Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ

Science

Volumn 274, Issue 5295, 1996, Pages 2100-2103

  Hu, Erding ^a   Kim, Jae Bum ^a   Sarraf, Pasha ^a   Spiegelman, Bruce M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; STEM CELL; TRANSCRIPTION REGULATION;

3T3 CELLS; ADIPOCYTES; ANIMALS; BLOOD; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIFFERENTIATION; CELL LINE; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FLAVONOIDS; INSULIN; LIGANDS; MICE; MITOGENS; MUTATION; PHOSPHORYLATION; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA;

EID: 0038776380     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5295.2100     Document Type: Article

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57. We thank members of the B.M.S. laboratory, especially P. Peraldi and R. Brun, for helpful discussions and suggestions. We also thank J. Blenis, T. Roberts, and C. Marshall for reagents. E.H. is supported by a postdoctoral fellowship from Sandoz-Dana-Farber drug discovery program. This work is supported by a NIH grant to B.M.S. (R37DK31405).