Human AP endonuclease 1 (APE1): From mechanistic insights to druggable target in cancer

Cancer Treatment Reviews

Volumn 36, Issue 5, 2010, Pages 425-435

  Abbotts, Rachel ^a   Madhusudan, Srinivasan ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

APE1; Cancer; Human AP endonuclease 1; Small molecule inhibitors

Indexed keywords

DEOXYRIBONUCLEASE I; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA GLYCOSYLTRANSFERASE; DNA TOPOISOMERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARATHYROID HORMONE; PROTEIN P300; REPLICATION FACTOR C; SMALL INTERFERING RNA; ALKYLATING AGENT; APEX1 PROTEIN, HUMAN; DNA;

ACETYLATION; AMINO TERMINAL SEQUENCE; APOPTOSIS; BREAST CANCER; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL PROLIFERATION; CHROMOSOME; COLORECTAL CARCINOMA; CYTOPLASM; DNA CLEAVAGE; DNA REPAIR; DNA SYNTHESIS; DOWN REGULATION; ENZYME ACTIVITY; EXCISION REPAIR; HUMAN; IN VIVO STUDY; IONIZING RADIATION; MYELOID LEUKEMIA; PROGNOSIS; PROTEIN EXPRESSION; REVIEW; RNA INTERFERENCE; TUMOR GROWTH; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; NEOPLASMS;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; DNA REPAIR; DNA, NEOPLASM; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HUMANS; NEOPLASMS;

EID: 77955095659     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2009.12.006     Document Type: Review

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