A nicotine antagonist, mecamylamine, reduces cue-induced cocaine craving in cocaine-dependent subjects

Neuropsychopharmacology

Volumn 20, Issue 3, 1999, Pages 297-307

  Reid, Malcolm S ^a   Mickalian, Joanne D ^b   Delucchi, Kevin L ^b   Berger, S Paul ^b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Addiction; Cocaine; Craving; Mecamylamine; Nicotine

Indexed keywords

COCAINE; MECAMYLAMINE; PLACEBO;

ADULT; ANXIETY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COCAINE DEPENDENCE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HEART RATE; HUMAN; MALE; MOOD; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN CONDUCTANCE; SKIN TEMPERATURE; WITHDRAWAL SYNDROME;

ADOLESCENT; ADULT; AGED; BEHAVIOR, ADDICTIVE; COCAINE-RELATED DISORDERS; CROSS-OVER STUDIES; CUES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MECAMYLAMINE; MIDDLE AGED; NICOTINIC ANTAGONISTS; SMOKING;

EID: 0032954369     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(98)00076-1     Document Type: Article

References (24)

1. Berger S.P., Hall S.M., Mickalian J.D., Reid M.S., Crawford C.A., Delucchi K.L., Carr K., Hall S. Haloperidol antagonism of cue-elicited cocaine craving. Lancet. 347:1996;504-508.
2. Budney A.J., Higgins S.T., Hughes J.R., Bickel W.K. Nicotine and caffeine use in cocaine-dependent individuals. J Subst Abuse. 5:1993;117-130.
3. Childress A.R., McLellan A.T., O'Brien C.P. Conditioned responses in a methadone population. A comparison of laboratory, clinic and natural setting J Subst Abuse Treat. 3:1986;173-179.
4. Ehrman R.N., Robbins S.J., Childress A.R., O'Brien C.P. Conditioned responses to cocaine-related stimuli in cocaine abuse patients. Psychopharmacol. 107:1992;523-529.
5. Eissenberg T., Griffiths R.R., Stitzer M.L. Mecamylamine does not precipitate withdrawal in cigarette smokers. Psychopharm. 127:1996;328-336.
6. Fagerström K.O. Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. Addictive Behav. 3:1978;235-241.
7. First MB, Spitzer RL, Gibbon M, Williams JBW (1996): Structured Clinical Interview for DSM-IV Axis I Disorders - Patient Edition (SCID-I/P, Version 2.0), Biometrics Research Department, New York State Psychiatric Institute, New York.
8. Henningfield J.E., Clayton R., Pollin W. Involvement of tobacco in alcoholism and illicit drug use. Brit J Addict. 85:1990;279-292.
9. Horger B.A., Giles M.K., Schenk S. Preexposure to amphetamine and nicotine predisposes rats to self-administer a low dose of cocaine. Psychopharmacol. 107:1992;271-276.
10. Kranzler H.R., Bauer L.O. Bromocriptine and cocaine cue reactivity in cocaine-dependent patients. Brit J Addict. 87:1992;1537-1548.
11. McLellan A.T., Luborsky L., O'Brien C.P., Woody G.E. An improved evaluation instrument for substance abuse patients. The Addiction Severity Index J Nervous Mental Disease. 168:1980;26-33.
12. McNair DM, Lorr M, Droppelman LF (1971): Manual: Profile of Mood States, San Diego, California, Educational and Industrial Testing Service.
13. Nemeth-Coslett R., Henningfield J.E., O'Keefe M.K., Griffiths R.R. Effects of mecamylamine on human cigarette smoking and subjective ratings. Psychopharm. 88:1986;420-425.
14. O'Brien C.P., Childress A.R., McLellan T., Ehrman R. Integrating systemic cue exposure with standard treatment in recovering drug dependent patients. Addictive Behav. 15:1990;355-365.
15. O'Brien C.P., Childress A.R., McLellan A.T., Ehrman R. Classical conditioning in drug-dependent humans. Annal NY Acad Sci. 654:1992;400-415.
16. Reid M.S., Mickalian J.D., Delucchi K.L., Hall S.M., Berger S.P. An acute dose of nicotine enhances cue-induced cocaine craving. Drug Alcohol Depend. 49:1998;95-104.
17. Robbins S.J., Ehrman R.N., Childress A.R., O'Brien C.P. Using cue reactivity to screen medications for cocaine abuse. a test of amantadine hydrochloride Addict Behav. 17:1992;491-499.
18. Rohsenow D.J., Niara R.S., Childress A.R., Abrams D.B., Monti P.M. Cue reactivity in addictive behaviors. theoretical and treatment implications Int J Addict. 25:1991;975-993.
19. Rose J.E., Behm F.M., Westman E.C., Levin E.D., Stein R.M., Ripka G.V. Mecamylamine combined with nicotine skin patches facilitates smoking cessation beyond nicotine patch treatment alone. Clin Pharmacol Therapeutics. 56:1994;86-99.
20. Rose J.E., Sampson A., Levin E.D., Henningfield J.E. Mecamylamine increases nicotine preference and attennuates nicotine discrimination. Pharmacol Biocem Behav. 32:1989;933-938.
21. Satel S.L., Krystal J.H., Delgado P.L., Kosten T.R., Charney D.S. Tryptophan depletion and attenuation of cue-induced craving for cocaine. Am J Psychiatry. 152:1995;778-783.
22. Sees K.L., Clark H.W. Substance abusers want to stop smoking! Alcohol: Clin Experiment Res. 15:1991;152.
23. U.S. Department of Health and Human Services (1988): The health consequences of smoking: Nicotine addiction: A report of the Surgeon General, (DHHS Publication No. CDC 8-8406), Washington, D.C., U.S. Government Printing Office.
24. Wickelgren I. Getting the brain's attention. Science. 278:1997;35-37.