메뉴 건너뛰기




Volumn 9, Issue SUPPL. 2, 2007, Pages 140-146

Regulation of pancreatic β-cell function by the forkhead protein FoxO1

Author keywords

Diabetes; Glycolysis; Incretin; Premature senescence; Transcriptional repression; cell rest

Indexed keywords

BIM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; EPIDERMAL GROWTH FACTOR RECEPTOR; EXENDIN 4; FAS LIGAND; GLUCAGON LIKE PEPTIDE 1; HEPATOCYTE NUCLEAR FACTOR 3BETA; HISTONE ACETYLTRANSFERASE PCAF; NEUROGENIC DIFFERENTIATION FACTOR; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN KINASE B; SIRTUIN; SOMATOMEDIN B; SOMATOMEDIN C; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

EID: 35148877285     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2007.00782.x     Document Type: Conference Paper
Times cited : (97)

References (46)
  • 1
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • Biggs WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A 1999; 96: 7421-7426.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7421-7426
    • Biggs, W.H.1    Meisenhelder, J.2    Hunter, T.3    Cavenee, W.K.4    Arden, K.C.5
  • 2
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999; 96: 857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3
  • 3
    • 0033546192 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
    • Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem 1999; 274: 17184-17192.
    • (1999) J Biol Chem , vol.274 , pp. 17184-17192
    • Guo, S.1    Rena, G.2    Cichy, S.3    He, X.4    Cohen, P.5    Unterman, T.6
  • 5
    • 0033522897 scopus 로고    scopus 로고
    • Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
    • Nakae J, Park BC, Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem 1999; 274: 15982-15985.
    • (1999) J Biol Chem , vol.274 , pp. 15982-15985
    • Nakae, J.1    Park, B.C.2    Accili, D.3
  • 6
    • 0033546439 scopus 로고    scopus 로고
    • Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
    • Rena G, Guo S, Cichy SC, Unterman TG, Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 1999; 274: 17179-17183.
    • (1999) J Biol Chem , vol.274 , pp. 17179-17183
    • Rena, G.1    Guo, S.2    Cichy, S.C.3    Unterman, T.G.4    Cohen, P.5
  • 7
    • 0039425278 scopus 로고    scopus 로고
    • Negative regulation of the forkhead transcription factor FKHR by Akt
    • Tang ED, Nunez G, Barr FG, Guan KL. Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem 1999; 274: 16741-16746.
    • (1999) J Biol Chem , vol.274 , pp. 16741-16746
    • Tang, E.D.1    Nunez, G.2    Barr, F.G.3    Guan, K.L.4
  • 8
    • 11244320393 scopus 로고    scopus 로고
    • FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
    • Essers MA, Weijzen S, de Vries-Smits AM et al. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. Embo J 2004; 23: 4802-4812.
    • (2004) Embo J , vol.23 , pp. 4802-4812
    • Essers, M.A.1    Weijzen, S.2    de Vries-Smits, A.M.3
  • 9
    • 11144357466 scopus 로고    scopus 로고
    • IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu MC, Lee DF, Xia W et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004; 117: 225-237.
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1    Lee, D.F.2    Xia, W.3
  • 10
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A, Sweeney LB, Sturgill JF et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303: 2011-2015.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3
  • 11
    • 3042750643 scopus 로고    scopus 로고
    • Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
    • Daitoku H, Hatta M, Matsuzaki H et al. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A 2004; 101: 10042-10047.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10042-10047
    • Daitoku, H.1    Hatta, M.2    Matsuzaki, H.3
  • 12
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • Motta MC, Divecha N, Lemieux M et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004; 116: 551-563.
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1    Divecha, N.2    Lemieux, M.3
  • 14
    • 27744518040 scopus 로고    scopus 로고
    • FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    • Kitamura YI, Kitamura T, Kruse JP et al. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab 2005; 2: 153-163.
    • (2005) Cell Metab , vol.2 , pp. 153-163
