-
1
-
-
74549189337
-
New insights into checkpoint kinase 1 in the DNA damaging response signalling network
-
Y. Dai, and S. Grant New insights into checkpoint kinase 1 in the DNA damaging response signalling network Clin. Cancer Res. 16 2010 376 383
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 376-383
-
-
Dai, Y.1
Grant, S.2
-
2
-
-
68249126215
-
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
-
T.H. Stracker Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response DNA Repair 8 2009 1047 1054
-
(2009)
DNA Repair
, vol.8
, pp. 1047-1054
-
-
Stracker, T.H.1
-
3
-
-
63749131243
-
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
-
H.C. Reinhardt, and M.B. Yaffe Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2 Curr. Opin. Cell Biol. 21 2009 245 255
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 245-255
-
-
Reinhardt, H.C.1
Yaffe, M.B.2
-
4
-
-
78649237831
-
Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents
-
S. Leijen Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents Curr. Clin. Pharmacol. 5 2010 186 191
-
(2010)
Curr. Clin. Pharmacol.
, vol.5
, pp. 186-191
-
-
Leijen, S.1
-
5
-
-
36949012288
-
Targeted cancer therapies based on the inhibition of DNA strand break repair
-
DOI 10.1038/sj.onc.1210879, PII 1210879
-
M.J. O'Connor Targeted cancer therapies based on the inhibition of DNA strand break repair Oncogene 26 2007 7816 7824 (Pubitemid 350242461)
-
(2007)
Oncogene
, vol.26
, Issue.56
, pp. 7816-7824
-
-
O'Connor, M.J.1
Martin, N.M.B.2
Smith, G.C.M.3
-
7
-
-
67649390962
-
Checkpoint kinase inhibitors: A review of the patent literature
-
J.W. Janetka, and S. Ashwell Checkpoint kinase inhibitors: a review of the patent literature Expert Opin. Ther. Pat. 19 2009 165 197
-
(2009)
Expert Opin. Ther. Pat.
, vol.19
, pp. 165-197
-
-
Janetka, J.W.1
Ashwell, S.2
-
8
-
-
38949147038
-
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
-
DOI 10.1038/sj.bjc.6604208, PII 6604208
-
N. Bucher, and C.D. Britten G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer Br. J. Cancer 98 2008 523 528 (Pubitemid 351214533)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.3
, pp. 523-528
-
-
Bucher, N.1
Britten, C.D.2
-
9
-
-
79651470785
-
Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
-
C.X. Ma Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics Trends Mol. Med. 17 2011 88 96
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 88-96
-
-
Ma, C.X.1
-
11
-
-
0037108873
-
2-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1
-
2-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1 Cancer Res. 62 2002 5743 5748 (Pubitemid 35204730)
-
(2002)
Cancer Research
, vol.62
, Issue.20
, pp. 5743-5748
-
-
Yu, Q.1
La Rose, J.2
Zhang, H.3
Takemura, H.4
Kohn, K.W.5
Pommier, Y.6
-
12
-
-
77953722717
-
Probing the probes: Fitness factors for small molecule tools
-
P. Workman, and I. Collins Probing the probes: fitness factors for small molecule tools Chem. Biol. 17 2010 561 577
-
(2010)
Chem. Biol.
