Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 24, 2011, Pages 9851-9856

  Krawczyk, Przemek M ^a   Eppink, Berina ^b   Essers, Jeroen ^b   Stap, Jan ^a   Rodermond, Hans ^c   Odijk, Hanny ^b   Zelensky, Alex ^b   Van Bree, Chris ^c   Stalpers, Lukas J ^c   Buist, Marrije R ^c   Soullié, Thomas ^b   Rens, Joost ^b   Verhagen, Hence J M ^b   O'Connor, Mark J ^d   Frankene, Nicolaas A P ^c   Ten Hagen, Timo L M ^b   Kanaar, Roland ^b   Aten, Jacob A ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d ASTRAZENECA   (United Kingdom)

Author keywords

Anti cancer treatment; Double strand break; RAD51

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; HEAT SHOCK PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CONTROLLED STUDY; DNA REPAIR; ENZYME INHIBITION; FEMALE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; HYPERTHERMIA; IN VIVO STUDY; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SENSITIZATION; TUMOR MODEL;

ANIMALS; BENZOQUINONES; BRCA2 PROTEIN; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; DNA REPAIR; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; FEMALE; HELA CELLS; HOT TEMPERATURE; HUMANS; IMMUNOBLOTTING; LACTAMS, MACROCYCLIC; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; PHTHALAZINES; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASES; QUINAZOLINES; RATS; RECOMBINATION, GENETIC; RNA INTERFERENCE; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN;

EID: 79960003299     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101053108     Document Type: Article

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