Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome

Journal of Clinical Investigation

Volumn 119, Issue 6, 2009, Pages 1696-1705

  Nijnik, Anastasia ^a   Dawson, Sara ^b   Crockford, Tanya L ^a   Woodbine, Lisa ^c   Visetnoi, Supawan ^a   Bennett, Sophia ^a   Jones, Margaret ^d   Turner, Gareth D ^d   Jeggo, Penelope A ^c   Goodnow, Christopher C ^b   Cornall, Richard J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Australian National University   (Australia)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE 4; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CANCER INCIDENCE; CELL COUNT; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA LIGASE IV SYNDROME; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GROWTH RETARDATION; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; LYMPHOCYTE; LYMPHOCYTE FUNCTION; LYMPHOCYTOPENIA; LYMPHOID ORGAN; MOUSE; MOUSE STRAIN; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; THYMOMA;

ANIMALS; ANTIBODY FORMATION; CELL DIFFERENTIATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DNA LIGASES; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN ISOTYPES; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; SYNDROME; THYMUS NEOPLASMS;

EID: 67651007816     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI32743     Document Type: Article

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