Hydroxy Metabolites of the Alzheimer's Drug Candidate 3-[(2,4-Dimethoxy)Benzylidene]-Anabaseine Dihydrochloride (GTS-21): Their Molecular Properties, Interactions with Brain Nicotinic Receptors, and Brain Penetration

Molecular Pharmacology

Volumn 65, Issue 1, 2004, Pages 56-67

  Kem, William R ^a   Mahnir, Vladimir M ^a,c   Prokai, Laszlo ^b   Papke, Roger L ^b   Cao, Xuefang ^a   LeFrancois, Susan ^a   Wildeboer, Kristin ^a   Prokai Tatrai, Katalin ^a   Porter Papke, Julia ^a   Soti, Ferenc ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c Bachem Holding AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; 3 [(2 HYDROXY 4 METHOXY)BENZYLIDENE]ANABASEINE; 3 [(2,4 DIHYDROXY)BENZYLIDENE]ANABASEINE; 3 [(4 HYDROXY 2 METHOXY)BENZYLIDENE]ANABASEINE; ANABASINE DERIVATIVE; BENZYLIDENE DERIVATIVE; CYTOCHROME P450; DRUG METABOLITE; NICOTINIC RECEPTOR; OCTANOL; PARTIAL AGONIST; PYRIDINE DERIVATIVE; RADIOLIGAND; TETRAHYDROPYRIDYL NITROGEN; UNCLASSIFIED DRUG; WATER;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEALKYLATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CONFORMATION; DRUG METABOLISM; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IONIZATION; LIVER MICROSOME METABOLISM; MALE; MOLECULAR MODEL; NONHUMAN; PARTITION COEFFICIENT; PKA; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMALS; BENZYLIDENE COMPOUNDS; BIOTRANSFORMATION; BRAIN; DRUG INTERACTIONS; HUMANS; MICROSOMES, LIVER; MOLECULAR CONFORMATION; NICOTINIC AGONISTS; PYRIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 9144251593     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.1.56     Document Type: Article

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