, vol.17
, pp. 561-577
-
-
Workman, P.1
Collins, I.2
-
13
-
-
52949139387
-
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
-
S.D. Zabludoff AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies Mol. Cancer Ther. 7 2008 2955 2966
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 2955-2966
-
-
Zabludoff, S.D.1
-
14
-
-
53349156857
-
Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1
-
A. Blasina Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1 Mol. Cancer Ther. 7 2008 2394 2404
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 2394-2404
-
-
Blasina, A.1
-
15
-
-
33846856967
-
CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo
-
DOI 10.1158/1078-0432.CCR-06-1424
-
A. Tse CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo Clin. Cancer Res. 13 2007 591 602 (Pubitemid 46225366)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.I2
, pp. 591-602
-
-
Tse, A.N.1
Rendahl, K.G.2
Sheikh, T.3
Cheema, H.4
Aardalen, K.5
Embry, M.6
Ma, S.7
Moler, E.J.8
Zhi, J.N.9
De Menezes, D.E.L.10
Hibner, B.11
Gesner, T.G.12
Schwartz, G.K.13
-
16
-
-
73949130389
-
The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106
-
M.I. Walton The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106 Mol. Cancer Ther. 9 2010 89 100
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 89-100
-
-
Walton, M.I.1
-
17
-
-
73349093106
-
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}- amide]
-
A.G. Jobson Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}- amide] J. Pharmacol. Exp. Ther. 331 2009 816 826
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.331
, pp. 816-826
-
-
Jobson, A.G.1
-
18
-
-
78751660013
-
Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2
-
J.J. Caldwell Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2 J. Med. Chem. 54 2010 580 590
-
(2010)
J. Med. Chem.
, vol.54
, pp. 580-590
-
-
Caldwell, J.J.1
-
19
-
-
33646732627
-
Chk2 molecular interaction map and rationale for Chk2 inhibitors
-
Y. Pommier Chk2 molecular interaction map and rationale for Chk2 inhibitors Clin. Cancer Res. 12 2005 2657 2661
-
(2005)
Clin. Cancer Res.
, vol.12
, pp. 2657-2661
-
-
Pommier, Y.1
-
20
-
-
36448973875
-
CHK2 kinase: Cancer susceptibility and cancer therapy - Two sides of the same coin?
-
DOI 10.1038/nrc2251, PII NRC2251
-
L. Antoni CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? Nat. Rev. Cancer 7 2007 925 936 (Pubitemid 350165855)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.12
, pp. 925-936
-
-
Antoni, L.1
Sodha, N.2
Collins, I.3
Garrett, M.D.4
-
21
-
-
33748364583
-
Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: Implications for cancer therapy
-
DOI 10.1158/1535-7163.MCT-06-0077
-
Z. Xiao Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy Mol. Cancer Ther. 5 2006 1935 1943 (Pubitemid 44336564)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.8
, pp. 1935-1943
-
-
Xiao, Z.1
Xue, J.2
Sowin, T.J.3
Zhang, H.4
-
23
-
-
8444252707
-
Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: Differential activity in cells expressing or not p53
-
L. Carrassa Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53 Cell Cycle 3 2004 1177 1181 (Pubitemid 40268636)
-
(2004)
Cell Cycle
, vol.3
, Issue.9
, pp. 1177-1181
-
-
Carrassa, L.1
Broggini, M.2
Erba, E.3
Damia, G.4
-
24
-
-
77954306375
-
1 arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionising radiation and Chk1 inhibitors
-
1 arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionising radiation and Chk1 inhibitors Cell Prolif. 43 2010 365 371
-
(2010)
Cell Prolif.
, vol.43
, pp. 365-371
-
-
Petersen, L.1
-
25
-
-
33947330745
-
2/M transition
-
C.M. Sturgeon, and M. Roberge G2 checkpoint kinase inhibitors exert their radiosensitising effects prior to the G2/M transition Cell Cycle 6 2007 572 575 (Pubitemid 46440430)
-
(2007)
Cell Cycle
, vol.6
, Issue.5
, pp. 572-575
-
-
Sturgeon, C.M.1
Roberge, M.2
-
26
-
-
33646589980
-
Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage
-
C.M. Sturgeon Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage Mol. Cancer Ther. 5 2006 885 889
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 885-889
-
-
Sturgeon, C.M.1
-
27
-
-
65949109031
-
Radiosensitization by Chir-124, a selective CHK1 inhibitor. Effects of p53 and cell cycle checkpoints
-
Y. Tao Radiosensitization by Chir-124, a selective CHK1 inhibitor. Effects of p53 and cell cycle checkpoints Cell Cycle 8 2009 1196 1205
-
(2009)
Cell Cycle
, vol.8
, pp. 1196-1205
-
-
Tao, Y.1
-
28
-
-
20144371717
-
Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles
-
DOI 10.1021/jm0495935
-
K.L. Arienti Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles J. Med. Chem. 48 2005 1873 1885 (Pubitemid 40396318)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.6
, pp. 1873-1885
-
-
Arienti, K.L.1
Brunmark, A.2
Axe, F.U.3
McClure, K.4
Lee, A.5
Blevitt, J.6
Neff, D.K.7
Huang, L.8
Crawford, S.9
Pandit, C.R.10
Karlsson, L.11
Breitenbucher, J.G.12
-
29
-
-
34147177714
-
Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2
-
DOI 10.1158/1535-7163.MCT-06-0567
-
L. Carlessi Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2 Mol. Cancer Ther. 6 2007 935 944 (Pubitemid 46554563)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.3
, pp. 935-944
-
-
Carlessi, L.1
Buscemi, G.2
Larson, G.3
Hong, Z.4
Wu, J.Z.5
Delia, D.6
-
30
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
H. Takai Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription EMBO J. 21 2002 5195 5205
-
(2002)
EMBO J.
