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Volumn 284, Issue 4 47-4, 2003, Pages

Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation

Author keywords

Pancreatic duodenal homeobox 1; Ribonucleic acid interference; Small ubiquitin related modifier 1

Indexed keywords

COMPLEMENTARY DNA; INSULIN; LACTACYSTIN; SUMO 1 PROTEIN; TRANSCRIPTION FACTOR PDX 1;

EID: 0037376447     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00390.2002     Document Type: Article
Times cited : (85)

References (53)
  • 1
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp TR, Bernards R, and Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553, 2002.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 2
    • 0031007661 scopus 로고    scopus 로고
    • Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells
    • Carry MD, Lillquist JS, Peshavaria M, Stein R, and Soeller WC. Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells. J Biol Chem 272: 11986-11993, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 11986-11993
    • Carry, M.D.1    Lillquist, J.S.2    Peshavaria, M.3    Stein, R.4    Soeller, W.C.5
  • 3
    • 0032535483 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway: On protein death and cell life
    • Ciechanover A. The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J 17: 7151-7160, 1998.
    • (1998) EMBO J , vol.17 , pp. 7151-7160
    • Ciechanover, A.1
  • 4
    • 0032135131 scopus 로고    scopus 로고
    • SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation
    • Desterro JM, Rodriguez MS, and Hay RT. SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell 2:233-239, 1998.
    • (1998) Mol Cell , vol.2 , pp. 233-239
    • Desterro, J.M.1    Rodriguez, M.S.2    Hay, R.T.3
  • 5
    • 0033537828 scopus 로고    scopus 로고
    • Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1
    • Desterro JM, Rodriguez MS, Kemp GD, and Hay RT. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J Biol Chem 274: 10618-10624, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 10618-10624
    • Desterro, J.M.1    Rodriguez, M.S.2    Kemp, G.D.3    Hay, R.T.4
  • 6
    • 0033553415 scopus 로고    scopus 로고
    • Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance
    • Egawa K, Sharma PM, Nakashima N, Huang Y, Huver E, Boss GR, and Olefsky JM. Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance. J Biol Chem 274: 14306-14314, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 14306-14314
    • Egawa, K.1    Sharma, P.M.2    Nakashima, N.3    Huang, Y.4    Huver, E.5    Boss, G.R.6    Olefsky, J.M.7
  • 7
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498, 2001.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 8
    • 0035489991 scopus 로고    scopus 로고
    • Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1
    • Elrick LJ and Docherty K. Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1. Diabetes 50: 2244-2252, 2001.
    • (2001) Diabetes , vol.50 , pp. 2244-2252
    • Elrick, L.J.1    Docherty, K.2
  • 10
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon GJ. RNA interference. Nature 418: 244-251, 2002.
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 11
    • 0034070570 scopus 로고    scopus 로고
    • Adult human pancreatic duct, and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1
    • Heimberg H, Bouwens L, Heremans Y, Van De Casteele M, Lefebvre V, and Pipeleers D. Adult human pancreatic duct, and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1. Diabetes 49: 571-579, 2000.
    • (2000) Diabetes , vol.49 , pp. 571-579
    • Heimberg, H.1    Bouwens, L.2    Heremans, Y.3    Van De Casteele, M.4    Lefebvre, V.5    Pipeleers, D.6
  • 13
    • 0033168391 scopus 로고    scopus 로고
    • The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS
    • Hessabi B, Ziegler P, Schmidt I, Hessabi C, and Walther R. The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS. Eur J Biochem 263: 170-177, 1999.
    • (1999) Eur J Biochem , vol.263 , pp. 170-177
    • Hessabi, B.1    Ziegler, P.2    Schmidt, I.3    Hessabi, C.4    Walther, R.5
  • 15
    • 0030794729 scopus 로고    scopus 로고
    • The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba 2p heterodimer
    • Johnson ES, Schwienhorst I, Dohmen RJ, and Blobel G. The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J 16: 5509-5519, 1997.
    • (1997) EMBO J , vol.16 , pp. 5509-5519
    • Johnson, E.S.1    Schwienhorst, I.2    Dohmen, R.J.3    Blobel, G.4
  • 16
    • 0028149890 scopus 로고
    • Insulinpromoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, and Edlund H. Insulinpromoter-factor 1 is required for pancreas development in mice. Nature 371: 606-609, 1994.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 17
    • 1842410751 scopus 로고    scopus 로고
    • Preferential modification of nuclear proteins by a novel ubiquitin-like molecule
    • Kamitani T, Nguyen HP, and Yeh ET. Preferential modification of nuclear proteins by a novel ubiquitin-like molecule. J Biol Chem 272:14001-14004, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 14001-14004
