Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

Molecular Cancer Therapeutics

Volumn 8, Issue 10, 2009, Pages 2894-2902

  Golding, Sarah E ^a   Rosenberg, Elizabeth ^a   Valerie, Nicholas ^a   Hussaini, Isa ^d   Frigerio, Mark ^e   Cockcroft, Xiaoling F ^e   Wei, Yee Chong ^e   Hummersone, Marc ^e   Rigoreau, Laurent ^e   Menear, Keith A ^e   O'Connor, Mark J ^e   Povirk, Lawrence F ^a,b   Van Meter, Timothy ^c   Valerie, Kristoffer ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e KuDOS Pharmaceuticals Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2,6 DIMETHYLMORPHOLIN 4 YL] N [5 (6 MORPHOLIN 4 YL 4 OXO 4H PYRAN 2 YL) 9H THIOXANTHEN 2 YL]ACETAMIDE; 2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ANTINEOPLASTIC AGENT; ATM PROTEIN; KU 60019; OKADAIC ACID; PROTEIN KINASE B; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ATAXIA TELANGIECTASIA; CANCER CELL; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FIBROBLAST; GLIOMA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL MOVEMENT; CELL SURVIVAL; DNA-BINDING PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GAMMA RAYS; GLIOMA; HUMANS; INSULIN; MAP KINASE SIGNALING SYSTEM; MORPHOLINES; NEOPLASM INVASIVENESS; PHOSPHOSERINE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRONES; RADIATION-SENSITIZING AGENTS; THIOXANTHENES; TUMOR SUPPRESSOR PROTEINS;

EID: 70350238489     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0519     Document Type: Article

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