메뉴 건너뛰기




Volumn 54, Issue 1-3, 2012, Pages 233-246

Role of non-homologous end joining in V(D)J recombination

Author keywords

Genomic stability; Immunodeficiencies; Non homologous end joining (NHEJ); V(D)J recombination

Indexed keywords

DNA; T LYMPHOCYTE RECEPTOR;

EID: 84867847788     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-012-8329-z     Document Type: Review
Times cited : (57)

References (185)
  • 1
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • 6300689 1:CAS:528:DyaL3sXhslOhtr0%3D
    • Tonegawa S. Somatic generation of antibody diversity. Nature. 1983;302(5909):575-81.
    • (1983) Nature , vol.302 , Issue.5909 , pp. 575-581
    • Tonegawa, S.1
  • 2
    • 0842303307 scopus 로고    scopus 로고
    • Unraveling V(D)J recombination; Insights into gene regulation
    • 14744439 1:CAS:528:DC%2BD2cXhtVals7s%3D
    • Jung D, Alt FW. Unraveling V(D)J recombination; insights into gene regulation. Cell. 2004;116(2):299-311.
    • (2004) Cell , vol.116 , Issue.2 , pp. 299-311
    • Jung, D.1    Alt, F.W.2
  • 3
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • 11983152 1:CAS:528:DC%2BD38Xjt1eqtbk%3D
    • Bassing CH, Swat W, Alt FW. The mechanism and regulation of chromosomal V(D)J recombination. Cell. 2002;109(Suppl):S45-55.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 4
    • 23844471918 scopus 로고    scopus 로고
    • A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination
    • 10.1016/j.immuni.2005.07.004 16111638 1:CAS:528:DC%2BD2MXpvVCnu70%3D
    • West KL, Singha NC, De Ioannes P, Lacomis L, Erdjument-Bromage H, Tempst P, et al. A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination. Immunity. 2005;23(2):203-12. doi: 10.1016/j.immuni.2005.07.004.
    • (2005) Immunity , vol.23 , Issue.2 , pp. 203-212
    • West, K.L.1    Singha, N.C.2    De Ioannes, P.3    Lacomis, L.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 5
    • 35349024178 scopus 로고    scopus 로고
    • A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement
    • 10.1016/j.immuni.2007.09.005 17936034 1:CAS:528:DC%2BD2sXht1ygur%2FF
    • Liu Y, Subrahmanyam R, Chakraborty T, Sen R, Desiderio S. A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity. 2007;27(4):561-71. doi: 10.1016/j.immuni.2007.09.005.
    • (2007) Immunity , vol.27 , Issue.4 , pp. 561-571
    • Liu, Y.1    Subrahmanyam, R.2    Chakraborty, T.3    Sen, R.4    Desiderio, S.5
  • 6
    • 37249041657 scopus 로고    scopus 로고
    • RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
    • 10.1038/nature06431 18033247 1:CAS:528:DC%2BD2sXhsVaqtrzK
    • Matthews AG, Kuo AJ, Ramon-Maiques S, Han S, Champagne KS, Ivanov D, et al. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 2007;450(7172):1106-10. doi: 10.1038/nature06431.
    • (2007) Nature , vol.450 , Issue.7172 , pp. 1106-1110
    • Matthews, A.G.1    Kuo, A.J.2    Ramon-Maiques, S.3    Han, S.4    Champagne, K.S.5    Ivanov, D.6
  • 7
    • 37649026007 scopus 로고    scopus 로고
    • The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2
    • 10.1073/pnas.0709170104 18025461 1:CAS:528:DC%2BD2sXhsVSru7bM
    • Ramon-Maiques S, Kuo AJ, Carney D, Matthews AG, Oettinger MA, Gozani O, et al. The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci USA. 2007;104(48):18993-8. doi: 10.1073/pnas.0709170104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.48 , pp. 18993-18998
    • Ramon-Maiques, S.1    Kuo, A.J.2    Carney, D.3    Matthews, A.G.4    Oettinger, M.A.5    Gozani, O.6
  • 8
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • 9094713 1:CAS:528:DyaK2sXisVygtbs%3D
    • Agrawal A, Schatz DG. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell. 1997;89(1):43-53.
    • (1997) Cell , vol.89 , Issue.1 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 9
    • 0031433517 scopus 로고    scopus 로고
    • Growth retardation and leaky SCID phenotype of Ku70-deficient mice
    • 9390689 1:CAS:528:DyaK2sXnvVWnsLY%3D
    • Gu Y, Seidl KJ, Rathbun GA, Zhu C, Manis JP, van der Stoep N, et al. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity. 1997;7(5):653-65.
    • (1997) Immunity , vol.7 , Issue.5 , pp. 653-665
    • Gu, Y.1    Seidl, K.J.2    Rathbun, G.A.3    Zhu, C.4    Manis, J.P.5    Van Der Stoep, N.6
  • 10
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • 8756720 1:CAS:528:DyaK28XltVSks7Y%3D
    • Zhu C, Bogue MA, Lim DS, Hasty P, Roth DB. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell. 1996;86(3):379-89.
    • (1996) Cell , vol.86 , Issue.3 , pp. 379-389
    • Zhu, C.1    Bogue, M.A.2    Lim, D.S.3    Hasty, P.4    Roth, D.B.5
  • 11
    • 0029778191 scopus 로고    scopus 로고
    • Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
    • 8700231 1:CAS:528:DyaK28XkvFGjtL4%3D
    • Nussenzweig A, Chen C, da Costa Soares V, Sanchez M, Sokol K, Nussenzweig MC, et al. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature. 1996;382(6591):551-5.
    • (1996) Nature , vol.382 , Issue.6591 , pp. 551-555
    • Nussenzweig, A.1    Chen, C.2    Da Costa Soares, V.3    Sanchez, M.4    Sokol, K.5    Nussenzweig, M.C.6
  • 12
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • 1356077 1:CAS:528:DyaK38XmsV2rs7k%3D
    • Roth DB, Menetski JP, Nakajima PB, Bosma MJ, Gellert M. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell. 1992;70(6):983-91.
    • (1992) Cell , vol.70 , Issue.6 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 13
    • 0032247578 scopus 로고    scopus 로고
    • Hairpin coding end opening is mediated by RAG1 and RAG2 proteins
    • 9885569 1:CAS:528:DyaK1MXjslaitQ%3D%3D
    • Besmer E, Mansilla-Soto J, Cassard S, Sawchuk DJ, Brown G, Sadofsky M, et al. Hairpin coding end opening is mediated by RAG1 and RAG2 proteins. Mol Cell. 1998;2(6):817-28.
    • (1998) Mol Cell , vol.2 , Issue.6 , pp. 817-828
    • Besmer, E.1    Mansilla-Soto, J.2    Cassard, S.3    Sawchuk, D.J.4    Brown, G.5    Sadofsky, M.6
  • 14
    • 0032973315 scopus 로고    scopus 로고
    • DNA hairpin opening mediated by the RAG1 and RAG2 proteins
    • 10330156 1:CAS:528:DyaK1MXjt1yjurg%3D
    • Shockett PE, Schatz DG. DNA hairpin opening mediated by the RAG1 and RAG2 proteins. Mol Cell Biol. 1999;19(6):4159-66.
    • (1999) Mol Cell Biol , vol.19 , Issue.6 , pp. 4159-4166
    • Shockett, P.E.1    Schatz, D.G.2
  • 15
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • 10346816 1:CAS:528:DyaK1MXjslGjurw%3D
    • Paull TT, Gellert M. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev. 1999;13(10):1276-88.
    • (1999) Genes Dev , vol.13 , Issue.10 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 16
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang procesing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • 11955432 1:CAS:528:DC%2BD38XisFOgsrc%3D
    • Ma Y, Pannicke U, Schwarz K, Lieber MR. Hairpin opening and overhang procesing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell. 2002;108:781-94.
    • (2002) Cell , vol.108 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 17
    • 0033387958 scopus 로고    scopus 로고
    • The RAG1/RAG2 complex constitutes a 3′ flap endonuclease: Implications for junctional diversity in V(D)J and transpositional recombination
    • 10635319 1:CAS:528:DC%2BD3cXislarsQ%3D%3D
    • Santagata S, Besmer E, Villa A, Bozzi F, Allingham JS, Sobacchi C, et al. The RAG1/RAG2 complex constitutes a 3′ flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination. Mol Cell. 1999;4(6):935-47.
    • (1999) Mol Cell , vol.4 , Issue.6 , pp. 935-947
    • Santagata, S.1    Besmer, E.2    Villa, A.3    Bozzi, F.4    Allingham, J.S.5    Sobacchi, C.6
  • 18
    • 77949658435 scopus 로고    scopus 로고
    • DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis
    • 10.1016/j.dnarep.2010.01.001 20117966 1:CAS:528:DC%2BC3cXjvFyqtrs%3D
    • Gu J, Li S, Zhang X, Wang LC, Niewolik D, Schwarz K, et al. DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair. 2010;9(4):429-37. doi: 10.1016/j.dnarep.2010.01.001.
    • (2010) DNA Repair , vol.9 , Issue.4 , pp. 429-437
    • Gu, J.1    Li, S.2    Zhang, X.3    Wang, L.C.4    Niewolik, D.5    Schwarz, K.6
  • 19
    • 0032085295 scopus 로고    scopus 로고
    • The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
    • 9651580 1:CAS:528:DyaK1cXktlKltLk%3D
    • Paull TT, Gellert M. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell. 1998;1(7):969-79.
    • (1998) Mol Cell , vol.1 , Issue.7 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 20
    • 0036932453 scopus 로고    scopus 로고
    • Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice
    • 12504013 1:CAS:528:DC%2BD3sXjslOisw%3D%3D
    • Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, et al. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell. 2002;10(6):1379-90.
    • (2002) Mol Cell , vol.10 , Issue.6 , pp. 1379-1390
    • Rooney, S.1    Sekiguchi, J.2    Zhu, C.3    Cheng, H.L.4    Manis, J.5    Whitlow, S.6
  • 21
    • 0032185230 scopus 로고    scopus 로고
    • DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes
    • 9809069 1:CAS:528:DyaK1cXntFSks74%3D
    • Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell. 1998;2(4):477-84.
    • (1998) Mol Cell , vol.2 , Issue.4 , pp. 477-484
    • Grawunder, U.1    Zimmer, D.2    Fugmann, S.3    Schwarz, K.4    Lieber, M.R.5
  • 22
    • 50249154761 scopus 로고    scopus 로고
    • Role and regulation of human XRCC4-like factor/cernunnos
    • 10.1002/jcb.21726 18335491 1:CAS:528:DC%2BD1cXpvVOjtrY%3D
    • Dahm K. Role and regulation of human XRCC4-like factor/cernunnos. J Cell Biochem. 2008;104(5):1534-40. doi: 10.1002/jcb.21726.
    • (2008) J Cell Biochem , vol.104 , Issue.5 , pp. 1534-1540
    • Dahm, K.1
  • 23
    • 0041931065 scopus 로고    scopus 로고
    • Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu
    • 12932354 1:CAS:528:DC%2BD3sXotlGqsb8%3D
    • Bertocci B, De Smet A, Berek C, Weill JC, Reynaud CA. Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu. Immunity. 2003;19(2):203-11.
    • (2003) Immunity , vol.19 , Issue.2 , pp. 203-211
    • Bertocci, B.1    De Smet, A.2    Berek, C.3    Weill, J.C.4    Reynaud, C.A.5
  • 24
    • 33745997776 scopus 로고    scopus 로고
    • Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo
    • 10.1016/j.immuni.2006.04.013 16860755 1:CAS:528:DC%2BD28XotVeqtLY%3D
    • Bertocci B, De Smet A, Weill JC, Reynaud CA. Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. Immunity. 2006;25(1):31-41. doi: 10.1016/j.immuni.2006.04.013.
    • (2006) Immunity , vol.25 , Issue.1 , pp. 31-41
    • Bertocci, B.1    De Smet, A.2    Weill, J.C.3    Reynaud, C.A.4
  • 25
    • 0021216208 scopus 로고
    • Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
    • 6092963 1:CAS:528:DyaL2MXhvVynuw%3D%3D
    • Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, et al. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature. 1984;311(5988):752-5.
