Cernunnos interacts with the XRCC4·DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1

Journal of Biological Chemistry

Volumn 281, Issue 20, 2006, Pages 13857-13860

  Callebaut, Isabelle ^a   Malivert, Laurent ^b   Fischer, Alain ^b,c   Mornon, Jean Paul ^a   Revy, Patrick ^b,c   De Villartay, Jean Pierre ^b,c  

^a UNIVERSITÉ PIERRE ET MARIE CURIE   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYMES; IMMUNOLOGY; MOLECULAR BIOLOGY; YEAST;

IMMUNODEFICIENCY; MICROCEPHALY; NONHOMOLOGOUS END JOINING (NHEJ);

GENETIC ENGINEERING;

NONHOMOLOGOUS END JOINING FACTOR NEJ1; NUCLEIC ACID BINDING PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE IV; PROTEIN CERNUNNOS; PROTEIN XRCC4; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DISEASE SEVERITY; DNA STRAND BREAKAGE; ENZYME DEFICIENCY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MICROCEPHALY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; YEAST;

AMINO ACID SEQUENCE; CELL LINE; DNA LIGASES; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 33744938713     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C500473200     Document Type: Article

References (29)

1. Revy, P., Buck, D., Le Deist, F., and de Villartay, J. P. (2005) Adv. Immunol 87, 237-295
2. Sancar, A., Lindsey-Boltz, L. A., Unsal-Kacmaz, K., and Linn, S. (2004) Annu. Rev. Biochem. 73, 39-85
3. Weterings, E., and van Gent, D. C. (2004) DNA Repair (Amst.) 3, 1425-1435
4. Valencia, M., Bentele, M., Vaze, M. B., Herrmann, G., Kraus, E., Lee, S. E., Schar, P., and Haber, J. E. (2001) Nature 414, 666-669
5. Frank-Vaillant, M., and Marcand, S. (2001) Genes Dev. 15, 3005-3012
6. Kegel, A., Sjostrand, J. O., and Astrom, S. U. (2001) Curr. Biol. 11, 1611-1617
7. Buck, D., Malivert, L., de Chasseval, R., Barraud, A., Fondanèche, M. C., Sanal, O., Plebani, A., Stéphan, J. L., Hufnagel, M., Le Deist, F., Fischer, A., Durandy, A., de Villartay, J. P., and Revy, P. (2006) Cell 124, 287-299
8. O'Driscoll, M., Cerosaletti, K. M., Girard, P. M., Dai, Y., Stumm, M., Kysela, B., Hirsch, B., Gennery, A., Palmer, S. E., Seidel, J., Gatti, R. A., Varon, R., Oettinger, M. A., Neitzel, H., Jeggo, P. A., and Concannon, P. (2001) Mol. Cell 8, 1175-1185
9. Ben-Omran, T. I., Cerosaletti, K., Concannon, P., Weitzman, S., and Nezarati, M. M. (2005) Am. J. Med. Genet. A 137, 283-287
10. Buck, D., Moshous, D., de Chasseval, R., Ma, Y., Le Deist, F., Cavazzana-Calvo, M., Fischer, A., Casanova, J. L., Lieber, M. R., and De Villartay, J. P. (2006) Eur. J. Immunol. 36, 224-235
11. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Nucleic Acids Res. 25, 3389-3402
12. Gaboriaud, C., Bissery, V., Benchetrit, T., and Mornon, J. P. (1987) FEBS Lett. 224, 149-155
13. Callebaut, I., Labesse, G., Durand, P., Poupon, A., Canard, L., Chomilier, J., Henrissat, B., and Mornon, J. P. (1997) Cell Mol. Life Sci. 53, 621-645
14. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
15. Ahnesorg, P., Smith, P., and Jackson, S. P. (2006) Cell 124, 301-313
16. Junop, M. S., Modesti, M., Guarne, A., Ghirlando, R., Gellert, M., and Yang, W. (2000) EMBO J. 19, 5962-5970
17. Lee, K. J., Huang, J., Takeda, Y., and Dynan, W. S. (2000) J. Biol. Chem. 275, 34787-34796
18. Modesti, M., Junop, M. S., Ghirlando, R., van de Rakt, M., Gellert, M., Yang, W., and Kanaar, R. (2003) J. Mol. Biol. 334, 215-228
19. Modesti, M., Hesse, J. E., and Gellert, M. (1999) EMBO J. 18, 2008-2018
20. Sibanda, B. L., Critchlow, S. E., Begun, J., Pei, X. Y., Jackson, S. P., Blundell, T. L., and Pellegrini, L. (2001) Nat. Struct. Biol. 8, 1015-1019
21. Gao, Y., Sun, Y., Frank, K. M., Dikkes, P., Fujiwara, Y., Seidl, K. J., Sekiguchi, J. M., Rathbun, G. A., Swat, W., Wang, J., Bronson, R. T., Malynn, B. A., Bryans, M., Zhu, C., Chaudhuri, J., Davidson, L., Ferrini, R., Stamato, T., Orkin, S. H., Greenberg, M. E., and Alt, F. W. (1998) Cell 95, 891-902
22. Ooi, S. L., Shoemaker, D. D., and Boeke, J. D. (2001) Science 294, 2552-2556
23. Dai, Y., Kysela, B., Hanakahi, L. A., Manolis, K., Riballo, E., Stumm, M., Harville, T. O., West, S. C., Oettinger, M. A., and Jeggo, P. A. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2462-2467
24. Noordzij, J. G., Verkaik, N. S., Hartwig, N. G., de Groot, R., van Gent, D. C., and van Dongen, J. J. (2000) Blood 96, 203-209
25. Corneo, B., Moshous, D., Gungor, T., Wulffrat, N., Philippet, P., Le Deist, F., Fischer, A., and de Villartay, J. P. (2001) Blood 97, 2772-2776
26. George, R. A., Lin, K., and Heringa, J. (2005) Nucleic Acids Res. 33, W160-W163
27. Astrom, S. U., Okamura, S. M., and Rine, J. (1999) Nature 397, 310
28. Lee, S. E., Paques, F., Sylvan, J., and Haber, J. E. (1999) Curr. Biol. 9, 767-770
29. Clikeman, J. A., Khalsa, G. J., Barton, S. L., and Nickoloff, J. A. (2001) Genetics 157, 579-589