    • Kitamura, Y.I.1    Kitamura, T.2    Kruse, J.P.3
  • 15
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000; 404: 782-787.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 17
    • 0034609737 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic bcl-2 family member bim is regulated by the forkhead transcription factor FKHR-L1
    • Dijkers PF, Medemadagger RH, Lammers JJ, Koenderman L, Coffer PJ. Expression of the pro-apoptotic bcl-2 family member bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 2000; 10: 1201-1204.
    • (2000) Curr Biol , vol.10 , pp. 1201-1204
    • Dijkers, P.F.1    Medemadagger, R.H.2    Lammers, J.J.3    Koenderman, L.4    Coffer, P.J.5
  • 18
    • 0036651790 scopus 로고    scopus 로고
    • A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
    • Ramaswamy S, Nakamura N, Sansal I, Bergeron L, Sellers WR. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2002; 2: 81-91.
    • (2002) Cancer Cell , vol.2 , pp. 81-91
    • Ramaswamy, S.1    Nakamura, N.2    Sansal, I.3    Bergeron, L.4    Sellers, W.R.5
  • 20
    • 0035951791 scopus 로고    scopus 로고
    • 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts
    • 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem 2001; 276: 2531-2537.
    • (2001) J Biol Chem , vol.276 , pp. 2531-2537
    • Frippiat, C.1    Chen, Q.M.2    Zdanov, S.3    Magalhaes, J.P.4    Remacle, J.5    Toussaint, O.6
  • 21
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto S, Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 2002; 295: 2450-2452.
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 22
    • 0036629251 scopus 로고    scopus 로고
    • Cell cycle and death control: Long live forkheads
    • Burgering BM, Kops GJ. Cell cycle and death control: Long live forkheads. Trends Biochem Sci 2002; 27: 352-360.
    • (2002) Trends Biochem Sci , vol.27 , pp. 352-360
    • Burgering, B.M.1    Kops, G.J.2
  • 23
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999; 96: 329-339.
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 24
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
    • Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet 1999; 23: 32-40.
    • (1999) Nat Genet , vol.23 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4    Flint, C.L.5    White, M.F.6
  • 25
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • Withers DJ, Sanchez-Gutierrez J, Towery H et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998; 391: 900-904.
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1    Sanchez-Gutierrez, J.2    Towery, H.3
  • 26
    • 0033755408 scopus 로고    scopus 로고
    • Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
    • Kubota N, Tobe K, Terauchi Y et al. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 2000; 49: 1880-1889.
    • (2000) Diabetes , vol.49 , pp. 1880-1889
    • Kubota, N.1    Tobe, K.2    Terauchi, Y.3
  • 27
    • 0036950665 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    • Kitamura T, Nakae J, Kitamura Y et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 2002; 110: 1839-1847.
    • (2002) J Clin Invest , vol.110 , pp. 1839-1847
    • Kitamura, T.1    Nakae, J.2    Kitamura, Y.3
  • 28
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994; 371: 606-609.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 29
    • 0032525981 scopus 로고    scopus 로고
    • Edlund H, beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
    • Ahlgren U, Jonsson J, Jonsson L, Simu K. Edlund H, beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 1998; 12: 1763-1768.
    • (1998) Genes Dev , vol.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonsson, J.2    Jonsson, L.3    Simu, K.4
  • 31
    • 33644865024 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
    • Kawamori D, Kaneto H, Nakatani Y et al. The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J Biol Chem 2006; 281: 1091-1098.
    • (2006) J Biol Chem , vol.281 , pp. 1091-1098
    • Kawamori, D.1    Kaneto, H.2    Nakatani, Y.3
  • 32
    • 0345618266 scopus 로고    scopus 로고
    • Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes
    • Hennige AM, Burks DJ, Ozcan U et al. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest 2003; 112: 1521-1532.
