Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

EMBO Journal

Volumn 23, Issue 19, 2004, Pages 3874-3885

  Koch, Christine Anne ^a,b,c   Agyei, Roger ^a   Galicia, Sarah ^a   Metalnikov, Pavel ^a   O'Donnell, Paul ^a   Starostine, Andrei ^a   Weinfeld, Michael ^d   Durocher, Daniel ^a,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d CROSS CANCER INSTITUTE   (Canada)

Author keywords

DNA double strand breaks; DNA repair; FHA domain; Nonhomologous end joining; Xrcc4

Indexed keywords

NDA LIGASE IV; PHOSPHOPEPTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; PROTEIN XRCC4; UNCLASSIFIED DRUG;

ARTICLE; DNA BINDING; DNA CLEAVAGE; DNA REPAIR; IONIZING RADIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RADIOSENSITIVITY;

ANIMALS; CHO CELLS; CRICETINAE; DNA; DNA DAMAGE; DNA LIGASES; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; KIDNEY; PHOSPHOPEPTIDES; PHOSPHORYLATION; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE; RADIATION, IONIZING; SACCHAROMYCES CEREVISIAE PROTEINS;

MAMMALIA;

EID: 6344238643     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600375     Document Type: Article

References (33)

1. Bryans M, Valenzano MC, Stamato TD (1999) Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. Mutat Res 433: 53-58
2. Burack WR, Shaw AS (2000) Signal transduction: hanging on a scaffold. Curr Opin Cell Biol 12: 211-216
3. Caldecott KW (2003) DNA single-strand break repair and spinocerebellar ataxia. Cell 112: 7-10
4. Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC (2002) Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J 21: 2827-2832
5. Chen L, Trujillo K, Sung P, Tomkinson AE (2000) Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase. J Biol Chem 275: 26196-26205
6. Coquerelle T, Bopp A, Kessler B, Hagen U (1973) Strand breaks and K′ end-groups in DNA of irradiated thymocytes. Int J Radiat Biol Relat Stud Phys Chem Med 24: 397-404
7. Critchlow SE, Bowater RP, Jackson SP (1997) Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr Biol 7: 588-598
8. Durocher D, Jackson SP (2002) The FHA domain. FEBS Lett 513: 58-66
9. Gellert M (2002) V(D)J recombination: RAG proteins, repair factors, and regulation. Anna Rev Biochem 71: 101-132
10. Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M, Lieber MR (1997) Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388: 492-495
11. Grawunder U, Zimmer D, Kulesza P, Lieber MR (1998) Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo. J Biol Chem 273: 24708-24714
12. Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF (2002) Conversion of phosphoglycolate to phosphate termini on 3′ overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1. J Biol Chem 277: 27162-27168
13. Junop MS, Modesti M, Guarne A, Ghirlando R, Gellert M, Yang W (2000) Crystal structure of the Xrcc4 DNA repair protein and implications for end joining. EMBO J 19: 5962-5970
14. Karimi-Busheri F, Daly G, Robins P, Canas B, Pappin DJ, Sgouros J, Miller GG, Fakhrai H, Davis EM, Le Beau MM, Weinfeld M (1999) Molecular characterization of a human DNA kinase. J Biol Chem 274: 24187-24194
15. Leber R, Wise TW, Mizuta R, Meek K (1998) The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. J Biol Chem 273: 1794-1801
16. Lee KJ, Huang J, Takeda Y, Dynan WS (2000) DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system. J Biol Chem 275: 34787-34796
17. Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD, Taccioli GE, Alt FW (1995) The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 83: 1079-1089
18. Lieber MR, Ma Y, Pannicke U, Schwarz K (2003) Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol 4: 712-720
19. Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA, Caldecott KW (2004) The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell 117: 17-28
20. Ma Y, Pannicke U, Schwarz K, Lieber MR (2002) Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108: 781-794
21. Matsumoto Y, Suzuki N, Namba N, Umeda N, Ma XJ, Morita A, Tomita M, Enomoto A, Serizawa S, Hirano K, Sakaia K, Yasuda H, Hosoi Y (2000) Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation. FEBS Lett 478: 67-71
22. Mills KD, Ferguson DO, Alt FW (2003) The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev 194: 77-95
23. Modesti M, Hesse JE, Geliert M (1999) DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity. EMBO J 18: 2008-2018
24. Modesti M, Junop MS, Ghirlando R, van de Rakt M, Gellert M, Yang W, Kanaar R (2003) Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive. J Mol Biol 334: 215-228
25. Pawson T, Gish GD, Nash P (2001) SH2 domains, interaction modules and cellular wiring. Trends Cell Biol 11: 504-511
26. Pinna LA (2002) Protein kinase CK2: a challenge to canons. J Cell Sci 115: 3873-3878
27. Plo I, Liao ZY, Barcelo JM, Kohlhagen G, Caldecott KW, Weinfeld M, Pommier Y (2003) Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions. DNA Repair (Amst) 2: 1087-1100
28. Sarno S, Moro S, Meggio F, Zagotto G, Dal Ben D, Ghisellini P, Battistutta R, Zanotti G, Pinna LA (2002) Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther 93: 159-168
29. Smith GC, Jackson SP (1999) The DNA-dependent protein kinase. Genes Dev 13: 916-934
30. Teo SH, Jackson SP (2000) Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks. Curr Biol 10: 165-168
31. Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW (2001) XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell 104: 107-117
32. Yaffe MB, Leparc GG, Lai J, Obata T, Volinia S, Cantley LC (2001) A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol 19: 348-353
33. Yu Y, Wang W, Ding Q, Ye R, Chen D, Merkle D, Schriemer D, Meek K, Lees-Miller SP (2003) DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. DNA Repair (Amst) 2: 1239-1252