    • (1984) Nature , vol.311 , Issue.5988 , pp. 752-755
    • Desiderio, S.V.1    Yancopoulos, G.D.2    Paskind, M.3    Thomas, E.4    Boss, M.A.5    Landau, N.6
  • 26
    • 0037416170 scopus 로고    scopus 로고
    • VDJ recombination: Artemis and its in vivo role in hairpin opening
    • 12615895 1:CAS:528:DC%2BD3sXhvFyrtLw%3D
    • Mansilla-Soto J, Cortes P. VDJ recombination: Artemis and its in vivo role in hairpin opening. J Exp Med. 2003;197(5):543-7.
    • (2003) J Exp Med , vol.197 , Issue.5 , pp. 543-547
    • Mansilla-Soto, J.1    Cortes, P.2
  • 27
    • 79957525844 scopus 로고    scopus 로고
    • Polymerases in nonhomologous end joining: Building a bridge over broken chromosomes
    • 10.1089/ars.2010.3429 20649463 1:CAS:528:DC%2BC3MXmtl2ksrs%3D
    • Ramsden DA. Polymerases in nonhomologous end joining: building a bridge over broken chromosomes. Antioxid Redox Signal. 2011;14(12):2509-19. doi: 10.1089/ars.2010.3429.
    • (2011) Antioxid Redox Signal , vol.14 , Issue.12 , pp. 2509-2519
    • Ramsden, D.A.1
  • 28
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • 8073949 1:CAS:528:DyaK2cXmt1yjtbY%3D
    • Lewis SM. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv Immunol. 1994;56:27-150.
    • (1994) Adv Immunol , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 30
    • 0030862399 scopus 로고    scopus 로고
    • Human severe combined immunodeficiency: Genetic, phenotypic, and functional diversity in one hundred eight infants
    • 9063412 1:STN:280:DyaK2s3hsleqsw%3D%3D
    • Buckley RH, Schiff RI, Schiff SE, Markert ML, Williams LW, Harville TO, et al. Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants. J Pediatr. 1997;130(3):378-87.
    • (1997) J Pediatr , vol.130 , Issue.3 , pp. 378-387
    • Buckley, R.H.1    Schiff, R.I.2    Schiff, S.E.3    Markert, M.L.4    Williams, L.W.5    Harville, T.O.6
  • 31
    • 13144249155 scopus 로고    scopus 로고
    • Severe combined immunodeficiency. A model disease for molecular immunology and therapy
    • 10.1111/j.0105-2896.2005.00223.x 15661024 1:CAS:528:DC%2BD2MXhvFyns78%3D
    • Fischer A, LeDeist F, Hacein-Bey-Abina S, Andre-Schmutz I, Basile Gde S, de Villartay JP, et al. Severe combined immunodeficiency. A model disease for molecular immunology and therapy. Immunol Rev. 2005;203:98-109. doi: 10.1111/j.0105-2896.2005.00223.x.
    • (2005) Immunol Rev , vol.203 , pp. 98-109
    • Fischer, A.1    Ledeist, F.2    Hacein-Bey-Abina, S.3    Andre-Schmutz, I.4    Basile Gde, S.5    De Villartay, J.P.6
  • 32
    • 0035832510 scopus 로고    scopus 로고
    • Primary immunodeficiency diseases: An experimental model for molecular medicine
    • 10.1016/S0140-6736(00)04959-X 11410213 1:STN:280:DC%2BD3MzkslOhtA%3D%3D
    • Fischer A. Primary immunodeficiency diseases: an experimental model for molecular medicine. Lancet. 2001;357(9271):1863-9. doi: 10.1016/S0140-6736(00) 04959-X.
    • (2001) Lancet , vol.357 , Issue.9271 , pp. 1863-1869
    • Fischer, A.1
  • 33
    • 0035161258 scopus 로고    scopus 로고
    • V(D)J recombination defects in lymphocytes due to RAG mutations: Severe immunodeficiency with a spectrum of clinical presentations
    • 11133745 1:CAS:528:DC%2BD3MXis1eqtQ%3D%3D
    • Villa A, Sobacchi C, Notarangelo LD, Bozzi F, Abinun M, Abrahamsen TG, et al. V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations. Blood. 2001;97(1):81-8.
    • (2001) Blood , vol.97 , Issue.1 , pp. 81-88
    • Villa, A.1    Sobacchi, C.2    Notarangelo, L.D.3    Bozzi, F.4    Abinun, M.5    Abrahamsen, T.G.6
  • 34
    • 0035917489 scopus 로고    scopus 로고
    • Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
    • 11336668 1:CAS:528:DC%2BD3MXjtFOkt7s%3D
    • Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F, et al. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell. 2001;105(2):177-86.
    • (2001) Cell , vol.105 , Issue.2 , pp. 177-186
    • Moshous, D.1    Callebaut, I.2    De Chasseval, R.3    Corneo, B.4    Cavazzana-Calvo, M.5    Le Deist, F.6
  • 35
    • 33645785057 scopus 로고    scopus 로고
    • A severe form of human combined immunodeficiency due to mutations in DNA ligase IV
    • 16585603 1:CAS:528:DC%2BD28XjtV2gtL8%3D
    • Enders A, Fisch P, Schwarz K, Duffner U, Pannicke U, Nikolopoulos E, et al. A severe form of human combined immunodeficiency due to mutations in DNA ligase IV. J Immunol. 2006;176(8):5060-8.
    • (2006) J Immunol , vol.176 , Issue.8 , pp. 5060-5068
    • Enders, A.1    Fisch, P.2    Schwarz, K.3    Duffner, U.4    Pannicke, U.5    Nikolopoulos, E.6
  • 36
    • 31044440630 scopus 로고    scopus 로고
    • Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly
    • 10.1016/j.cell.2005.12.030 16439204 1:CAS:528:DC%2BD28Xht1KktLk%3D
    • Buck D, Malivert L, de Chasseval R, Barraud A, Fondaneche MC, Sanal O, et al. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell. 2006;124(2):287-99. doi: 10.1016/j.cell.2005.12.030.
    • (2006) Cell , vol.124 , Issue.2 , pp. 287-299
    • Buck, D.1    Malivert, L.2    De Chasseval, R.3    Barraud, A.4    Fondaneche, M.C.5    Sanal, O.6
  • 37
    • 84863727700 scopus 로고    scopus 로고
    • Two SCID cases with Cernunnos-XLF deficiency successfully treated by hematopoietic stem cell transplantation
    • 10.1111/j.1399-3046.2011.01491.x 21535335
    • Cagdas D, Ozgur TT, Asal GT, Revy P, De Villartay JP, van der Burg M, et al. Two SCID cases with Cernunnos-XLF deficiency successfully treated by hematopoietic stem cell transplantation. Pediatr Transplant. 2011;. doi: 10.1111/j.1399-3046.2011.01491.x.
    • (2011) Pediatr Transplant
    • Cagdas, D.1    Ozgur, T.T.2    Asal, G.T.3    Revy, P.4    De Villartay, J.P.5    Van Der Burg, M.6
  • 38
    • 61749104245 scopus 로고    scopus 로고
    • A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining
    • 10.1172/JCI37141 19075392
    • van der Burg M, Ijspeert H, Verkaik NS, Turul T, Wiegant WW, Morotomi-Yano K, et al. A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest. 2009;119(1):91-8. doi: 10.1172/JCI37141.
    • (2009) J Clin Invest. , vol.119 , Issue.1 , pp. 91-98
    • Van Der Burg, M.1    Ijspeert, H.2    Verkaik, N.S.3    Turul, T.4    Wiegant, W.W.5    Morotomi-Yano, K.6
  • 39
    • 0037312006 scopus 로고    scopus 로고
    • Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis
    • 12569164 1:CAS:528:DC%2BD3sXpvFSntQ%3D%3D
    • Moshous D, Pannetier C, Chasseval Rd R, Deist Fl F, Cavazzana-Calvo M, Romana S, et al. Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis. J Clin Invest. 2003;111(3):381-7.
    • (2003) J Clin Invest , vol.111 , Issue.3 , pp. 381-387
    • Moshous, D.1    Pannetier, C.2    Chasseval Rd, R.3    Deist Fl, F.4    Cavazzana-Calvo, M.5    Romana, S.6
  • 40
    • 67651007816 scopus 로고    scopus 로고
    • Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome
    • 10.1172/JCI32743 19451691 1:CAS:528:DC%2BD1MXntVCjtb4%3D
    • Nijnik A, Dawson S, Crockford TL, Woodbine L, Visetnoi S, Bennett S, et al. Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. J Clin Invest. 2009;119(6):1696-705. doi: 10.1172/JCI32743.
    • (2009) J Clin Invest. , vol.119 , Issue.6 , pp. 1696-1705
    • Nijnik, A.1    Dawson, S.2    Crockford, T.L.3    Woodbine, L.4    Visetnoi, S.5    Bennett, S.6
  • 41
    • 20244376003 scopus 로고    scopus 로고
    • Damaging-agent sensitivity of Artemis-deficient cell lines
    • 15770702 1:CAS:528:DC%2BD2MXjslSgur4%3D
    • Musio A, Marrella V, Sobacchi C, Rucci F, Fariselli L, Giliani S, et al. Damaging-agent sensitivity of Artemis-deficient cell lines. Eur J Immunol. 2005;35(4):1250-6.
    • (2005) Eur J Immunol , vol.35 , Issue.4 , pp. 1250-1256
    • Musio, A.1    Marrella, V.2    Sobacchi, C.3    Rucci, F.4    Fariselli, L.5    Giliani, S.6
  • 42
    • 37549055036 scopus 로고    scopus 로고
    • Defective Artemis nuclease is characterized by coding joints with microhomology in long palindromic-nucleotide stretches
    • 10.1002/eji.200737624 18034425
    • van der Burg M, Verkaik NS, den Dekker AT, Barendregt BH, Pico-Knijnenburg I, Tezcan I, et al. Defective Artemis nuclease is characterized by coding joints with microhomology in long palindromic-nucleotide stretches. Eur J Immunol. 2007;37(12):3522-8. doi: 10.1002/eji.200737624.
    • (2007) Eur J Immunol , vol.37 , Issue.12 , pp. 3522-3528
    • Van Der Burg, M.1    Verkaik, N.S.2    Den Dekker, A.T.3    Barendregt, B.H.4    Pico-Knijnenburg, I.5    Tezcan, I.6
  • 43
    • 3242881897 scopus 로고    scopus 로고
    • An overview of three new disorders associated with genetic instability: LIG4 syndrome. RS-SCID and ATR-Seckel syndrome
    • 10.1016/j.dnarep.2004.03.025
    • O'Driscoll M, Gennery AR, Seidel J, Concannon P, Jeggo PA. An overview of three new disorders associated with genetic instability: LIG4 syndrome. RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst). 2004;3(8-9):1227-35. doi: 10.1016/j.dnarep.2004.03.025.
    • (2004) DNA Repair (Amst) , vol.3 , Issue.8-9 , pp. 1227-1235
    • O'Driscoll, M.1    Gennery, A.R.2    Seidel, J.3    Concannon, P.4    Jeggo, P.A.5
  • 45
    • 0000263266 scopus 로고
    • Familial reticuloendotheliosis with eosinophilia
    • 10.1056/NEJM196508192730806 14328107 1:STN:280:DyaF2M7jt1Oruw%3D%3D
    • Omenn GS. Familial reticuloendotheliosis with eosinophilia. N Engl J Med. 1965;273:427-32. doi: 10.1056/NEJM196508192730806.
    • (1965) N Engl J Med , vol.273 , pp. 427-432
    • Omenn, G.S.1
  • 47
    • 22744449873 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation in Omenn syndrome: A single-center experience
    • 10.1038/sj.bmt.1705017 15908971 1:STN:280:DC%2BD2MvgtVCkug%3D%3D
    • Mazzolari E, Moshous D, Forino C, De Martiis D, Offer C, Lanfranchi A, et al. Hematopoietic stem cell transplantation in Omenn syndrome: a single-center experience. Bone Marrow Transplant. 2005;36(2):107-14. doi: 10.1038/sj.bmt. 1705017.
    • (2005) Bone Marrow Transplant , vol.36 , Issue.2 , pp. 107-114
    • Mazzolari, E.1    Moshous, D.2    Forino, C.3    De Martiis, D.4    Offer, C.5    Lanfranchi, A.6
  • 48
    • 0032577548 scopus 로고    scopus 로고
    • Partial V(D)J recombination activity leads to Omenn syndrome
    • 9630231 1:CAS:528:DyaK1cXjsl2qsrk%3D
    • Villa A, Santagata S, Bozzi F, Giliani S, Frattini A, Imberti L, et al. Partial V(D)J recombination activity leads to Omenn syndrome. Cell. 1998;93(5):885-96.
    • (1998) Cell , vol.93 , Issue.5 , pp. 885-896
    • Villa, A.1    Santagata, S.2    Bozzi, F.3    Giliani, S.4    Frattini, A.5    Imberti, L.6
  • 49
    • 0035353213 scopus 로고    scopus 로고
    • Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome
    • 11313270 1:CAS:528:DC%2BD3MXjtlSiu7k%3D
    • Corneo B, Moshous D, Gungor T, Wulffraat N, Philippet P, Le Deist FL, et al. Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome. Blood. 2001;97(9):2772-6.
    • (2001) Blood , vol.97 , Issue.9 , pp. 2772-2776
    • Corneo, B.1    Moshous, D.2    Gungor, T.3    Wulffraat, N.4    Philippet, P.5    Le Deist, F.L.6
  • 50
    • 19344374008 scopus 로고    scopus 로고
    • Omenn syndrome due to ARTEMIS mutations
    • Ege M, Ma Y, Manfras B, Kalwak K, Lu H, Lieber MR et al. Omenn syndrome due to ARTEMIS mutations. Blood. 2005;105(11):4179-86.
    • (2005) Blood , vol.105 , Issue.11 , pp. 4179-4186
    • Ege, M.1    Ma, Y.2    Manfras, B.3    Kalwak, K.4    Lu, H.5
  • 51
    • 80255127503 scopus 로고    scopus 로고
    • Omenn syndrome does not live by V(D)J recombination alone
    • 10.1097/ACI.0b013e32834c311a 22001740 1:CAS:528:DC%2BC3MXhtlyhu7jO
    • Marrella V, Maina V, Villa A. Omenn syndrome does not live by V(D)J recombination alone. Curr Opin Allergy Clin Immunol. 2011;11(6):525-31. doi: 10.1097/ACI.0b013e32834c311a.
    • (2011) Curr Opin Allergy Clin Immunol , vol.11 , Issue.6 , pp. 525-531
    • Marrella, V.1    Maina, V.2    Villa, A.3
  • 52
    • 77951163493 scopus 로고    scopus 로고
    • Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination
    • 10.1172/JCI41305 20234091 1:CAS:528:DC%2BC3cXksVChtrw%3D
    • Couedel C, Roman C, Jones A, Vezzoni P, Villa A, Cortes P. Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination. J Clin Investig. 2010;120(4):1337-44. doi: 10.1172/JCI41305.
    • (2010) J Clin Investig , vol.120 , Issue.4 , pp. 1337-1344
    • Couedel, C.1    Roman, C.2    Jones, A.3    Vezzoni, P.4    Villa, A.5    Cortes, P.6
  • 53
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • 10.1038/cr.2007.111 18157161 1:CAS:528:DC%2BD1cXisVSjug%3D%3D
    • Shrivastav M, De Haro LP, Nickoloff JA. Regulation of DNA double-strand break repair pathway choice. Cell Res. 2008;18(1):134-47. doi: 10.1038/cr.2007.111.
    • (2008) Cell Res , vol.18 , Issue.1 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 54
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • 10.1038/35077232 11357144 1:CAS:528:DC%2BD3MXktVSjs74%3D
    • Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature. 2001;411(6835):366-74. doi: 10.1038/35077232.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 55
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • 10.1016/j.molcel.2007.11.015 18082599 1:CAS:528:DC%2BD1cXktVWisQ%3D%3D
    • Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell. 2007;28(5):739-45. doi: 10.1016/j.molcel.2007.11.015.
    • (2007) Mol Cell , vol.28 , Issue.5 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 56
    • 0142025259 scopus 로고    scopus 로고
    • Interactive competition between homologous recombination and non-homologous end joining
    • 14573792 1:CAS:528:DC%2BD3sXotlSjsbs%3D
    • Allen C, Halbrook J, Nickoloff JA. Interactive competition between homologous recombination and non-homologous end joining. Mol Cancer Res. 2003;1(12):913-20.
    • (2003) Mol Cancer Res , vol.1 , Issue.12 , pp. 913-920
    • Allen, C.1    Halbrook, J.2    Nickoloff, J.A.3
  • 57
    • 0034461607 scopus 로고    scopus 로고
    • Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells
    • 11074004 1:CAS:528:DC%2BD3MXitFGrsLs%3D
    • Richardson C, Jasin M. Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells. Mol Cell Biol. 2000;20(23):9068-75.
    • (2000) Mol Cell Biol , vol.20 , Issue.23 , pp. 9068-9075
    • Richardson, C.1    Jasin, M.2
  • 58
    • 0034951142 scopus 로고    scopus 로고
    • Double-strand-break-induced homologous recombination in mammalian cells
    • 11356153 1:CAS:528:DC%2BD3MXkslentbk%3D
    • Johnson RD, Jasin M. Double-strand-break-induced homologous recombination in mammalian cells. Biochem Soc Trans. 2001;29(Pt 2):196-201.
    • (2001) Biochem Soc Trans , vol.29 , Issue.PART 2 , pp. 196-201
    • Johnson, R.D.1    Jasin, M.2
  • 59
    • 0036261707 scopus 로고    scopus 로고
    • Sensing and repairing DNA double-strand breaks
    • 12016139 1:CAS:528:DC%2BD38XktFyqs70%3D
    • Jackson SP. Sensing and repairing DNA double-strand breaks. Carcinogenesis. 2002;23(5):687-96.
    • (2002) Carcinogenesis , vol.23 , Issue.5 , pp. 687-696
    • Jackson, S.P.1
  • 60
    • 0942268167 scopus 로고    scopus 로고
    • Repair of DNA double strand breaks by non-homologous end joining
    • 14726021 1:CAS:528:DC%2BD2cXjsVyqsw%3D%3D
    • Lees-Miller SP, Meek K. Repair of DNA double strand breaks by non-homologous end joining. Biochimie. 2003;85(11):1161-73.
    • (2003) Biochimie , vol.85 , Issue.11 , pp. 1161-1173
    • Lees-Miller, S.P.1    Meek, K.2
  • 61
    • 4544362838 scopus 로고    scopus 로고
    • The mechanism of non-homologous end-joining: A synopsis of synapsis
    • 10.1016/j.dnarep.2004.06.003 1:CAS:528:DC%2BD2cXnsleitbw%3D
    • Weterings E, van Gent DC. The mechanism of non-homologous end-joining: a synopsis of synapsis. DNA Repair (Amst). 2004;3(11):1425-35. doi: 10.1016/j.dnarep.2004.06.003.
    • (2004) DNA Repair (Amst) , vol.3 , Issue.11 , pp. 1425-1435
    • Weterings, E.1    Van Gent, D.C.2
  • 62
    • 0033560796 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase
    • 10215620 1:CAS:528:DyaK1MXivFGkur4%3D
    • Smith GC, Jackson SP. The DNA-dependent protein kinase. Genes Dev. 1999;13(8):916-34.
    • (1999) Genes Dev , vol.13 , Issue.8 , pp. 916-934
    • Smith, G.C.1    Jackson, S.P.2
  • 63
    • 0037124373 scopus 로고    scopus 로고
    • Synapsis of DNA ends by DNA-dependent protein kinase
    • 10.1093/emboj/cdf299 12065431 1:CAS:528:DC%2BD38XlsVSlurY%3D
    • DeFazio LG, Stansel RM, Griffith JD, Chu G. Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J. 2002;21(12):3192-200. doi: 10.1093/emboj/cdf299.
    • (2002) EMBO J , vol.21 , Issue.12 , pp. 3192-3200
    • Defazio, L.G.1    Stansel, R.M.2    Griffith, J.D.3    Chu, G.4
  • 64
    • 78649446475 scopus 로고    scopus 로고
    • A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
    • 10.1016/j.dnarep.2010.09.019 21030321 1:CAS:528:DC%2BC3cXhsVygsb%2FK
    • Dobbs TA, Tainer JA, Lees-Miller SP. A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair. 2010;9(12):1307-14. doi: 10.1016/j.dnarep.2010.09.019.
    • (2010) DNA Repair , vol.9 , Issue.12 , pp. 1307-1314
    • Dobbs, T.A.1    Tainer, J.A.2    Lees-Miller, S.P.3
  • 65
    • 9744220428 scopus 로고    scopus 로고
    • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
    • 10.1016/j.molcel.2004.10.029 15574327 1:CAS:528:DC%2BD2cXhtFaku7zM
    • Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ, et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell. 2004;16(5):715-24. doi: 10.1016/j.molcel.2004.10.029.
    • (2004) Mol Cell , vol.16 , Issue.5 , pp. 715-724
    • Riballo, E.1    Kuhne, M.2    Rief, N.3    Doherty, A.4    Smith, G.C.5    Recio, M.J.6
  • 66
    • 23044453811 scopus 로고    scopus 로고
    • A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining
    • doi: 10.1016/j.molcel.2005.06.012
    • Nick McElhinny SA, Havener JM, Garcia-Diaz M, Juarez R, Bebenek K, Kee BL et al. A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol Cell. 2005;19(3):357-66.doi: 10.1016/j.molcel.2005.06.012.
    • (2005) Mol Cell , vol.19 , Issue.3 , pp. 357-366
    • Nick McElhinny, S.A.1    Havener, J.M.2    Garcia-Diaz, M.3    Juarez, R.4    Bebenek, K.5
  • 67
    • 41149153412 scopus 로고    scopus 로고
    • DNA polymerases in adaptive immunity
    • 10.1038/nri2281 18340343 1:CAS:528:DC%2BD1cXjs1antb8%3D
    • Weill JC, Reynaud CA. DNA polymerases in adaptive immunity. Nat Rev Immunol. 2008;8(4):302-12. doi: 10.1038/nri2281.
    • (2008) Nat Rev Immunol , vol.8 , Issue.4 , pp. 302-312
    • Weill, J.C.1    Reynaud, C.A.2
  • 68
    • 77951621112 scopus 로고    scopus 로고
    • Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends
    • 10.1038/nature08926 20383123 1:CAS:528:DC%2BC3cXksFamu78%3D
    • Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, et al. Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends. Nature. 2010;464(7292):1214-7. doi: 10.1038/nature08926.
    • (2010) Nature , vol.464 , Issue.7292 , pp. 1214-1217
    • Roberts, S.A.1    Strande, N.2    Burkhalter, M.D.3    Strom, C.4    Havener, J.M.5    Hasty, P.6
  • 69
    • 80054683238 scopus 로고    scopus 로고
    • Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3′ exonuclease and can participate in DNA end joining in a biochemical system
    • 10.1074/jbc.M111.287797 21885877 1:CAS:528:DC%2BC3MXhtlSqtL7M
    • Li S, Kanno S, Watanabe R, Ogiwara H, Kohno T, Watanabe G, et al. Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3′ exonuclease and can participate in DNA end joining in a biochemical system. J Biol Chem. 2011;286(42):36368-77. doi: 10.1074/jbc.M111.287797.
    • (2011) J Biol Chem , vol.286 , Issue.42 , pp. 36368-36377
    • Li, S.1    Kanno, S.2    Watanabe, R.3    Ogiwara, H.4    Kohno, T.5    Watanabe, G.6
  • 70
    • 59849089955 scopus 로고    scopus 로고
    • Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    • 10.1042/BJ20080413 19133841 1:CAS:528:DC%2BD1MXlvFOhsQ%3D%3D
    • Mahaney BL, Meek K, Lees-Miller SP. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J. 2009;417(3):639-50. doi: 10.1042/BJ20080413.