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
-
31
-
-
79955623625
-
A novel Chk1 inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe
-
10.1007/s10637-009-9361-2
-
O. Riesterer A novel Chk1 inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe Invest. New Drugs 2009 10.1007/s10637-009-9361-2
-
(2009)
Invest. New Drugs
-
-
Riesterer, O.1
-
32
-
-
77950650401
-
In vitro and in vivo radiation sensitization of human tumour cells by a novel checkpoint kinase inhibitor, AZD7762
-
J.B. Mitchell In vitro and in vivo radiation sensitization of human tumour cells by a novel checkpoint kinase inhibitor, AZD7762 Clin. Cancer Res. 16 2010 2076 2084
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 2076-2084
-
-
Mitchell, J.B.1
-
33
-
-
77953770987
-
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair
-
M.A. Morgan Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair Cancer Res. 70 2010 4972 4981
-
(2010)
Cancer Res.
, vol.70
, pp. 4972-4981
-
-
Morgan, M.A.1
-
34
-
-
77955525117
-
RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells
-
S. Arora RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells Gynecol. Oncol. 118 2010 220 227
-
(2010)
Gynecol. Oncol.
, vol.118
, pp. 220-227
-
-
Arora, S.1
-
35
-
-
67649842315
-
Cisplatin-induced DNA damage activates replication checkpoint signalling components that differentially affect tumour cell survival
-
J.M. Wagner, and L.M. Karnitz Cisplatin-induced DNA damage activates replication checkpoint signalling components that differentially affect tumour cell survival Mol. Pharmacol. 76 2009 208 214
-
(2009)
Mol. Pharmacol.
, vol.76
, pp. 208-214
-
-
Wagner, J.M.1
Karnitz, L.M.2
-
36
-
-
78650208984
-
Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents
-
S. Zenvirt Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents Oncogene 29 2010 6149 6159
-
(2010)
Oncogene
, vol.29
, pp. 6149-6159
-
-
Zenvirt, S.1
-
37
-
-
77949414415
-
Oxaliplatin responses in colorectal cells are modulated by CHK2 kinase inhibitors
-
I.M. Pires Oxaliplatin responses in colorectal cells are modulated by CHK2 kinase inhibitors Br. J. Pharmacol. 159 2010 1326 1338
-
(2010)
Br. J. Pharmacol.
, vol.159
, pp. 1326-1338
-
-
Pires, I.M.1
-
38
-
-
77953506262
-
Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase
-
S. McNeely Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase Cell Cycle 9 2010 995 1004
-
(2010)
Cell Cycle
, vol.9
, pp. 995-1004
-
-
McNeely, S.1
-
39
-
-
33846567414
-
Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo
-
D.J. Matthews Pharmacological abrogation of S-phase checkpoint enhances the anti-tumour activity of gemcitabine in vivo Cell Cycle 6 2007 104 110 (Pubitemid 46173886)
-
(2007)
Cell Cycle
, vol.6
, Issue.1
, pp. 104-110
-
-
Matthews, D.J.1
Yakes, F.M.2
Chen, J.3
Tadano, M.4
Bornheim, L.5
Clary, D.O.6
Tai, A.7
Wagner, J.M.8
Miller, N.9
Kim, Y.D.10
Robertson, S.11
Murray, L.12
Karnitz, L.M.13
-
40
-
-
67650085633
-
Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer
-
D.O. Azorsa Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer J. Transl. Med. 7 2009 43
-
(2009)
