Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism

Biochemical and Biophysical Research Communications

Volumn 340, Issue 2, 2006, Pages 449-456

  Tsatsos, Nikolas G ^a   Towle, Howard C ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cyclic AMP; Glucose; Hepatocyte; Protein kinase A; Transcriptional regulation

Indexed keywords

GLUCOSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; GENE EXPRESSION; LIVER CELL; MALE; MOLECULAR MODEL; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GLUCOSE; HEPATOCYTES; HUMANS; MALE; MODELS, BIOLOGICAL; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS;

ANIMALIA;

EID: 29644446917     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.029     Document Type: Article

References (26)

1. H.C. Towle, E.N. Kaytor, and H.-M. Shih Regulation of the expression of lipogenic enzyme genes by carbohydrate Annu. Rev. Nutr. 17 1997 405 433
2. J. Girard, P. Ferre, and F. Foufelle Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes Annu. Rev. Nutr. 17 1997 325 352
3. S. Vaulont, M. Vasseur-Cognet, and A. Kahn Glucose regulation of gene transcription J. Biol. Chem. 275 2000 31555 31558
4. M. Foretz, C. Guichard, P. Ferre, and F. Foufelle Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes Proc. Natl. Acad. Sci. USA 96 1999 12737 12742
5. J.D. Horton, and I. Shimomura Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis Curr. Opin. Lipidol. 10 1999 143 150
6. T.F. Osborne Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action J. Biol. Chem. 275 2000 32379 32382
7. S.-H. Koo, A.K. Dutcher, and H.C. Towle Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver J. Biol. Chem. 276 2001 9437 9445
8. R. Dentin, J.P. Pegorier, F. Benhamed, F. Foufelle, P. Ferre, V. Fauveau, M.A. Magnuson, J. Girard, and C. Postic Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression J. Biol. Chem. 279 2004 20314 20326
9. H.C. Towle Glucose as a regulator of eukaryotic gene transcription Trends Endocrinol. Metab. 2005
10. M.-O. Bergot, M.-J.M. Diaz-Guerra, N. Puzenat, M. Raymondjean, and A. Kahn Cis-regulation of the l-type pyruvate kinase gene promoter by glucose, insulin and cyclic AMP Nucleic Acids Res. 20 1992 1871 1878
11. Z. Liu, K.S. Thompson, and H.C. Towle Carbohydrate regulation of the rat l-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family J. Biol. Chem. 268 1993 12787 12795
12. 14 gene: context of the CACGTG motif determines the specificity of carbohydrate regulation J. Biol. Chem. 269 1994 9380 9387
13. C. Rufo, M. Teran-Garcia, M. Makamura, S.-H. Koo, H.C. Towle, and S.D. Clarke Involvement of a unique carbohydrate responsive factor in the glucose regulation of rat liver fatty acid synthase gene transcription J. Biol. Chem. 276 2001 21969 21975
14. B.L. O'Callaghan, S.-H. Koo, Y. Wu, H.C. Freake, and H.C. Towle Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes J. Biol. Chem. 276 2001 16033 16039
15. H. Yamashita, M. Takenoshita, M. Sakurai, R.K. Bruick, W.J. Henzel, W. Shillinglaw, D. Arnot, and K. Uyeda A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver Proc. Natl. Acad. Sci. USA 98 2001 9116 9121
16. T. Kawaguchi, M. Takenoshita, Y. Li, T. Kabashima, and K. Uyeda Glucose and cAMP regulate the l-type pyruvate kinase gene by phosphorylation/ dephosphorylation of the carbohydrate response element binding protein Proc. Natl. Acad. Sci. USA 98 2001 13710 13715
17. S. Ishii, K. Iizuka, B.C. Miller, and K. Uyeda Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription Proc. Natl. Acad. Sci. USA 101 2004 15597 15602
18. A.K. Stoeckman, L. Ma, and H.C. Towle Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes J. Biol. Chem. 279 2004 15662 15669
19. L. Ma, N.G. Tsatsos, and H.C. Towle Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes J. Biol. Chem. 280 2005 12019 12027
20. K. Iizuka, R.K. Bruick, G. Liang, J.D. Horton, and K. Uyeda Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis Proc. Natl. Acad. Sci. USA 101 2004 7281 7286
21. E.N. Kaytor, H.-M. Shih, and H.C. Towle Carbohydrate regulation of hepatic gene expression. Evidence against a role for the upstream stimulatory factor J. Biol. Chem. 272 1997 7525 7531
22. A.N. Billin, A.L. Eilers, K.L. Coulter, J.S. Logan, and D.E. Ayer Mondo A, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network Mol. Cell. Biol. 20 2000 8845 8854
23. S.N. Ho, H.D. Hunt, R.M. Horton, J.K. Pullen, and L.R. Pease Site-directed mutagenesis by overlap extension using the polymerase chain reaction Gene 77 1989 51 59
24. M. Nishimura, and K. Uyeda Purification and characterization of a novel xylulose 5-phosphate-activated protein phosphatase catalyzing dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase J. Biol. Chem. 270 1995 26341 26346
25. T. Kabashima, T. Kawaguchi, B.E. Wadzinski, and K. Uyeda Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver Proc. Natl. Acad. Sci. USA 100 2003 5107 5112
26. A.L. Eilers, E. Sundwell, M. Lin, A.A. Sullivan, and D.E. Ayer A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex Mol. Cell. Biol. 22 2002 8514 8526