    • (2009) Biochem J , vol.417 , Issue.3 , pp. 639-650
    • Mahaney, B.L.1    Meek, K.2    Lees-Miller, S.P.3
  • 71
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • 10.1146/annurev.biochem.052308.093131 20192759 1:CAS:528: DC%2BC3cXpslShsbY%3D
    • Lieber MR. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 72
    • 63449084054 scopus 로고    scopus 로고
    • MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks
    • 10.1084/jem.20081326 19221393 1:CAS:528:DC%2BD1MXjsVaisbc%3D
    • Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, et al. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med. 2009;206(3):669-79. doi: 10.1084/jem.20081326.
    • (2009) J Exp Med , vol.206 , Issue.3 , pp. 669-679
    • Helmink, B.A.1    Bredemeyer, A.L.2    Lee, B.S.3    Huang, C.Y.4    Sharma, G.G.5    Walker, L.M.6
  • 73
    • 77951057068 scopus 로고    scopus 로고
    • 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
    • 10.1084/jem.20100244 20368578 1:CAS:528:DC%2BC3cXkvFGrsLw%3D
    • Bothmer A, Robbiani DF, Feldhahn N, Gazumyan A, Nussenzweig A, Nussenzweig MC. 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med. 2010;207(4):855-65. doi: 10.1084/jem.20100244.
    • (2010) J Exp Med , vol.207 , Issue.4 , pp. 855-865
    • Bothmer, A.1    Robbiani, D.F.2    Feldhahn, N.3    Gazumyan, A.4    Nussenzweig, A.5    Nussenzweig, M.C.6
  • 74
    • 25444475799 scopus 로고    scopus 로고
    • Repair of Double-Strand DNA Breaks by the Human Nonhomologous DNA End Joining Pathway: The Iterative Processing Model
    • Ma Y, Lu H, Schwarz K, Lieber MR. Repair of Double-Strand DNA Breaks by the Human Nonhomologous DNA End Joining Pathway: The Iterative Processing Model. Cell Cycle. 2005;4(9):1193-200.
    • (2005) Cell Cycle. , vol.4 , Issue.9 , pp. 1193-1200
    • Ma, Y.1    Lu, H.2    Schwarz, K.3    Lieber, M.R.4
  • 75
    • 38049115657 scopus 로고    scopus 로고
    • The mechanism of human nonhomologous DNA end joining
    • 17999957 1:CAS:528:DC%2BD1cXhtVOnug%3D%3D
    • Lieber MR. The mechanism of human nonhomologous DNA end joining. J Biol Chem. 2008;283(1):1-5.
    • (2008) J Biol Chem , vol.283 , Issue.1 , pp. 1-5
    • Lieber, M.R.1
  • 76
    • 20644463916 scopus 로고    scopus 로고
    • The Artemis: DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
    • 15936993 1:CAS:528:DC%2BD2MXlsFCqsr4%3D
    • Ma Y, Schwarz K, Lieber MR. The Artemis: DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair. 2005;4:845-51.
    • (2005) DNA Repair , vol.4 , pp. 845-851
    • Ma, Y.1    Schwarz, K.2    Lieber, M.R.3
  • 77
    • 9744241712 scopus 로고    scopus 로고
    • A biochemically defined system for mammalian nonhomologous DNA end joining
    • 15574326 1:CAS:528:DC%2BD2cXhtFaku7%2FF
    • Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, Koiwai O, et al. A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell. 2004;16(5):701-13.
    • (2004) Mol Cell , vol.16 , Issue.5 , pp. 701-713
    • Ma, Y.1    Lu, H.2    Tippin, B.3    Goodman, M.F.4    Shimazaki, N.5    Koiwai, O.6
  • 78
    • 37849018404 scopus 로고    scopus 로고
    • Ku recruits XLF to DNA double-strand breaks
    • 10.1038/sj.embor.7401137 18064046 1:CAS:528:DC%2BD1cXhvFKlsg%3D%3D
    • Yano K, Morotomi-Yano K, Wang SY, Uematsu N, Lee KJ, Asaithamby A, et al. Ku recruits XLF to DNA double-strand breaks. EMBO Rep. 2008;9(1):91-6. doi: 10.1038/sj.embor.7401137.
    • (2008) EMBO Rep , vol.9 , Issue.1 , pp. 91-96
    • Yano, K.1    Morotomi-Yano, K.2    Wang, S.Y.3    Uematsu, N.4    Lee, K.J.5    Asaithamby, A.6
  • 79
    • 33845484385 scopus 로고    scopus 로고
    • Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
    • 10.1073/pnas.0609061103 17124166 1:CAS:528:DC%2BD28XhtlahtrzM
    • Mari PO, Florea BI, Persengiev SP, Verkaik NS, Bruggenwirth HT, Modesti M, et al. Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci USA. 2006;103(49):18597-602. doi: 10.1073/pnas.0609061103.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.49 , pp. 18597-18602
    • Mari, P.O.1    Florea, B.I.2    Persengiev, S.P.3    Verkaik, N.S.4    Bruggenwirth, H.T.5    Modesti, M.6
  • 80
    • 34247477667 scopus 로고    scopus 로고
    • Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
    • 10.1083/jcb.200608077 17438073 1:CAS:528:DC%2BD2sXks1Kqtrs%3D
    • Uematsu N, Weterings E, Yano K, Morotomi-Yano K, Jakob B, Taucher-Scholz G, et al. Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol. 2007;177(2):219-29. doi: 10.1083/jcb. 200608077.
    • (2007) J Cell Biol , vol.177 , Issue.2 , pp. 219-229
    • Uematsu, N.1    Weterings, E.2    Yano, K.3    Morotomi-Yano, K.4    Jakob, B.5    Taucher-Scholz, G.6
  • 81
    • 45749124305 scopus 로고    scopus 로고
    • Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway
    • 18418068 1:CAS:528:DC%2BD1cXptF2jtr8%3D
    • Yano K, Chen DJ. Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway. Cell Cycle. 2008;7(10):1321-5.
    • (2008) Cell Cycle , vol.7 , Issue.10 , pp. 1321-1325
    • Yano, K.1    Chen, D.J.2
  • 82
    • 64949182233 scopus 로고    scopus 로고
    • Molecular mechanism of protein assembly on DNA double-strand breaks in the non-homologous end-joining pathway
    • 1:CAS:528:DC%2BD1MXmtVSqs7s%3D
    • Yano K, Morotomi-Yano K, Adachi N, Akiyama H. Molecular mechanism of protein assembly on DNA double-strand breaks in the non-homologous end-joining pathway. J Radiat Res (Tokyo). 2009;50(2):97-108.
    • (2009) J Radiat Res (Tokyo) , vol.50 , Issue.2 , pp. 97-108
    • Yano, K.1    Morotomi-Yano, K.2    Adachi, N.3    Akiyama, H.4
  • 84
    • 23644452672 scopus 로고    scopus 로고
    • The repair of DNA damages/modifications during the maturation of the immune system: Lessons from human primary immunodeficiency disorders and animal models
    • 10.1016/S0065-2776(05)87007-5 16102576 1:CAS:528:DC%2BD1cXhsVOru7Y%3D
    • Revy P, Buck D, le Deist F, de Villartay JP. The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models. Adv Immunol. 2005;87:237-95. doi: 10.1016/S0065-2776(05)87007-5.
    • (2005) Adv Immunol , vol.87 , pp. 237-295
    • Revy, P.1    Buck, D.2    Le Deist, F.3    De Villartay, J.P.4
  • 85
    • 79953032797 scopus 로고    scopus 로고
    • Mechanisms that promote and suppress chromosomal translocations in lymphocytes
    • 10.1146/annurev-immunol-031210-101329 21219174 1:CAS:528: DC%2BC3MXltlKns7Y%3D
    • Gostissa M, Alt FW, Chiarle R. Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu Rev Immunol. 2011;29:319-50. doi: 10.1146/annurev-immunol-031210-101329.
    • (2011) Annu Rev Immunol , vol.29 , pp. 319-350
    • Gostissa, M.1    Alt, F.W.2    Chiarle, R.3
  • 86
    • 77950955761 scopus 로고    scopus 로고
    • Origin of chromosomal translocations in lymphoid cancer
    • 10.1016/j.cell.2010.03.016 20371343 1:CAS:528:DC%2BC3cXlsVSgtLY%3D
    • Nussenzweig A, Nussenzweig MC. Origin of chromosomal translocations in lymphoid cancer. Cell. 2010;141(1):27-38. doi: 10.1016/j.cell.2010.03.016.
    • (2010) Cell , vol.141 , Issue.1 , pp. 27-38
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 87
    • 0020663062 scopus 로고
    • A severe combined immunodeficiency mutation in the mouse
    • 6823332 1:STN:280:DyaL3s7hsFehsw%3D%3D
    • Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature. 1983;301(5900):527-30.
    • (1983) Nature , vol.301 , Issue.5900 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 88
    • 0023801238 scopus 로고
    • The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
    • 3167977 1:CAS:528:DyaL1MXhs1OgtL8%3D
    • Lieber MR, Hesse JE, Lewis S, Bosma GC, Rosenberg N, Mizuuchi K, et al. The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell. 1988;55(1):7-16.
    • (1988) Cell , vol.55 , Issue.1 , pp. 7-16
    • Lieber, M.R.1    Hesse, J.E.2    Lewis, S.3    Bosma, G.C.4    Rosenberg, N.5    Mizuuchi, K.6
  • 89
    • 0027156278 scopus 로고
    • Impairment of V(D)J recombination in double-strand break repair mutants
    • 8469973 1:CAS:528:DyaK3sXit1OntLw%3D
    • Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW. Impairment of V(D)J recombination in double-strand break repair mutants. Science. 1993;260(5105):207-10.
    • (1993) Science , vol.260 , Issue.5105 , pp. 207-210
    • Taccioli, G.E.1    Rathbun, G.2    Oltz, E.3    Stamato, T.4    Jeggo, P.A.5    Alt, F.W.6
  • 90
    • 13444301307 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination versus class switch recombination: Similarities and differences
    • 10.1016/S0065-2776(04)86002-4 15705419 1:CAS:528:DC%2BD2MXksFGnur0%3D
    • Dudley DD, Chaudhuri J, Bassing CH, Alt FW. Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol. 2005;86:43-112. doi: 10.1016/S0065-2776(04)86002-4.
    • (2005) Adv Immunol , vol.86 , pp. 43-112
    • Dudley, D.D.1    Chaudhuri, J.2    Bassing, C.H.3    Alt, F.W.4
  • 91
    • 0345505218 scopus 로고    scopus 로고
    • Nonhomologous end joining and V(D)J recombination require an additional factor
    • 10.1073/pnas.0437964100 12604777 1:CAS:528:DC%2BD3sXitVaisrg%3D
    • Dai Y, Kysela B, Hanakahi LA, Manolis K, Riballo E, Stumm M, et al. Nonhomologous end joining and V(D)J recombination require an additional factor. Proc Natl Acad Sci U S A. 2003;100(5):2462-7. doi: 10.1073/pnas.0437964100.
    • (2003) Proc Natl Acad Sci U S A. , vol.100 , Issue.5 , pp. 2462-2467
    • Dai, Y.1    Kysela, B.2    Hanakahi, L.A.3    Manolis, K.4    Riballo, E.5    Stumm, M.6
  • 92
    • 31044432090 scopus 로고    scopus 로고
    • XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
    • 10.1016/j.cell.2005.12.031 16439205 1:CAS:528:DC%2BD28Xht1KktLY%3D
    • Ahnesorg P, Smith P, Jackson SP. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell. 2006;124(2):301-13. doi: 10.1016/j.cell.2005.12.031.
    • (2006) Cell , vol.124 , Issue.2 , pp. 301-313
    • Ahnesorg, P.1    Smith, P.2    Jackson, S.P.3
  • 93
    • 3142686957 scopus 로고    scopus 로고
    • Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: Implications for the enforcement of the 12/23 rule
    • 10.1074/jbc.M403706200 15123719 1:CAS:528:DC%2BD2cXlsVCluro%3D
    • Sawchuk DJ, Mansilla-Soto J, Alarcon C, Singha NC, Langen H, Bianchi ME, et al. Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule. J Biol Chem. 2004;279(28):29821-31. doi: 10.1074/jbc.M403706200.
