Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 31, 2011, Pages 12663-12668

  Ropars, Virginie ^a   Drevet, Pascal ^a   Legrand, Pierre ^b   Baconnais, Sonia ^c   Amram, Jeremy ^a   Faure, Guilhem ^a   Márquez, José A ^d   Piétrement, Olivier ^c   Guerois, Raphaël ^a   Callebaut, Isabelle ^e   Le Cam, Eric ^c   Revy, Patrick ^f,g   De Villartay, Jean Pierre ^f,g   Charbonnier, Jean Baptiste ^a  

^a SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^b SYNCHROTRON SOLEIL   (France)

^c CNRS   (France)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^e UNIVERSITÉ PIERRE ET MARIE CURIE   (France)

^f INSERM   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

DNA repair; Immunodeficiency; Nonhomologous end joining; Protein protein interaction; V(D)J recombination

Indexed keywords

CERNUNNOS XLF PROTEIN; CORE PROTEIN; UNCLASSIFIED DRUG; XRCC4 PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CALORIMETRY; CRYSTAL STRUCTURE; DNA STRUCTURE; DOUBLE STRANDED DNA BREAK; MICROFILAMENT; NONHOMOLOGOUS DNA END JOINING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; TRANSMISSION ELECTRON MICROSCOPY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ASPARTIC ACID; BINDING SITES; BLOTTING, WESTERN; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; GLUTAMIC ACID; HUMANS; METHIONINE; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PHENYLALANINE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

MAMMALIA;

EID: 79961219743     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100758108     Document Type: Article

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