-
1
-
-
0020474084
-
Variety in the level of gene control in eukaryotic cells
-
Darnell J. E. Jr., Variety in the level of gene control in eukaryotic cells Nature 1982 297 5865 365 371
-
(1982)
Nature
, vol.297
, Issue.5865
, pp. 365-371
-
-
Darnell Jr., J.E.1
-
2
-
-
0021099154
-
Very short repeats and coordinate induction of genes
-
Davidson E. H., Jacobs H. T., Britten R. J., Very short repeats and coordinate induction of genes Nature 1983 301 5900 468 470
-
(1983)
Nature
, vol.301
, Issue.5900
, pp. 468-470
-
-
Davidson, E.H.1
Jacobs, H.T.2
Britten, R.J.3
-
3
-
-
0025900438
-
In situ distinction between steroid receptor binding and transactivation at a target gene
-
McDonnell D. P., Nawaz Z., O'Malley B. W., In situ distinction between steroid receptor binding and transactivation at a target gene Molecular and Cellular Biology 1991 11 9 4350 4355 (Pubitemid 21895828)
-
(1991)
Molecular and Cellular Biology
, vol.11
, Issue.9
, pp. 4350-4355
-
-
McDonnell, D.P.1
Nawaz, Z.2
O'Malley, B.W.3
-
5
-
-
34147112806
-
Regulation of SRC family coactivators by post-translational modifications
-
DOI 10.1016/j.cellsig.2007.02.002, PII S0898656807000484
-
Li S., Shang Y., Regulation of SRC family coactivators by post-translational modifications Cellular Signalling 2007 19 6 1101 1112 (Pubitemid 46561570)
-
(2007)
Cellular Signalling
, vol.19
, Issue.6
, pp. 1101-1112
-
-
Li, S.1
Shang, Y.2
-
6
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
DOI 10.1038/414782a
-
Zimmet P., Alberti K. G. M. M., Shaw J., Global and societal implications of the diabetes epidemic Nature 2001 414 6865 782 787 (Pubitemid 34000780)
-
(2001)
Nature
, vol.414
, Issue.6865
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.M.M.2
Shaw, J.3
-
7
-
-
0026110135
-
Banting lecture 1990. -cells in type II diabetes mellitus
-
Porte D. Jr., Banting lecture 1990. -cells in type II diabetes mellitus Diabetes 1991 40 2 166 180
-
(1991)
Diabetes
, vol.40
, Issue.2
, pp. 166-180
-
-
Porte Jr., D.1
-
8
-
-
0027953703
-
Banting lecture: Insulin action, diabetogenes, and the cause of type II diabetes
-
Kahn C. R., Banting lecture: insulin action, diabetogenes, and the cause of type II diabetes Diabetes 1994 43 8 1066 1084 (Pubitemid 24230714)
-
(1994)
Diabetes
, vol.43
, Issue.8
, pp. 1066-1084
-
-
Kahn, C.R.1
-
9
-
-
0029037649
-
Pathophysiology of insulin resistance in human disease
-
Reaven G. M., Pathophysiology of insulin resistance in human disease Physiological Reviews 1995 75 3 473 486
-
(1995)
Physiological Reviews
, vol.75
, Issue.3
, pp. 473-486
-
-
Reaven, G.M.1
-
10
-
-
39749147110
-
Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
-
DOI 10.1038/nrm2327, PII NRM2327
-
Muoio D. M., Newgard C. B., Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and -cell failure in type 2 diabetes Nature Reviews Molecular Cell Biology 2008 9 3 193 205 (Pubitemid 351301824)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.3
, pp. 193-205
-
-
Muoio, D.M.1
Newgard, C.B.2
-
11
-
-
41949114990
-
Role of mitochondrial dysfunction in insulin resistance
-
DOI 10.1161/CIRCRESAHA.107.165472, PII 0000301220080229000005
-
Kim J. A., Wei Y., Sowers J. R., Role of mitochondrial dysfunction in insulin resistance Circulation Research 2008 102 4 401 414 (Pubitemid 351651099)
-
(2008)
Circulation Research
, vol.102
, Issue.4
, pp. 401-414
-
-
Kim, J.-A.1
Wei, Y.2
Sowers, J.R.3
-
12
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
DOI 10.1210/er.2007-0015
-
Eizirik D. L., Cardozo A. K., Cnop M., The role for endoplasmic reticulum stress in diabetes mellitus Endocrine Reviews 2008 29 1 42 61 (Pubitemid 351252746)
-
(2008)
Endocrine Reviews
, vol.29
, Issue.1
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
15
-
-
13244287966
-
Regulation of FoxO activity by CBP/p300-mediated acetylation
-
DOI 10.1016/j.tibs.2004.12.002, PII S0968000404003019
-
van der Heide L. P., Smidt M. P., Regulation of FoxO activity by CBP/p300-mediated acetylation Trends in Biochemical Sciences 2005 30 2 81 86 (Pubitemid 40187300)
-
(2005)
Trends in Biochemical Sciences
, vol.30
, Issue.2
, pp. 81-86
-
-
Van Der Heide, L.P.1
Smidt, M.P.2
-
16
-
-
0026636883
-
The regulation of transcription by phosphorylation
-
Hunter T., Karin M., The regulation of transcription by phosphorylation Cell 1992 70 3 375 387
-
(1992)
Cell
, vol.70
, Issue.3
, pp. 375-387
-
-
Hunter, T.1
Karin, M.2
-
17
-
-
0033845842
-
Regulation of transcription factor function by phosphorylation
-
Whitmarsh A. J., Davis R. J., Regulation of transcription factor function by phosphorylation Cellular and Molecular Life Sciences 2000 57 8-9 1172 1183 (Pubitemid 30663475)
-
(2000)
Cellular and Molecular Life Sciences
, vol.57
, Issue.8-9
, pp. 1172-1183
-
-
Whitmarsh, A.J.1
Davis, R.J.2
-
18
-
-
34247583996
-
Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins
-
DOI 10.1038/nature05815, PII NATURE05815
-
Hart G. W., Housley M. P., Slawson C., Cycling of O-linked -N-acetylglucosamine on nucleocytoplasmic proteins Nature 2007 446 7139 1017 1022 (Pubitemid 46676063)
-
(2007)
Nature
, vol.446
, Issue.7139
, pp. 1017-1022
-
-
Hart, G.W.1
Housley, M.P.2
Slawson, C.3
-
19
-
-
58649095123
-
Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose
-
Hu Y., Suarez J., Fricovsky E., Wang H., Scott B. T., Trauger S. A., Han W., Hu Y., Oyeleye M. O., Dillmann W. H., Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose Journal of Biological Chemistry 2009 284 1 547 555
-
(2009)
Journal of Biological Chemistry
, vol.284
, Issue.1
, pp. 547-555
-
-
Hu, Y.1
Suarez, J.2
Fricovsky, E.3
Wang, H.4
Scott, B.T.5
Trauger, S.A.6
Han, W.7
Hu, Y.8
Oyeleye, M.O.9
Dillmann, W.H.10
-
20
-
-
0037442984
-
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase
-
DOI 10.1242/jcs.00246
-
Love D. C., Kochran J., Cathey R. L., Shin S. H., Hanover J. A., Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase Journal of Cell Science 2003 116, part 4 647 654 (Pubitemid 36231303)
-
(2003)
Journal of Cell Science
, vol.116
, Issue.4
, pp. 647-654
-
-
Love, D.C.1
Kochran, J.2
Cathey, R.L.3
Shin, S.-H.4
Hanover, J.A.5
-
21
-
-
55649110871
-
O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity
-
Issad T., Kuo M., O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity Trends in Endocrinology and Metabolism 2008 19 10 380 389
-
(2008)
Trends in Endocrinology and Metabolism
, vol.19
, Issue.10
, pp. 380-389
-
-
Issad, T.1
Kuo, M.2
-
22
-
-
77949283280
-
Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease
-
Lefebvre T., Dehennaut V., Guinez C., Olivier S., Drougat L., Mir A. M., Mortuaire M., Vercoutter-Edouart A. S., Michalski J. C., Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease Biochimica et Biophysica Acta 2010 1800 2 67 79
-
(2010)
Biochimica et Biophysica Acta
, vol.1800
, Issue.2
, pp. 67-79
-
-
Lefebvre, T.1
Dehennaut, V.2
Guinez, C.3
Olivier, S.4
Drougat, L.5
Mir, A.M.6
Mortuaire, M.7
Vercoutter-Edouart, A.S.8
Michalski, J.C.9
-
23
-
-
0037123605
-
Emerging roles of ubiquitin in transcription regulation
-
DOI 10.1126/science.1067466
-
Conaway R. C., Brower C. S., Conaway J. W., Emerging roles of ubiquitin in transcription regulation Science 2002 296 5571 1254 1258 (Pubitemid 34522769)
-
(2002)
Science
, vol.296
, Issue.5571
, pp. 1254-1258
-
-
Conaway, R.C.1
Brower, C.S.2
Conaway, J.W.3
-
24
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman M. H., Ciechanover A., The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction Physiological Reviews 2002 82 2 373 428 (Pubitemid 34654457)
-
(2002)
Physiological Reviews
, vol.82
, Issue.2
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
25
-
-
0037335034
-
How the ubiquitin-proteasome system controls transcription
-
DOI 10.1038/nrm1049
-
Muratani M., Tansey W. P., How the ubiquitin-proteasome system controls transcription Nature Reviews Molecular Cell Biology 2003 4 3 192 201 (Pubitemid 36288041)
-
(2003)
Nature Reviews Molecular Cell Biology
, vol.4
, Issue.3
, pp. 192-201
-
-
Muratani, M.1
Tansey, W.P.2
-
26
-
-
24344445216
-
Something about SUMO inhibits transcription
-
DOI 10.1016/j.gde.2005.07.004, PII S0959437X05001309
-
Gill G., Something about SUMO inhibits transcription Current Opinion in Genetics and Development 2005 15 5 536 541 (Pubitemid 41262410)
-
(2005)
Current Opinion in Genetics and Development
, vol.15
, Issue.5 SPEC. ISS.
, pp. 536-541
-
-
Gill, G.1
-
27
-
-
0037382641
-
Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity
-
DOI 10.1016/S0959-437X(03)00021-2
-
Gill G., Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity Current Opinion in Genetics and Development 2003 13 2 108 113 (Pubitemid 36369733)
-
(2003)
Current Opinion in Genetics and Development
, vol.13
, Issue.2
, pp. 108-113
-
-
Gill, G.1
-
28
-
-
0041837510
-
Nuclear and unclear functions of sumo
-
DOI 10.1038/nrm1200
-
Seeler J. S., Dejean A., Nuclear and unclear functions of SUMO Nature Reviews Molecular Cell Biology 2003 4 9 690 699 (Pubitemid 37082184)
-
(2003)
Nature Reviews Molecular Cell Biology
, vol.4
, Issue.9
, pp. 690-699
-
-
Seeler, J.-S.1
Dejean, A.2
-
29
-
-
0035945243
-
Transcription factor Sp3 is regulated by acetylation
-
Braun H., Koop R., Ertmer A., Nacht S., Suske G., Transcription factor Sp3 is regulated by acetylation Nucleic Acids Research 2001 29 24 4994 5000 (Pubitemid 34065414)
-
(2001)
Nucleic Acids Research
, vol.29
, Issue.24
, pp. 4994-5000
-
-
Braun, H.1
Koop, R.2
Ertmer, A.3
Nacht, S.4
Suske, G.5
-
30
-
-
0032135131
-
SUMO-1 modification of i B inhibits NF- B activation
-
Desterro J. M. P., Rodriguez M. S., Hay R. T., SUMO-1 modification of I B inhibits NF- B activation Molecular Cell 1998 2 2 233 239
-
(1998)
Molecular Cell
, vol.2
, Issue.2
, pp. 233-239
-
-
Desterro, J.M.P.1
Rodriguez, M.S.2
Hay, R.T.3
-
31
-
-
22744459667
-
Is insulin signaling molecules misguided in diabetes for ubiquitin-proteasome mediated degradation?