    • (2004) J Biol Chem , vol.279 , Issue.28 , pp. 29821-29831
    • Sawchuk, D.J.1    Mansilla-Soto, J.2    Alarcon, C.3    Singha, N.C.4    Langen, H.5    Bianchi, M.E.6
  • 94
    • 41849137645 scopus 로고    scopus 로고
    • Evidence for Ku70/Ku80 association with full-length RAG1
    • 10.1093/nar/gkn049 18281312 1:CAS:528:DC%2BD1cXktl2ksr4%3D
    • Raval P, Kriatchko AN, Kumar S, Swanson PC. Evidence for Ku70/Ku80 association with full-length RAG1. Nucleic Acids Res. 2008;36(6):2060-72. doi: 10.1093/nar/gkn049.
    • (2008) Nucleic Acids Res , vol.36 , Issue.6 , pp. 2060-2072
    • Raval, P.1    Kriatchko, A.N.2    Kumar, S.3    Swanson, P.C.4
  • 95
    • 0036533433 scopus 로고    scopus 로고
    • A recombinase diversified: New functions of the RAG proteins
    • 11869896 1:CAS:528:DC%2BD38XhsFCqsrY%3D
    • Brandt VL, Roth DB. A recombinase diversified: new functions of the RAG proteins. Curr Opin Immunol. 2002;14(2):224-9.
    • (2002) Curr Opin Immunol , vol.14 , Issue.2 , pp. 224-229
    • Brandt, V.L.1    Roth, D.B.2
  • 96
    • 0036682980 scopus 로고    scopus 로고
    • Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination
    • 10.1101/gad.984502 12154124 1:CAS:528:DC%2BD38XmtFalu7Y%3D
    • Tsai CL, Drejer AH, Schatz DG. Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination. Genes Dev. 2002;16(15):1934-49. doi: 10.1101/gad.984502.
    • (2002) Genes Dev , vol.16 , Issue.15 , pp. 1934-1949
    • Tsai, C.L.1    Drejer, A.H.2    Schatz, D.G.3
  • 97
    • 64649092651 scopus 로고    scopus 로고
    • The roles of the RAG1 and RAG2 non-core regions in V(D)J recombination and lymphocyte development
    • 10.1007/s00005-009-0011-3 1:CAS:528:DC%2BD1MXkt1yhurk%3D
    • Jones JM, Simkus C. The roles of the RAG1 and RAG2 non-core regions in V(D)J recombination and lymphocyte development. Arch Immunol Ther Exp (Warsz). 2009;57(2):105-16. doi: 10.1007/s00005-009-0011-3.
    • (2009) Arch Immunol Ther Exp (Warsz) , vol.57 , Issue.2 , pp. 105-116
    • Jones, J.M.1    Simkus, C.2
  • 98
    • 79953029378 scopus 로고    scopus 로고
    • The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3
    • 10.1016/j.imlet.2011.01.005 21256161 1:CAS:528:DC%2BC3MXjvV2mu7k%3D
    • Jones JM, Bhattacharyya A, Simkus C, Vallieres B, Veenstra TD, Zhou M. The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3. Immunol Lett. 2011;136(2):156-62. doi: 10.1016/j.imlet.2011.01.005.
    • (2011) Immunol Lett , vol.136 , Issue.2 , pp. 156-162
    • Jones, J.M.1    Bhattacharyya, A.2    Simkus, C.3    Vallieres, B.4    Veenstra, T.D.5    Zhou, M.6
  • 99
    • 34848843525 scopus 로고    scopus 로고
    • Rag mutations reveal robust alternative end joining
    • 10.1038/nature06168 17898768 1:CAS:528:DC%2BD2sXhtV2is7%2FP
    • Corneo B, Wendland RL, Deriano L, Cui X, Klein IA, Wong SY, et al. Rag mutations reveal robust alternative end joining. Nature. 2007;449(7161):483-6. doi: 10.1038/nature06168.
    • (2007) Nature , vol.449 , Issue.7161 , pp. 483-486
    • Corneo, B.1    Wendland, R.L.2    Deriano, L.3    Cui, X.4    Klein, I.A.5    Wong, S.Y.6
  • 100
    • 36749007206 scopus 로고    scopus 로고
    • Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway
    • 10.1073/pnas.0610928104 17939999 1:CAS:528:DC%2BD2sXht1KgtLfN
    • Cui X, Meek K. Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway. Proc Natl Acad Sci USA. 2007;104(43):17046-51. doi: 10.1073/pnas.0610928104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.43 , pp. 17046-17051
    • Cui, X.1    Meek, K.2
  • 101
    • 79952255995 scopus 로고    scopus 로고
    • The RAG2 C terminus suppresses genomic instability and lymphomagenesis
    • 10.1038/nature09755 21368836 1:CAS:528:DC%2BC3MXis1CrsLw%3D
    • Deriano L, Chaumeil J, Coussens M, Multani A, Chou Y, Alekseyenko AV, et al. The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature. 2011;471(7336):119-23. doi: 10.1038/nature09755.
    • (2011) Nature , vol.471 , Issue.7336 , pp. 119-123
    • Deriano, L.1    Chaumeil, J.2    Coussens, M.3    Multani, A.4    Chou, Y.5    Alekseyenko, A.V.6
  • 102
    • 53749091190 scopus 로고    scopus 로고
    • WDNA damage and repair during lymphoid development: Antigen receptor diversity, genomic integrity and lymphomagenesis
    • Puebla-Osorio N, Zhu C. DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis. Immunol Res. 2008;41(2):103-22.
    • (2008) Immunol Res. , vol.41 , Issue.2 , pp. 103-122
    • Puebla-Osorio, N.1    Zhu, C.2
  • 103
    • 0347994908 scopus 로고    scopus 로고
    • Autoubiquitylation of the V(D)J recombinase protein RAG1
    • 10.1073/pnas.2637012100 14671314 1:CAS:528:DC%2BD2cXhtVeqtA%3D%3D
    • Jones JM, Gellert M. Autoubiquitylation of the V(D)J recombinase protein RAG1. Proc Nat Acad Sci USA. 2003;100(26):15446-51. doi: 10.1073/pnas. 2637012100.
    • (2003) Proc Nat Acad Sci USA , vol.100 , Issue.26 , pp. 15446-15451
    • Jones, J.M.1    Gellert, M.2
  • 104
    • 74749102792 scopus 로고    scopus 로고
    • The RING domain of RAG1 ubiquitylates histone H3: A novel activity in chromatin-mediated regulation of V(D)J joining
    • 10.1016/j.molcel.2009.12.035 20122409 1:CAS:528:DC%2BC3cXltlWrtrc%3D
    • Grazini U, Zanardi F, Citterio E, Casola S, Goding CR, McBlane F. The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining. Mol Cell. 2010;37(2):282-93. doi: 10.1016/j.molcel.2009.12.035.
    • (2010) Mol Cell , vol.37 , Issue.2 , pp. 282-293
    • Grazini, U.1    Zanardi, F.2    Citterio, E.3    Casola, S.4    Goding, C.R.5    McBlane, F.6
  • 105
    • 84857059697 scopus 로고    scopus 로고
    • VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity
    • 10.1038/emboj.2011.455 22157821
    • Kassmeier MD, Mondal K, Palmer VL, Raval P, Kumar S, Perry GA, et al. VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity. EMBO J. 2011;. doi: 10.1038/emboj.2011.455.
    • (2011) EMBO J
    • Kassmeier, M.D.1    Mondal, K.2    Palmer, V.L.3    Raval, P.4    Kumar, S.5    Perry, G.A.6
  • 106
    • 2342565902 scopus 로고    scopus 로고
    • A means to a DNA end: The many roles of Ku
    • 15122350 1:CAS:528:DC%2BD2cXjsFSltLw%3D
    • Downs JA, Jackson SP. A means to a DNA end: the many roles of Ku. Nat Rev Mol Cell Biol. 2004;5(5):367-78.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , Issue.5 , pp. 367-378
    • Downs, J.A.1    Jackson, S.P.2
  • 107
    • 78650238493 scopus 로고    scopus 로고
    • The ACF1 complex is required for DNA double-strand break repair in human cells
    • 10.1016/j.molcel.2010.12.003 21172662 1:CAS:528:DC%2BC3cXhsF2itr7P
    • Lan L, Ui A, Nakajima S, Hatakeyama K, Hoshi M, Watanabe R, et al. The ACF1 complex is required for DNA double-strand break repair in human cells. Mol Cell. 2010;40(6):976-87. doi: 10.1016/j.molcel.2010.12.003.
    • (2010) Mol Cell , vol.40 , Issue.6 , pp. 976-987
    • Lan, L.1    Ui, A.2    Nakajima, S.3    Hatakeyama, K.4    Hoshi, M.5    Watanabe, R.6
  • 108
    • 0033572709 scopus 로고    scopus 로고
    • Geometry of a complex formed by double strand break repair proteins at a single DNA end: Recruitment of DNA-PKcs induces inward translocation of Ku protein
    • 10572166 1:CAS:528:DC%2BD3cXlsVGn
    • Yoo S, Dynan WS. Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein. Nucleic Acids Res. 1999;27(24):4679-86.
    • (1999) Nucleic Acids Res , vol.27 , Issue.24 , pp. 4679-4686
    • Yoo, S.1    Dynan, W.S.2
  • 109
    • 14844292557 scopus 로고    scopus 로고
    • DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks
    • 15520013 1:CAS:528:DC%2BD2MXhsV2qur8%3D
    • Drouet J, Delteil C, Lefrancois J, Concannon P, Salles B, Calsou P. DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks. J Biol Chem. 2005;280(8):7060-9.
    • (2005) J Biol Chem , vol.280 , Issue.8 , pp. 7060-7069
    • Drouet, J.1    Delteil, C.2    Lefrancois, J.3    Concannon, P.4    Salles, B.5    Calsou, P.6
  • 110
    • 0030837472 scopus 로고    scopus 로고
    • V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation
    • 9252118 1:CAS:528:DyaK2sXltFWhtrc%3D
    • Bogue MA, Wang C, Zhu C, Roth DB. V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation. Immunity. 1997;7(1):37-47.
    • (1997) Immunity , vol.7 , Issue.1 , pp. 37-47
    • Bogue, M.A.1    Wang, C.2    Zhu, C.3    Roth, D.B.4
  • 112
    • 0034001205 scopus 로고    scopus 로고
    • Ku recruits the XRCC4-ligase IV complex to DNA ends
    • 10757784 1:CAS:528:DC%2BD3cXivFSktrg%3D
    • Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA. Ku recruits the XRCC4-ligase IV complex to DNA ends. Mol Cell Biol. 2000;20(9):2996-3003.
    • (2000) Mol Cell Biol , vol.20 , Issue.9 , pp. 2996-3003
    • Nick McElhinny, S.A.1    Snowden, C.M.2    McCarville, J.3    Ramsden, D.A.4
  • 113
    • 61749092799 scopus 로고    scopus 로고
    • The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends
    • 10.1128/MCB.00971-08 19103741 1:CAS:528:DC%2BD1MXitlymu74%3D
    • Weterings E, Verkaik NS, Keijzers G, Florea BI, Wang SY, Ortega LG, et al. The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends. Mol Cell Biol. 2009;29(5):1134-42. doi: 10.1128/MCB.00971-08.
    • (2009) Mol Cell Biol , vol.29 , Issue.5 , pp. 1134-1142
    • Weterings, E.1    Verkaik, N.S.2    Keijzers, G.3    Florea, B.I.4    Wang, S.Y.5    Ortega, L.G.6
  • 114
    • 0036293744 scopus 로고    scopus 로고
    • Association of DNA polymerase mu (pol mu) with Ku and ligase IV: Role for pol mu in end-joining double-strand break repair
    • 12077346 1:CAS:528:DC%2BD38XltVOqt7w%3D
    • Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA. Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol Cell Biol. 2002;22(14):5194-202.
    • (2002) Mol Cell Biol , vol.22 , Issue.14 , pp. 5194-5202
    • Mahajan, K.N.1    Nick McElhinny, S.A.2    Mitchell, B.S.3    Ramsden, D.A.4
  • 115
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • 8422676 1:CAS:528:DyaK3sXnsF2rug%3D%3D
    • Gottlieb TM, Jackson SP. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell. 1993;72(1):131-42.
