Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 2, 2001, Pages 646-656

  Papke, Roger L ^a,c   Sanberg, Paul R ^b   Shytle, R Douglas ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CHOLINERGIC RECEPTOR; MECAMYLAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; NONHUMAN; OOCYTE; PRIORITY JOURNAL; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ANIMALS; BINDING, COMPETITIVE; ELECTROPHYSIOLOGY; HUMANS; MECAMYLAMINE; NEURONS; NICOTINIC ANTAGONISTS; OOCYTES; RECEPTORS, NICOTINIC; RNA, MESSENGER; STEREOISOMERISM; XENOPUS LAEVIS;

EID: 0035037736     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells
2. Renal elimination of 3-methylaminoisocamphane hydrochloride (mecamylamine)
3. 3H]mecamylamine binding to rat brain membranes. Studies with mecamylamine and nicotine analogues
4. Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes
5. Accumbal dopamine overflow after ethanol: Localization of the antagonizing effect of mecamylamine
6. Voluntary ethanol intake in the rat: Effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment
7. Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha2beta 2, h alpha2beta4, h alpha3beta2, h alpha3beta4, h alpha4beta2, h alpha4beta4 and h alpha7 expressed in Xenopus oocytes
8. Nicotinic receptor subtypes in the developing chick brain: Appearance of a species containing the α4, β2 and α5 gene products
9. The alpha 5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain
10. α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells
11. α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
12. Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine
13. Acetylcholine-evoked curents in cultured neurones dissociated from rat parasympathetic cardiac ganglia
14. Muscle-type nicotinic acetylcholine receptor delta subunit determines sensitivity to noncompetitive inhibitors while gamma subunit regulates divalent permeability
15. Synaptic potentials mediated via α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons
16. Rapid relief of block by mecamylamine of neuronal nicotinic acetylcholine receptors of rat chromaffin cells in vitro: An electrophysiological and modeling study
17. A novel nicotinic-cholinergic role in behavioral sensitization to amphetamine-induced stereotypy in mice
18. Central actions of nicotine antagonists
19. What is the nature of mecamylamine's antagonism of the central effects of nicotine?
20. A study of the N-methyl-D-aspartate antagonistic properties of anticholinergic drugs
21. Molecular distinction between fetal and adult forms of muscle acetylcholine receptor
22. Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration
23. Corticosterone-attenuating and anxiolytic properties of mecamylamine in the rat
24. Mecamylamine is a selective non-competitive antagonist of N-methyl-D-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina
25. Glutamate receptors in the mammalian CNS
26. The kinetic properties of neuronal nicotinic receptors: Genetic basis of functional diversity
27. Inhibition of nicotinic acetylcholine receptors by BTMPS (Tinuvin 770), an additive to medical plastics
28. The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes
29. A nicotine antagonist, mecamylamine, reduces cue-induced cocaine craving in cocaine-dependent subjects
30. Nicotine-mecamylamine treatment for smoking cessation: The role of pre-cessation therapy
31. Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone
32. Treatment of Tourette's syndrome with mecamylamine
33. Preparation of optically active secondary amines by thermal decomposition of (methylbenzyl)urea analogs: Absolute configuration of (+)- and (-)-mecamylamine
34. Chemistry and structure-activity relationships of mecamylamine and derivatives
35. Ganglionic blocking properties of 3-methylaminoisocamphane hydrochloride (mecamylamine): A secondary amine
36. Synthesis of 2-exo- and 2-endo-mecamylamine analogues. Structure-activity relationships for nicotinic antagonism in the central nervous system
37. Clinical evaluation of mecamylamine for withdrawal from nicotine dependence
38. Dose-specific improvements in memory-related performance by rats and aged monkeys administered the nicotinic-cholinergic antagonist mecamylamine
39. The acetylcholine receptor of the neuromuscular junction recognizes mecamylamine as a noncompetitive antagonist
40. Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes
41. Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain