Solving the α-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists

Journal of the American Chemical Society

Volumn 132, Issue 10, 2010, Pages 3514-3522

  Muttenthaler, Markus ^a   Nevin, Simon T ^a   Grishin, Anton A ^a,b   Ngo, Shyuan T ^a   Choy, Peng T ^a   Daly, Norelle L ^a   Hu, Shu Hong ^a   Armishaw, Christopher J ^a,c   Wang, Ching I A ^a   Lewis, Richard J ^a   Martin, Jennifer L ^a   Noakes, Peter G ^a   Craik, David J ^a   Adams, David J ^a,b   Alewood, Paul F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b RMIT UNIVERSITY   (Australia)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPHILICS; BIOPHYSICAL PROPERTIES; CONOTOXINS; DIAPHRAGM MUSCLE; DISULFIDE BONDS; HIGH SPECIFICITY; ISOSTERIC; MINI-PROTEINS; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHR); PHASE METHODS; SELENOCYSTEINE; STRUCTURAL SUBCLASS; XENOPUS OOCYTE;

DRUG THERAPY; PROTEINS; RESINS; SELENIUM; SELENIUM COMPOUNDS; TOBACCO;

PLASMA STABILITY;

ALPHA CONOTOXIN; ALPHA CONOTOXIN MII; NICOTINIC RECEPTOR BLOCKING AGENT; RESIN; SELENIUM; SELENOCYSTEINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DIAPHRAGM MUSCLE; DISULFIDE BOND; NONHUMAN; OOCYTE; RAT; X RAY; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; CONOTOXINS; CRYSTALLOGRAPHY, X-RAY; DIAPHRAGM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE CONTRACTION; NICOTINIC ANTAGONISTS; OOCYTES; PROTEIN FOLDING; PROTEIN STABILITY; RATS; RECEPTORS, NICOTINIC; RESINS, SYNTHETIC; SELENOCYSTEINE; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 77949391358     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja910602h     Document Type: Article

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