-
DOI 10.1007/s11010-005-1083-y
-
Balasubramanyam M., Sampathkumar R., Mohan V., Is insulin signaling molecules misguided in diabetes for ubiquitin-proteasome mediated degradation? Molecular and Cellular Biochemistry 2005 275 1-2 117 125 (Pubitemid 41030987)
-
(2005)
Molecular and Cellular Biochemistry
, vol.275
, Issue.1-2
, pp. 117-125
-
-
Balasubramanyam, M.1
Sampathkumar, R.2
Mohan, V.3
-
32
-
-
0032769911
-
Insulin regulates expression of metabolic genes through divergent signaling pathways
-
Hall R. K., Granner D. K., Insulin regulates expression of metabolic genes through divergent signaling pathways Journal of Basic and Clinical Physiology and Pharmacology 1999 10 2 119 133 (Pubitemid 29387586)
-
(1999)
Journal of Basic and Clinical Physiology and Pharmacology
, vol.10
, Issue.2
, pp. 119-133
-
-
Hall, R.K.1
Granner, D.K.2
-
33
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet A., Bonni A., Zigmond M. J., Lin M. Z., Juo P., Hu L. S., Anderson M. J., Arden K. C., Blenis J., Greenberg M. E., Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor Cell 1999 96 6 857 868 (Pubitemid 29165088)
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
34
-
-
0033522897
-
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway
-
Nakae J., Park B. C., Accili D., Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway Journal of Biological Chemistry 1999 274 23 15982 15985
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.23
, pp. 15982-15985
-
-
Nakae, J.1
Park, B.C.2
Accili, D.3
-
35
-
-
25444442080
-
Triple layer control: Phosphorylation, acetylation and ubiquitination of FOXO proteins
-
Vogt P. K., Jiang H., Aoki M., Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins Cell Cycle 2005 4 7 908 913 (Pubitemid 41359756)
-
(2005)
Cell Cycle
, vol.4
, Issue.7
, pp. 908-913
-
-
Vogt, P.K.1
Jiang, H.2
Aoki, M.3
-
36
-
-
0032830572
-
Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: Transcription factor FKHR binds the insulin response sequence
-
DOI 10.2337/diabetes.48.9.1885
-
Ayala J. E., Streeper R. S., Desgrosellier J. S., Durham S. K., Suwanichkul A., Svitek C. A., Goldman J. K., Barr F. G., Powell D. R., O'Brien R. M., Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence Diabetes 1999 48 9 1885 1889 (Pubitemid 29415214)
-
(1999)
Diabetes
, vol.48
, Issue.9
, pp. 1885-1889
-
-
Ayala, J.E.1
Streeper, R.S.2
Desgrosellier, J.S.3
Durham, S.K.4
Suwanichkul, A.5
Svitek, C.A.6
Goldman, J.K.7
Barr, F.G.8
Powell, D.R.9
O'Brien, R.M.10
-
37
-
-
0034806293
-
Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells
-
DOI 10.1006/bbrc.2001.5261
-
Barthel A., Schmoll D., Krger K. D., Bahrenberg G., Walther R., Roth R. A., Joost H. G., Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells Biochemical and Biophysical Research Communications 2001 285 4 897 902 (Pubitemid 32918020)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.285
, Issue.4
, pp. 897-902
-
-
Barthel, A.1
Schmoll, D.2
Kruger, K.-D.3
Bahrenberg, G.4
Walther, R.5
Roth, R.A.6
Joost, H.-G.7
-
38
-
-
0037342151
-
Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR
-
DOI 10.2337/diabetes.52.3.642
-
Daitoku H., Yamagata K., Matsuzaki H., Hatta M., Fukamizu A., Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR Diabetes 2003 52 3 642 649 (Pubitemid 36323569)
-
(2003)
Diabetes
, vol.52
, Issue.3
, pp. 642-649
-
-
Daitoku, H.1
Yamagata, K.2
Matsuzaki, H.3
Hatta, M.4
Fukamizu, A.5
-
39
-
-
0033546439
-
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
-
Rena G., Shaodong G., Cichy S. C., Unterman T. G., Cohen P., Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B Journal of Biological Chemistry 1999 274 24 17179 17183
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.24
, pp. 17179-17183
-
-
Rena, G.1
Shaodong, G.2
Cichy, S.C.3
Unterman, T.G.4
Cohen, P.5
-
40
-
-
33750032892
-
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
-
DOI 10.1126/science.1130512
-
Huang H., Regan K. M., Lou Z., Chen J., Tindall D. J., CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage Science 2006 314 5797 294 297 (Pubitemid 44571973)
-
(2006)
Science
, vol.314
, Issue.5797
, pp. 294-297
-
-
Huang, H.1
Regan, K.M.2
Lou, Z.3
Chen, J.4
Tindall, D.J.5
-
41
-
-
1242276189
-
D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a
-
DOI 10.1038/sj.embor.7400048
-
Rena G., Bain J., Elliott M., Cohen P., D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a EMBO Reports 2004 5 1 60 65 (Pubitemid 38228529)
-
(2004)
EMBO Reports
, vol.5
, Issue.1
, pp. 60-65
-
-
Rena, G.1
Bain, J.2
Elliott, M.3
Cohen, P.4
-
42
-
-
0035340356
-
329 in vitro, a novel in vivo phosphorylation site
-
Woods Y. L., Rena G., Morrice N., Barthel A., Becker W., Shaodong G., Unterman T. G., Cohen P., The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site Biochemical Journal 2001 355, part 3 597 607 (Pubitemid 32434075)
-
(2001)
Biochemical Journal
, vol.355
, Issue.3
, pp. 597-607
-
-
Woods, Y.L.1
Rena, G.2
Morrice, N.3
Barthel, A.4
Becker, W.5
Shaodong, G.6
Unterman, T.G.7
Cohen, P.8
-
43
-
-
0035868368
-
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting
-
DOI 10.1042/0264-6021:3540605
-
Rena G., Prescott A. R., Guo S., Cohen P., Unterman T. G., Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting Biochemical Journal 2001 354, part 3 605 612 (Pubitemid 32269724)
-
(2001)
Biochemical Journal
, vol.354
, Issue.3
, pp. 605-612
-
-
Rena, G.1
Prescott, A.R.2
Guo, S.3
Cohen, P.4
Unterman, T.G.5
-
44
-
-
4544312844
-
Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins
-
DOI 10.1073/pnas.0405454101
-
Aoki M., Jiang H., Vogt P. K., Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins Proceedings of the National Academy of Sciences of the United States of America 2004 101 37 13613 13617 (Pubitemid 39238451)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.37
, pp. 13613-13617
-
-
Aoki, M.1
Jiang, H.2
Vogt, P.K.3
-
45
-
-
13444252337
-
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
-
DOI 10.1073/pnas.0406789102
-
Huang H., Regan K. M., Wang F., Wang D., Smith D. I., van Deursen J. M. A., Tindall D. J., Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation Proceedings of the National Academy of Sciences of the United States of America 2005 102 5 1649 1654 (Pubitemid 40209222)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.5
, pp. 1649-1654
-
-
Huang, H.1
Regan, K.M.2
Wang, F.3
Wang, D.4
Smith, D.I.5
Van Deursen, J.M.A.6
Tindall, D.J.7
-
46
-
-
0141706357
-
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
-
DOI 10.1073/pnas.1934283100
-
Matsuzaki H., Daitoku H., Hatta M., Tanaka K., Fukamizu A., Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation Proceedings of the National Academy of Sciences of the United States of America 2003 100 20 11285 11290 (Pubitemid 37205927)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.20
, pp. 11285-11290
-
-
Matsuzaki, H.1
Daitoku, H.2
Hatta, M.3
Tanaka, K.4
Fukamizu, A.5
-
47
-
-
3042750643
-
Silent information regulator 2 potentiates Foxo 1-mediated transcription through its deacetylase activity
-
DOI 10.1073/pnas.0400593101
-
Daitoku H., Hatta M., Matsuzaki H., Aratani S., Ohshima T., Miyagishi M., Nakajima T., Fukamizu A., Silent information regulator 2 potentiates Foxo 1-mediated transcription through its deacetylase activity Proceedings of the National Academy of Sciences of the United States of America 2004 101 27 10042 10047 (Pubitemid 38891191)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.27
, pp. 10042-10047
-
-
Daitoku, H.1
Hatta, M.2
Matsuzaki, H.3
Aratani, S.4
Ohshima, T.5
Miyagishi, M.6
Nakajima, T.7
Fukamizu, A.8
-
48
-
-
23844485211
-
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
-
DOI 10.1073/pnas.0502738102
-
Matsuzaki H., Daitoku H., Hatta M., Aoyama H., Yoshimochi K., Fukamizu A., Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation Proceedings of the National Academy of Sciences of the United States of America 2005 102 32 11278 11283 (Pubitemid 41153811)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.32
, pp. 11278-11283
-
-
Matsuzaki, H.1
Daitoku, H.2
Hatta, M.3
Aoyama, H.4
Yoshimochi, K.5
Fukamizu, A.6
-
49
-
-
77956260966
-
Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization
-
Qiang L., Banks A. S., Accili D., Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization Journal of Biological Chemistry 2010 285 35 27396 27401
-
(2010)
Journal of Biological Chemistry
, vol.285
, Issue.35
, pp. 27396-27401
-
-
Qiang, L.1
Banks, A.S.2
Accili, D.3
-
50
-
-
20144365700
-
Nuclear trapping of the forkhead transcription factor FoxO1 via sirt-dependent deacetylation promotes expression of glucogenetic genes
-
DOI 10.1074/jbc.M412357200
-
Frescas D., Valenti L., Accili D., Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes Journal of Biological Chemistry 2005 280 21 20589 20595 (Pubitemid 40776761)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20589-20595
-
-
Frescas, D.1
Valenti, L.2
Accili, D.3
-
51
-
-
78650171440
-
Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver
-
Park J. M., Kim T. H., Bae J. S., Kim M. Y., Kim K. S., Ahn Y. H., Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver Biochemical and Biophysical Research Communications 2010 403 3-4 329 334
-
(2010)
Biochemical and Biophysical Research Communications
, vol.403
, Issue.34
, pp. 329-334
-
-
Park, J.M.1
Kim, T.H.2
Bae, J.S.3
Kim, M.Y.4
Kim, K.S.5
Ahn, Y.H.6
-
53
-
-
39749171700
-
O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene
-
Kuo M., Zilberfarb V., Gangneux N., Christeff N., Issad T., O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene FEBS Letters 2008 582 5 829 834
-
(2008)
FEBS Letters
, vol.582
, Issue.5
, pp. 829-834
-
-
Kuo, M.1
Zilberfarb, V.2
Gangneux, N.3
Christeff, N.4
Issad, T.5
-
54
-
-
42649105106
-
O-GlcNAc modification of FoxO1 increases its transcriptional activity: A role in the glucotoxicity phenomenon?
