CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage

Science

Volumn 314, Issue 5797, 2006, Pages 294-297

  Huang, Haojie ^a,b,c   Regan, Kevin M ^a,b   Lou, Zhenkun ^b   Chen, Junjie ^b   Tindall, Donald J ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b Mayo Clinic College of Medicine   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN-DEPENDENT KINASE 2 (CDK2); DNA DAMAGE; FORKHEAD BOX O (FOXO) TRANSCRIPTION FACTORS;

CELL CULTURE; CYTOLOGY; DNA; ENZYME INHIBITION; GENES; RNA;

ENZYME KINETICS;

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE 2; PROTEIN P53; SERINE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR;

CELL ORGANELLE; DNA; RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DEATH; CELL SURVIVAL; CELLULAR DISTRIBUTION; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SILENCING; GENOTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

ANIMALS; APOPTOSIS; CAMPTOTHECIN; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE 2; CYTOPLASM; DNA DAMAGE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MICE; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33750032892     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1130512     Document Type: Article

References (21)

1. J. Bartek, C. Lukas, J. Lukas, Nat. Rev. Mol. Cell Biol. 5, 792 (2004).
2. S. Matsuoka, M. Huang, S. J. Elledge, Science 282, 1893 (1998).
3. M. B. Kastan et al., Cell 71, 587 (1992).
4. N. Mailand et al., Science 288, 1425 (2000).
5. J. Falck, N. Mailand, R. G. Syljuasen, J, Bartek, J. Lukas, Nature 410, 842 (2001).
6. A. Brunet et al., Cell 96, 857 (1999).
7. J. Gilley, P. J. Coffer, J. Ham, J. Cell Biol. 162, 613 (2003).
8. V. Modur, R. Nagarajan, B. M. Evers, J. Milbrandt, J. Biol. Chem. 277, 47928 (2002).
9. D. Chatterjee et al., Cancer Res. 61, 7148 (2001).
10. C. Paquet, E. Schmitt, M. Beauchemin, R. Bertrand, Apoptosis 9, 815 (2004).
11. G. J. Kops et al., Nature 419, 316 (2002).
12. R. H. Medema, G. J. Kops, J. L. Bos, B. M. Burgering, Nature 404, 782 (2000).
13. A. Brunet et al., J. Cell Biol. 156, 817 (2002).
14. R. Fan et al., Cancer Res. 64, 8526 (2004).
15. E. L. Greer, A. Brunet, Oncogene 24, 7410 (2005).
16. J. Ford, M. Jiang, J. Milner, Cancer Res. 65, 10457 (2005).
17. J. Bartkova et al., Nature 434, 864 (2005).
18. V. G. Gorgoulis et al., Nature 434, 907 (2005).
19. C. H. Spruck, K. A. Won, S. I. Reed, Nature 401, 297 (1999).
20. A. Hirao et al., Science 287, 1824 (2000).
21. We thank K. L. Guan, M. Pagano, P. A. Khavari, M. E. Greenberg, and J. L. Bos for reagents and S. M. Dehm, A. Tang, and H. V. Heemers for stimulating discussions and critical reading of the manuscript. This work was supported by NIH grants DK65236, DK60920, and CA91956 and by the T. J. Martell Foundation.