메뉴 건너뛰기




Volumn 86, Issue 3, 1996, Pages 379-389

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; DNA BINDING; DNA PROTEIN COMPLEX; DNA TRANSPOSITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN PROCESSING; SCID MOUSE; T LYMPHOCYTE;

EID: 0030576534     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80111-7     Document Type: Article
Times cited : (397)

References (79)
  • 1
    • 0023551350 scopus 로고
    • Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter
    • Adra, C.N., Boer, P.H., and McBurney, M.W. (1987). Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter. Gene 60, 65-74.
    • (1987) Gene , vol.60 , pp. 65-74
    • Adra, C.N.1    Boer, P.H.2    McBurney, M.W.3
  • 2
    • 0029871975 scopus 로고    scopus 로고
    • The interwoven architecture of the Mu transposase couples DNA synapsis to catalysis
    • Aldaz, H., Schuster, E., and Baker, T.A. (1996). The interwoven architecture of the Mu transposase couples DNA synapsis to catalysis. Cell 85, 257-269.
    • (1996) Cell , vol.85 , pp. 257-269
    • Aldaz, H.1    Schuster, E.2    Baker, T.A.3
  • 3
    • 0026458080 scopus 로고
    • DNA-promoted assembly of the active tetramer of the Mu transposase
    • Baker, T.A., and Mizuuchi, K. (1992). DNA-promoted assembly of the active tetramer of the Mu transposase. Genes Dev. 6, 2221-2232.
    • (1992) Genes Dev. , vol.6 , pp. 2221-2232
    • Baker, T.A.1    Mizuuchi, K.2
  • 5
    • 0029886929 scopus 로고    scopus 로고
    • Mechanism of V(D)J recombination
    • Bogue, M., and Roth, D.B. (1996). Mechanism of V(D)J recombination. Curr. Opin. Immunol. 8, 175-180.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 175-180
    • Bogue, M.1    Roth, D.B.2
  • 6
    • 0029881698 scopus 로고    scopus 로고
    • p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes
    • Bogue, M., Zhu, C., Aguilar-Cordova, E., Donehower, L.A., and Roth, D.B. (1996). p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes. Genes Dev. 10, 553-565.
    • (1996) Genes Dev. , vol.10 , pp. 553-565
    • Bogue, M.1    Zhu, C.2    Aguilar-Cordova, E.3    Donehower, L.A.4    Roth, D.B.5
  • 7
    • 0020663062 scopus 로고
    • A severe combined immunodeficiency mutation in the mouse
    • Bosma, G.C., Custer, R.P., and Bosma, M.J. (1983). A severe combined immunodeficiency mutation in the mouse. Nature 301, 527-530.
    • (1983) Nature , vol.301 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 9
    • 0026018228 scopus 로고
    • T-lymphocyte development in scid mice is arrested shortly after the initiation of T cell receptor δ gene recombination
    • Carroll, A.M. and Bosma, M.J. (1991). T-lymphocyte development in scid mice is arrested shortly after the initiation of T cell receptor δ gene recombination. Genes Dev. 5, 1357-1366.
    • (1991) Genes Dev. , vol.5 , pp. 1357-1366
    • Carroll, A.M.1    Bosma, M.J.2
  • 10
    • 0025201179 scopus 로고
    • A DNA-activated protein kinase from HeLa cell nuclei
    • Carter, T., Vancurova, I., Sun, I., Lou, W., and DeLeon, S. (1990). A DNA-activated protein kinase from HeLa cell nuclei. Mol. Cell. Biol. 10, 6460-6471.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 6460-6471
    • Carter, T.1    Vancurova, I.2    Sun, I.3    Lou, W.4    DeLeon, S.5
  • 11
    • 0030041564 scopus 로고    scopus 로고
    • Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair
    • Chen, F., Peterson, S.R., Story, M.D., and Chen, D.J. (1996). Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair. Mutat. Res. 362, 9-19.