-
Kuo M., Zilberfarb V., Gangneux N., Christeff N., Issad T., O-GlcNAc modification of FoxO1 increases its transcriptional activity: a role in the glucotoxicity phenomenon? Biochimie 2008 90 5 679 685
-
(2008)
Biochimie
, vol.90
, Issue.5
, pp. 679-685
-
-
Kuo, M.1
Zilberfarb, V.2
Gangneux, N.3
Christeff, N.4
Issad, T.5
-
55
-
-
47749149232
-
O-GlcNAc regulates FoxO activation in response to glucose
-
Housley M. P., Rodgers J. T., Udeshi N. D., Kelly T. J., Shabanowitz J., Hunt D. F., Puigserver P., Hart G. W., O-GlcNAc regulates FoxO activation in response to glucose Journal of Biological Chemistry 2008 283 24 16283 16292
-
(2008)
Journal of Biological Chemistry
, vol.283
, Issue.24
, pp. 16283-16292
-
-
Housley, M.P.1
Rodgers, J.T.2
Udeshi, N.D.3
Kelly, T.J.4
Shabanowitz, J.5
Hunt, D.F.6
Puigserver, P.7
Hart, G.W.8
-
56
-
-
64149111641
-
A PGC-1 -O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose
-
Housley M. P., Udeshi N. D., Rodgers J. T., Shabanowitz J., Puigserver P., Hunt D. F., Hart G. W., A PGC-1 -O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose Journal of Biological Chemistry 2009 284 8 5148 5157
-
(2009)
Journal of Biological Chemistry
, vol.284
, Issue.8
, pp. 5148-5157
-
-
Housley, M.P.1
Udeshi, N.D.2
Rodgers, J.T.3
Shabanowitz, J.4
Puigserver, P.5
Hunt, D.F.6
Hart, G.W.7
-
57
-
-
0035855905
-
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
-
DOI 10.1038/35093131
-
Herzig S., Long F., Jhala U. S., Hedrick S., Quinn R., Bauer A., Rudolph D., Schutz G., Yoon C., Puigserver P., Spiegelman B., Montminy M., CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 Nature 2001 413 6852 179 183 (Pubitemid 32867880)
-
(2001)
Nature
, vol.413
, Issue.6852
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
Hedrick, S.4
Quinn, R.5
Bauer, A.6
Rudolph, D.7
Schutz, G.8
Yoon, C.9
Puigserver, P.10
Spiegelman, B.11
Montminy, M.12
-
58
-
-
0024445798
-
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
-
DOI 10.1016/0092-8674(89)90013-5
-
Gonzalez G. A., Montminy M. R., Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 Cell 1989 59 4 675 680 (Pubitemid 19282874)
-
(1989)
Cell
, vol.59
, Issue.4
, pp. 675-680
-
-
Gonzalez, G.A.1
Montminy, M.R.2
-
59
-
-
0025753154
-
2+/calmodulin- As well as cAMP-dependent protein kinase
-
Dash P. K., Karl K. A., Colicos M. A., Prywes R., Kandel E. R., cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase Proceedings of the National Academy of Sciences of the United States of America 1991 88 11 5061 5065 (Pubitemid 21914683)
-
(1991)
Proceedings of the National Academy of Sciences of the United States of America
, vol.88
, Issue.11
, pp. 5061-5065
-
-
Dash, P.K.1
Karl, K.A.2
Colicos, M.A.3
Prywes, R.4
Kandel, E.R.5
-
60
-
-
0027166104
-
Coupling of hormonal stimulation and transcription via the cyclic AMP- responsive factor CREB is rate limited by nuclear entry of protein kinase A
-
Hagiwara M., Brindle P., Harootunian A., Armstrong R., Rivier J., Vale W., Tsien R., Montminy M. R., Coupling of hormonal stimulation and transcription via the cyclic AMP- responsive factor CREB is rate limited by nuclear entry of protein kinase A Molecular and Cellular Biology 1993 13 8 4852 4859 (Pubitemid 23220391)
-
(1993)
Molecular and Cellular Biology
, vol.13
, Issue.8
, pp. 4852-4859
-
-
Hagiwara, M.1
Brindle, P.2
Harootunian, A.3
Armstrong, R.4
Rivier, J.5
Vale, W.6
Tsien, R.7
Montminy, M.R.8
-
61
-
-
0027433708
-
Phosphorylated CREB binds specifically to the nuclear protein CBP
-
DOI 10.1038/365855a0
-
Chrivia J. C., Kwok R. P. S., Lamb N., Hagiwara M., Montminy M. R., Goodman R. H., Phosphorylated CREB binds specifically to the nuclear protein CBP Nature 1993 365 6449 855 859 (Pubitemid 23341031)
-
(1993)
Nature
, vol.365
, Issue.6449
, pp. 855-859
-
-
Chrivia, J.C.1
Kwok, R.P.S.2
Lamb, N.3
Hagiwara, M.4
Montminy, M.R.5
Goodman, R.H.6
-
62
-
-
0030480969
-
The CBP co-activator is a histone acetyltransferase
-
DOI 10.1038/384641a0
-
Bannister A. J., Kouzarides T., The CBP co-activator is a histone acetyltransferase Nature 1996 384 6610 641 643 (Pubitemid 27021517)
-
(1996)
Nature
, vol.384
, Issue.6610
, pp. 641-643
-
-
Bannister, A.J.1
Kouzarides, T.2
-
63
-
-
0030606239
-
The transcriptional coactivators p300 and CBP are histone acetyltransferases
-
DOI 10.1016/S0092-8674(00)82001-2
-
Ogryzko V. V., Schiltz R. L., Russanova V., Howard B. H., Nakatani Y., The transcriptional coactivators p300 and CBP are histone acetyltransferases Cell 1996 87 5 953 959 (Pubitemid 26404293)
-
(1996)
Cell
, vol.87
, Issue.5
, pp. 953-959
-
-
Ogryzko, V.V.1
Schiltz, R.L.2
Russanova, V.3
Howard, B.H.4
Nakatani, Y.5
-
64
-
-
0000735813
-
Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-β enhanceosome in vitro
-
DOI 10.1073/pnas.95.21.12191
-
Kim T. K., Kim T. H., Maniatis T., Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon- enhanceosome in vitro Proceedings of the National Academy of Sciences of the United States of America 1998 95 21 12191 12196 (Pubitemid 28483741)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.21
, pp. 12191-12196
-
-
Kim, T.K.1
Kim, T.H.2
Maniatis, T.3
-
65
-
-
0030029419
-
Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator
-
DOI 10.1074/jbc.271.5.2373
-
Kee B. L., Arias J., Montminy M. R., Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator Journal of Biological Chemistry 1996 271 5 2373 2375 (Pubitemid 26047835)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.5
, pp. 2373-2375
-
-
Kee, B.L.1
Arias, J.2
Montminy, M.R.3
-
66
-
-
0027943988
-
Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity
-
Sun P., Enslen H., Myung P. S., Maurer R. A., Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity Genes and Development 1994 8 21 2527 2539
-
(1994)
Genes and Development
, vol.8
, Issue.21
, pp. 2527-2539
-
-
Sun, P.1
Enslen, H.2
Myung, P.S.3
Maurer, R.A.4
-
67
-
-
0032161642
-
Analysis of an activator:Coactivator complex reveals an essential role for secondary structure in transcriptional activation
-
Parker D., Jhala U. S., Radhakrishnan I., Yaffe M. B., Reyes C., Shulman A. I., Cantley L. C., Wright P. E., Montminy M., Analysis of an activator: coactivator complex reveals an essential role for secondary structure in transcriptional activation Molecular Cell 1998 2 3 353 359 (Pubitemid 128379275)
-
(1998)
Molecular Cell
, vol.2
, Issue.3
, pp. 353-359
-
-
Parker, D.1
Jhala, U.S.2
Radhakrishnan, I.3
Yaffe, M.B.4
Reyes, C.5
Shulman, A.I.6
Cantley, L.C.7
Wright, P.E.8
Montminy, M.9
-
68
-
-
1942437537
-
Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress
-
DOI 10.1073/pnas.0307718101
-
Shi Y., Venkataraman S. L., Dodson G. E., Mabb A. M., LeBlanc S., Tibbetts R. S., Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress Proceedings of the National Academy of Sciences of the United States of America 2004 101 16 5898 5903 (Pubitemid 38520500)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.16
, pp. 5898-5903
-
-
Shi, Y.1
Venkataraman, S.L.2
Dodson, G.E.3
Mabb, A.M.4
LeBlanc, S.5
Tibbetts, R.S.6
-
69
-
-
34250375258
-
Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage
-
DOI 10.1074/jbc.M610674200
-
Shanware N. P., Trinh A. T., Williams L. M., Tibbetts R. S., Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage Journal of Biological Chemistry 2007 282 9 6283 6291 (Pubitemid 47100879)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.9
, pp. 6283-6291
-
-
Shanware, N.P.1
Trinh, A.T.2
Williams, L.M.3
Tibbetts, R.S.4
-
70
-
-
0142091390
-
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells
-
DOI 10.1073/pnas.1932773100
-
Iourgenko V., Zhang W., Mickanin C., Daly I., Jiang C., Hexham J. M., Orth A. P., Miraglia L., Meltzer J., Garza D., Chirn G. W., McWhinnie E., Cohen D., Skelton J., Terry R., Yu Y., Bodian D., Buxton F. P., Zhu J., Song C., Labow M. A., Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells Proceedings of the National Academy of Sciences of the United States of America 2003 100 21 12147 12152 (Pubitemid 37271529)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.21
, pp. 12147-12152
-
-
Iourgenko, V.1
Zhang, W.2
Mickanin, C.3
Daly, I.4
Jiang, C.5
Hexham, J.M.6
Orth, A.P.7
Miraglia, L.8
Meltzer, J.9
Garza, D.10
Chirn, G.-W.11
McWhinnie, E.12
Cohen, D.13
Skelton, J.14
Terry, R.15
Yu, Y.16
Bodian, D.17
Buxton, F.P.18
Zhu, J.19
Song, C.20
Labow, M.A.21
more..
-
71
-
-
0141922981
-
TORCs: Transducers of regulated CREB activity
-
DOI 10.1016/j.molcel.2003.08.013
-
Conkright M. D., Canettieri G., Screaton R., Guzman E., Miraglia L., Hogenesch J. B., Montminy M., TORCs: transducers of regulated CREB activity Molecular Cell 2003 12 2 413 423 (Pubitemid 37238928)
-
(2003)
Molecular Cell
, vol.12
, Issue.2
, pp. 413-423
-
-
Conkright, M.D.1
Canettieri, G.2
Screaton, R.3
Guzman, E.4
Miraglia, L.5
Hogenesch, J.B.6
Montminy, M.7
-
72
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
Koo S. H., Flechner L., Qi L., Zhang X., Screaton R. A., Jeffries S., Hedrick S., Xu W., Boussouar F., Brindle P., Takemori H., Montminy M., The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism Nature 2005 437 7062 1109 1111
-
(2005)
Nature
, vol.437
, Issue.7062
, pp. 1109-1111
-
-
Koo, S.H.1
Flechner, L.2
Qi, L.3
Zhang, X.4
Screaton, R.A.5
Jeffries, S.6
Hedrick, S.7
Xu, W.8
Boussouar, F.9
Brindle, P.10
Takemori, H.11
Montminy, M.12
-
73
-
-
77649253906
-
Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity
-
Wang Y., Inoue H., Ravnskjaer K., Viste K., Miller N., Liu Y., Hedrick S., Vera L., Montminy M., Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity Proceedings of the National Academy of Sciences of the United States of America 2010 107 7 3087 3092
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, Issue.7
, pp. 3087-3092
-
-
Wang, Y.1
Inoue, H.2
Ravnskjaer, K.3
Viste, K.4
Miller, N.5
Liu, Y.6
Hedrick, S.7
Vera, L.8
Montminy, M.9
-
74
-
-
40449128605
-
Hepatic glucose sensing via the CREB coactivator CRTC2
-
DOI 10.1126/science.1151363
-
Dentin R., Hedrick S., Xie J., Yates J. III, Montminy M., Hepatic glucose sensing via the CREB coactivator CRTC2 Science 2008 319 5868 1402 1405 (Pubitemid 351354877)
-
(2008)
Science
, vol.319
, Issue.5868
, pp. 1402-1405
-
-
Dentin, R.1
Hedrick, S.2
Xie, J.3
Yates III, J.4
Montminy, M.5
-
75
-
-
0344874201
-
Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease
-
Diraison F., Moulin P. H., Beylot M., Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease Diabetes and Metabolism 2003 29 5 478 485 (Pubitemid 37474259)
-
(2003)
Diabetes and Metabolism
, vol.29
, Issue.5
, pp. 478-485
-
-
Diraison, F.1
Moulin, P.H.2
Beylot, M.3
-
76
-
-
0031887281
-
Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification
-
Diraison F., Beylot M., Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification American Journal of PhysiologyEndocrinology and Metabolism 1998 274 2, part 1 E321 E327
-
(1998)
American Journal of PhysiologyEndocrinology and Metabolism
, vol.274
, Issue.2 PART 1
-
-
Diraison, F.1
Beylot, M.2
-
77
-
-
14544289119
-
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): Two key regulators of glucose metabolism and lipid synthesis in liver
-
DOI 10.1016/j.biochi.2004.11.008
-
Dentin R., Girard J., Postic C., Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver Biochimie 2005 87 1 81 86 (Pubitemid 40298769)
-
(2005)
Biochimie
, vol.87
, Issue.1 SPEC. ISS.