    • (1993) Cell , vol.72 , Issue.1 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 116
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
    • 9768756 1:CAS:528:DyaK1cXmslKhtr8%3D
    • Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, Alt FW. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity. 1998;9(3):367-76.
    • (1998) Immunity , vol.9 , Issue.3 , pp. 367-376
    • Gao, Y.1    Chaudhuri, J.2    Zhu, C.3    Davidson, L.4    Weaver, D.T.5    Alt, F.W.6
  • 117
    • 0033198709 scopus 로고    scopus 로고
    • Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
    • 10446239 1:CAS:528:DyaK1MXmtFCntb0%3D
    • Gell D, Jackson SP. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res. 1999;27(17):3494-502.
    • (1999) Nucleic Acids Res , vol.27 , Issue.17 , pp. 3494-3502
    • Gell, D.1    Jackson, S.P.2
  • 118
    • 0037423743 scopus 로고    scopus 로고
    • Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment
    • 12547193 1:CAS:528:DC%2BD3sXlt12htQ%3D%3D
    • Calsou P, Delteil C, Frit P, Drouet J, Salles B. Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment. J Mol Biol. 2003;326(1):93-103.
    • (2003) J Mol Biol , vol.326 , Issue.1 , pp. 93-103
    • Calsou, P.1    Delteil, C.2    Frit, P.3    Drouet, J.4    Salles, B.5
  • 119
    • 0037187199 scopus 로고    scopus 로고
    • Defining interactions between DNA-PK and ligase IV/XRCC4
    • 1:CAS:528:DC%2BD38XhvVWitL8%3D
    • Hsu HL, Yannone SM, Chen DJ. Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst). 2002;1(3):225-35.
    • (2002) DNA Repair (Amst) , vol.1 , Issue.3 , pp. 225-235
    • Hsu, H.L.1    Yannone, S.M.2    Chen, D.J.3
  • 120
    • 0031939411 scopus 로고    scopus 로고
    • The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase
    • 9430729 1:CAS:528:DyaK1cXktFGmtA%3D%3D
    • Leber R, Wise TW, Mizuta R, Meek K. The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. J Biol Chem. 1998;273(3):1794-801.
    • (1998) J Biol Chem , vol.273 , Issue.3 , pp. 1794-1801
    • Leber, R.1    Wise, T.W.2    Mizuta, R.3    Meek, K.4
  • 121
    • 0034662228 scopus 로고    scopus 로고
    • Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination
    • 10908332 1:CAS:528:DC%2BD3cXlvFOrsbw%3D
    • Kienker LJ, Shin EK, Meek K. Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination. Nucleic Acids Res. 2000;28(14):2752-61.
    • (2000) Nucleic Acids Res , vol.28 , Issue.14 , pp. 2752-2761
    • Kienker, L.J.1    Shin, E.K.2    Meek, K.3
  • 122
    • 0032938747 scopus 로고    scopus 로고
    • Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
    • 10207111 1:CAS:528:DyaK1MXislSksLs%3D
    • Kurimasa A, Kumano S, Boubnov NV, Story MD, Tung CS, Peterson SR, et al. Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol Cell Biol. 1999;19(5):3877-84.
    • (1999) Mol Cell Biol , vol.19 , Issue.5 , pp. 3877-3884
    • Kurimasa, A.1    Kumano, S.2    Boubnov, N.V.3    Story, M.D.4    Tung, C.S.5    Peterson, S.R.6
  • 123
    • 22044445683 scopus 로고    scopus 로고
    • DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining
    • 1:CAS:528:DC%2BD2MXmtFSnsL4%3D
    • Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP. DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. DNA Repair (Amst). 2005;4(9):1006-18.
    • (2005) DNA Repair (Amst) , vol.4 , Issue.9 , pp. 1006-1018
    • Douglas, P.1    Gupta, S.2    Morrice, N.3    Meek, K.4    Lees-Miller, S.P.5
  • 125
    • 0242268028 scopus 로고    scopus 로고
    • DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination
    • 1:CAS:528:DC%2BD3sXos1Ogsr4%3D
    • Yu Y, Wang W, Ding Q, Ye R, Chen D, Merkle D, et al. DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. DNA Repair (Amst). 2003;2(11):1239-52.
    • (2003) DNA Repair (Amst) , vol.2 , Issue.11 , pp. 1239-1252
    • Yu, Y.1    Wang, W.2    Ding, Q.3    Ye, R.4    Chen, D.5    Merkle, D.6
  • 126
    • 52049117396 scopus 로고    scopus 로고
    • DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks
    • 1:CAS:528:DC%2BD1cXhtFCrsrrI
    • Yu Y, Mahaney BL, Yano K, Ye R, Fang S, Douglas P, et al. DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA Repair (Amst). 2008;7(10):1680-92.
    • (2008) DNA Repair (Amst) , vol.7 , Issue.10 , pp. 1680-1692
    • Yu, Y.1    Mahaney, B.L.2    Yano, K.3    Ye, R.4    Fang, S.5    Douglas, P.6
  • 127
    • 34147216135 scopus 로고    scopus 로고
    • Artemis Links ATM to G2/M Checkpoint Recovery Via Regulation of Cdk1-Cyclin B
    • Geng L, Zhang X, Zheng S, Legerski RJ. Artemis Links ATM to G2/M Checkpoint Recovery Via Regulation of Cdk1-Cyclin B. Mol Cell Biol. 2007;27(7):2625-35.
    • (2007) Mol Cell Biol , vol.27 , Issue.7 , pp. 2625-2635
    • Geng, L.1    Zhang, X.2    Zheng, S.3    Legerski, R.J.4
  • 128
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • 12231622 1:CAS:528:DC%2BD38XnsFelsrg%3D
    • Chan DW, Chen BP, Prithivirajsingh S, Kurimasa A, Story MD, Qin J, et al. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev. 2002;16(18):2333-8.
    • (2002) Genes Dev , vol.16 , Issue.18 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.2    Prithivirajsingh, S.3    Kurimasa, A.4    Story, M.D.5    Qin, J.6
  • 129
    • 0043133778 scopus 로고    scopus 로고
    • Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
    • 12897153 1:CAS:528:DC%2BD3sXmt1SrtLc%3D
    • Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, et al. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Biol. 2003;23(16):5836-48.
    • (2003) Mol Cell Biol , vol.23 , Issue.16 , pp. 5836-5848
    • Ding, Q.1    Reddy, Y.V.2    Wang, W.3    Woods, T.4    Douglas, P.5    Ramsden, D.A.6
  • 130
    • 57949116437 scopus 로고    scopus 로고
    • DNA-PK: The means to justify the ends?
    • 19117531 1:CAS:528:DC%2BD1MXpsFeisr0%3D
    • Meek K, Dang V, Lees-Miller SP. DNA-PK: the means to justify the ends? Adv Immunol. 2008;99:33-58.
    • (2008) Adv Immunol , vol.99 , pp. 33-58
    • Meek, K.1    Dang, V.2    Lees-Miller, S.P.3
  • 131
    • 84863230094 scopus 로고    scopus 로고
    • XRCC4's interaction with XLF is required for coding (but not signal) end joining
    • doi: 10.1093/nar/gkr1315
    • Roy S, Andres SN, Vergnes A, Neal JA, Xu Y, Yu Y et al. XRCC4's interaction with XLF is required for coding (but not signal) end joining. Nucleic acids research. 2012. doi: 10.1093/nar/gkr1315.
    • (2012) Nucleic Acids Research
    • Roy, S.1    Andres, S.N.2    Vergnes, A.3    Neal, J.A.4    Xu, Y.5    Et Al., Y.Y.6
  • 132
    • 80053620911 scopus 로고    scopus 로고
    • Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair
    • 10.1101/gad.16872411 21979916 1:CAS:528:DC%2BC3MXhtlyhtr%2FF
    • Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K, et al. Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev. 2011;25(19):2031-40. doi: 10.1101/gad.16872411.
    • (2011) Genes Dev , vol.25 , Issue.19 , pp. 2031-2040
    • Malewicz, M.1    Kadkhodaei, B.2    Kee, N.3    Volakakis, N.4    Hellman, U.5    Viktorsson, K.6
  • 133
    • 1342300521 scopus 로고    scopus 로고
    • The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination
    • 14744996 1:CAS:528:DC%2BD2cXhtVCitLw%3D
    • Poinsignon C, Moshous D, Callebaut I, de Chasseval R, Villey I, de Villartay JP. The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination. J Exp Med. 2004;199(3):315-21.
    • (2004) J Exp Med , vol.199 , Issue.3 , pp. 315-321
    • Poinsignon, C.1    Moshous, D.2    Callebaut, I.3    De Chasseval, R.4    Villey, I.5    De Villartay, J.P.6
  • 134
    • 33646090620 scopus 로고    scopus 로고
    • Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin
    • 10.1016/j.jmb.2006.02.061 16600297 1:CAS:528:DC%2BD28XjvVamsbo%3D
    • Soubeyrand S, Pope L, De Chasseval R, Gosselin D, Dong F, de Villartay JP, et al. Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin. J Mol Biol. 2006;358(5):1200-11. doi: 10.1016/j.jmb.2006.02.061.
    • (2006) J Mol Biol , vol.358 , Issue.5 , pp. 1200-1211
    • Soubeyrand, S.1    Pope, L.2    De Chasseval, R.3    Gosselin, D.4    Dong, F.5    De Villartay, J.P.6
  • 135
    • 33750685856 scopus 로고    scopus 로고
    • DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs
    • 10.1074/jbc.M606023200 16914548 1:CAS:528:DC%2BD28XhtFKgtbvF
    • Niewolik D, Pannicke U, Lu H, Ma Y, Wang LC, Kulesza P, et al. DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs. J Biol Chem. 2006;281(45):33900-9. doi: 10.1074/jbc.M606023200.
    • (2006) J Biol Chem , vol.281 , Issue.45 , pp. 33900-33909
    • Niewolik, D.1    Pannicke, U.2    Lu, H.3    Ma, Y.4    Wang, L.C.5    Kulesza, P.6
  • 136
    • 33748089029 scopus 로고    scopus 로고
    • DNA-PK autophosphorylation facilitates Artemis endonuclease activity
    • 16874298 1:CAS:528:DC%2BD28XovVSqu78%3D
    • Goodarzi AA, Yu Y, Riballo E, Douglas P, Walker SA, Ye R, et al. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J. 2006;25(16):3880-9.
    • (2006) EMBO J , vol.25 , Issue.16 , pp. 3880-3889
    • Goodarzi, A.A.1    Yu, Y.2    Riballo, E.3    Douglas, P.4    Walker, S.A.5    Ye, R.6
  • 137
    • 33645834965 scopus 로고    scopus 로고
    • Radiation-induced delayed cell death in a hypomorphic Artemis cell line
    • 16540517 1:CAS:528:DC%2BD28XjtV2gtb0%3D
    • Evans PM, Woodbine L, Riballo E, Gennery AR, Hubank M, Jeggo PA. Radiation-induced delayed cell death in a hypomorphic Artemis cell line. Hum Mol Genet. 2006;15(8):1303-11.
    • (2006) Hum Mol Genet , vol.15 , Issue.8 , pp. 1303-1311
    • Evans, P.M.1    Woodbine, L.2    Riballo, E.3    Gennery, A.R.4    Hubank, M.5    Jeggo, P.A.6
  • 138
    • 0242291081 scopus 로고    scopus 로고
    • Artemis, a novel guardian of the genome
    • 14628082 1:CAS:528:DC%2BD2cXht1SntL8%3D
    • Dudasova Z, Chovanec M. Artemis, a novel guardian of the genome. Neoplasma. 2003;50(5):311-8.
    • (2003) Neoplasma , vol.50 , Issue.5 , pp. 311-318
    • Dudasova, Z.1    Chovanec, M.2
  • 139
    • 75149180100 scopus 로고    scopus 로고
    • The most frequent DCLRE1C (ARTEMIS) mutations are based on homologous recombination events
    • 10.1002/humu.21168 19953608 1:CAS:528:DC%2BC3cXislans74%3D
    • Pannicke U, Honig M, Schulze I, Rohr J, Heinz GA, Braun S, et al. The most frequent DCLRE1C (ARTEMIS) mutations are based on homologous recombination events. Hum Mutat. 2010;31(2):197-207. doi: 10.1002/humu.21168.
