Expression of nigrostriatal α6-containing nicotinic acetylcholine receptors is selectively reduced, but not eliminated, by β3 subunit gene deletion

Molecular Pharmacology

Volumn 67, Issue 6, 2005, Pages 2007-2015

  Gotti, Cecilia ^a   Moretti, Milena ^a   Clementi, Francesco ^a   Riganti, Loredana ^a   Michael McIntosh, J ^c   Collins, Allan C ^b   Marks, Michael J ^b   Whiteaker, Paul ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CONOTOXIN MII; EPIBATIDINE; IODINE 125; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA6; NICOTINIC RECEPTOR BETA3; RECEPTOR ANTIBODY; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; PROTEIN SUBUNIT;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; GENE DELETION; GENE EXPRESSION; IMMUNOPRECIPITATION; LIGAND BINDING; MESENCEPHALON; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PHYSIOLOGY; RAT; SUBSTANTIA NIGRA;

AMINO ACID SEQUENCE; ANIMALS; CORPUS STRIATUM; GENE DELETION; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PROTEIN SUBUNITS; RATS; RECEPTORS, NICOTINIC; SUBSTANTIA NIGRA;

EID: 21744452511     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.105.011940     Document Type: Article

References (26)

1. Azam L, Winzer-Serhan UH, Chen YL, and Leslie FM (2002) Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons. J Comp Neurol 444:260-274.
2. Cartier GE, Yoshikami DJ, Gray WR, Luo S, Olivera BM, and McIntosh JM (1996) A new α-conotoxin which targets α3β2 nicotinic receptors. J Biol Chem 271:7522-7528.
3. Champtiaux N, Han ZY, Bessis A, Rossi FM, Zoli M, Marubio L, McIntosh JM, and Changeux JP (2002) Distribution and pharmacology of alpha6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci 22:1208-1217.
4. Champtiaux N, Gotti C, Cordero-Erausquin M, David D, Przybylski C, Léna C, Le Novère N, del Mar Arroyo-Jimenez M, Clementi F, Moretti M, et al. (2003) Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knockout mice. J Neurosci 23:7820-7829.
5. Corringer PJ, Le Novère N, and Changeux JP (2000) Nicotinic receptors at the amino acid level. Annu Rev Pharmacol Toxicol 40:431-458.
6. Cui C, Booker TK, Allen RS, Grady SR, Whiteaker P, Marks MJ, Salminen O, Tritto T, Butt CM, Allen WR, et al. (2003) The β3 nicotinic receptor subunit: a component of α-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviours. J Neurosci 23:11045-11053.
7. Di Chiara G (2000) Role of dopamine in the behavioural actions of nicotine related to addiction. Eur J Pharmacol 393:295-314.
8. Gerzanich V, Peng X, Wang F, Wells G, Anand R, Fletcher S, and Lindstrom J (1995) Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol 48:774-782.
9. Gotti C and Clementi F (2004) Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 74:363-396.
10. Groot-Kormelink PJ, Luyten W, Colquhoun D, and Sivilotti LG (1998) A reporter mutation approach shows incorporation of the "orphan" subunit β3 into a functional nicotinic receptor. J Biol Chem 273:15317-15320.
11. Klink R, de Kerchove-d'Exaerde A, Zoli M, and Changeux JP (2001) Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 21:1452-1463.
12. Kuryatov A, Olale F, Cooper J, Choi C, and Lindstrom J (2000) Human alpha6 AChR subtypes: subunit composition, assembly, and pharmacological responses. Neuropharmacology 39:2570-2590.
13. Le Novère N and Changeux JP (1995) Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. J Mol Evol 40:155-172.
14. Le Novère N, Zoli M, and Changeux JP (1996) Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. Eur J Neurosci 8:2428-2439.
15. Lindstrom J (2000) The structure of neuronal nicotinic receptors, in Neuronal Nicotinic Receptors: Handbook of Experimental Pharmacology (Clementi F, Fornasari D, and Gotti C eds) vol. 144, p. 101-162, Springer, Berlin.
16. Marks MJ, Pauly JR, Gross SD, Deneris ES, Hermans-Borgmeyer I, Heinemann SF, and Collins AC (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci 12:2765-2784.
17. Marubio LM, Gardier AM, Durier S, David D, Klink R, Arroyo-Jimenez MM, McIntosh JM, Rossi F, Champtiaux N, Zoli M, et al. (2003) Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors. Eu J Neurosci 17:1329-1337.
18. Moretti M, Vailati S, Zoli M, Lippi G, Riganti L, Longhi R, Viegi A, Clementi F, and Gotti C (2004) Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience. Mol Pharmacol 66:85-96.
19. Munson PJ and Rodbard D (1980) LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239.
20. Picciotto MR, Zoli M, Rimondini R, Lena C, Marubio LM, Pich EM, Fuxe K, and Changeux JP (1998) Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature (Lond) 391:173-177.
21. Quik M, Sun JD, Whiteaker P, McCallum SE, Marks MJ, Musachio J, McIntosh JM, Collins AC, and Grady SR (2003) Differential decline in striatal receptor subtype function after nigrostriatal damage in mice. Mol Pharmacol 63:1169-1179.
22. Salminen O, Murphy KL, McIntosh JM, Drago J, Marks MJ, Collins AC, and Grady SR (2004) Subunit composition and pharmacology of two classes of striatal pre-synaptic nicotinic acetylcholine receptors mediating dopamine release in mice. Mol Pharmacol 65:1526-1535.
23. Vailati S, Moretti M, Balestra B, McIntosh M, Clementi F, and Gotti C (2000) β3 subunit is present in different nicotinic receptor subtypes in chick retina. Eur J Pharmacol 393:23-30.
24. 125I-α-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain. Mol Pharmacol 57:913-925.
25. Yu CR and Role LW (1998) Functional contribution of the alpha 7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurones. J Physiol (Lond) 509:651-665.
26. Zoli M, Moretti M, Zanardi A, McIntosh MJ, Clementi F, and Gotti C (2002) Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. J Neurosci 22:8785-8789.