, pp. 81-86
-
-
Dentin, R.1
Girard, J.2
Postic, C.3
-
78
-
-
66349134748
-
Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL
-
Brown M. S., Goldstein J. L., Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL Journal of Lipid Research 2009 50 S15 S27
-
(2009)
Journal of Lipid Research
, vol.50
-
-
Brown, M.S.1
Goldstein, J.L.2
-
79
-
-
33646148946
-
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKC /
-
Taniguchi C. M., Kondo T., Sajan M., Luo J., Bronson R., Asano T., Farese R., Cantley L. C., Kahn C. R., Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKC / Cell Metabolism 2006 3 5 343 353
-
(2006)
Cell Metabolism
, vol.3
, Issue.5
, pp. 343-353
-
-
Taniguchi, C.M.1
Kondo, T.2
Sajan, M.3
Luo, J.4
Bronson, R.5
Asano, T.6
Farese, R.7
Cantley, L.C.8
Kahn, C.R.9
-
80
-
-
70350417158
-
Akt2 is required for hepatic lipid accumulation in models of insulin resistance
-
Leavens K. F., Easton R. M., Shulman G. I., Previs S. F., Birnbaum M. J., Akt2 is required for hepatic lipid accumulation in models of insulin resistance Cell Metabolism 2009 10 5 405 418
-
(2009)
Cell Metabolism
, vol.10
, Issue.5
, pp. 405-418
-
-
Leavens, K.F.1
Easton, R.M.2
Shulman, G.I.3
Previs, S.F.4
Birnbaum, M.J.5
-
81
-
-
23844530704
-
Fbw7
-
DOI 10.1016/j.cmet.2005.04.010, PII S155041310500118X
-
Sundqvist A., Bengoechea-Alonso M. T., Ye X., Lukiyanchuk V., Jin J., Harper J. W., Ericsson J., Control of lipid metabolism by phosphorylation- dependent degradation of the SREBP family of transcription factors by SCF(Fbw7) Cell Metabolism 2005 1 6 379 391 (Pubitemid 43960622)
-
(2005)
Cell Metabolism
, vol.1
, Issue.6
, pp. 379-391
-
-
Sundqvist, A.1
Bengoechea-Alonso, M.T.2
Ye, X.3
Lukiyanchuk, V.4
Jin, J.5
Harper, J.W.6
Ericsson, J.7
-
82
-
-
65549140251
-
A phosphorylation cascade controls the degradation of active SREBP1
-
Bengoechea-Alonso M. T., Ericsson J., A phosphorylation cascade controls the degradation of active SREBP1 Journal of Biological Chemistry 2009 284 9 5885 5895
-
(2009)
Journal of Biological Chemistry
, vol.284
, Issue.9
, pp. 5885-5895
-
-
Bengoechea-Alonso, M.T.1
Ericsson, J.2
-
83
-
-
0034721772
-
MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro
-
Roth G., Kotzka J., Kremer L., Lehr S., Lohaus C., Meyer H. E., Krone W., Mller-Wieland D., MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro Journal of Biological Chemistry 2000 275 43 33302 33307
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.43
, pp. 33302-33307
-
-
Roth, G.1
Kotzka, J.2
Kremer, L.3
Lehr, S.4
Lohaus, C.5
Meyer, H.E.6
Krone, W.7
Mller-Wieland, D.8
-
84
-
-
33744821064
-
Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation
-
Lu M., Shyy J. Y. J., Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation American Journal of PhysiologyCell Physiology 2006 290 6 C1477 C1486
-
(2006)
American Journal of PhysiologyCell Physiology
, vol.290
, Issue.6
-
-
Lu, M.1
Shyy, J.Y.J.2
-
85
-
-
19344377132
-
Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP
-
DOI 10.1016/j.bbrc.2005.04.112, PII S0006291X05008958
-
Yellaturu C. R., Deng X., Cagen L. M., Wilcox H. G., Park E. A., Raghow R., Elam M. B., Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP Biochemical and Biophysical Research Communications 2005 332 1 174 180 (Pubitemid 40719470)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.332
, Issue.1
, pp. 174-180
-
-
Yellaturu, C.R.1
Deng, X.2
Cagen, L.M.3
Wilcox, H.G.4
Park, E.A.5
Raghow, R.6
Elam, M.B.7
-
86
-
-
67449084097
-
Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation
-
Yoon Y. S., Seo W. Y., Lee M. W., Kim S. T., Koo S. H., Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation Journal of Biological Chemistry 2009 284 16 10446 10452
-
(2009)
Journal of Biological Chemistry
, vol.284
, Issue.16
, pp. 10446-10452
-
-
Yoon, Y.S.1
Seo, W.Y.2
Lee, M.W.3
Kim, S.T.4
Koo, S.H.5
-
87
-
-
0037930875
-
Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway
-
DOI 10.1074/jbc.M212448200
-
Hirano Y., Murata S., Tanaka K., Shimizu M., Sato R., Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway Journal of Biological Chemistry 2003 278 19 16809 16819 (Pubitemid 36799550)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.19
, pp. 16809-16819
-
-
Hirano, Y.1
Murata, S.2
Tanaka, K.3
Shimizu, M.4
Sato, R.5
-
88
-
-
0037378516
-
Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors
-
DOI 10.1128/MCB.23.7.2587-2599.2003
-
Giandomenico V., Simonsson M., Grnroos E., Ericsson J., Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors Molecular and Cellular Biology 2003 23 7 2587 2599 (Pubitemid 36351037)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.7
, pp. 2587-2599
-
-
Giandomenico, V.1
Simonsson, M.2
Gronroos, E.3
Ericsson, J.4
-
89
-
-
77958595135
-
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
-
Ponugoti B., Kim D. H., Xiao Z., Smith Z., Miao J., Zang M., Wu S. Y., Chiang C. M., Veenstra T. D., Kemper J. K., SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism Journal of Biological Chemistry 2010 285 44 33959 33970
-
(2010)
Journal of Biological Chemistry
, vol.285
, Issue.44
, pp. 33959-33970
-
-
Ponugoti, B.1
Kim, D.H.2
Xiao, Z.3
Smith, Z.4
Miao, J.5
Zang, M.6
Wu, S.Y.7
Chiang, C.M.8
Veenstra, T.D.9
Kemper, J.K.10
-
90
-
-
38449087713
-
ChREBP, a transcriptional regulator of glucose and lipid metabolism
-
DOI 10.1146/annurev.nutr.27.061406.093618
-
Postic C., Dentin R., Denechaud P. D., Girard J., ChREBP, a transcriptional regulator of glucose and lipid metabolism Annual Review of Nutrition 2007 27 179 192 (Pubitemid 351373354)
-
(2007)
Annual Review of Nutrition
, vol.27
, pp. 179-192
-
-
Postic, C.1
Dentin, R.2
Denechaud, P.-D.3
Girard, J.4
-
91
-
-
0030753971
-
Regulation of the expression of lipogenic enzyme genes by carbohydrate
-
DOI 10.1146/annurev.nutr.17.1.405
-
Towle H. C., Kaytor E. N., Shih H. M., Regulation of the expression of lipogenic enzyme genes by carbohydrate Annual Review of Nutrition 1997 17 405 433 (Pubitemid 27328807)
-
(1997)
Annual Review of Nutrition
, vol.17
, pp. 405-433
-
-
Towle, H.C.1
Kaytor, E.N.2
Shih, H.-M.3
-
92
-
-
0035923516
-
Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein
-
DOI 10.1073/pnas.231370798
-
Kawaguchi T., Takenoshita M., Kabashima T., Uyeda K., Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein Proceedings of the National Academy of Sciences of the United States of America 2001 98 24 13710 13715 (Pubitemid 33115963)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.24
, pp. 13710-13715
-
-
Kawaguchi, T.1
Takenoshita, M.2
Kabashima, T.3
Uyeda, K.4
-
93
-
-
0037040185
-
Mechanism for fatty acid "sparing" effect on glucose-induced transcription: Regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
-
DOI 10.1074/jbc.M107895200
-
Kawaguchi T., Osatomi K., Yamashita H., Kabashima T., Uyeda K., Mechanism for fatty acid sparing effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase Journal of Biological Chemistry 2002 277 6 3829 3835 (Pubitemid 34968632)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.6
, pp. 3829-3835
-
-
Kawaguchi, T.1
Osatomi, K.2
Yamashita, H.3
Kabashima, T.4
Uyeda, K.5
-
94
-
-
0038561165
-
Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
-
DOI 10.1073/pnas.0730817100
-
Kabashima T., Kawaguchi T., Wadzinski B. E., Uyeda K., Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver Proceedings of the National Academy of Sciences of the United States of America 2003 100 9 5107 5112 (Pubitemid 36542666)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.9
, pp. 5107-5112
-
-
Kabashima, T.1
Kawaguchi, T.2
Wadzinski, B.E.3
Uyeda, K.4
-
95
-
-
33745297834
-
Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module
-
DOI 10.2337/db05-0822
-
Li M. V., Chang B., Imamura M., Poungvarin N., Chan L., Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module Diabetes 2006 55 5 1179 1189 (Pubitemid 44195353)
-
(2006)
Diabetes
, vol.55
, Issue.5
, pp. 1179-1189
-
-
Li, M.V.1
Chang, B.2
Imamura, M.3
Poungvarin, N.4
Chan, L.5
-
96
-
-
29644446917
-
Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism
-
DOI 10.1016/j.bbrc.2005.12.029, PII S0006291X05027610
-
Tsatsos N. G., Towle H. C., Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism Biochemical and Biophysical Research Communications 2006 340 2 449 456 (Pubitemid 43021769)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.340
, Issue.2
, pp. 449-456
-
-
Tsatsos, N.G.1
Towle, H.C.2
-
97
-
-
79959473762
-
O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver
-
Guinez C., Filhoulaud G., Rayah-Benhamed F., Marmier S., Dubuquoy C., Dentin R., Moldes M., Burnol A. F., Yang X., Lefebvre T., Girard J., Postic C., O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver Diabetes 2011 60 5 1399 1413
-
(2011)
Diabetes
, vol.60
, Issue.5
, pp. 1399-1413
-
-
Guinez, C.1
Filhoulaud, G.2
Rayah-Benhamed, F.3
Marmier, S.4
Dubuquoy, C.5
Dentin, R.6
Moldes, M.7
Burnol, A.F.8
Yang, X.9
Lefebvre, T.10
Girard, J.11
Postic, C.12
-
98
-
-
33745863033
-
Islet β cell failure in type 2 diabetes
-
DOI 10.1172/JCI29103
-
Prentki M., Nolan C. J., Islet cell failure in type 2 diabetes Journal of Clinical Investigation 2006 116 7 1802 1812 (Pubitemid 44033300)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 1802-1812
-
-
Prentki, M.1
Nolan, C.J.2
-
99
-
-
34548670709
-
Role of FoxO proteins in pancreatic β cells
-
DOI 10.1507/endocrj.KR-109
-
Kitamura T., Kitamura Y. I., Role of FoxO proteins in pancreatic cells Endocrine Journal 2007 54 4 507 515 (Pubitemid 47414596)
-
(2007)
Endocrine Journal
, vol.54
, Issue.4
, pp. 507-515
-
-
Kitamura, T.1
Ido Kitamura, Y.2
-
100
-
-
35148877285
-
Regulation of pancreatic β-cell function by the forkhead protein FoxO1
-
DOI 10.1111/j.1463-1326.2007.00782.x
-
Buteau J., Accili D., Regulation of pancreatic -cell function by the forkhead protein FoxO1 Diabetes, Obesity and Metabolism 2007 9 supplement 2 140 146 (Pubitemid 47543136)
-
(2007)
Diabetes, Obesity and Metabolism
, vol.9
, Issue.SUPPL. 2
, pp. 140-146
-
-
Buteau, J.1
Accili, D.2
-
101
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth
-
DOI 10.1172/JCI200216857
-
Kitamura T., Nakae J., Kitamura Y., Kido Y., Biggs W. H., Wright C. V. E., White M. F., Arden K. C., Accili D., The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic cell growth Journal of Clinical Investigation 2002 110 12 1839 1847 (Pubitemid 36076491)
-
(2002)
Journal of Clinical Investigation
, vol.110
, Issue.12