J. Transl. Med.
, vol.7
, pp. 43
-
-
Azorsa, D.O.1
-
41
-
-
58149500122
-
Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells
-
L.A. Parsels Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells Mol. Cancer Ther. 8 2009 45 54
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 45-54
-
-
Parsels, L.A.1
-
42
-
-
52649127811
-
Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil
-
M. Ganzinelli Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil Clin. Cancer Res. 14 2008 5131 5141
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 5131-5141
-
-
Ganzinelli, M.1
-
43
-
-
0030870632
-
Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function
-
R.G. Shao Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function Cancer Res. 57 1997 4029 4035
-
(1997)
Cancer Res.
, vol.57
, pp. 4029-4035
-
-
Shao, R.G.1
-
44
-
-
17144377827
-
The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons
-
DOI 10.1074/jbc.M411890200
-
K. Flatten The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons J. Biol. Chem. 280 2005 14349 14355 (Pubitemid 40517339)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 14349-14355
-
-
Flatten, K.1
Dai, N.T.2
Vroman, B.T.3
Loegering, D.4
Erlichman, C.5
Karnitz, L.M.6
Kaufmann, S.H.7
-
45
-
-
37249004667
-
The mammalian DNA replication elongation checkpoint: Implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses
-
C. Conti The mammalian DNA replication elongation checkpoint. Implication of CHK1 and relationship with origin firing as determined by single DNA molecule and single cell analyses Cell Cycle 6 2007 2760 2767 (Pubitemid 350277167)
-
(2007)
Cell Cycle
, vol.6
, Issue.22
, pp. 2760-2767
-
-
Conti, C.1
Seiler, J.A.2
Pommier, Y.3
-
46
-
-
34547902426
-
The intra-S-phase checkpoint affects both DNA replication initiation and elongation: Single-cell and -DNA fiber analyses
-
DOI 10.1128/MCB.02278-06
-
J.A. Seiler The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses Mol. Cell Biol. 27 2007 5806 5818 (Pubitemid 47257835)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.16
, pp. 5806-5818
-
-
Seiler, J.A.1
Conti, C.2
Syed, A.3
Aladjem, M.I.4
Pommier, Y.5
-
47
-
-
78751520563
-
CCT241533 is a potent and selective inhibitor of CHK2 which potentiates the cytotoxicity of PARP inhibitors
-
V.E. Anderson CCT241533 is a potent and selective inhibitor of CHK2 which potentiates the cytotoxicity of PARP inhibitors Cancer Res. 71 2010 463 472
-
(2010)
Cancer Res.
, vol.71
, pp. 463-472
-
-
Anderson, V.E.1
-
50
-
-
33846636785
-
Chk1 Is Required for Spindle Checkpoint Function
-
DOI 10.1016/j.devcel.2007.01.003, PII S1534580707000044
-
G. Zachos Chk1 is required for spindle checkpoint function Dev. Cell 12 2007 247 260 (Pubitemid 46193970)
-
(2007)
Developmental Cell
, vol.12
, Issue.2
, pp. 247-260
-
-
Zachos, G.1
Black, E.J.2
Walker, M.3
Scott, M.T.4
Vagnarelli, P.5
Earnshaw, W.C.6
Gillespie, D.A.F.7
-
51
-
-
68049107474
-
PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates docetaxel-induced efficacy in xenografts
-
C. Zhang PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates docetaxel-induced efficacy in xenografts Clin. Cancer Res. 15 2009 4630 4640
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 4630-4640
-
-
Zhang, C.1
-
52
-
-
77958149646
-
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells
-
C. Mitchell Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells Mol. Pharmacol. 78 2010 909 917
-
(2010)
Mol. Pharmacol.
