C/EBPα induces adipogenesis through PPARγ: A unified pathway

Genes and Development

Volumn 16, Issue 1, 2002, Pages 22-26

  Rosen, Evan D ^a,e   Hsu, Chung Hsin ^a,e   Wang, Xinzhong ^b,f   Sakai, Shuichi ^c,g   Freeman, Mason W ^b   Gonzalez, Frank J ^c   Spiegelman, Bruce M ^a,d  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f MILLENNIUM PHARMACEUTICALS INC   (United States)

^g CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Adipogenesis; C EBP ; PPAR ; PPAR null fibroblasts

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR; TROGLITAZONE; CELL RECEPTOR;

ADIPOCYTE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CONTROLLED STUDY; EFFECTOR CELL; EMBRYO; FIBROBLAST; GENE EXPRESSION; GENE EXPRESSION REGULATION; HETEROZYGOSITY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; WHITE ADIPOSE TISSUE; ANIMAL; CELL LINE; CYTOLOGY; GENETICS; PHYSIOLOGY;

ANIMALIA;

ADIPOCYTES; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; FIBROBLASTS; GENE EXPRESSION REGULATION; MICE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0036007024     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.948702     Document Type: Article

References (20)

1. PPAR gamma is required for placental, cardiac, and adipose tissue development
2. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
3. C/EBPβ, when expressed from the C/EBPα gene locus, can functionally replace C/EBPα in liver but not in adipose tissue
4. Retroviral expression in embryonic stem cells and hematopoietic stem cells
5. Differentiation of embryonic stem cells into adipocytes in vitro
6. Modulation of the murine peroxisome proliferator-activated receptor γ 2 promoter activity by CCAAT/enhancer-binding proteins
7. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARγ and C/EBPα
8. Tumor induction of VEGF promoter activity in stromal cells
9. Manipulation of adenovirus vectors
10. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
11. PPAR γ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
12. CCAAT/enhancer binding protein α is sufficient to initiate the 3T3-L1 adipocyte differentiation program
13. C/EBPα is required for differentiation of white, but not brown, adipose tissue
14. PPARγ is required for the differentiation of adipose tissue in vivo and in vitro
15. Transcriptional regulation of adipogenesis
16. Quantitative studies of mouse embryo cells in culture and their development into established lines
17. Stimulation of adipogenesis in fibroblasts by PPAR γ 2, a lipid-activated transcription factor
18. Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression
19. Cross-regulation of C/EBP α and PPAR γ controls the transcriptional pathway of adipogenesis and insulin sensitivity
20. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins