Inactivation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

Cancer Research

Volumn 59, Issue 4, 1999, Pages 793-797

  Esteller, Manel ^a   Hamilton, Stanley R ^b   Burger, Peter C ^b   Baylin, Stephen B ^a   Herman, James G ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA REPAIR; GENE DELETION; GENE INACTIVATION; GENE MUTATION; GENE REARRANGEMENT; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; METHYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

CPG ISLANDS; DNA METHYLATION; DNA REPAIR; GENES, RAS; HUMANS; MUTATION; NEOPLASMS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROMOTER REGIONS (GENETICS);

EID: 0033557903     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. 6-alkylguanine-DNA alkyltransferase regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50: 6119-6129, 1990.
2. Coulondre, C., and Miller, J. H. Genetic studies of the lac represser IV. Mutagenic specificity in the lacl gene of Escherichia coli. J. Mol. Biol., 117: 577-606, 1977.
3. Erickson, L. C., Laurent, G., Sharkey, N. A., and Kohn, K. W. DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells. Nature (Lond.), 288: 727-729, 1980.
4. 6-alkylguanine-DNA-alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis (Lond.), 7: 745-749, 1986.
5. 6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary. Cancer Res., 51: 4131-4134, 1991.
6. 6-methylguanine-DNA methyltransferase gene MGMT in human normal and tumor tissues. J. Natl. Cancer Inst., 84: 337-340, 1992.
7. Day, R. S., III, Ziolkowski, C. H., Scudiero, D. A., Meyer, S. A., Lubiniecki, A. S., Girardi, A. J., Galloway, S. M., and Bynum, G. D. Defective repair of alkylated DNA by human tumor and SV40-transformed human cell strains. Nature (Lond.), 288: 724-727, 1980.
8. 6-methylguanine DNA methyltransferase gene MGMT in MER+ and MER-human tumor cells. Cancer Res., 50: 7908-7911, 1990.
9. 6-methylguanine-DNA methyltransferase gene (MGMT) MRNA levels in MER+ and MER-human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique. Cancer Commun., 2: 13-20, 1990.
10. 6-methylguanine-DNA methyltransferase (MGMT) expression in Mer-human tumor cell lines. Carcinogenesis (Lond.), 16: 2255-2257, 1995.
11. Baylin, S. B., Herman, J. G., Graff, J. R., Vertino, P. M., and Issa, J. P. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv. Cancer Res., 72: 141-196, 1998.
12. Harris, L. C., Potter, P. M., Tano, K., Shiota, S., Mitra, S., and Brent, T. P. Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene. Nucleic Acids Res., 19: 6163-6167, 1991.
13. 6-methylguanine-DNA methyltransferase gene correlates with MGMT expression in human glioma cells. Cancer Res., 56: 13916-13924, 1996.
14. 6-Methylguanine-DNA methyltransferase gene. Cancer Res., 57: 3672-3677, 1997.
15. 6-Methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol. Cell. Biol., 17: 5612-5619, 1997.
16. Herman, J. G., Graff, J. R., Myohanen, S., Nelkin, B. D., and Baylin, S. B. Methylation-specific PCR. A novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA, 93: 9821-9826, 1996.
17. 6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies. Cancer Res., 50: 58-61, 1990.
18. Reese, J. S., Koc, O. N., Lee, K. M., Liu, L., Allay, J. A., Phillips, W. P., Jr., and Gerson, S. L. Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea. Proc. Natl. Acad. Sci. USA, 93: 14088-14093, 1996.
19. Branch, P., Hampson, R., and Karran, P. DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypcs in human colorectal carcinoma cell lines. Cancer Res., 55: 2304-2309, 1995.
20. 6-alkylguanine-DNA alkyltransferase expression in normal and malignant human colon. Clin. Cancer Res., 2: 577-584, 1996.
21. Silber, J. R., Bobola, M. S., Ghatan, S., Blank, A., Kolstoe, D. D., and Berger, M. S. O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics. Cancer Res., 58: 1068-1073, 1998.
22. Kokkinakis, D. M., Ahmed, M. M., Delgado, R., Fruitwala, M. M., Mohiuddin, M., and Albores-Saavedra, J. Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents. Cancer Res., 57: 5360-5368, 1997.
23. 6-methylguanine-DNA methyltransferase expression in human lung carcinomas. Carcinogenesis (Lond.), 19: 1247-1250, 1998.
24. 6-alkylguanine-DNA alkyltransferase activity in human brain tumors. Tohoku J. Exp Med., 165: 223-228, 1991.
25. Sukumar, S., Notario, V., Martin-Zanca, D., and Barbacid, M. Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature (Lond.), 306: 658-661, 1983.
26. Sakumi, K., Shiraishi, A., Shimizu, S., Tsuzuki, T., Ishikawa, T., and Sekiguchi, M. Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice. Cancer Res., 57: 2415-2418, 1997.
27. 6-alkylguanine-DNA alkyltransferase. Science (Washington DC), 259: 219-222, 1993.
28. 6-methylguanine-DNA methyltransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis. Cancer Res., 56: 3244-3249, 1996.
29. Zaidi, N. H., Pretlow, T. P., O'Riordan, M. A., Dumenco, L. L., Allay, E., and Gerson, S. L. Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis (Lond.), 16: 451-456, 1995.
30. Barbacid, M. ras genes. Annu. Rev. Biochem., 56: 779-827, 1987.
31. Belinsky, S. A., Devereux, T. R., Maronpot, R. R., Stoner, G. D., and Anderson, M. W. Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines. Cancer Res., 49: 5305-5311, 1989.
32. Inga, A., Iannone, R., Campomenosi, P., Molina, F., Menichini, P., Abbondandolo, A., and Fronza, G. Mutational fingerprint induced by the antineoplastic drug chloroethylcyclohexyl-nitrosourea in mammalian cells. Cancer Res., 55: 4658-4663, 1995.
33. 6-Methylguanine-DNA methyltransferase activity in human tumors. Carcinogenesis (Lond.), 13: 1503-1507, 1992.