    • (1996) Mutat. Res. , vol.362 , pp. 9-19
    • Chen, F.1    Peterson, S.R.2    Story, M.D.3    Chen, D.J.4
  • 12
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocynate-phenol-chloroform extraction
    • Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocynate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 13
    • 0028151601 scopus 로고
    • Rescue of T cell-specific V(D)J recombination in SCID mice by DNA damaging agents
    • Danska, J.S., Pflumio, F., Williams, C.J., Huner, O., Dick, J.E., and Guidos, C.J. (1994). Rescue of T cell-specific V(D)J recombination in SCID mice by DNA damaging agents. Science 266, 450-455.
    • (1994) Science , vol.266 , pp. 450-455
    • Danska, J.S.1    Pflumio, F.2    Williams, C.J.3    Huner, O.4    Dick, J.E.5    Guidos, C.J.6
  • 14
    • 0029864993 scopus 로고    scopus 로고
    • Initiation of V(D)J recombination in vitro: The 12/23 rule
    • Eastman, Q.M., Leu, T.M.J., and Schatz, D.G. (1996). Initiation of V(D)J recombination in vitro: the 12/23 rule. Nature 380, 85-88.
    • (1996) Nature , vol.380 , pp. 85-88
    • Eastman, Q.M.1    Leu, T.M.J.2    Schatz, D.G.3
  • 15
    • 0029928176 scopus 로고    scopus 로고
    • Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants
    • Errami, A., Smider, V., Rathmell, W.K., He, D.M., Hendrickson, E.A., Zdzienicka, M.Z., and Chu, G. (1996). Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. Mol. Cell. Biol. 16, 1519-1526.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1519-1526
    • Errami, A.1    Smider, V.2    Rathmell, W.K.3    He, D.M.4    Hendrickson, E.A.5    Zdzienicka, M.Z.6    Chu, G.7
  • 16
    • 0028897304 scopus 로고
    • DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair
    • Finnie, N.J., Gottlieb, T.M., Blunt, T., Jeggo, P.A., and Jackson, S.P. (1995). DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 92, 320-324.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 320-324
    • Finnie, N.J.1    Gottlieb, T.M.2    Blunt, T.3    Jeggo, P.A.4    Jackson, S.P.5
  • 17
    • 0028363754 scopus 로고
    • Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant
    • Getts, R.C., and Stamato, T.D. (1994). Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. J. Biol. Chem. 269, 15981-15984.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15981-15984
    • Getts, R.C.1    Stamato, T.D.2
  • 18
    • 0026454716 scopus 로고
    • Regulation by proteolysis: Energy-dependent proteases and their targets
    • Gottesman, S., and Maurizi, M.R. (1992). Regulation by proteolysis: energy-dependent proteases and their targets. Microbiol. Rev. 56, 592-621.
    • (1992) Microbiol. Rev. , vol.56 , pp. 592-621
    • Gottesman, S.1    Maurizi, M.R.2
  • 19
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • Gottlieb, T.M., and Jackson, S.P. (1993). The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142.
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 21
    • 0025754262 scopus 로고
    • Strand breaks without DNA rearrangement in V(D)J recombination
    • Hendrickson, E.A., Liu, V.F., and Weaver, D.T. (1991). Strand breaks without DNA rearrangement in V(D)J recombination. Mol. Cell. Biol. 11, 3155-3162.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3155-3162
    • Hendrickson, E.A.1    Liu, V.F.2    Weaver, D.T.3
  • 22
    • 0028791446 scopus 로고
    • DNA double-strand break repair and V(D)J recombination: Involvement of DNA-PK
    • Jackson, S.P., and Jeggo, P.A. (1995). DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem. Sci. 20, 412-415.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 412-415
    • Jackson, S.P.1    Jeggo, P.A.2
  • 23
    • 0026331952 scopus 로고
    • T cell receptor γ and δ gene rearrangements in scid thymocytes: Similarity to those in normal thymocytes
    • Kienker, L.J., Kuziel, W.A., Garni-Wagner, B.A., Kumar, V., and Tucker, P.W. (1991). T cell receptor γ and δ gene rearrangements in scid thymocytes: similarity to those in normal thymocytes. J. Immunol. 147, 4351-4359.
