., MIRZA, S., LUKAS, R.J. & MARTIN, B.R. (2004). Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol. Pharmacol., 66, 675-682.
12. DI ANGELANTONIO, S., GINIATULLIN, R., COSTA, V., SOKOLOVA, E. & NISTRI, A. (2003a). Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomie nerve cells. Br. J. Pharmacol., 139, 1061-1073.
13. DI ANGELANTONIO, S., MATTEONI, C., FABBRETTI, E. & NISTRI, A. (2003b). Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells. Eur. J. Neurosci., 17, 2313-2322.
14. DOUGHERTY, J.J., WU, J. & NICHOLS, R.A. (2003). Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex. J. Neurosci., 23, 6740-6747.
15. FENSTER, C.P., WHITWORTH, T.L., SHEFFIELD, E.B., QUICK, M.W. & LESTER, R.A. (1999). Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine. J. Neurosci., 19, 4804-4814.
16. FISCHER, H., ORR-URTREGER, A., ROLE, L.W. & HUCK, S. (2005). Selective deletion of the alpha5 subunit differentially affects somatic-dendritic versus axonally targeted nicotinic ACh receptors in mouse. J. Physiol., 563, 119-137.
17. FREE, R.B., MCKAY, S.B., GOTTLIEB, P.D., BOYD, R.T. & MCKAY, D.B. (2005). Expression of native alpha3beta4* neuronal nicotinic receptors: binding and functional studies investigating turnover of surface and intracellular receptor populations. Mol. Pharmacol., 67, 2040-2048.
18. GENTRY, C.L. & LUKAS, R.J. (2002). Regulation of nicotinic acetylcholine receptor numbers and function by chronic nicotine exposure. Curr. Drug Targets CNS Neurol. Disord., 1, 359-385.
19. GOTTI, C. & CLEMENTI, F. (2004). Neuronal nicotinic receptors: from structure to pathology. Prog. Neurobiol., 74, 363-396.
20. GOTTI, C., RIGANTI, L., VAILATI, S. & CLEMENTI, F. (2005). Brain neuronal nicotinic receptors as new targets for drug discovery. Current Pharmaceutical Design, in press.
21. HARKNESS, P.C. & MILLAR, N.S. (2002). Changes in conformation and subcellular distribution of alpha4beta2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras. J. Neurosci., 22, 10172-10181.
22. HOGG, R.C., RAGGENBASS, M. & BERTRAND, D. (2003). Nicotinic acetylcholine receptors: from structure to brain function. Rev. Physiol. Biochem. Pharmacol., 147, 1-46.
23. HOULIHAN, L.M., SLATER, Y., GUERRA, D.L., PENG, J.H., KUO, Y.P., LUKAS, R.J., CASSELS, B.K. & BERMUDEZ, I. (2001). Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors. J. Neurochem., 78, 1029-1043.
24. JONES, S., SUDWEEKS, S. & YAKEL, J.L. (1999). Nicotinic receptors in the brain: correlating physiology with function. Trends Neurosci., 22, 555-561.
25. KAWAI, H. & BERG, D.K. (2001). Nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure. J. Neurochem., 78, 1367-1378.
26. LAI, A., PARAMESWARAN, N., KHWAJA, M., WHITEAKER, P., LINDSTROM, J.M., FAN, H., MCINTOSH, J.M., GRADY, S.R. & QUIK, M. (2005). Long-term nicotine treatment decreases striatal alpha6* nicotinic acetylcholine receptor sites and function in mice. Mol. Pharmacol., 67, 1639-1647.
27. LOPEZ-HERNANDEZ, G.Y., SANCHEZ-PADILLA, J., ORTIZ-ACEVEDO, A., LIZARDI-ORTIZ, J., SALAS-VINCENTY, J., ROJAS, L.V. & LASALDE-DOMINICCI, J.A. (2004). Nicotine-induced up-regulation and desensitization of alpha4beta2 neuronal nicotinic receptors depend on subunit ratio. J. Biol. Chem., 279, 38007-38015.
28. MARKS, M.J., PAULY, J.R., GROSS, S.D., DENERIS, E.S., HERMANS-BORGMEYER, I., HEINEMANN, S.F. & COLLINS, A.C. (1992). Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J. Neurosci., 12, 2765-2784.
29. MARKS, M.J., STITZEL, J.A. & COLLINS, A.C. (1985). Time course study of the effects of chronic nicotine infusion on drug response and brain receptors. J. Pharmacol. Exp. Ther., 235, 619-628.
30. MOLINARI, E.J., DELBONO, O., MESSI, M.L., RENGANATHAN, M., ARNERIC, S.P., SULLIVAN, J.P. & GOPALAKRISHNAN, M. (1998). Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands. Eur. J. Pharmacol., 347, 131-139.
31. MORETTI, M., VAILATI, S., ZOLI, M., LIPPI, G., RIGANTI, L., LONGHI, R., VIEGI, A., CLEMENTI, F. & GOTTI, C. (2004). Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience. Mol. Pharmacol., 66, 85-96.