    • (2003) J Clin Invest , vol.112 , pp. 1521-1532
    • Hennige, A.M.1    Burks, D.J.2    Ozcan, U.3
  • 33
    • 33644660954 scopus 로고    scopus 로고
    • Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance
    • Okamoto H, Hribal ML, Lin HV, Bennett WR, Ward A, Accili D. Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. J Clin Invest 2006; 116: 775-782.
    • (2006) J Clin Invest , vol.116 , pp. 775-782
    • Okamoto, H.1    Hribal, M.L.2    Lin, H.V.3    Bennett, W.R.4    Ward, A.5    Accili, D.6
  • 34
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
    • Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 2003; 52: 581-587.
    • (2003) Diabetes , vol.52 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5
  • 35
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 1996; 20: 463-466.
    • (1996) Free Radic Biol Med , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 36
    • 0029401861 scopus 로고
    • Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus
    • Welsh N, Margulis B, Borg LA et al. Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus. Mol Med 1995; 1: 806-820.
    • (1995) Mol Med , vol.1 , pp. 806-820
    • Welsh, N.1    Margulis, B.2    Borg, L.A.3
  • 37
    • 0029893530 scopus 로고    scopus 로고
    • Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells
    • Harbeck MC, Louie DC, Howland J, Wolf BA, Rothenberg PL. Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells. Diabetes 1996; 45: 711-717.
    • (1996) Diabetes , vol.45 , pp. 711-717
    • Harbeck, M.C.1    Louie, D.C.2    Howland, J.3    Wolf, B.A.4    Rothenberg, P.L.5
  • 38
    • 11144356337 scopus 로고    scopus 로고
    • Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
    • Sandri M, Sandri C, Gilbert A et al. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 2004; 117: 399-412.
    • (2004) Cell , vol.117 , pp. 399-412
    • Sandri, M.1    Sandri, C.2    Gilbert, A.3
  • 39
    • 2042425906 scopus 로고    scopus 로고
    • The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
    • Stitt TN, Drujan D, Clarke BA et al. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 2004; 14: 395-403.
    • (2004) Mol Cell , vol.14 , pp. 395-403
    • Stitt, T.N.1    Drujan, D.2    Clarke, B.A.3
  • 40
    • 0037147215 scopus 로고    scopus 로고
    • Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1)
    • Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ. Protein kinase B/ Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 2002; 277: 49676-49684.
    • (2002) J Biol Chem , vol.277 , pp. 49676-49684
    • Wrede, C.E.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    Rhodes, C.J.5
  • 41
    • 33846975788 scopus 로고    scopus 로고
    • Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1
    • Buteau J, Shlien A, Foisy S, Accili D. Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1. J Biol Chem 2007; 282: 287-293.
    • (2007) J Biol Chem , vol.282 , pp. 287-293
    • Buteau, J.1    Shlien, A.2    Foisy, S.3    Accili, D.4
  • 42
    • 33745315716 scopus 로고    scopus 로고
    • Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass
    • Buteau J, Spatz ML, Accili D. Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes 2006; 55: 1190-1196.
    • (2006) Diabetes , vol.55 , pp. 1190-1196
    • Buteau, J.1    Spatz, M.L.2    Accili, D.3
  • 43
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 2006; 3: 153-165.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 44
    • 0032768616 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
    • Buteau J, Roduit R, Susini S, Prentki M. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 1999; 42: 856-864.
    • (1999) Diabetologia , vol.42 , pp. 856-864
    • Buteau, J.1    Roduit, R.2    Susini, S.3    Prentki, M.4
  • 45
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000; 49: 741-748.
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3
  • 46
    • 0037221488 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor
    • Buteau J, Foisy S, Joly E, Prentki M. Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes 2003; 52: 124-132.
    • (2003) Diabetes , vol.52 , pp. 124-132
    • Buteau, J.1    Foisy, S.2    Joly, E.3    Prentki, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.