    • (2010) Hum Mutat , vol.31 , Issue.2 , pp. 197-207
    • Pannicke, U.1    Honig, M.2    Schulze, I.3    Rohr, J.4    Heinz, G.A.5    Braun, S.6
  • 141
    • 65549167891 scopus 로고    scopus 로고
    • Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability
    • Huang Y, Giblin W, Kubec M, Westfield G, St Charles J, Chadde L et al. Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability. J Exp Med. 2009;206(4):893-908.
    • (2009) J Exp Med. , vol.206 , Issue.4 , pp. 893-908
    • Huang, Y.1    Giblin, W.2    Kubec, M.3    Westfield, G.4    St Charles, J.5    Chadde, L.6
  • 142
    • 78751685654 scopus 로고    scopus 로고
    • A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis
    • doi: 10.1093/hmg/ddq524
    • Jacobs C, Huang Y, Masud T, Lu W, Westfield G, Giblin W et al. A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet.20(4):806-19. doi: 10.1093/hmg/ddq524.
    • Hum Mol Genet , vol.20 , Issue.4 , pp. 806-819
    • Jacobs, C.1    Huang, Y.2    Masud, T.3    Lu, W.4    Westfield, G.5    Giblin, W.6
  • 143
    • 0032185230 scopus 로고    scopus 로고
    • DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes
    • 9809069 1:CAS:528:DyaK1cXntFSks74%3D
    • Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell. 1998;2(4):477-84.
    • (1998) Mol Cell , vol.2 , Issue.4 , pp. 477-484
    • Grawunder, U.1    Zimmer, D.2    Fugmann, S.3    Schwarz, K.4    Lieber, M.R.5
  • 144
    • 0029024927 scopus 로고
    • Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination
    • 7760816 1:CAS:528:DyaK2MXlslyitbo%3D
    • Wei YF, Robins P, Carter K, Caldecott K, Pappin DJ, Yu GL, et al. Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Mol Cell Biol. 1995;15(6):3206-16.
    • (1995) Mol Cell Biol , vol.15 , Issue.6 , pp. 3206-3216
    • Wei, Y.F.1    Robins, P.2    Carter, K.3    Caldecott, K.4    Pappin, D.J.5    Yu, G.L.6
  • 145
    • 0029585872 scopus 로고
    • The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
    • 8548796 1:CAS:528:DyaK28XhsVOgug%3D%3D
    • Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD, et al. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell. 1995;83(7):1079-89.
    • (1995) Cell , vol.83 , Issue.7 , pp. 1079-1089
    • Li, Z.1    Otevrel, T.2    Gao, Y.3    Cheng, H.L.4    Seed, B.5    Stamato, T.D.6
  • 146
    • 0030743386 scopus 로고    scopus 로고
    • Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
    • 10.1038/41358 9242410 1:CAS:528:DyaK2sXltFKjs74%3D
    • Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M, et al. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature. 1997;388(6641):492-5. doi: 10.1038/41358.
    • (1997) Nature , vol.388 , Issue.6641 , pp. 492-495
    • Grawunder, U.1    Wilm, M.2    Wu, X.3    Kulesza, P.4    Wilson, T.E.5    Mann, M.6
  • 147
    • 50649116450 scopus 로고    scopus 로고
    • Eukaryotic DNA ligases: Structural and functional insights
    • 10.1146/annurev.biochem.77.061306.123941 18518823 1:CAS:528: DC%2BD1cXos1Ohsbw%3D
    • Ellenberger T, Tomkinson AE. Eukaryotic DNA ligases: structural and functional insights. Annu Rev Biochem. 2008;77:313-38. doi: 10.1146/annurev. biochem.77.061306.123941.
    • (2008) Annu Rev Biochem , vol.77 , pp. 313-338
    • Ellenberger, T.1    Tomkinson, A.E.2
  • 148
    • 0032537803 scopus 로고    scopus 로고
    • DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains
    • 9705934 1:CAS:528:DyaK1cXks1Ggt7k%3D
    • Grawunder U, Zimmer D, Leiber MR. DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains. Curr Biol. 1998;8(15):873-6.
    • (1998) Curr Biol , vol.8 , Issue.15 , pp. 873-876
    • Grawunder, U.1    Zimmer, D.2    Leiber, M.R.3
  • 149
    • 66349086714 scopus 로고    scopus 로고
    • Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4
    • 10.1128/MCB.01895-08 19332554 1:CAS:528:DC%2BD1MXmvVCqsbc%3D
    • Wu PY, Frit P, Meesala S, Dauvillier S, Modesti M, Andres SN, et al. Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4. Mol Cell Biol. 2009;29(11):3163-72. doi: 10.1128/MCB.01895-08.
    • (2009) Mol Cell Biol , vol.29 , Issue.11 , pp. 3163-3172
    • Wu, P.Y.1    Frit, P.2    Meesala, S.3    Dauvillier, S.4    Modesti, M.5    Andres, S.N.6
  • 150
    • 79961117807 scopus 로고    scopus 로고
    • BRCT domains: Easy as one, two, three
    • 21734457 1:CAS:528:DC%2BC38Xktlaqug%3D%3D
    • Leung CC, Glover JN. BRCT domains: easy as one, two, three. Cell Cycle. 2011;10(15):2461-70.
    • (2011) Cell Cycle , vol.10 , Issue.15 , pp. 2461-2470
    • Leung, C.C.1    Glover, J.N.2
  • 151
    • 0142147272 scopus 로고    scopus 로고
    • The BRCT domain is a phospho-protein binding domain
    • 10.1126/science.1088753 14576433 1:CAS:528:DC%2BD3sXotlWqt7k%3D
    • Yu X, Chini CC, He M, Mer G, Chen J. The BRCT domain is a phospho-protein binding domain. Science. 2003;302(5645):639-42. doi: 10.1126/science.1088753.
    • (2003) Science , vol.302 , Issue.5645 , pp. 639-642
    • Yu, X.1    Chini, C.C.2    He, M.3    Mer, G.4    Chen, J.5
  • 152
    • 0142240342 scopus 로고    scopus 로고
    • BRCT repeats as phosphopeptide-binding modules involved in protein targeting
    • 10.1126/science.1088877 14576432 1:CAS:528:DC%2BD3sXotlWqt7g%3D
    • Manke IA, Lowery DM, Nguyen A, Yaffe MB. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science. 2003;302(5645):636-9. doi: 10.1126/science.1088877.
    • (2003) Science , vol.302 , Issue.5645 , pp. 636-639
    • Manke, I.A.1    Lowery, D.M.2    Nguyen, A.3    Yaffe, M.B.4
  • 153
    • 0842346435 scopus 로고    scopus 로고
    • Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system
    • 10.1016/j.dnarep.2003.11.005 1:CAS:528:DC%2BD2cXpsVGqsw%3D%3D
    • Lee KJ, Jovanovic M, Udayakumar D, Bladen CL, Dynan WS. Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system. DNA Repair (Amst). 2004;3(3):267-76. doi: 10.1016/j.dnarep.2003.11.005.
    • (2004) DNA Repair (Amst) , vol.3 , Issue.3 , pp. 267-276
    • Lee, K.J.1    Jovanovic, M.2    Udayakumar, D.3    Bladen, C.L.4    Dynan, W.S.5
  • 154
    • 0033119394 scopus 로고    scopus 로고
    • DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity
    • 10.1093/emboj/18.7.2008 10202163 1:CAS:528:DyaK1MXivVyksL8%3D
    • Modesti M, Hesse JE, Gellert M. DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity. EMBO J. 1999;18(7):2008-18. doi: 10.1093/emboj/18.7.2008.
    • (1999) EMBO J , vol.18 , Issue.7 , pp. 2008-2018
    • Modesti, M.1    Hesse, J.E.2    Gellert, M.3
  • 155
    • 0032544413 scopus 로고    scopus 로고
    • Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo
    • 9733770 1:CAS:528:DyaK1cXmtlyqt7Y%3D
    • Grawunder U, Zimmer D, Kulesza P, Lieber MR. Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo. J Biol Chem. 1998;273(38):24708-14.
    • (1998) J Biol Chem , vol.273 , Issue.38 , pp. 24708-24714
    • Grawunder, U.1    Zimmer, D.2    Kulesza, P.3    Lieber, M.R.4
  • 156
    • 0032971199 scopus 로고    scopus 로고
    • Absence of DNA ligase IV protein in XR-1 cells: Evidence for stabilization by XRCC4
    • 10047779 1:CAS:528:DyaK1MXhtFGitbk%3D
    • Bryans M, Valenzano MC, Stamato TD. Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. Mutat Res. 1999;433(1):53-8.
    • (1999) Mutat Res , vol.433 , Issue.1 , pp. 53-58
    • Bryans, M.1    Valenzano, M.C.2    Stamato, T.D.3
  • 157
    • 78549233397 scopus 로고    scopus 로고
    • Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: Implications for nonhomologous end joining
    • 10.1074/jbc.M109.058719 20852255 1:CAS:528:DC%2BC3cXhsVCrt7zF
    • Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, et al. Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining. J Biol Chem. 2010;285(48):37619-29. doi: 10.1074/jbc.M109.058719.
    • (2010) J Biol Chem , vol.285 , Issue.48 , pp. 37619-37629
    • Mani, R.S.1    Yu, Y.2    Fang, S.3    Lu, M.4    Fanta, M.5    Zolner, A.E.6
  • 158
    • 6344238643 scopus 로고    scopus 로고
    • Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
    • 10.1038/sj.emboj.7600375 15385968 1:CAS:528:DC%2BD2cXnvFCgtrs%3D
    • Koch CA, Agyei R, Galicia S, Metalnikov P, O'Donnell P, Starostine A, et al. Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J. 2004;23(19):3874-85. doi: 10.1038/sj.emboj.7600375.
    • (2004) EMBO J , vol.23 , Issue.19 , pp. 3874-3885
    • Koch, C.A.1    Agyei, R.2    Galicia, S.3    Metalnikov, P.4    O'Donnell, P.5    Starostine, A.6
  • 159
    • 0037013895 scopus 로고    scopus 로고
    • Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining
    • 10.1093/emboj/21.11.2827 12032095 1:CAS:528:DC%2BD38XkvV2isLY%3D
    • Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC. Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J. 2002;21(11):2827-32. doi: 10.1093/emboj/21.11.2827.
    • (2002) EMBO J , vol.21 , Issue.11 , pp. 2827-2832
    • Chappell, C.1    Hanakahi, L.A.2    Karimi-Busheri, F.3    Weinfeld, M.4    West, S.C.5
  • 160
    • 0032585526 scopus 로고    scopus 로고
    • Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
    • 9889105 1:CAS:528:DyaK1MXhvFCguw%3D%3D
    • Barnes DE, Stamp G, Rosewell I, Denzel A, Lindahl T. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr Biol. 1998;8(25):1395-8.
    • (1998) Curr Biol , vol.8 , Issue.25 , pp. 1395-1398
    • Barnes, D.E.1    Stamp, G.2    Rosewell, I.3    Denzel, A.4    Lindahl, T.5
  • 161
    • 0032417640 scopus 로고    scopus 로고
    • A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
    • 9875844 1:CAS:528:DyaK1MXjslyltg%3D%3D
    • Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 1998;95(7):891-902.
    • (1998) Cell , vol.95 , Issue.7 , pp. 891-902
    • Gao, Y.1    Sun, Y.2    Frank, K.M.3    Dikkes, P.4    Fujiwara, Y.5    Seidl, K.J.6
  • 162
    • 0032511976 scopus 로고    scopus 로고
    • Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
    • 10.1038/24172 9823897 1:CAS:528:DyaK1cXnslart7s%3D
    • Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL, et al. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 1998;396(6707):173-7. doi: 10.1038/24172.
    • (1998) Nature , vol.396 , Issue.6707 , pp. 173-177
    • Frank, K.M.1    Sekiguchi, J.M.2    Seidl, K.J.3    Swat, W.4    Rathbun, G.A.5    Cheng, H.L.6
  • 163
    • 0033634973 scopus 로고    scopus 로고
    • DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
    • S1097-2765(00)80264-6 10911993 1:CAS:528:DC%2BD3cXks1Kktr4%3D
    • Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, et al. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell. 2000;5(6):993-1002. doi: S1097-2765(00)80264-6.