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs III, W.H.5
Wright, C.V.E.6
White, M.F.7
Arden, K.C.8
Accili, D.9
-
102
-
-
0036787607
-
Regulation of insulin action and pancreatic -cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
-
Nakae J., Biggs W. H. III, Kitamura T., Cavenee W. K., Wright C. V. E., Arden K. C., Accili D., Regulation of insulin action and pancreatic -cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 Nature Genetics 2002 32 2 245 253
-
(2002)
Nature Genetics
, vol.32
, Issue.2
, pp. 245-253
-
-
Nakae, J.1
Biggs III, W.H.2
Kitamura, T.3
Cavenee, W.K.4
Wright, C.V.E.5
Arden, K.C.6
Accili, D.7
-
103
-
-
33845270456
-
Transcription factors regulating β-cell function
-
DOI 10.1530/eje.1.02277
-
Cerf M. E., Transcription factors regulating -cell function European Journal of Endocrinology 2006 155 5 671 679 (Pubitemid 44857490)
-
(2006)
European Journal of Endocrinology
, vol.155
, Issue.5
, pp. 671-679
-
-
Cerf, M.E.1
-
104
-
-
33644865024
-
The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
-
Kawamori D., Kaneto H., Nakatani Y., Matsuoka T. A., Matsuhisa M., Hori M., Yamasaki Y., The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation Journal of Biological Chemistry 2006 281 2 1091 1098
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.2
, pp. 1091-1098
-
-
Kawamori, D.1
Kaneto, H.2
Nakatani, Y.3
Matsuoka, T.A.4
Matsuhisa, M.5
Hori, M.6
Yamasaki, Y.7
-
105
-
-
10744227975
-
2-terminal Kinase
-
DOI 10.2337/diabetes.52.12.2896
-
Kawamori D., Kajimoto Y., Kaneto H., Umayahara Y., Fujitani Y., Miyatsuka T., Watada H., Leibiger I. B., Yamasaki Y., Hori M., Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH2-terminal kinase Diabetes 2003 52 12 2896 2904 (Pubitemid 37466858)
-
(2003)
Diabetes
, vol.52
, Issue.12
, pp. 2896-2904
-
-
Kawamori, D.1
Kajimoto, Y.2
Kaneto, H.3
Umayahara, Y.4
Fujitani, Y.5
Miyatsuka, T.6
Watada, H.7
Leibiger, I.B.8
Yamasaki, Y.9
Hori, M.10
-
106
-
-
25144454432
-
Increased dosage of mammalian Sir2 in pancreatic cells enhances glucose-stimulated insulin secretion in mice
-
Moynihan K. A., Grimm A. A., Plueger M. M., Bernal-Mizrachi E., Ford E., Cras-Méneur C., Permutt M. A., Imai S. I., Increased dosage of mammalian Sir2 in pancreatic cells enhances glucose-stimulated insulin secretion in mice Cell Metabolism 2005 2 2 105 117
-
(2005)
Cell Metabolism
, vol.2
, Issue.2
, pp. 105-117
-
-
Moynihan, K.A.1
Grimm, A.A.2
Plueger, M.M.3
Bernal-Mizrachi, E.4
Ford, E.5
Cras-Méneur, C.6
Permutt, M.A.7
Imai, S.I.8
-
107
-
-
27744518040
-
FoxO1 protects against pancreatic cell failure through NeuroD and MafA induction
-
Kitamura Y. I., Kitamura T., Kruse J. P., Raum J. C., Stein R., Gu W., Accili D., FoxO1 protects against pancreatic cell failure through NeuroD and MafA induction Cell Metabolism 2005 2 3 153 163
-
(2005)
Cell Metabolism
, vol.2
, Issue.3
, pp. 153-163
-
-
Kitamura, Y.I.1
Kitamura, T.2
Kruse, J.P.3
Raum, J.C.4
Stein, R.5
Gu, W.6
Accili, D.7
-
108
-
-
0037709390
-
The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 β-cells
-
DOI 10.1016/S0003-9861(03)00234-0
-
Gao Y., Miyazaki J. I., Hart G. W., The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 -cells Archives of Biochemistry and Biophysics 2003 415 2 155 163 (Pubitemid 36794127)
-
(2003)
Archives of Biochemistry and Biophysics
, vol.415
, Issue.2
, pp. 155-163
-
-
Gao, Y.1
Miyazaki, J.-I.2
Hart, G.W.3
-
109
-
-
34447515852
-
Glucose mediates the translocation of neuroD1 by O-linked glycosylation
-
DOI 10.1074/jbc.M701762200
-
Andrali S. S., Qian Q., zcan S., Glucose mediates the translocation of neuroD1 by O-linked glycosylation Journal of Biological Chemistry 2007 282 21 15589 15596 (Pubitemid 47093263)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.21
, pp. 15589-15596
-
-
Andrali, S.S.1
Qian, Q.2
Ozcan, S.3
-
110
-
-
33846488647
-
Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats
-
DOI 10.1093/glycob/cwl067
-
Akimoto Y., Hart G. W., Wells L., Vosseller K., Yamamoto K., Munetomo E., Ohara-Imaizumi M., Nishiwaki C., Nagamatsu S., Hirano H., Kawakami H., Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats Glycobiology 2007 17 2 127 140 (Pubitemid 46152531)
-
(2007)
Glycobiology
, vol.17
, Issue.2
, pp. 127-140
-
-
Akimoto, Y.1
Hart, G.W.2
Wells, L.3
Vosseller, K.4
Yamamoto, K.5
Munetomo, E.6
Ohara-Imaizumi, M.7
Nishiwaki, C.8
Nagamatsu, S.9
Hirano, H.10
Kawakami, H.11
-
111
-
-
14544298788
-
NeuroD: The predicted and the suprising
-
Chae J. H., Stein G. H., Lee J. E., NeuroD: the predicted and the suprising Molecules and Cells 2004 18 3 271 288 (Pubitemid 40298021)
-
(2004)
Molecules and Cells
, vol.18
, Issue.3
, pp. 271-288
-
-
Chae, J.H.1
Stein, G.H.2
Lee, J.E.3
-
112
-
-
34548488370
-
Oxidative stress and the JNK pathway in diabetes
-
Kaneto H., Matsuoka T. A., Nakatani Y., Kawamori D., Matsuhisa M., Yamasaki Y., Oxidative stress and the JNK pathway in diabetes Current diabetes reviews 2005 1 1 65 72
-
(2005)
Current Diabetes Reviews
, vol.1
, Issue.1
, pp. 65-72
-
-
Kaneto, H.1
Matsuoka, T.A.2
Nakatani, Y.3
Kawamori, D.4
Matsuhisa, M.5
Yamasaki, Y.6
-
113
-
-
0030846574
-
The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic β-cells
-
DOI 10.1074/jbc.272.33.20936
-
Macfarlane W. M., Smith S. B., James R. F. L., Clifton A. D., Doza Y. N., Cohen P., Docherty K., The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic -cells Journal of Biological Chemistry 1997 272 33 20936 20944 (Pubitemid 27355666)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.33
, pp. 20936-20944
-
-
Macfarlane, W.M.1
Smith, S.B.2
James, R.F.L.3
Clifton, A.D.4
Doza, Y.N.5
Cohen, P.6
Docherty, K.7
-
114
-
-
0033534620
-
Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic -cells
-
Macfarlane W. M., McKinnon C. M., Felton-Edkins Z. A., Cragg H., James R. F. L., Docherty K., Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic -cells Journal of Biological Chemistry 1999 274 2 1011 1016
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.2
, pp. 1011-1016
-
-
MacFarlane, W.M.1
McKinnon, C.M.2
Felton-Edkins, Z.A.3
Cragg, H.4
James, R.F.L.5
Docherty, K.6
-
115
-
-
0034717337
-
Glucose-stimulated preproinsulin gene expression and nuclear trans- location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2
-
DOI 10.1074/jbc.275.21.15977
-
Rafiq I., da Silva Xavier G., Hooper S., Rutter G. A., Glucose-stimulated preproinsulin gene expression and nuclear translocation of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2 Journal of Biological Chemistry 2000 275 21 15977 15984 (Pubitemid 30366902)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.21
, pp. 15977-15984
-
-
Rafiq, I.1
Da Silva Xavier, G.2
Hooper, S.3
Rutter, G.A.4
-
116
-
-
0037376447
-
Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation
-
Kishi A., Nakamura T., Nishio Y., Maegawa H., Kashiwagi A., Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation American Journal of PhysiologyEndocrinology and Metabolism 2003 284 4 E830 E840
-
(2003)
American Journal of PhysiologyEndocrinology and Metabolism
, vol.284
, Issue.4
-
-
Kishi, A.1
Nakamura, T.2
Nishio, Y.3
Maegawa, H.4
Kashiwagi, A.5
-
117
-
-
33646549635
-
Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms
-
DOI 10.1074/jbc.M511597200
-
Boucher M. J., Selander L., Carlsson L., Edlund H., Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms Journal of Biological Chemistry 2006 281 10 6395 6403 (Pubitemid 43847571)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.10
, pp. 6395-6403
-
-
Boucher, M.-J.1
Selander, L.2
Carlsson, L.3
Edlund, H.4
-
118
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
-
DOI 10.1038/nm1166
-
Cai D., Yuan M., Frantz D. F., Melendez P. A., Hansen L., Lee J., Shoelson S. E., Local and systemic insulin resistance resulting from hepatic activation of IKK- and NF- B Nature Medicine 2005 11 2 183 190 (Pubitemid 40321354)
-
(2005)
Nature Medicine
, vol.11
, Issue.2
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
119
-
-
79151478555
-
Type 2 diabetes as an inflammatory disease
-
Donath M. Y., Shoelson S. E., Type 2 diabetes as an inflammatory disease Nature Reviews Immunology 2011 11 2 98 107
-
(2011)
Nature Reviews Immunology
, vol.11
, Issue.2
, pp. 98-107
-
-
Donath, M.Y.1
Shoelson, S.E.2
-
120
-
-
34047119110
-
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
-
DOI 10.2337/db06-0911
-
Hosogai N., Fukuhara A., Oshima K., Miyata Y., Tanaka S., Segawa K., Furukawa S., Tochino Y., Komuro R., Matsuda M., Shimomura I., Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation Diabetes 2007 56 4 901 911 (Pubitemid 46525054)
-
(2007)
Diabetes
, vol.56
, Issue.4
, pp. 901-911
-
-
Hosogai, N.1
Fukuhara, A.2
Oshima, K.3
Miyata, Y.4
Tanaka, S.5
Segawa, K.6
Furukawa, S.7
Tochino, Y.8
Komuro, R.9
Matsuda, M.10
Shimomura, I.11
-
121
-
-
35148854599
-
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
-
Ye J., Gao Z., Yin J., He Q., Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice American Journal of PhysiologyEndocrinology and Metabolism 2007 293 4 E1118 E1128
-
(2007)
American Journal of PhysiologyEndocrinology and Metabolism
, vol.293
, Issue.4
-
-
Ye, J.1
Gao, Z.2
Yin, J.3
He, Q.4
-
122
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
DOI 10.1172/JCI200319246
-
Weisberg S. P., McCann D., Desai M., Rosenbaum M., Leibel R. L., Ferrante A. W. Jr., Obesity is associated with macrophage accumulation in adipose tissue Journal of Clinical Investigation 2003 112 12 1796 1808 (Pubitemid 38063703)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
123
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
DOI 10.1172/JCI200319451
-
Xu H., Barnes G. T., Yang Q., Tan G., Yang D., Chou C. J., Sole J., Nichols A., Ross J. S., Tartaglia L. A., Chen H., Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance Journal of Clinical Investigation 2003 112 12 1821 1830 (Pubitemid 38063705)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
124
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
DOI 10.1172/JCI29881
-
Lumeng C. N., Bodzin J. L., Saltiel A. R., Obesity induces a phenotypic switch in adipose tissue macrophage polarization Journal of Clinical Investigation 2007 117 1 175 184 (Pubitemid 46048464)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.1
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
125
-
-
33847073149
-
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
-
Lumeng C. N., DeYoung S. M., Bodzin J. L., Saltiel A. R., Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity Diabetes 2007 56 1 16 23