    • (1991) J. Immunol. , vol.147 , pp. 4351-4359
    • Kienker, L.J.1    Kuziel, W.A.2    Garni-Wagner, B.A.3    Kumar, V.4    Tucker, P.W.5
  • 24
    • 0029009013 scopus 로고
    • A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen
    • Kim, D., Ouyang, H., Yang, S.-H., Nussenzweig, A., Burgman, P., and Li, G.C. (1995). A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen. J. Biol. Chem. 270, 15277-15284.
    • (1995) J. Biol. Chem. , vol.270 , pp. 15277-15284
    • Kim, D.1    Ouyang, H.2    Yang, S.-H.3    Nussenzweig, A.4    Burgman, P.5    Li, G.C.6
  • 26
    • 0028239578 scopus 로고
    • Participation of the bacteriophage Mu A protein and host factors in the initiation of Mu DNA synthesis in vitro
    • Kruklitis, R., and Nakai, H. (1994). Participation of the bacteriophage Mu A protein and host factors in the initiation of Mu DNA synthesis in vitro. J. Biol. Chem. 269, 16469-16477.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16469-16477
    • Kruklitis, R.1    Nakai, H.2
  • 27
    • 0030020897 scopus 로고    scopus 로고
    • ClpX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis
    • Kruklitis, R., Welty, D.J., and Nakai, H. (1996). ClpX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis. EMBO J. 15, 935-944.
    • (1996) EMBO J. , vol.15 , pp. 935-944
    • Kruklitis, R.1    Welty, D.J.2    Nakai, H.3
  • 29
    • 0025224761 scopus 로고
    • Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
    • Lees-Miller, S.P., Chen, Y.-R., and Anderson, C.W. (1990). Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol. Cell. Biol. 10, 6472-6481.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 6472-6481
    • Lees-Miller, S.P.1    Chen, Y.-R.2    Anderson, C.W.3
  • 30
    • 0028863006 scopus 로고
    • Disassembly of the Mu transposase tetramer by the ClpX chaperone
    • Levchenko, I., Luo, L., and Baker, T.A. (1995). Disassembly of the Mu transposase tetramer by the ClpX chaperone. Genes Dev. 9, 2399-2408.
    • (1995) Genes Dev. , vol.9 , pp. 2399-2408
    • Levchenko, I.1    Luo, L.2    Baker, T.A.3
  • 31
    • 0027983024 scopus 로고
    • P nucleotide insertions and the resolution of hairpin DNA structures in mammalian cells
    • Lewis, S.M. (1994a). P nucleotide insertions and the resolution of hairpin DNA structures in mammalian cells. Proc. Natl. Acad. Sci. USA 91, 1332-1336.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1332-1336
    • Lewis, S.M.1
  • 32
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • Lewis, S.M. (1994b). The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56, 27-150.
    • (1994) Adv. Immunol. , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 33
    • 0026052160 scopus 로고
    • Cutting and closing without recombination in V(D)J joining
    • Lewis, S.M., and Hesse, J.E. (1991). Cutting and closing without recombination in V(D)J joining. EMBO J. 10, 3631-3639.
    • (1991) EMBO J. , vol.10 , pp. 3631-3639
    • Lewis, S.M.1    Hesse, J.E.2
  • 34
    • 0024255703 scopus 로고
    • Novel strand exchanges in V(D)J recombination
    • Lewis, S.M., Hesse, J.E., Mizuuchi, K., and Gellert, M. (1988). Novel strand exchanges in V(D)J recombination. Cell 55, 1099-1107.
    • (1988) Cell , vol.55 , pp. 1099-1107
    • Lewis, S.M.1    Hesse, J.E.2    Mizuuchi, K.3    Gellert, M.4
  • 35
    • 0023801238 scopus 로고
    • The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
    • Lieber, M.R., Hesse, J.E., Lewis, S., Bosma, G.C., Rosenberg, N., Mizuuchi, K., Bosma, M.J., and Gellert, M. (1988). The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell 55, 7-16.
    • (1988) Cell , vol.55 , pp. 7-16
    • Lieber, M.R.1    Hesse, J.E.2    Lewis, S.3    Bosma, G.C.4    Rosenberg, N.5    Mizuuchi, K.6    Bosma, M.J.7    Gellert, M.8
  • 37
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to nonselectable genes
    • Mansour, S.L., Thomas, K.R., and Capecchi, M.R. (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to nonselectable genes. Nature 336, 348-352.
