Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

EMBO Journal

Volumn 24, Issue 20, 2005, Pages 3635-3646

  Hansen, Scott B ^a   Sulzenbacher, Gerlind ^b   Huxford, Tom ^a   Marchot, Pascale ^c   Taylor, Palmer ^a   Bourne, Yves ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Centre National de la Recherche Scientifique   (France)

^c CNRS   (France)

Author keywords

conotoxin; Acetylcholine binding protein; Conformational flexibility; Crystal structure; Nicotinic acetylcholine receptor

Indexed keywords

ALPHA BUNGAROTOXIN; COBROTOXIN; EPIBATIDINE; LOBELINE; METHYLLYCACONITINE;

APLYSIA; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CRYSTAL STRUCTURE; EXTRACELLULAR MATRIX; GENE LOCUS; GENE STRUCTURE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SURFACE PROPERTY;

AMINO ACID SEQUENCE; ANIMALS; APLYSIA; CARRIER PROTEINS; LIGANDS; MOLECULAR SEQUENCE DATA; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RECEPTORS, NICOTINIC;

APLYSIA; APLYSIA CALIFORNICA; GASTROPODA;

EID: 27144473613     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600828     Document Type: Article

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