Insulin Regulates Expression Of Metabolic Genes Through Divergent Signaling Pathways

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 10, Issue 2, 1999, Pages 119-134

  Hall, Robert K ^a   Granner, Daryl K ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

gene regulation; hexokinase II; insulin; phosphoenolpyruvate carboxykinase; signal transduction

Indexed keywords

HEXOKINASE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE UTILIZATION; HORMONAL REGULATION; HUMAN; HUMAN CELL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; HEXOKINASE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SIGNAL TRANSDUCTION;

EID: 0032769911     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/JBCPP.1999.10.2.119     Document Type: Article

References (47)

1. Granner, DK, O'Brien, RM. Molecular physiology and genetics of NIDDM. Diabetes Care 1992; 15; 369–395.
2. Defronzo, RA. The triumvirate; ß-cell, muscle, liver; a collusion responsible for NIDDM. Diabetes 1988; 37; 667–687.
3. Kahn, CR. Insulin action, diabetogenes and the cause of type 2 diabetes. Diabetes 1994; 43; 1066–1084.
4. Granner, D, Pilkis, S. The genes of hepatic glucose metabolism. J Biol Chem 1990; 265; 10173–10176.
5. O'Brien, R, Granner, D. Regulation of gene expression by insulin. Biochem J 1991; 278; 609–619.
6. Lemaigre, FP, Rousseau, GG. Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver. Biochem J 1994; 303; 1–14.
7. O'Brien, RM, Granner, DK. The regulation of gene expression by insulin. Physiol Rev 1996; 76: 1109–1161.
8. Sutherland, C, O'Brien, RM, Granner, DK. The regulation of gene transcription by insulin and the search for diabetogenes. In; Alberti KGMM, Zimmet P, DeFronzo RA, Keen H, eds. International Textbook of Diabetes Mellitus, 2nd Ed. Chichester, NY; J Wiley and Sons Ltd., 1997; 489–504.
9. Ogawa, W, Matozaki, T, Kasuga, M. Role of binding proteins to lRS-1 in insulin signalling. Mol Cell Biochem 1998; 182; 13–22.
10. White, MF. The IRS-signalling system; A network of docking proteins that mediate insulin action. Mol Cell Biochem 1998; 182; 3–11.
11. O'Brien, RM, Granner, DK. PEPCK gene as model of inhibitory effects of insulin on gene transcription. Diabetes Care 1990; 13; 327–339.
12. Printz, RL, Osawa, H, Ardehali, H, Koch, S, Granner, DK. Hexokinase 11 gene; structure, regulation and promoter organization. Biochem Soc Trans 1997; 25; 107–112.
13. Sutherland, C, O'Brien, RM, Granner, DK. Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. J Biol Chem 1995; 270; 15501–15506.
14. Osawa, H, Sutherland, C, Robey, RB, Printz, RL, Granner, DK. Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin. J Biol Chem 1996; 271: 16690–16694.
15. Sutherland, CD, O'Brien, RM, Granner, DK. New connections in the regulation of PEPCK gene expression by insulin. Phil Trans R Soc Lond B 1996; 351: 191–199.
16. Sasaki, K, Cripe, TP, Koch, SR, Andreone, TL, Petersen, DD, Beale, EG, Granner, DK. Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription: The dominant role of insulin. J Biol Chem 1984; 259: 152421–5251.
17. Lucas, PC, O'Brien, RM, Mitchell, JA, Davis, CM, Imai, E, Forman, BM, Samuels, HH, Granner, DK. A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene. Proc Natl Acad Sci. USA 1991; 88: 2184–2188.
18. Imai, E, Stromstedt, P-E, Quinn, PG, Carlstedt-Duke, J, Gustafsson, J-A, Granner, DK. Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 1990; 10: 4712–4719.
19. Granner, D, O'Brien, R, Imai, E, Forest, C, Mitchell, J, Lucas, P. A complex hormone response unit regulates transcription of the phosphoenolpyruvate carboxykinase gene: From metabolic pathways to molecular biology. Rec Prog HormRes 1991; 47: 319–348.
20. Lucas, PC, Granner, DK. Hormone response domains in gene transcription. Ann Rev Biochem 1992; 61: 1131–1173.
21. Hall, RK, Sladek, FM, Granner, DK. The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of the phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. Proc Natl Acad Sci USA 1995; 92: 412–416.
22. Scott, DK, Mitchell, JA, Granner, DK. The orphan receptor COUP-TF binds to a third glucocorticoid accessory factor element within the phosphoenolpyruvate carboxykinase gene promoter. J Biol Chem 1996; 271: 31909–31914.