    • (1988) Nature , vol.336 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 38
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane, J.F., van Gent, D.C., Ramsden, D.A., Romeo, C., Cuomo, C.A., Gellert, M., and Oettinger, M.A. (1995). Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387-395.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    Van Gent, D.C.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6    Oettinger, M.A.7
  • 39
    • 0025188130 scopus 로고
    • The Wnt-1 (int-1) proto-oncogene is required for development of a large region of mouse brain
    • McMahon, A.P., and Bradley, A. (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of mouse brain. Cell 62, 1073-1085.
    • (1990) Cell , vol.62 , pp. 1073-1085
    • McMahon, A.P.1    Bradley, A.2
  • 40
    • 0028359550 scopus 로고
    • A new component of bacteriophage Mu replicative transposition machinery: The Escherichia coli ClpX protein
    • Mhammedi-Alaoui, A., Pato, M., Gama, M.-J., and Toussaint, A. (1994). A new component of bacteriophage Mu replicative transposition machinery: the Escherichia coli ClpX protein. Mol. Microbiol. 11, 1109-1116.
    • (1994) Mol. Microbiol. , vol.11 , pp. 1109-1116
    • Mhammedi-Alaoui, A.1    Pato, M.2    Gama, M.-J.3    Toussaint, A.4
  • 41
    • 0029334490 scopus 로고
    • A simple assay for puromycin N-acetyltransferase: Selectable marker and reporter
    • Mielke, C., Tummler, M., and Bode, J. (1995). A simple assay for puromycin N-acetyltransferase: selectable marker and reporter. Trends Genet. 11, 258-259.
    • (1995) Trends Genet. , vol.11 , pp. 258-259
    • Mielke, C.1    Tummler, M.2    Bode, J.3
  • 42
    • 0022827675 scopus 로고
    • Mechanism of interaction between Ku protein and DNA
    • Mimori, T., and Hardin, J.A. (1986). Mechanism of interaction between Ku protein and DNA. J. Biol. Chem. 261, 10375-10379.
    • (1986) J. Biol. Chem. , vol.261 , pp. 10375-10379
    • Mimori, T.1    Hardin, J.A.2
  • 44
    • 0028286463 scopus 로고
    • DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps
    • Morozov, V.E., Falzon, M., Anderson, C.W., and Kuff, E.L. (1994). DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. Biol. Chem. 269, 16684-16688.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16684-16688
    • Morozov, V.E.1    Falzon, M.2    Anderson, C.W.3    Kuff, E.L.4
  • 46
    • 0028147898 scopus 로고
    • Production and characterization of recombinant human Ku antigen
    • Ono, M., Tucker, P.W., and Capra, J.D. (1994). Production and characterization of recombinant human Ku antigen. Nucl. Acids Res. 22, 3918-3924.
    • (1994) Nucl. Acids Res. , vol.22 , pp. 3918-3924
    • Ono, M.1    Tucker, P.W.2    Capra, J.D.3
  • 47
    • 0026045833 scopus 로고
    • Analysis of the mechanism of interaction of simian Ku protein with DNA
    • Paillard, S., and Strauss, F. (1991). Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucl. Acids Res. 19, 5619-5624.
    • (1991) Nucl. Acids Res. , vol.19 , pp. 5619-5624
    • Paillard, S.1    Strauss, F.2
  • 49
    • 0027245559 scopus 로고
    • V(D)J recombination in mammalian mutants defective in DNA double-strand break repair
    • Pergola, F., Zdzienicka, M.Z., and Lieber, M.R. (1993). V(D)J recombination in mammalian mutants defective in DNA double-strand break repair. Mol. Cell. Biol. 13, 3464-3471.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3464-3471
    • Pergola, F.1    Zdzienicka, M.Z.2    Lieber, M.R.3
  • 50
    • 0028902932 scopus 로고
    • Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand break repair mutant mammalian cells
    • Peterson, S.R., Kurimasa, A., Oshimura, M., Dynan, W.S., Bradbury, E.M., and Chen, D.J. (1995). Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand break repair mutant mammalian cells. Proc. Natl. Acad. Sci. USA 92, 3171-3174.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3171-3174
    • Peterson, S.R.1    Kurimasa, A.2    Oshimura, M.3    Dynan, W.S.4    Bradbury, E.M.5    Chen, D.J.6
  • 51
    • 0022651692 scopus 로고
    • Differential effects of polyadenylation regions on gene expression in mammalian cells
    • Pfarr, D.S., Rieser, L.A., Woychik, R.P., Rottman, F.M., Rosenberg, M., and Reff, M.E. (1986). Differential effects of polyadenylation regions on gene expression in mammalian cells. DNA 5, 115-122.