-
(2007)
Diabetes
, vol.56
, Issue.1
, pp. 16-23
-
-
Lumeng, C.N.1
Deyoung, S.M.2
Bodzin, J.L.3
Saltiel, A.R.4
-
126
-
-
70449411932
-
Molecular mechanisms involved in obesity-associated insulin resistance: Therapeutical approach
-
Fernndez-Veledo S., Nieto-Vazquez I., Vila-Bedmar R., Garcia-Guerra L., Alonso-Chamorro M., Lorenzo M., Molecular mechanisms involved in obesity-associated insulin resistance: therapeutical approach Archives of Physiology and Biochemistry 2009 115 4 227 239
-
(2009)
Archives of Physiology and Biochemistry
, vol.115
, Issue.4
, pp. 227-239
-
-
Fernndez-Veledo, S.1
Nieto-Vazquez, I.2
Vila-Bedmar, R.3
Garcia-Guerra, L.4
Alonso-Chamorro, M.5
Lorenzo, M.6
-
127
-
-
33745216724
-
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
-
Kanda H., Tateya S., Tamori Y., Kotani K., Hiasa K. I., Kitazawa R., Kitazawa S., Miyachi H., Maeda S., Egashira K., Kasuga M., MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity Journal of Clinical Investigation 2006 116 6 1494 1505
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.6
, pp. 1494-1505
-
-
Kanda, H.1
Tateya, S.2
Tamori, Y.3
Kotani, K.4
Hiasa, K.I.5
Kitazawa, R.6
Kitazawa, S.7
Miyachi, H.8
Maeda, S.9
Egashira, K.10
Kasuga, M.11
-
129
-
-
34247857663
-
Obesity, Inflammation, and Insulin Resistance
-
DOI 10.1053/j.gastro.2007.03.059, PII S0016508507005859
-
Shoelson S. E., Herrero L., Naaz A., Obesity, inflammation, and insulin resistance Gastroenterology 2007 132 6 2169 2180 (Pubitemid 46693756)
-
(2007)
Gastroenterology
, vol.132
, Issue.6
, pp. 2169-2180
-
-
Shoelson, S.E.1
Herrero, L.2
Naaz, A.3
-
130
-
-
33750457370
-
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
-
DOI 10.1038/sj.onc.1209937, PII 1209937
-
Perkins N. D., Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway Oncogene 2006 25 51 6717 6730 (Pubitemid 44657848)
-
(2006)
Oncogene
, vol.25
, Issue.51
, pp. 6717-6730
-
-
Perkins, N.D.1
-
131
-
-
0035979737
-
Duration of nuclear NF-κB action regulated by reversible acetylation
-
DOI 10.1126/science.1062374
-
Chen L. F., Fischle W., Verdin E., Greene W. C., Duration of nuclear NF- B action regulated by reversible acetylation Science 2001 293 5535 1653 1657 (Pubitemid 32807844)
-
(2001)
Science
, vol.293
, Issue.5535
, pp. 1653-1657
-
-
Chen, L.-F.1
Fischle, W.2
Verdin, E.3
Greene, W.C.4
-
132
-
-
3242719545
-
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
-
DOI 10.1038/sj.emboj.7600244
-
Yeung F., Hoberg J. E., Ramsey C. S., Keller M. D., Jones D. R., Frye R. A., Mayo M. W., Modulation of NF- B-dependent transcription and cell survival by the SIRT1 deacetylase EMBO Journal 2004 23 12 2369 2380 (Pubitemid 38954844)
-
(2004)
EMBO Journal
, vol.23
, Issue.12
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
Keller, M.D.4
Jones, D.R.5
Frye, R.A.6
Mayo, M.W.7
-
133
-
-
0033527448
-
The nuclear factor- B engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter
-
Berghe W. V., de Bosscher K., Boone E., Plaisance S., Haegeman G., The nuclear factor- B engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter Journal of Biological Chemistry 1999 274 45 32091 32098
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.45
, pp. 32091-32098
-
-
Berghe, W.V.1
De Bosscher, K.2
Boone, E.3
Plaisance, S.4
Haegeman, G.5
-
134
-
-
61749095297
-
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
-
Yoshizaki T., Milne J. C., Imamura T., Schenk S., Sonoda N., Babendure J. L., Lu J. C., Smith J. J., Jirousek M. R., Olefsky J. M., SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes Molecular and Cellular Biology 2009 29 5 1363 1374
-
(2009)
Molecular and Cellular Biology
, vol.29
, Issue.5
, pp. 1363-1374
-
-
Yoshizaki, T.1
Milne, J.C.2
Imamura, T.3
Schenk, S.4
Sonoda, N.5
Babendure, J.L.6
Lu, J.C.7
Smith, J.J.8
Jirousek, M.R.9
Olefsky, J.M.10
-
136
-
-
0037462725
-
Post-activation turn-off of NF-κB-dependent transcription is regulated by acetylation of p65
-
DOI 10.1074/jbc.M209572200
-
Kiernan R., Brs V., Ng R. W. M., Coudart M. P., El Messaoudi S., Sardet C., Jin D. Y., Emiliani S., Benkirane M., Post-activation turn-off of NF- B-dependent transcription is regulated by acetylation of p65 Journal of Biological Chemistry 2003 278 4 2758 2766 (Pubitemid 36801357)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.4
, pp. 2758-2766
-
-
Kiernan, R.1
Bres, V.2
Ng, R.W.M.3
Coudart, M.-P.4
El Messaoudi, S.5
Sardet, C.6
Jin, D.-Y.7
Emiliani, S.8
Benkirane, M.9
-
137
-
-
5644235488
-
NF-κB: A multifaceted transcription factor regulated at several levels
-
DOI 10.1002/cbic.200400144
-
Schmitz M. L., Mattioli I., Buss H., Kracht M., NF- B: a multifaceted transcription factor regulated at several levels ChemBioChem 2004 5 10 1348 1358 (Pubitemid 39371504)
-
(2004)
ChemBioChem
, vol.5
, Issue.10
, pp. 1348-1358
-
-
Schmitz, M.L.1
Mattioli, I.2
Buss, H.3
Kracht, M.4
-
138
-
-
0037451357
-
Transcriptional activation of the NF-κB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
-
DOI 10.1093/emboj/cdg139
-
Vermeulen L., de Wilde G., van Damme P., Berghe W. V., Haegeman G., Transcriptional activation of the NF- B p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1) EMBO Journal 2003 22 6 1313 1324 (Pubitemid 36362695)
-
(2003)
EMBO Journal
, vol.22
, Issue.6
, pp. 1313-1324
-
-
Vermeulen, L.1
De Wilde, G.2
Van Damme, P.3
Vanden Berghe, W.4
Haegeman, G.5
-
139
-
-
0042525909
-
Essential role of RelA Ser311 phosphorylation by ζPKC in NF-κB transcriptional activation
-
DOI 10.1093/emboj/cdg370
-
Duran A., Diaz-Meco M. T., Moscat J., Essential role of RelA Ser311 phosphorylation by PKC in NF- B transcriptional activation EMBO Journal 2003 22 15 3910 3918 (Pubitemid 36975717)
-
(2003)
EMBO Journal
, vol.22
, Issue.15
, pp. 3910-3918
-
-
Duran, A.1
Diaz-Meco, M.T.2
Moscat, J.3
-
140
-
-
0032589462
-
I B kinases phosphorylate NF- B p65 subunit on serine 536 in the transactivation domain
-
Sakurai H., Chiba H., Miyoshi H., Sugita T., Toriumi W., I B kinases
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.43
, pp. 30353-30356
-
-
Sakurai, H.1
Chiba, H.2
Miyoshi, H.3
Sugita, T.4
Toriumi, W.5
-
141
-
-
0034693133
-
Tumor necrosis factor -induced phosphorylation of RelA/p65 on ser 529 is controlled by casein kinase II
-
Wang D., Westerheide S. D., Hanson J. L., Baldwin A. S. Jr., Tumor necrosis factor -induced phosphorylation of RelA/p65 on Ser 529 is controlled by casein kinase II Journal of Biological Chemistry 2000 275 42 32592 32597
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.42
, pp. 32592-32597
-
-
Wang, D.1
Westerheide, S.D.2
Hanson, J.L.3
Baldwin Jr., A.S.4
-
142
-
-
10744221904
-
Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling
-
DOI 10.1128/MCB.23.21.7780-7793.2003
-
Fujita F., Taniguchi Y., Kato T., Narita Y., Furuya A., Ogawa T., Sakurai H., Joh T., Itoh M., Delhase M., Karin M., Nakanishi M., Identification of NAP1, a regulatory subunit of I B kinase-related kinases that potentiates NF- B signaling Molecular and Cellular Biology 2003 23 21 7780 7793 (Pubitemid 37271475)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.21
, pp. 7780-7793
-
-
Fujita, F.1
Taniguchi, Y.2
Kato, T.3
Narita, Y.4
Furuya, A.5
Ogawa, T.6
Sakurai, H.7
Joh, T.8
Itoh, M.9
Delhase, M.10
Karin, M.11
Nakanishi, M.12
-
143
-
-
0347955360
-
Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA
-
DOI 10.1016/S1097-2765(03)00490-8
-
Ryo A., Suizu F., Yoshida Y., Perrem K., Liou Y. C., Wulf G., Rottapel R., Yamaoka S., Lu K. P., Regulation of NF- B signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA Molecular Cell 2003 12 6 1413 1426 (Pubitemid 38037011)
-
(2003)
Molecular Cell
, vol.12
, Issue.6
, pp. 1413-1426
-
-
Ryo, A.1
Suizu, F.2
Yoshida, Y.3
Perrem, K.4
Liou, Y.-C.5
Wulf, G.6
Rottapel, R.7
Yamaoka, S.8
Lu, K.P.9
-
144
-
-
70350399479
-
Tumor necrosis factor- induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor- B activation
-
Fan Y., Mao R., Zhao Y., Yu Y., Sun W., Song P., Shi Z., Zhang D., Yvon E., Zhang H., Fu S., Yang J., Tumor necrosis factor- induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor- B activation Journal of Biological Chemistry 2009 284 43 29290 29297
-
(2009)
Journal of Biological Chemistry
, vol.284
, Issue.43
, pp. 29290-29297
-
-
Fan, Y.1
Mao, R.2
Zhao, Y.3
Yu, Y.4
Sun, W.5
Song, P.6
Shi, Z.7
Zhang, D.8
Yvon, E.9
Zhang, H.10
Fu, S.11
Yang, J.12
-
145
-
-
0037016688
-
Tumor necrosis factor α increases the expression of glycosyltransferases and sulfotransferases responsible for the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa
-
DOI 10.1074/jbc.M109958200
-
Delmotte P., Degroote S., Lafitte J. J., Lamblin G., Perini J. M., Roussel P., Tumor necrosis factor increases the expression of glycosyltransferases and sulfotransferases responsible for the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa Journal of Biological Chemistry 2002 277 1 424 431 (Pubitemid 34952075)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.1
, pp. 424-431
-
-
Delmotte, P.1
Degroote, S.2
Lafitte, J.-J.3
Lamblin, G.4
Perini, J.-M.5
Roussel, P.6
-
146
-
-
0036231781
-
Flux through the hexosamine pathway is a determinant of nuclear factor κB-dependent promoter activation
-
James L. R., Tang D., Ingram A., Ly H., Thai K., Cai L., Seholey J. W., Flux through the hexosamine pathway is a determinant of nuclear factor B-dependent promoter activation Diabetes 2002 51 4 1146 1156 (Pubitemid 34438362)
-
(2002)
Diabetes
, vol.51
, Issue.4
, pp. 1146-1156
-
-
James, L.R.1
Tang, D.2
Ingram, A.3
Ly, H.4
Thai, K.5
Cai, L.6
Seholey, J.W.7
-
147
-
-
56249095514
-
NF B activation is associated with its O-GlcNAcylation state under hyperglycemic conditions
-
Won H. Y., Sang Y. P., Hyung W. N., Do H. K., Jeong G. K., Eun S. K., Yu S. K., Hyun C. L., Kwan S. K., Jin W. C., NF B activation is associated with its O-GlcNAcylation state under hyperglycemic conditions Proceedings of the National Academy of Sciences of the United States of America 2008 105 45 17345 17350
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.45
, pp. 17345-17350
-
-
Won, H.Y.1
Sang, Y.P.2
Hyung, W.N.3
Do, H.K.4
Jeong, G.K.5
Eun, S.K.6
Yu, S.K.7
Hyun, C.L.8
Kwan, S.K.9
Jin, W.C.10
-
148
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
Olefsky J. M., Glass C. K., Macrophages, inflammation, and insulin resistance Annual Review of Physiology 2010 72 219 246
-
(2010)
Annual Review of Physiology
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
