Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance

FASEB Journal

Volumn 22, Issue 10, 2008, Pages 3450-3457

  Einstein, Francine H ^a   Fishman, Sigal ^a   Bauman, Jeffery ^a   Thompson, Reid F ^a   Huffman, Derek M ^a   Atzmon, Gil ^a   Barzilai, Nir ^a   Muzumdar, Radhika H ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ANGIOTENSINOGEN; FAT; GLUCOSAMINE; HEXOSAMINE; INSULIN; LEPTIN; RESISTIN; TRANSCRIPTION FACTOR SP1; PLASMINOGEN ACTIVATOR INHIBITOR 1;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; GENE EXPRESSION; GLYCOSYLATION; HYPERINSULINEMIA; INSULIN RESISTANCE; MOLECULAR SENSOR; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; RAT; ADIPOSE TISSUE; AGE; ANIMAL; DIABETES MELLITUS; DRUG EFFECT; GENETICS; METABOLISM; RAT STRAIN;

ANIMALIA; RATTUS;

ADIPONECTIN; ADIPOSE TISSUE; AGE FACTORS; AGING; ANGIOTENSINOGEN; ANIMALS; DIABETES MELLITUS; GENE EXPRESSION; GLUCOSAMINE; GLYCOSYLATION; HEXOSAMINES; INSULIN; INSULIN RESISTANCE; LEPTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, INBRED STRAINS; RESISTIN; SP1 TRANSCRIPTION FACTOR;

EID: 54049127745     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.08-109041     Document Type: Article

References (32)

1. Anderson, R. M., and Weindruch, R. (2006) Calorie restriction: progress during mid-2005-mid-2006. Exp. Gerontol. 41, 1247-1249
2. Weindruch, R., and Sohal, R. S. (1997) Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N. Engl. J. Med. 337, 986-994
3. Masoro, E. J. (2005) Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913-922
4. Masoro, E. J. (2000) Caloric restriction and aging: an update. Exp. Gerontol. 35, 299-305
5. Rossetti, L. (2000) Perspective: hexosamines and nutrient sensing. Endocrinology 141, 1922-1925
6. Obici, S., Wang, J., Chowdury, R., Feng, Z., Siddhanta, U., Morgan, K., and Rossetti, L. (2002) Identification of a biochemical link between energy intake and energy expenditure. J. Clin. Invest. 109, 1599-1605
7. Hawkins, M., Barzilai, N., Liu, R., Hu, M., Chen, W., and Rossetti, L. (1997) Role of the glucosamine pathway in fat-induced insulin resistance. J. Clin. Invest. 99, 2173-2182
8. DeFronzo, R. A., Tobin, J. D., and Andres, R. (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237, E214-E223
9. Barzilai, N., She, L., Liu, B. Q., Vuguin, P., Cohen, P., Wang, J., and Rossetti, L. (1999) Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 48, 94-98
10. Fishman, S., Muzumdar, R. H., Atzmon, G., Ma, X., Yang, X., Einstein, F. H., and Barzilai, N. (2007) Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo. FASEB J. 21, 53-60
11. Muzumdar, R. H., Ma, X., Fishman, S., Yang, X., Atzmon, G., Vuguin, P., Einstein, F. H., Hwang, D., Cohen, P., and Barzilai, N. (2006) Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action. Diabetes 55, 2788-2796
12. Rossetti, L., Smith, D., Shulman, G. I., Papachristou, D., and DeFronzo, R. A. (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J. Clin. Invest. 79, 1510-1515
13. Rossetti, L., and Giaccari, A. (1990) Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats. J. Clin. Invest. 85, 1785-1792
14. Gupta, G., Cases, J. A., She, L., Ma, X. H., Yang, X. M., Hu, M., Wu, J., Rossetti, L., and Barzilai, N. (2000) Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation. Am. J. Physiol. 278, E985-E991
15. Einstein, F. H., Atzmon, G., Yang, X. M., Ma, X. H., Rincon, M., Rudin, E., Muzumdar, R., and Barzilai, N. (2005) Differential responses of visceral and subcutaneous fat depots to nutrients. Diabetes 54, 672-678
16. Rossetti, L., and Hu, M. (1993) Skeletal muscle glycogenolysis is more sensitive to insulin than is glucose transport/phosphorylation. Relation to the insulin-mediated inhibition of hepatic glucose production. J. Clin. Invest. 92, 2963-2974
17. Giaccari, A., and Rossetti, L. (1992) Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. J. Clin. Invest. 89, 36-45
18. Giaccari, A., and Rossetti, L. (1989) Isocratic high-performance liquid chromatographic determination of the concentration and specific radioactivity of phosphoenolpyruvate and uridine diphosphate glucose in tissue extracts. J. Chromatogr. 497, 69-78
19. Anumula, K. R., and Taylor, P. B. (1991) Quantitative determination of phenyl isothiocyanate-derivatized amino sugars and amino sugar alcohols by high-performance liquid chromatography. Anal. Biochem. 197, 113-120
20. Liu, L., Karkanias, G. B., Morales, J. C., Hawkins, M., Barzilai, N., Wang, J., and Rossetti, L. (1998) Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J. Biol. Chem. 273, 31160-31167
21. Barzilai, N., Wang, J., Massilon, D., Vuguin, P., Hawkins, M., and Rossetti, L. (1997) Leptin selectively decreases visceral adiposity and enhances insulin action. J. Clin. Invest. 100, 3105-3110
22. Rossetti, L., Hawkins, M., Chen, W., Gindi, J., and Barzilai, N. (1995) In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. J. Clin. Invest. 96, 132-140
23. Hotamisligil, G. S., Murray, D. L., Choy, L. N., and Spiegelman, B. M. (1994) Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc. Natl. Acad. Sci. U. S. A. 91, 4854-4858
24. Kapahi, P., and Zid, B. (2004) TOR pathway: linking nutrient sensing to life span. Sci. Aging Knowl. Environ. 2004, PE34
25. Corton, J. C., and Brown-Borg, H. M. (2005) Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity. J. Gerontol. Biol. Med. Sci. 60, 1494-1509
26. Iwasaki, K., Gleiser, C. A., Masoro, E. J., McMahan, C. A., Seo, E. J., and Yu, B. P. (1988) Influence of the restriction of individual dietary components on longevity and age-related disease of Fischer rats: the fat component and the mineral component. J. Gerontol. 43, B13-B21
27. Gabriely, I., Ma, X. H., Yang, X. M., Rossetti, L., and Barzilai, N. (2002) Leptin resistance during aging is independent of fat mass. Diabetes 51, 1016-1021
28. Muzumdar, R., Ma, X., Yang, X., Atzmon, G., Bernstein, J., Karkanias, G., and Barzilai, N. (2003) Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB J. 17, 1130-1132
29. Gazdag, A. C., Wetter, T. J., Davidson, R. T., Robinson, K. A., Buse, M. G., Yee, A. J., Turcotte, L. P., and Cartee, G. D. (2000) Lower calorie intake enhances muscle insulin action and reduces hexosamine levels. Am. J. Physiol. 278, R504-R512
30. Goldberg, H. J., Whiteside, C. I., and Fantus, I. G. (2002) The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta. J. Biol. Chem. 277, 33833-33841
31. Gabriely, I., Yang, X. M., Cases, J. A., Ma, X. H., Rossetti, L., and Barzilai, N. (2002) Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway. Atherosclerosis 160, 115-122
32. Goldberg, H. J., Whiteside, C. I., Hart, G. W., and Fantus, I. G. (2006) Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells. Endocrinology 147, 222-231