23. Wang, J-C, Stromstedt, P-E, O'Brien, RM, Granner, DK. Hepatic nuclear factor 3 is an accessory factor required for the stimulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. Mol Endocrinol 1996; 10: 794–800.
24. Yamada, K, Duong, DT, Wang, J-C, Scott, DK, Granner, DK. CCAAT/enhancer binding protein is an accessory factor from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoter. J Biol Chem 1999; in press.
25. O'Brien, RM, Lucas, PC, Forest, CD, Magnuson, MA, Granner, DK. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science 1990; 249: 533–537.
26. Nakajima, T, Fukamizu, A, Takahashi, J, Gage, FH, Fisher, T, Blenis, J, Montminy, MR. The signal-dependent coactivator CBP is a nuclear target for pp90rsk. Cell 1996; 86: 465–474.
27. Clarke, JF, Young, PW, Yonezawa, K, Kasuga, M, Holman, GD. Inhibition of the translocation of GLUTI and GLUT4 in 3T3-L1 cells by the phospatidyl-inositol 3-kinase inhibitor, wortmannin. Biochem J 1994; 300: 631–635.
28. Welsh, GI, Foulstone, EJ, Young, SW, Tavare, JM, Proud, CG. Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem J 1994; 303: 15–20.
29. Messina, JL. Insulin's regulation of c-fos gene transcription in hepatoma cells. J Biol Chem 1990; 265: 11700–11705.
30. Griffiths, MR, Block, EJ, Culbert, AA, Dickens, M, Shaw, PE, Gillespie, DAF, Tavare, JM. Insulin stimulated expression of c-fos, fra 1 and c-jun accompanies the activation of the activator protein-1 (AP-1) transcriptional complex. Biochem J 1998; 335: 19–26.
31. Granner, D, Andreone, T, Sasaki, K, Beale, E. Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin. Nature 1983; 305: 549–551.
32. Short, MK, Clouthier, DE, Schaefer, IM, Hammer, RE, Magnuson, MA, Beale, EG. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol 1992; 12: 1007–1020.
33. Friedman, JE, Yun, JS, Patel, YM, McGrane, MM, Hanson, RW. Glucocroticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes. J Biol Chem 1993; 268: 12952–12957.
34. Sheperd, PR, Withers, DJ, Siddle, K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998; 333: 471–490.
35. Cichy, SB, Uddin, S, Danilkovich, A, Guo, S, Klippel, A, Unterman, TG. Protcin kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence. J Biol Chem 1998; 273: 6482–6487.
36. Liao, J, Barthel, A, Nakatani, K, Roth, RA. Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene. J Biol Chem 1998; 273: 27320–27324.
37. Kohn, AD, Barthel, A, Kovacina, KS, Boge, A, Wallach, B, Summers, SA, Birnbaum, MJ, Scott, PH, Lawrence, JC Jr, Roth RA. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. J Biol Chem 1998; 273: 11937–11943.
38. Agati, JM, Yeagley, D, Quinn, PG. Assesment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phophoenolpyruvate carboxykinase gene transcription. J Biol Chem 1998; 273: 18751–18759.
39. Gabbay, RA, Sutherland, C, Gnudi, L, Kahn, BB, O'Brien, RM, Granner, DK, Flier, JS. Insulin regulation of PEPCK gene expression does not require activation of the Ras/MAP kinase signalling pathway. J Biol Chem 1996; 271: 1890–1897.
40. Sutherland, C, Waltner-Law, M, Gnudi, L, Kahn, BB, Granner, DK. Activation of the Ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin. J Biol Chem 1998; 273; 3198–3204.
41. Osawa, H, Printz, RL, Whitesell, RR, Granner, DK. Regulation of hexokinase II gene transcription and glucose phosphorylation by catecholamines, cyclic AMP and insulin in muscle and fat cells. Diabetes 1995; 44; 1426–1432.
42. Osawa, H, Robey, RB, Printz, RL, Granner, DK. Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat hexokinase II gene. J Biol Chem 1996; 271; 17296–17303.
43. Satoh, T, Nakafuku, M, Kaziro, Y. Function of Ras as a molecular switch in signal transduction. J Biol Chem 1992; 267; 24149–24152.
44. Karin, M. Mitogen-activated protein kinase cascades as regulators of stress responses. Ann NY Acad Sei 1998; 851; 139–146.
45. Ceresa, BP, Pessin, JE. Insulin regulation of the Ras activation/inactivation cycle. Mol Cell Biochem 1998; 182; 23–29.
46. Chu, DTW, Davis, CM, Chrapkiewicz, NB, Granner, DK. Reciprocal regulation of gene transcription by insulin; Inhibition of the phosphoenolpyruvate carboxykinase gene and stimulation of gene 33 in a single cell type. J Biol Chem 1988; 263; 13007–13011.
47. Chrapkiewicz, NB, Davis, CM, Chu, DTW, Caldwell, CM, Granner, DK. Rat gene 33: Analysis of its structure, messenger RNA, and basal promoter activity. Nucl Acid Res 1989; 17; 6651–6667.