32. NELSON, M.E., KURYATOV, A., CHOI, C.H., ZHOU, Y. & LINDSTROM, J. (2003). Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors. Mol. Pharmacol., 63, 332-341.
33. NGUYEN, H.N., RASMUSSEN, B.A. & PERRY, D.C. (2004). Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment. J. Neurochem., 90, 40-49.
34. PAPKE, R.L. & HEINEMANN, S.F. (1994). Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit. Mol. Pharmacol., 45, 142-149.
35. PARADISO, K.G. & STEINBACH, J.H. (2003). Nicotine is highly effective at producing desensitization of rat alpha4beta2 neuronal nicotinic receptors. J. Physiol., 553, 857-871.
36. PATON, W.D. & ZAIMIS, E.J. (1949). The pharmacological actions of polymethylene bistrimethyl-ammonium salts. Br. J. Pharmacol., 4, 381-400.
37. PENG, X., GERZANICH, V., ANAND, R., WANG, F. & LINDSTROM, J. (1997). Chronic nicotine treatment up-regulates alpha3 and alpha7 acetylcholine receptor subtypes expressed by the human neuroblastoma cell line SH-SY5Y. Mol. Pharmacol., 51, 776-784.
38. PENG, X., GERZANICH, V., ANAND, R., WHITING, P.J. & LINDSTROM, J. (1994). Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol. Pharmacol., 46, 523-530.
39. QUIK, M. (2004). Smoking, nicotine and Parkinson's disease. Trends Neurosci., 27, 561-568.
40. RIDLEY, D.L., ROGERS, A. & WONNACOTT, S. (2001). Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells. Br. J. Pharmacol., 133, 1286-1295.
41. SALLETTE, J., BOHLER, S., BENOIT, P., SOUDANT, M., PONS, S., LE NOVERE, N., CHANGEUX, J.P. & CORRINGER, P.J. (2004). An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine. J. Biol. Chem., 279, 18767-18775.
42. SALLETTE, J., PONS, S., DEVILLERS-THIERY, A., SOUDANT, M., PRADO DE CARVALHO, L., CHANGEUX, J.P. & CORRINGER, P.J. (2005). Nicotine upregulates its own receptors through enhanced intracellular maturation. Neuron, 46, 595-607.
43. SCHMUCK, K., ULLMER, C., ENGELS, P. & LUBBERT, H. (1994). Cloning and functional characterization of the human 5-HT2B serotonin receptor. FEBS Lett., 342, 85-90.
44. SCHROEDER, K.M., WU, J., ZHAO, L. & LUKAS, R.J. (2003). Regulation by cycloheximide and lowered temperature of cell-surface alpha7-nicotinic acetylcholine receptor expression on transfected SH-EP1 cells. J. Neurochem., 85, 581-591.
45. SCHWARTZ, R.D. & KELLAR, K.J. (1985). In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs. J. Neurochem., 45, 427-433.
46. SLATER, Y.E., HOULIHAN, L.M., MASKELL, P.D., EXLEY, R., BERMUDEZ, I., LUKAS, R.J., VALDIVIA, A.C. & CASSELS, B.K. (2003). Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes. Neuropharmacology, 44, 503-515.
47. VILLARROYA, M., GANDIA, L., LOPEZ, M.G., GARCIA, A.G., CUETO, S., GARCIA-NAVIO, J.L. & ALVAREZ-BUILLA, J. (1996). Synthesis and pharmacology of alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptor. Bioorg Med. Chem., 4, 1177-1183.
48. WANG, F., NELSON, M.E., KURYATOV, A., OLALE, F., COOPER, J., KEYSER, K. & LINDSTROM, J. (1998). Chronic nicotine treatment up-regulates human alpha3 beta2 but not alpha3 beta4 acetylcholine receptors stably transfected in human embryonic kidney cells. J. Biol. Chem., 273, 28721-28732.
49. WANG, H.Y., LEE, D.H., D'ANDREA, M.R., PETERSON, P.A., SHANK, R.P. & REITZ, A.B. (2000). beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J. Biol. Chem., 275, 5626-5632.
50. WENGER, B.W., BRYANT, D.L., BOYD, R.T. & McKAY, D.B. (1997). Evidence for spare nicotinic acetylcholine receptors and a beta 4 subunit in bovine adrenal chromaffin cells: studies using bromoacetylcholine, epibatidine, cytisine and mAb35. J. Pharmacol. Exp. Ther., 281, 905-913.
51. WHITEAKER, P., SHARPLES, C.G. & WONNACOTT, S. (1998). Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition. Mol. Pharmacol., 53, 950-962.
52. WONG, E.T., HOLSTAD, S.G., MENNERICK, S.J., HONG, S.E., ZORUMSKI, C.F. & ISENBERG, K.E. (1995). Pharmacological and physiological properties of a putative ganglionic nicotinic receptor, alpha 3 beta 4, expressed in transfected eucaryotic cells. Brain Res. Mol. Brain Res., 28, 101-109.