149
-
-
0029948212
-
Mechanism of free fatty acid-induced insulin resistance in humans
-
Roden M., Price T. B., Perseghin G., Petersen K. F., Rothman D. L., Cline G. W., Shulman G. I., Mechanism of free fatty acid-induced insulin resistance in humans Journal of Clinical Investigation 1996 97 12 2859 2865 (Pubitemid 26197099)
-
(1996)
Journal of Clinical Investigation
, vol.97
, Issue.12
, pp. 2859-2865
-
-
Roden, M.1
Price, T.B.2
Perseghin, G.3
Petersen, K.F.4
Rothman, D.L.5
Cline, G.W.6
Shulman, G.I.7
-
150
-
-
0031014830
-
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
-
Boden G., Role of fatty acids in the pathogenesis of insulin resistance and NIDDM Diabetes 1997 46 1 3 10 (Pubitemid 27009941)
-
(1997)
Diabetes
, vol.46
, Issue.1
, pp. 3-10
-
-
Boden, G.1
-
151
-
-
0028342686
-
Mechanisms of fatty acid-induced inhibition of glucose uptake
-
Boden G., Chen X., Ruiz J., White J. V., Rossetti L., Mechanisms of fatty acid-induced inhibition of glucose uptake Journal of Clinical Investigation 1994 93 6 2438 2446 (Pubitemid 24177157)
-
(1994)
Journal of Clinical Investigation
, vol.93
, Issue.6
, pp. 2438-2446
-
-
Boden, G.1
Chen, X.2
Ruiz, J.3
White, J.V.4
Rossetti, L.5
-
152
-
-
0032954778
-
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
-
Dresner A., Laurent D., Marcucci M., Griffin M. E., Dufour S., Cline G. W., Slezak L. A., Andersen D. K., Hundal R. S., Rothman D. L., Petersen K. F., Shulman G. I., Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity Journal of Clinical Investigation 1999 103 2 253 259 (Pubitemid 29053143)
-
(1999)
Journal of Clinical Investigation
, vol.103
, Issue.2
, pp. 253-259
-
-
Dresner, A.1
Laurent, D.2
Marcucci, M.3
Griffin, M.E.4
Dufour, S.5
Cline, G.W.6
Slezak, L.A.7
Andersen, D.K.8
Hundal, R.S.9
Rothman, D.L.10
Petersen, K.F.11
Shulman, G.I.12
-
153
-
-
0034076660
-
Fuel selection in human skeletal muscle in insulin resistance: A reexamination
-
Kelley D. E., Mandarino L. J., Fuel selection in human skeletal muscle in insulin resistance: a reexamination Diabetes 2000 49 5 677 683 (Pubitemid 30339979)
-
(2000)
Diabetes
, vol.49
, Issue.5
, pp. 677-683
-
-
Kelley, D.E.1
Mandarino, L.J.2
-
154
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α
-
Itani S. I., Ruderman N. B., Schmieder F., Boden G., Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and I B- Diabetes 2002 51 7 2005 2011 (Pubitemid 34729001)
-
(2002)
Diabetes
, vol.51
, Issue.7
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
Boden, G.4
-
155
-
-
1642377274
-
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
-
DOI 10.1056/NEJMoa031314
-
Petersen K. F., Dufour S., Befroy D., Garcia R., Shulman G. I., Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes The New England Journal of Medicine 2004 350 7 664 671 (Pubitemid 38364625)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.7
, pp. 664-671
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
Garcia, R.4
Shulman, G.I.5
-
156
-
-
0034903710
-
Prevention of fat-induced insulin resistance by salicylate
-
DOI 10.1172/JCI200111559
-
Kim J. K., Kim Y. J., Fillmore J. J., Chen Y., Moore I., Lee J., Yuan M., Li Z. W., Karin M., Perret P., Shoelson S. E., Shulman G. I., Prevention of fat-induced insulin resistance by salicylate Journal of Clinical Investigation 2001 108 3 437 446 (Pubitemid 32730790)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.3
, pp. 437-446
-
-
Kim, J.K.1
Kim, Y.-J.2
Fillmore, J.J.3
Chen, Y.4
Moore, I.5
Lee, J.6
Yuan, M.7
Li, Z.W.8
Karin, M.9
Perret, P.10
Shoelson, S.E.11
Shulman, G.I.12
-
157
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ
-
DOI 10.1126/science.1061620
-
Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z. W., Karin M., Shoelson S. E., Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikk Science 2001 293 5535 1673 1677 (Pubitemid 32807849)
-
(2001)
Science
, vol.293
, Issue.5535
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.-W.5
Karin, M.6
Shoelson, S.E.7
-
158
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
Houstis N., Rosen E. D., Lander E. S., Reactive oxygen species have a causal role in multiple forms of insulin resistance Nature 2006 440 7086 944 948
-
(2006)
Nature
, vol.440
, Issue.7086
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
159
-
-
0037153158
-
A central, role for JNK in obesity and insulin resistance
-
DOI 10.1038/nature01137
-
Hirosumi J., Tuncman G., Chang L., Grgn C. Z., Uysal K. T., Maeda K., Karin M., Hotamisligil G. S., A central, role for JNK in obesity and insulin resistance Nature 2002 420 6913 333 336 (Pubitemid 35398190)
-
(2002)
Nature
, vol.420
, Issue.6913
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
160
-
-
29944445284
-
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
-
DOI 10.1007/s00424-005-1509-0
-
van Loon L. J. C., Goodpaster B. H., Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state Pflugers Archiv 2006 451 5 606 616 (Pubitemid 43042172)
-
(2006)
Pflugers Archiv European Journal of Physiology
, vol.451
, Issue.5
, pp. 606-616
-
-
Van Loon, L.J.C.1
Goodpaster, B.H.2
-
161
-
-
0033213631
-
PPARγ is required for the differentiation of adipose tissue in vivo and in vitro
-
DOI 10.1016/S1097-2765(00)80211-7
-
Rosen E. D., Sarraf P., Troy A. E., Bradwin G., Moore K., Milstone D. S., Spiegelman B. M., Mortensen R. M., PPAR is required for the differentiation of adipose tissue in vivo and in vitro Molecular Cell 1999 4 4 611 617 (Pubitemid 29531140)
-
(1999)
Molecular Cell
, vol.4
, Issue.4
, pp. 611-617
-
-
Rosen, E.D.1
Sarraf, P.2
Troy, A.E.3
Bradwin, G.4
Moore, K.5
Milstone, D.S.6
Spiegelman, B.M.7
Mortensen, R.M.8
-
162
-
-
77955274518
-
PPAR in adipocyte differentiation and metabolismnovel insights from genome-wide studies
-
Siersbk R., Nielsen R., Mandrup S., PPAR in adipocyte differentiation and metabolismnovel insights from genome-wide studies FEBS Letters 2010 584 15 3242 3249
-
(2010)
FEBS Letters
, vol.584
, Issue.15
, pp. 3242-3249
-
-
Siersbk, R.1
Nielsen, R.2
Mandrup, S.3
-
163
-
-
0033200389
-
Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation
-
DOI 10.1101/gad.13.17.2231
-
Tang Q. Q., Lane M. D., Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation Genes and Development 1999 13 17 2231 2241 (Pubitemid 29426728)
-
(1999)
Genes and Development
, vol.13
, Issue.17
, pp. 2231-2241
-
-
Tang, Q.-Q.1
Lane, M.D.2
-
164
-
-
0029062839
-
Transcriptional regulation of gene expression during adipocyte differentiation
-
MacDougald O. A., Lane M. D., Transcriptional regulation of gene expression during adipocyte differentiation Annual Review of Biochemistry 1995 64 345 373
-
(1995)
Annual Review of Biochemistry
, vol.64
, pp. 345-373
-
-
MacDougald, O.A.1
Lane, M.D.2
-
165
-
-
0033083803
-
Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity
-
DOI 10.1016/S1097-2765(00)80306-8
-
Wu Z., Rosen E. D., Brun R., Hauser S., Adelmant G., Troy A. E., McKeon C., Darlington G. J., Spiegelman B. M., Cross-regulation of C/EBP and PPAR controls the transcriptional pathway of adipogenesis and insulin sensitivity Molecular Cell 1999 3 2 151 158 (Pubitemid 29292616)
-
(1999)
Molecular Cell
, vol.3
, Issue.2
, pp. 151-158
-
-
Wu, Z.1
Rosen, E.D.2
Brun, R.3
Hauser, S.4
Adelmant, G.5
Troy, A.E.6
McKeon, C.7
Darlington, G.J.8
Spiegelman, B.M.9
-
166
-
-
0036007024
-
C/EBPα induces adipogenesis through PPARγ: A unified pathway
-
DOI 10.1101/gad.948702
-
Rosen E. D., Hsu C. H., Wang X., Sakai S., Freeman M. W., Gonzalez F. J., Spiegelman B. M., C/EBP induces adipogenesis through PPAR : a unified pathway Genes and Development 2002 16 1 22 26 (Pubitemid 34049634)
-
(2002)
Genes and Development
, vol.16
, Issue.1
, pp. 22-26
-
-
Rosen, E.D.1
Hsu, C.-H.2
Wang, X.3
Sakai, S.4
Freeman, M.W.5
Gonzalez, F.J.6
Spiegelman, B.M.7
-
167
-
-
0038776380
-
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ
-
DOI 10.1126/science.274.5295.2100
-
Hu E., Kim J. B., Sarraf P., Spiegelman B. M., Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPAR Science 1996 274 5295 2100 2103 (Pubitemid 27020707)
-
(1996)
Science
, vol.274
, Issue.5295
, pp. 2100-2103
-
-
Hu, E.1
Kim, J.B.2
Sarraf, P.3
Spiegelman, B.M.4
-
168
-
-
33947430960
-
Endocrine functions of adipose tissue
-
DOI 10.1146/annurev.pathol.2.010506.091859, Annual Review of Pathology: Mechanisms of Disease
-
Waki H., Tontonoz P., Endocrine functions of adipose tissue Annual Review of Pathology 2007 2 31 56 (Pubitemid 46448059)
-
(2007)
Annual Review of Pathology
, vol.2
, pp. 31-56
-
-
Waki, H.1
Tontonoz, P.2
-
169
-
-
0037237279
-
The forkhead transcription factor Fox01 regulates adipocyte differentiation
-
DOI 10.1016/S1534-5807(02)00401-X, PII S153458070200401X
-
Nakae J., Kitamura T., Kitamura Y., Biggs W. H. III, Arden K. C., Accili D., The forkhead transcription factor Foxo1 regulates adipocyte differentiation Developmental Cell 2003 4 1 119 129 (Pubitemid 36105338)
-
(2003)
Developmental Cell
, vol.4
, Issue.1
, pp. 119-129
-
-
Nakae, J.1
Kitamura, T.2
Kitamura, Y.3
Biggs III, W.H.4
Arden, K.C.5
Accili, D.6
-
170
-
-
33845985335
-
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer- binding protein α transcriptional complex
-
DOI 10.1074/jbc.M607215200
-
Qiao L., Shao J., SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer- binding protein transcriptional complex Journal of Biological Chemistry 2006 281 52 39915 39924 (Pubitemid 46041795)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.52
, pp. 39915-39924
-
-
Qiao, L.1
Shao, J.2
-
171
-
-
33745834319
-
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
-
DOI 10.1172/JCI29126
-
Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K., Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome Journal of Clinical Investigation 2006 116 7 1784 1792 (Pubitemid 44033298)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 1784-1792
-
-
Kadowaki, T.1
Yamauchi, T.2
Kubota, N.3
Hara, K.4
Ueki, K.5
Tobe, K.6
-
172
-
-
44749090905
-
Sp1: Emerging roles-beyond constitutive activation of TATA-less housekeeping genes
-
Wierstra I., Sp1: emerging roles-beyond constitutive activation of TATA-less housekeeping genes Biochemical and Biophysical Research Communications 2008 372 1 1 13
-
(2008)
Biochemical and Biophysical Research Communications
, vol.372
, Issue.1
, pp. 1-13
-
-
Wierstra, I.1
-
173
-
-
0024280897
-
O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation
-
Jackson S. P., Tjian R., O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation Cell 1988 55 1 125 133