    • (1986) DNA , vol.5 , pp. 115-122
    • Pfarr, D.S.1    Rieser, L.A.2    Woychik, R.P.3    Rottman, F.M.4    Rosenberg, M.5    Reff, M.E.6
  • 53
    • 0028801363 scopus 로고
    • Formation and resolution of double-strand break intermediates in V(D)J rearrangement
    • Ramsden, D.A., and Gellert, M. (1995). Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes Dev. 9, 2409-2420.
    • (1995) Genes Dev. , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 54
    • 0028342645 scopus 로고
    • A DNA end-binding factor involved in double-strand break repair and V(D)J recombination
    • Rathmell, W.K., and Chu, G. (1994). A DNA end-binding factor involved in double-strand break repair and V(D)J recombination. Mol. Cell. Biol. 14, 4741-4748.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4741-4748
    • Rathmell, W.K.1    Chu, G.2
  • 55
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • Roth, D.B., Menetski, J.P., Nakajima, P.B., Bosma, M.J., and Gellert, M. (1992a). V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70, 983-991.
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 56
    • 0026762509 scopus 로고
    • V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals
    • Roth, D.B., Nakajima, P.B., Menetski, J.P., Bosma, M.J., and Gellert, M. (1992b). V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor δ rearrangement signals. Cell 69, 41-53.
    • (1992) Cell , vol.69 , pp. 41-53
    • Roth, D.B.1    Nakajima, P.B.2    Menetski, J.P.3    Bosma, M.J.4    Gellert, M.5
  • 57
    • 0027491330 scopus 로고
    • Characterization of broken DNA molecules associated with V(D)J recombination
    • Roth, D.B., Zhu, C., and Gellert, M. (1993). Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl. Acad. Sci. USA 90, 10788-10792.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10788-10792
    • Roth, D.B.1    Zhu, C.2    Gellert, M.3
  • 59
    • 0029986753 scopus 로고    scopus 로고
    • Mu transpositional recombination: Donor DNA cleavage and strand transfer in trans by the Mu transposase
    • Savilahti, H., and Mizuuchi, K. (1996). Mu transpositional recombination: donor DNA cleavage and strand transfer in trans by the Mu transposase. Cell 85, 271-280.
    • (1996) Cell , vol.85 , pp. 271-280
    • Savilahti, H.1    Mizuuchi, K.2
  • 60
    • 0029096898 scopus 로고
    • The phage Mu transpososome core: DNA requirements for assembly and function
    • Savilahti, H., Rice, P.A., and Mizuuchi, K. (1995). The phage Mu transpososome core: DNA requirements for assembly and function. EMBO J. 14, 4893-4903.
    • (1995) EMBO J. , vol.14 , pp. 4893-4903
    • Savilahti, H.1    Rice, P.A.2    Mizuuchi, K.3
  • 61
    • 0026032665 scopus 로고
    • Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription
    • Schlissel, M.S., Corcoran, L.M., and Baltimore, D. (1991). Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J. Exp. Med. 173, 711-720.
    • (1991) J. Exp. Med. , vol.173 , pp. 711-720
    • Schlissel, M.S.1    Corcoran, L.M.2    Baltimore, D.3
  • 62
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5́-phosphorylated, RAG-dependent, and cell-cycle-regulated
    • Schlissel, M., Constantinescu, A., Morrow, T., Baxter, M., and Peng, A. (1993). Double-strand signal sequence breaks in V(D)J recombination are blunt, 5́-phosphorylated, RAG-dependent, and cell-cycle-regulated. Genes Dev. 7, 2520-2532.