    • Kamitani, T.1    Nguyen, H.P.2    Yeh, E.T.3
  • 19
    • 0031104910 scopus 로고    scopus 로고
    • SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter, and defines a novel gene family
    • Lapenta V, Chiurazzi P, van der Spek P, Pizzuti A, Hanaoka F, and Brahe C. SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter, and defines a novel gene family. Genomics 40: 362-366, 1997.
    • (1997) Genomics , vol.40 , pp. 362-366
    • Lapenta, V.1    Chiurazzi, P.2    Van der Spek, P.3    Pizzuti, A.4    Hanaoka, F.5    Brahe, C.6
  • 20
    • 0033534620 scopus 로고    scopus 로고
    • Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells
    • Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, and Docherty K. Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells. J Biol Chem 274:1011-1016, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 1011-1016
    • Macfarlane, W.M.1    McKinnon, C.M.2    Felton-Edkins, Z.A.3    Cragg, H.4    James, R.F.5    Docherty, K.6
  • 21
    • 0030932134 scopus 로고    scopus 로고
    • A small ubiquitin-related polypeptide involved in targeting Ran-GAP 1 to nuclear pore complex protein RanBP2
    • Mahajan R, Delphin C, Guan T, Gerace L, and Melchior F. A small ubiquitin -related polypeptide involved in targeting Ran-GAP1 to nuclear pore complex protein RanBP2. Cell 88: 97-107, 1997.
    • (1997) Cell , vol.88 , pp. 97-107
    • Mahajan, R.1    Delphin, C.2    Guan, T.3    Gerace, L.4    Melchior, F.5
  • 22
    • 0032567759 scopus 로고    scopus 로고
    • Molecular characterization of the SUMO-1 modification of RanGAP 1, and its role in nuclear envelope association
    • Mahajan R, Gerace L, and Melchior F. Molecular characterization of the SUMO-1 modification of RanGAP1, and its role in nuclear envelope association. J Cell Biol 140: 259-270, 1998.
    • (1998) J Cell Biol , vol.140 , pp. 259-270
    • Mahajan, R.1    Gerace, L.2    Melchior, F.3
  • 24
    • 0030455748 scopus 로고    scopus 로고
    • A novel ubiquitinlike modification modulates the partitioning of the Ran-GTPaseactivating protein RanGAP 1 between the cytosol and the nuclear pore complex
    • Matunis MJ, Coutavas E, and Blobel G. A novel ubiquitinlike modification modulates the partitioning of the Ran-GTPaseactivating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol 135: 1457-1470, 1996.
    • (1996) J Cell Biol , vol.135 , pp. 1457-1470
    • Matunis, M.J.1    Coutavas, E.2    Blobel, G.3
  • 25
    • 0034523266 scopus 로고    scopus 로고
    • SUMO-nonclassical ubiquitin
    • Melchior F. SUMO-nonclassical ubiquitin. Annu Rev Cell Dev Biol 16: 591-626, 2000.
    • (2000) Annu Rev Cell Dev Biol , vol.16 , pp. 591-626
    • Melchior, F.1
  • 26
    • 0036210550 scopus 로고    scopus 로고
    • Regulation of insulin gene transcription
    • Melloul D, Marshak S, and Cerasi E. Regulation of insulin gene transcription. Diabetologia 45: 309-326, 2002.
    • (2002) Diabetologia , vol.45 , pp. 309-326
    • Melloul, D.1    Marshak, S.2    Cerasi, E.3
  • 27
    • 0028314969 scopus 로고
    • IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
    • Miller CP, McGehee RE Jr, and Habener JF. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J 13: 1145-1156, 1994.
    • (1994) EMBO J , vol.13 , pp. 1145-1156
    • Miller, C.P.1    McGehee R.E., Jr.2    Habener, J.F.3
  • 28
    • 0032739288 scopus 로고    scopus 로고
    • Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1
    • Moede T, Leibiger B, Pour HG, Berggren P, and Leibiger IB. Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1. FEBS Lett 461: 229-234, 1999.
    • (1999) FEBS Lett , vol.461 , pp. 229-234
    • Moede, T.1    Leibiger, B.2    Pour, H.G.3    Berggren, P.4    Leibiger, I.B.5
  • 34
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson H, Karlsson K, and Edlund T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12: 4251-4259, 1993.
    • (1993) EMBO J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 35
    • 0027944249 scopus 로고
    • Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes
    • Petersen HV, Setup P, Leonard J, Michelsen BK, and Madsen OD. Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc Natl Acad Sci USA 91: 10465-10469, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10465-10469
    • Petersen, H.V.1    Setup, P.2    Leonard, J.3    Michelsen, B.K.4    Madsen, O.D.5
  • 36
    • 0030772933 scopus 로고    scopus 로고
    • Targeting of substrates to the 26S proteasome
    • Pickart CM. Targeting of substrates to the 26S proteasome. FASEB J 11: 1055-1066, 1997.
    • (1997) FASEB J , vol.11 , pp. 1055-1066
    • Pickart, C.M.1
  • 37
    • 0034717337 scopus 로고    scopus 로고
    • Glucose-stimulated preproinsulin gene expression, and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2
    • Rafiq I, da Silva Xavier G, Hooper S, and Rutter GA. Glucose-stimulated preproinsulin gene expression, and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/ SAPK2. J Biol Chem 275: 15977-15984, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 15977-15984