-
(1988)
Cell
, vol.55
, Issue.1
, pp. 125-133
-
-
Jackson, S.P.1
Tjian, R.2
-
174
-
-
33746457809
-
Post-translational modification by O-GlcNAc: Another way to change protein function
-
DOI 10.1002/jcb.20926
-
Kudlow J. E., Post-translational modification by O-GlcNAc: another way to change protein function Journal of Cellular Biochemistry 2006 98 5 1062 1075 (Pubitemid 44128349)
-
(2006)
Journal of Cellular Biochemistry
, vol.98
, Issue.5
, pp. 1062-1075
-
-
Kudlow, J.E.1
-
175
-
-
34347391110
-
Sp1-mediated trancription is involved in the metabolism induction of leptin by insulin-stimulated glucose metabolism
-
DOI 10.1677/JME-06-0034
-
Moreno-Aliaga M. J., Swarbrick M. M., Lorente-Cebrin S., Stanhope K. L., Havel P. J., Martnez J. A., Sp1-mediated trancription is involved in the metabolism induction of leptin by insulin-stimulated glucose metabolism Journal of Molecular Endocrinology 2007 38 5-6 537 546 (Pubitemid 47019057)
-
(2007)
Journal of Molecular Endocrinology
, vol.38
, Issue.5-6
, pp. 537-546
-
-
Moreno-Aliaga, M.J.1
Swarbrick, M.M.2
Lorente-Cebrian, S.3
Stanhope, K.L.4
Havel, P.J.5
Martinez, J.A.6
-
176
-
-
0036141208
-
Hexosamines regulate leptin production in 3T3-L1 adipocytes through transcriptional mechanisms
-
DOI 10.1210/en.143.1.99
-
Zhang P., Klenk E. S., Lazzaro M. A., Williams L. B., Considine R. V., Hexosamines regulate leptin production in 3T3-L1 adipocytes through transcriptional mechanisms Endocrinology 2002 143 1 99 106 (Pubitemid 34056408)
-
(2002)
Endocrinology
, vol.143
, Issue.1
, pp. 99-106
-
-
Zhang, P.1
Klenk, E.S.2
Lazzaro, M.A.3
Williams, L.B.4
Considine, R.V.5
-
177
-
-
2442618838
-
The weight of leptin in immunity
-
La Cava A., Matarese G., The weight of leptin in immunity Nature Reviews Immunology 2004 4 5 371 379 (Pubitemid 38649279)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.5
, pp. 371-379
-
-
La Cava, A.1
Matarese, G.2
-
178
-
-
14644417152
-
Differential responses of visceral and subcutaneous fat depots to nutrients
-
DOI 10.2337/diabetes.54.3.672
-
Einstein F. H., Atzmon G., Yang X. M., Ma X. H., Rincon M., Rudin E., Muzumdar R., Barzilai N., Differential responses of visceral and subcutaneous fat depots to nutrients Diabetes 2005 54 3 672 678 (Pubitemid 40322069)
-
(2005)
Diabetes
, vol.54
, Issue.3
, pp. 672-678
-
-
Einstein, F.H.1
Atzmon, G.2
Yang, X.-M.3
Ma, X.-H.4
Rincon, M.5
Rudin, E.6
Muzumdar, R.7
Barzilai, N.8
-
179
-
-
33746669265
-
Sp1 mediates repression of the resistin gene by PPARγ agonists in 3T3-L1 adipocytes
-
DOI 10.1016/j.bbrc.2006.07.048, PII S0006291X06015968
-
Chung S. S., Choi H. H., Cho Y. M., Lee H. K., Park K. S., Sp1 mediates repression of the resistin gene by PPAR agonists in 3T3-L1 adipocytes Biochemical and Biophysical Research Communications 2006 348 1 253 258 (Pubitemid 44163507)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.348
, Issue.1
, pp. 253-258
-
-
Chung, S.S.1
Choi, H.H.2
Cho, Y.M.3
Lee, H.K.4
Park, K.S.5
-
180
-
-
54049127745
-
Enhanced activation of a nutrient-sensing pathway with age contributes to insulin resistance
-
Einstein F. H., Fishman S., Bauman J., Thompson R. F., Huffman D. M., Atzmon G., Barzilai N., Muzumdar R. H., Enhanced activation of a nutrient-sensing pathway with age contributes to insulin resistance FASEB Journal 2008 22 10 3450 3457
-
(2008)
FASEB Journal
, vol.22
, Issue.10
, pp. 3450-3457
-
-
Einstein, F.H.1
Fishman, S.2
Bauman, J.3
Thompson, R.F.4
Huffman, D.M.5
Atzmon, G.6
Barzilai, N.7
Muzumdar, R.H.8
-
181
-
-
0034730660
-
Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins
-
Hall R. K., Yamasaki T., Kucera T., Waltner-Law M., O'Brien R., Granner D. K., Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins Journal of Biological Chemistry 2000 275 39 30169 30175
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.39
, pp. 30169-30175
-
-
Hall, R.K.1
Yamasaki, T.2
Kucera, T.3
Waltner-Law, M.4
O'Brien, R.5
Granner, D.K.6
-
182
-
-
0034725048
-
Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins
-
DOI 10.1074/jbc.275.17.12497
-
Sato R., Okamoto A., Inoue J., Miyamoto W., Sakai Y., Emoto N., Shimano H., Maeda M., Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins Journal of Biological Chemistry 2000 275 17 12497 12502 (Pubitemid 30241393)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.17
, pp. 12497-12502
-
-
Sato, R.1
Okamoto, A.2
Inoue, J.3
Miyamoto, W.4
Sakai, Y.5
Emoto, N.6
Shimano, H.7
Maeda, M.8
-
183
-
-
0034730504
-
The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter
-
Moon Y. A., Lee J. J., Park S. W., Ahn Y. H., Kim K. S., The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter Journal of Biological Chemistry 2000 275 39 30280 30286
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.39
, pp. 30280-30286
-
-
Moon, Y.A.1
Lee, J.J.2
Park, S.W.3
Ahn, Y.H.4
Kim, K.S.5
-
184
-
-
0030868519
-
Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins
-
Magaa M. M., Lin S. S., Dooley K. A., Osborne T. F., Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins Journal of Lipid Research 1997 38 8 1630 1638 (Pubitemid 27427660)
-
(1997)
Journal of Lipid Research
, vol.38
, Issue.8
, pp. 1630-1638
-
-
Magana, M.M.1
Lin, S.S.2
Dooley, K.A.3
Osborne, T.F.4
-
185
-
-
0043210499
-
Acetyl-CoA carboxylase gene is regulated by sterol regulatory element-binding protein-1 in liver
-
Oh S. Y., Park S. K., Kim J. W., Ahn Y. H., Park S. W., Kim K. S., Acetyl-CoA carboxylase gene is regulated by sterol regulatory element-binding protein-1 in liver Journal of Biological Chemistry 2003 278 31 28410 28417
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.31
, pp. 28410-28417
-
-
Oh, S.Y.1
Park, S.K.2
Kim, J.W.3
Ahn, Y.H.4
Park, S.W.5
Kim, K.S.6
-
186
-
-
0028875426
-
Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways
-
Bennett M. K., Lopez J. M., Sanchez H. B., Osborne T. F., Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways Journal of Biological Chemistry 1995 270 43 25578 25583
-
(1995)
Journal of Biological Chemistry
, vol.270
, Issue.43
, pp. 25578-25583
-
-
Bennett, M.K.1
Lopez, J.M.2
Sanchez, H.B.3
Osborne, T.F.4
-
187
-
-
0040799893
-
Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2
-
Tabor D. E., Kim J. B., Spiegelman B. M., Edwards P. A., Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2 Journal of Biological Chemistry 1999 274 29 20603 20610
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.29
, pp. 20603-20610
-
-
Tabor, D.E.1
Kim, J.B.2
Spiegelman, B.M.3
Edwards, P.A.4
-
188
-
-
39549097750
-
Mouse Elovl-6 promoter is an SREBP target
-
Kumadaki S., Matsuzaka T., Kato T., Yahagi N., Yamamoto T., Okada S., Kobayashi K., Takahashi A., Yatoh S., Suzuki H., Yamada N., Shimano H., Mouse Elovl-6 promoter is an SREBP target Biochemical and Biophysical Research Communications 2008 368 2 261 266
-
(2008)
Biochemical and Biophysical Research Communications
, vol.368
, Issue.2
, pp. 261-266
-
-
Kumadaki, S.1
Matsuzaka, T.2
Kato, T.3
Yahagi, N.4
Yamamoto, T.5
Okada, S.6
Kobayashi, K.7
Takahashi, A.8
Yatoh, S.9
Suzuki, H.10
Yamada, N.11
Shimano, H.12
-
189
-
-
0029094172
-
Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription
-
Shih H. M., Liu Z., Towle H. C., Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription Journal of Biological Chemistry 1995 270 37 21991 21997
-
(1995)
Journal of Biological Chemistry
, vol.270
, Issue.37
, pp. 21991-21997
-
-
Shih, H.M.1
Liu, Z.2
Towle, H.C.3
-
190
-
-
0035844297
-
Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes
-
O'Callaghan B. L., Koo S. H., Wu Y., Freake H. C., Towle H. C., Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes Journal of Biological Chemistry 2001 276 19 16033 16039
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.19
, pp. 16033-16039
-
-
O'Callaghan, B.L.1
Koo, S.H.2
Wu, Y.3
Freake, H.C.4
Towle, H.C.5
-
191
-
-
0035877604
-
Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription
-
Rufo C., Teran-Garcia M., Nakamura M. T., Koo S. H., Towle H. C., Clarke S. D., Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription Journal of Biological Chemistry 2001 276 24 21969 21975
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.24
, pp. 21969-21975
-
-
Rufo, C.1
Teran-Garcia, M.2
Nakamura, M.T.3
Koo, S.H.4
Towle, H.C.5
Clarke, S.D.6
-
193
-
-
0027363297
-
Transcriptional activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-κB-like binding site
-
DOI 10.1016/0165-2478(93)90026-X
-
Muraoka O., Kaisho T., Tanabe M., Hirano T., Transcriptional activation of the interleukin-6 gene by HTLV-1 p40tax through an NF- B-like binding site Immunology Letters 1993 37 2-3 159 165 (Pubitemid 23303730)
-
(1993)
Immunology Letters
, vol.37
, Issue.2-3
, pp. 159-165
-
-
Muraoka, O.1
Kaisho, T.2
Tanabe, M.3
Hirano, T.4
-
194
-
-
0030962525
-
Cytokine induction of monocyte chemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF-κB and AP-1
-
Martin T., Cardarelli P. M., Parry G. C. N., Felts K. A., Cobb R. R., Cytokine induction of monocyte chemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF- B and AP-1 European Journal of Immunology 1997 27 5 1091 1097 (Pubitemid 27197210)
-
(1997)
European Journal of Immunology
, vol.27
, Issue.5
, pp. 1091-1097
-
-
Martin, T.1
Cardarelli, P.M.2
Parry, G.C.N.3
Felts, K.A.4
Cobb, R.R.5
-
195
-
-
0030813619
-
Identification of a placental enhancer for the human leptin gene
-
DOI 10.1074/jbc.272.48.30583
-
Bi S., Gavrilova O., Gong D. W., Mason M. M., Reitman M., Identification of a placental enhancer for the human leptin gene Journal of Biological Chemistry 1997 272 48 30583 30588 (Pubitemid 27512274)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.48
, pp. 30583-30588
-
-
Bi, S.1
Gavrilova, O.2
Gong, D.-W.3
Mason, M.M.4
Reitman, M.5
-
196
-
-
4544351272
-
The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3
-
DOI 10.1086/424761
-
Osawa H., Yamada K., Onuma H., Murakami A., Ochi M., Kawata H., Nishimiya T., Niiya T., Shimizu I., Nishida W., Hashiramoto M., Kanatsuka A., Fujii Y., Ohashi J., Makino H., The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3 American Journal of Human Genetics 2004 75 4 678 686 (Pubitemid 39244782)
-
(2004)
American Journal of Human Genetics
, vol.75
, Issue.4
, pp. 678-686
-
-
Osawa, H.1
Yamada, K.2
Onuma, H.3
Murakami, A.4
Ochi, M.5
Kawata, H.6
Nishimiya, T.7
Niiya, T.8
Shimizu, I.9
Nishida, W.10
Hashiramoto, M.11
Kanatsuka, A.12
Fujii, Y.13
Ohashi, J.14
Makino, H.15
|