    • (1993) Genes Dev. , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 64
    • 0025319851 scopus 로고
    • Defective V to J recombination of T cell receptor γ chain genes in scid mice
    • Schuler, W., Schuler, A., and Bosma, M.J. (1990). Defective V to J recombination of T cell receptor γ chain genes in scid mice. Eur. J. Immunol. 20, 545-550.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 545-550
    • Schuler, W.1    Schuler, A.2    Bosma, M.J.3
  • 66
    • 0028112944 scopus 로고
    • Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA
    • Smider, V., Rathmell, W.K., Lieber, M.R., and Chu, G. (1994). Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266, 288-291.
    • (1994) Science , vol.266 , pp. 288-291
    • Smider, V.1    Rathmell, W.K.2    Lieber, M.R.3    Chu, G.4
  • 67
    • 0028176620 scopus 로고
    • Scid cells efficiently integrate hairpin and linear DNA substrates
    • Staunton, J.E., and Weaver, D.T. (1994). scid cells efficiently integrate hairpin and linear DNA substrates. Mol. Cell. Biol. 14, 3876-3883.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3876-3883
    • Staunton, J.E.1    Weaver, D.T.2
  • 68
    • 0030155949 scopus 로고    scopus 로고
    • The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
    • Steen, S.B., Gomelsky, L., and Roth, D.B. (1996). The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells, 1, 543-553.
    • (1996) Genes Cells , vol.1 , pp. 543-553
    • Steen, S.B.1    Gomelsky, L.2    Roth, D.B.3
  • 69
    • 0023663468 scopus 로고
    • Transpososomes: Stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA
    • Surette, M.G., Buch, S.J., and Chaconas, G. (1987). Transpososomes: stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA. Cell 49, 253-262.
    • (1987) Cell , vol.49 , pp. 253-262
    • Surette, M.G.1    Buch, S.J.2    Chaconas, G.3
  • 70
    • 0027156278 scopus 로고
    • Impairment of V(D)J recombination in double-strand break repair mutants
    • Taccioli, G.E., Rathbun, G., Oltz, E., Stamato, T., Jeggo, P.A., and Alt, F.W. (1993). Impairment of V(D)J recombination in double-strand break repair mutants. Science 260, 207-210.
    • (1993) Science , vol.260 , pp. 207-210
    • Taccioli, G.E.1    Rathbun, G.2    Oltz, E.3    Stamato, T.4    Jeggo, P.A.5    Alt, F.W.6
  • 74
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • van Gent, D.C., Mizuuchi, K., and Gellert, M. (1996a). Similarities between initiation of V(D)J recombination and retroviral integration. Science 271, 1592-1594.
    • (1996) Science , vol.271 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    Gellert, M.3
  • 75
    • 0030009253 scopus 로고    scopus 로고
    • The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
    • van Gent, D.C., Ramsden, D.A., and Gellert, M. (1996b). The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85, 107-113.
    • (1996) Cell , vol.85 , pp. 107-113
    • Van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 76
    • 0029117310 scopus 로고
    • What to do at an end: DNA double-strand break repair
    • Weaver, D.T. (1995). What to do at an end: DNA double-strand break repair. Trends Genet. 11, 388-392.
    • (1995) Trends Genet. , vol.11 , pp. 388-392
    • Weaver, D.T.1
  • 78
    • 0029582791 scopus 로고
    • Equine severe combined immunodeficiency: A defect in V(D)J recombination and DNA-dependent protein kinase activity
    • Wiler, R., Leber, R., Moore, B.B., VanDyk, L.F., Perryman, L.E., and Meek, K. (1995). Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity. Proc. Natl. Acad. Sci. USA 92, 11485-11489.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11485-11489
    • Wiler, R.1    Leber, R.2    Moore, B.B.3    VanDyk, L.F.4    Perryman, L.E.5    Meek, K.6
  • 79
    • 0028958942 scopus 로고
    • Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination
    • Zhu, C., and Roth, D.B. (1995). Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity 2, 101-112.
    • (1995) Immunity , vol.2 , pp. 101-112
    • Zhu, C.1    Roth, D.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.