    • (2000) Mol Cell , vol.5 , Issue.6 , pp. 993-1002
    • Frank, K.M.1    Sharpless, N.E.2    Gao, Y.3    Sekiguchi, J.M.4    Ferguson, D.O.5    Zhu, C.6
  • 164
    • 79960066452 scopus 로고    scopus 로고
    • Requirement for DNA ligase IV during embryonic neuronal development
    • doi: 10.1523/JNEUROSCI.1324-11.2011
    • Gatz SA, Ju L, Gruber R, Hoffmann E, Carr AM, Wang ZQ et al. Requirement for DNA ligase IV during embryonic neuronal development. J Neurosci.31(27): 10088-100. doi: 10.1523/JNEUROSCI.1324-11.2011.
    • J Neurosci , vol.31 , Issue.27 , pp. 10088-10100
    • Gatz, S.A.1    Ju, L.2    Gruber, R.3    Hoffmann, E.4    Carr, A.M.5    Wang, Z.Q.6
  • 165
    • 0030870904 scopus 로고    scopus 로고
    • A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype
    • 9377575 1:CAS:528:DyaK2sXmslKqtLk%3D
    • Badie C, Goodhardt M, Waugh A, Doyen N, Foray N, Calsou P, et al. A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype. Cancer Res. 1997;57(20):4600-7.
    • (1997) Cancer Res , vol.57 , Issue.20 , pp. 4600-4607
    • Badie, C.1    Goodhardt, M.2    Waugh, A.3    Doyen, N.4    Foray, N.5    Calsou, P.6
  • 167
    • 18244362081 scopus 로고    scopus 로고
    • DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency
    • S1097-2765(01)00408-7 11779494
    • O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell. 2001;8(6):1175-85. doi: S1097-2765(01)00408-7.
    • (2001) Mol Cell , vol.8 , Issue.6 , pp. 1175-1185
    • O'Driscoll, M.1    Cerosaletti, K.M.2    Girard, P.M.3    Dai, Y.4    Stumm, M.5    Kysela, B.6
  • 168
    • 0038137214 scopus 로고    scopus 로고
    • Impact of DNA ligase IV on the fidelity of end joining in human cells
    • 12682366 1:CAS:528:DC%2BD3sXivFCisLw%3D
    • Smith J, Riballo E, Kysela B, Baldeyron C, Manolis K, Masson C, et al. Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res. 2003;31(8):2157-67.
    • (2003) Nucleic Acids Res , vol.31 , Issue.8 , pp. 2157-2167
    • Smith, J.1    Riballo, E.2    Kysela, B.3    Baldeyron, C.4    Manolis, K.5    Masson, C.6
  • 169
    • 49349083288 scopus 로고    scopus 로고
    • Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination
    • 18775323 1:CAS:528:DC%2BD1cXhtFant7rF
    • Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, et al. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell. 2008;31(5):631-40.
    • (2008) Mol Cell , vol.31 , Issue.5 , pp. 631-640
    • Li, G.1    Alt, F.W.2    Cheng, H.L.3    Brush, J.W.4    Goff, P.H.5    Murphy, M.M.6
  • 170
    • 78651386197 scopus 로고    scopus 로고
    • ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks
    • 10.1038/nature09604 21160472 1:CAS:528:DC%2BC3cXhsFKmu7jI
    • Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, et al. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011;469(7329):250-4. doi: 10.1038/nature09604.
    • (2011) Nature , vol.469 , Issue.7329 , pp. 250-254
    • Zha, S.1    Guo, C.2    Boboila, C.3    Oksenych, V.4    Cheng, H.L.5    Zhang, Y.6
  • 171
    • 37349113779 scopus 로고    scopus 로고
    • Crystal structure of human XLF: A twist in nonhomologous DNA end-joining
    • 18158905 1:CAS:528:DC%2BD1cXksFyhsg%3D%3D
    • Andres SN, Modesti M, Tsai CJ, Chu G, Junop MS. Crystal structure of human XLF: a twist in nonhomologous DNA end-joining. Mol Cell. 2007;28(6):1093-101.
    • (2007) Mol Cell , vol.28 , Issue.6 , pp. 1093-1101
    • Andres, S.N.1    Modesti, M.2    Tsai, C.J.3    Chu, G.4    Junop, M.S.5
  • 172
    • 38049034405 scopus 로고    scopus 로고
    • Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ
    • 18046455 1:CAS:528:DC%2BD1cXksVKjtA%3D%3D
    • Li Y, Chirgadze DY, Bolanos-Garcia VM, Sibanda BL, Davies OR, Ahnesorg P, et al. Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ. EMBO J. 2008;27(1):290-300.
    • (2008) EMBO J , vol.27 , Issue.1 , pp. 290-300
    • Li, Y.1    Chirgadze, D.Y.2    Bolanos-Garcia, V.M.3    Sibanda, B.L.4    Davies, O.R.5    Ahnesorg, P.6
  • 173
    • 50249154761 scopus 로고    scopus 로고
    • Role and regulation of human XRCC4-like factor/cernunnos
    • 18335491 1:CAS:528:DC%2BD1cXpvVOjtrY%3D
    • Dahm K. Role and regulation of human XRCC4-like factor/cernunnos. J Cell Biochem. 2008;104(5):1534-40.
    • (2008) J Cell Biochem , vol.104 , Issue.5 , pp. 1534-1540
    • Dahm, K.1
  • 174
    • 33744938713 scopus 로고    scopus 로고
    • Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1
    • 16571728 1:CAS:528:DC%2BD28XksFejurY%3D
    • Callebaut I, Malivert L, Fischer A, Mornon JP, Revy P, de Villartay JP. Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1. J Biol Chem. 2006;281(20):13857-60.
    • (2006) J Biol Chem , vol.281 , Issue.20 , pp. 13857-13860
    • Callebaut, I.1    Malivert, L.2    Fischer, A.3    Mornon, J.P.4    Revy, P.5    De Villartay, J.P.6
  • 175
    • 33846002032 scopus 로고    scopus 로고
    • Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/cernunnos
    • 17038309 1:CAS:528:DC%2BD28Xht1KitrnP
    • Hentges P, Ahnesorg P, Pitcher RS, Bruce CK, Kysela B, Green AJ, et al. Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/cernunnos. J Biol Chem. 2006;281(49):37517-26.
    • (2006) J Biol Chem , vol.281 , Issue.49 , pp. 37517-37526
    • Hentges, P.1    Ahnesorg, P.2    Pitcher, R.S.3    Bruce, C.K.4    Kysela, B.5    Green, A.J.6
  • 176
    • 36148957874 scopus 로고    scopus 로고
    • Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell
    • 17720816 1:CAS:528:DC%2BD2sXht1WlsrfE
    • Wu PY, Frit P, Malivert L, Revy P, Biard D, Salles B, et al. Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell. J Biol Chem. 2007;282(44):31937-43.
    • (2007) J Biol Chem , vol.282 , Issue.44 , pp. 31937-31943
    • Wu, P.Y.1    Frit, P.2    Malivert, L.3    Revy, P.4    Biard, D.5    Salles, B.6
  • 177
    • 34249685474 scopus 로고    scopus 로고
    • Length-dependent binding of human XLF to DNA and stimulation of XRCC4: DNA ligase IV activity
    • Lu H, Pannicke U, Schwarz K, Lieber MR. Length-dependent binding of human XLF to DNA and stimulation of XRCC4: DNA ligase IV activity. J Biol Chem. 2007.
    • (2007) J Biol Chem
    • Lu, H.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 178
    • 34249938518 scopus 로고    scopus 로고
    • Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
    • 17470781 1:CAS:528:DC%2BD2sXmtFCit7k%3D
    • Tsai CJ, Kim SA, Chu G. Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. Proc Natl Acad Sci USA. 2007;104(19):7851-6.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.19 , pp. 7851-7856
    • Tsai, C.J.1    Kim, S.A.2    Chu, G.3
  • 179
    • 34848841930 scopus 로고    scopus 로고
    • Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: Influence of terminal DNA sequence
    • 10.1093/nar/gkm579 17717001 1:CAS:528:DC%2BD2sXhtFWiu7vF
    • Gu J, Lu H, Tsai AG, Schwarz K, Lieber MR. Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence. Nucleic Acids Res. 2007;35(17):5755-62. doi: 10.1093/nar/gkm579.
    • (2007) Nucleic Acids Res , vol.35 , Issue.17 , pp. 5755-5762
    • Gu, J.1    Lu, H.2    Tsai, A.G.3    Schwarz, K.4    Lieber, M.R.5
  • 180
    • 59649122967 scopus 로고    scopus 로고
    • XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation
    • 19056826 1:CAS:528:DC%2BD1MXhtlGksLw%3D
    • Riballo E, Woodbine L, Stiff T, Walker SA, Goodarzi AA, Jeggo PA. XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Res. 2009;37(2):482-92.
    • (2009) Nucleic Acids Res , vol.37 , Issue.2 , pp. 482-492
    • Riballo, E.1    Woodbine, L.2    Stiff, T.3    Walker, S.A.4    Goodarzi, A.A.5    Jeggo, P.A.6
  • 181
    • 80052738767 scopus 로고    scopus 로고
    • XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair
    • 10.1074/jbc.M111.272641 21775435 1:CAS:528:DC%2BC3MXhtFCju7bO
    • Hammel M, Rey M, Yu Y, Mani RS, Classen S, Liu M, et al. XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair. J Biol Chem. 2011;286(37):32638-50. doi: 10.1074/jbc.M111.272641.
    • (2011) J Biol Chem , vol.286 , Issue.37 , pp. 32638-32650
    • Hammel, M.1    Rey, M.2    Yu, Y.3    Mani, R.S.4    Classen, S.5    Liu, M.6
  • 182
    • 78149459696 scopus 로고    scopus 로고
    • XLF regulates filament architecture of the XRCC4.ligase IV complex
    • 10.1016/j.str.2010.09.009 21070942 1:CAS:528:DC%2BC3cXhsValtbvJ
    • Hammel M, Yu Y, Fang S, Lees-Miller SP, Tainer JA. XLF regulates filament architecture of the XRCC4.ligase IV complex. Structure. 2010;18(11):1431-42. doi: 10.1016/j.str.2010.09.009.
    • (2010) Structure , vol.18 , Issue.11 , pp. 1431-1442
    • Hammel, M.1    Yu, Y.2    Fang, S.3    Lees-Miller, S.P.4    Tainer, J.A.5
  • 183
    • 79961219743 scopus 로고    scopus 로고
    • Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining
    • 10.1073/pnas.1100758108 21768349 1:CAS:528:DC%2BC3MXhtVenu7jE
    • Ropars V, Drevet P, Legrand P, Baconnais S, Amram J, Faure G, et al. Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining. Proc Nat Acad Sci USA. 2011;108(31):12663-8. doi: 10.1073/pnas.1100758108.
    • (2011) Proc Nat Acad Sci USA , vol.108 , Issue.31 , pp. 12663-12668
    • Ropars, V.1    Drevet, P.2    Legrand, P.3    Baconnais, S.4    Amram, J.5    Faure, G.6
  • 184
    • 79952573454 scopus 로고    scopus 로고
    • Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF
    • 10.1016/j.febslet.2011.02.020 21349273 1:CAS:528:DC%2BC3MXjtFOgtb4%3D
    • Yano K, Morotomi-Yano K, Lee KJ, Chen DJ. Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF. FEBS Lett. 2011;585(6):841-6. doi: 10.1016/j.febslet.2011.02.020.
    • (2011) FEBS Lett , vol.585 , Issue.6 , pp. 841-846
    • Yano, K.1    Morotomi-Yano, K.2    Lee, K.J.3    Chen, D.J.4
  • 185
    • 84863798398 scopus 로고    scopus 로고
    • Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs
    • doi: 10.1084/jem.2011143
    • Malu S, De Ioannes P, Kozlov M, Greene M, Francis D, Hanna M, et al. Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs. J Exp Med. 2012. doi: 10.1084/jem.20111437
    • (2012) J Exp Med
    • Malu, S.1    De Ioannes, P.2    Kozlov, M.3    Greene, M.4    Francis, D.5    Hanna, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.