, vol.78
, pp. 909-917
-
-
Mitchell, C.1
-
53
-
-
33751233835
-
A stronger DNA damage-induced G2 checkpoint due to over-activated CHK1 in the absence of PARP1
-
X.R. Lu A stronger DNA damage-induced G2 checkpoint due to over-activated CHK1 in the absence of PARP1 Cell Cycle 5 2006 2364 2370
-
(2006)
Cell Cycle
, vol.5
, pp. 2364-2370
-
-
Lu, X.R.1
-
54
-
-
33748065304
-
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
-
DOI 10.1158/0008-5472.CAN-06-0140
-
N. McCabe Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition Cancer Res. 66 2006 8109 8115 (Pubitemid 44299177)
-
(2006)
Cancer Research
, vol.66
, Issue.16
, pp. 8109-8115
-
-
McCabe, N.1
Turner, N.C.2
Lord, C.J.3
Kluzek, K.4
Bialkowska, A.5
Swift, S.6
Giavara, S.7
O'Connor, M.J.8
Tutt, A.N.9
Zdzienicka, M.Z.10
Smith, G.C.M.11
Ashworth, A.12
-
55
-
-
70349904767
-
The aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe
-
Y. Tao The aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe Cell Cycle 8 2009 3172 3181
-
(2009)
Cell Cycle
, vol.8
, pp. 3172-3181
-
-
Tao, Y.1
-
56
-
-
65449142073
-
CHK1 inhibition as a strategy for targeting Fanconi anemia (FA) DNA repair pathway deficient tumors
-
C.C. Chen CHK1 inhibition as a strategy for targeting Fanconi anemia (FA) DNA repair pathway deficient tumors Mol. Cancer 8 2009 24
-
(2009)
Mol. Cancer
, vol.8
, pp. 24
-
-
Chen, C.C.1
-
57
-
-
72249108356
-
Constitutive activation of the DNA damage signalling pathway in acute myeloid leukaemia with complex karyotype: Potential importance in checkpoint targeting therapy
-
C. Cavelier Constitutive activation of the DNA damage signalling pathway in acute myeloid leukaemia with complex karyotype: potential importance in checkpoint targeting therapy Cancer Res. 69 2009 8652 8661
-
(2009)
Cancer Res.
, vol.69
, pp. 8652-8661
-
-
Cavelier, C.1
-
58
-
-
79952775174
-
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
-
K.A. Cole RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma Proc. Natl. Acad. Sci. U.S.A. 108 2011 3336 3341
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 3336-3341
-
-
Cole, K.A.1
-
59
-
-
7444245571
-
2 DNA damage checkpoint inhibitor isogranulatimide
-
X. Jiang Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide Mol. Cancer Ther. 3 2004 1221 1227 (Pubitemid 39440167)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.10
, pp. 1221-1227
-
-
Jiang, X.1
Zhao, B.2
Britton, R.3
Lim, L.Y.4
Leong, D.5
Sanghera, J.S.6
Zhou, B.-B.S.7
Piers, E.8
Andersen, R.J.9
Roberge, M.10
-
61
-
-
33746891507
-
4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. structure-activity relationships for chromophore modification and phenyl ring substitution
-
DOI 10.1021/jm0512591
-
B.D. Palmer 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution J. Med. Chem. 49 2006 4896 4911 (Pubitemid 44201048)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.16
, pp. 4896-4911
-
-
Palmer, B.D.1
Thompson, A.M.2
Booth, R.J.3
Dobrusin, E.M.4
Kraker, A.J.5
Lee, H.H.6
Lunney, E.A.7
Mitchell, L.H.8
Ortwine, D.F.9
Smaill, J.B.10
Swan, L.M.11
Denny, W.A.12
-
62
-
-
79955735344
-
Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening
-
doi:10.1158/1535-7163.MCT-10-0928
-
Guzi, T. et al. (2011) Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol. Cancer Ther. doi:10.1158/1535-7163.MCT-10-0928.
-
(2011)
Mol. Cancer Ther.
-
-
Guzi, T.1
|