    • Rafiq, I.1    Da Silva Xavier, G.2    Hooper, S.3    Rutter, G.A.4
  • 38
    • 0035918226 scopus 로고    scopus 로고
    • SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting
    • Rodriguez MS, Dargemont C, and Hay RT. SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J Biol Chem 276: 12654-12659, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 12654-12659
    • Rodriguez, M.S.1    Dargemont, C.2    Hay, R.T.3
  • 40
    • 0034054669 scopus 로고    scopus 로고
    • Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3
    • Saitoh H and Hinchey J. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J Biol Chem 275: 6252-6258, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 6252-6258
    • Saitoh, H.1    Hinchey, J.2
  • 41
    • 0030963425 scopus 로고    scopus 로고
    • RanBP 2 associates with Ubc9p and a modified form of RanGAP1
    • Saitoh H, Pu R, Cavenagh M, and Dasso M. RanBP2 associates with Ubc9p and a modified form of RanGAP1. Proc Natl Acad Sci USA 94: 3736-3741, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3736-3741
    • Saitoh, H.1    Pu, R.2    Cavenagh, M.3    Dasso, M.4
  • 42
    • 0033976650 scopus 로고    scopus 로고
    • Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells
    • Sayo Y, Hosokawa H, Imachi H, Murao K, Sato M, Wong NC, Ishida T, and Takahara J. Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells. Eur J Biochem 267: 971-978, 2000.
    • (2000) Eur J Biochem , vol.267 , pp. 971-978
    • Sayo, Y.1    Hosokawa, H.2    Imachi, H.3    Murao, K.4    Sato, M.5    Wong, N.C.6    Ishida, T.7    Takahara, J.8
  • 43
    • 0035969102 scopus 로고    scopus 로고
    • SUMO of branched proteins and nuclear bodies
    • Seeler JS and Dejean A. SUMO: of branched proteins and nuclear bodies. Oncogene 20: 7243-7249, 2001.
    • (2001) Oncogene , vol.20 , pp. 7243-7249
    • Seeler, J.S.1    Dejean, A.2
  • 44
    • 0029166081 scopus 로고
    • The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site
    • Serup P, Petersen HV, Pedersen EE, Edlund H, Leonard J, Petersen JS, Larsson LI, and Madsen OD. The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site. Biochem J 310: 997-1003, 1995.
    • (1995) Biochem J , vol.310 , pp. 997-1003
    • Serup, P.1    Petersen, H.V.2    Pedersen, E.E.3    Edlund, H.4    Leonard, J.5    Petersen, J.S.6    Larsson, L.I.7    Madsen, O.D.8
  • 45
    • 0031031571 scopus 로고    scopus 로고
    • Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
    • Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, and Habener JF. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 15: 106-110, 1997.
    • (1997) Nat Genet , vol.15 , pp. 106-110
    • Stoffers, D.A.1    Zinkin, N.T.2    Stanojevic, V.3    Clarke, W.L.4    Habener, J.F.5
  • 46
    • 0030457705 scopus 로고    scopus 로고
    • Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
    • Waeber G, Thompson N, Nicod P, and Bonny C. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol 10: 1327-1334, 1996.
    • (1996) Mol Endocrinol , vol.10 , pp. 1327-1334
    • Waeber, G.1    Thompson, N.2    Nicod, P.3    Bonny, C.4
  • 47
    • 0033305746 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells
    • Wang X, Cahill CM, Pineyro MA, Zhou J, Doyle ME, and Egan JM. Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology 140: 4904-4907, 1999.
    • (1999) Endocrinology , vol.140 , pp. 4904-4907
    • Wang, X.1    Cahill, C.M.2    Pineyro, M.A.3    Zhou, J.4    Doyle, M.E.5    Egan, J.M.6
  • 48
    • 0035046251 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic betacells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism
    • Wang X, Zhou J, Doyle ME, and Egan JM. Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic betacells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology 142: 1820-1827, 2001.
    • (2001) Endocrinology , vol.142 , pp. 1820-1827
    • Wang, X.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 50
    • 0035890322 scopus 로고    scopus 로고
    • Intracellular targeting of proteins by sumoylation
    • Wilson VG and Rangasamy D. Intracellular targeting of proteins by sumoylation. Exp Cell Res 271: 57-65, 2001.
    • (2001) Exp Cell Res , vol.271 , pp. 57-65
    • Wilson, V.G.1    Rangasamy, D.2
  • 51
    • 0033572844 scopus 로고    scopus 로고
    • Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells
    • Wu H, MacFarlane WM, Tadayyon M, Arch JR, James RF, and Docherty K. Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells. Biochem J 344: 813-818, 1999.
    • (1999) Biochem J , vol.344 , pp. 813-818
    • Wu, H.1    MacFarlane, W.M.2    Tadayyon, M.3    Arch, J.R.4    James, R.F.5    Docherty, K.6
  • 53
    • 0034595239 scopus 로고    scopus 로고
    • Ubiquitin-like proteins: New wines in new bottles
    • Yeh ET, Gong L, and Kamitani T. Ubiquitin-like proteins: new wines in new bottles. Gene 248: 1-14, 2000.
    • (2000) Gene , vol.248 , pp. 1-14
    • Yeh, E.T.1    Gong, L.2    Kamitani, T.3


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