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Volumn 54, Issue 4, 2007, Pages 507-515

Role of FoxO proteins in pancreatic β cells

Author keywords

cell; Diabetes; FoxO1; Pancreas; Transcription factor

Indexed keywords

GLUCOSE; INSULIN; PROTEIN NKX 2.2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

EID: 34548670709     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.KR-109     Document Type: Review
Times cited : (95)

References (83)
  • 1
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994-999.
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6    Ruvkun, G.7
  • 2
    • 0030657540 scopus 로고    scopus 로고
    • daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • Lin K, Dorman JB, Rodan A, Kenyon C (1997) daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278: 1319-1322.
    • (1997) Science , vol.278 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 6
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • Biggs WH 3rd, Meisenhelder J, Hunter T, Cavenee WK, Arden KC (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96: 7421-7426.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7421-7426
    • Biggs 3rd, W.H.1    Meisenhelder, J.2    Hunter, T.3    Cavenee, W.K.4    Arden, K.C.5
  • 8
    • 0033546192 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
    • Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T (1999) Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem 274: 17184-17192.
    • (1999) J Biol Chem , vol.274 , pp. 17184-17192
    • Guo, S.1    Rena, G.2    Cichy, S.3    He, X.4    Cohen, P.5    Unterman, T.6
  • 10
    • 0033522897 scopus 로고    scopus 로고
    • Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
    • Nakae J, Park BC, Accili D (1999) Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem 274: 15982-15985.
    • (1999) J Biol Chem , vol.274 , pp. 15982-15985
    • Nakae, J.1    Park, B.C.2    Accili, D.3
  • 11
    • 0033546439 scopus 로고    scopus 로고
    • Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
    • Rena G, Guo S, Cichy SC, Unterman TG, Cohen P (1999) Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 274: 17179-17183.
    • (1999) J Biol Chem , vol.274 , pp. 17179-17183
    • Rena, G.1    Guo, S.2    Cichy, S.C.3    Unterman, T.G.4    Cohen, P.5
  • 12
    • 0039425278 scopus 로고    scopus 로고
    • Negative regulation of the forkhead transcription factor FKHR by Akt
    • Tang ED, Nunez G, Barr FG, Guan KL (1999) Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem 274: 16741-16746.
    • (1999) J Biol Chem , vol.274 , pp. 16741-16746
    • Tang, E.D.1    Nunez, G.2    Barr, F.G.3    Guan, K.L.4
  • 16
    • 33750032892 scopus 로고    scopus 로고
    • CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
    • Huang H, Regan KM, Lou Z, Chen J, Tindall DJ (2006) CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314: 294-297.
    • (2006) Science , vol.314 , pp. 294-297
    • Huang, H.1    Regan, K.M.2    Lou, Z.3    Chen, J.4    Tindall, D.J.5
  • 22
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM (2000) AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404: 782-787.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 23
    • 0034609737 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic bcl-2 family member bim is regulated by the forkhead transcription factor FKHR-L1
    • Dijkers PF, Medemadagger RH, Lammers JJ, Koenderman L, Coffer PJ (2000) Expression of the pro-apoptotic bcl-2 family member bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10: 1201-1204.
    • (2000) Curr Biol , vol.10 , pp. 1201-1204
    • Dijkers, P.F.1    Medemadagger, R.H.2    Lammers, J.J.3    Koenderman, L.4    Coffer, P.J.5
  • 24
    • 0036651790 scopus 로고    scopus 로고
    • A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
    • Ramaswamy S, Nakamura N, Sansal I, Bergeron L, Sellers WR (2002) A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2: 81-91.
    • (2002) Cancer Cell , vol.2 , pp. 81-91
    • Ramaswamy, S.1    Nakamura, N.2    Sansal, I.3    Bergeron, L.4    Sellers, W.R.5
  • 25
    • 0034655373 scopus 로고    scopus 로고
    • Apoptosis or senescence-like growth arrest: Influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts
    • Chen QM, Liu J, Merrett JB (2000) Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem J 347: 543-551.
    • (2000) Biochem J , vol.347 , pp. 543-551
    • Chen, Q.M.1    Liu, J.2    Merrett, J.B.3
  • 26
    • 0035951791 scopus 로고    scopus 로고
    • Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts
    • Frippiat C, Chen QM, Zdanov S, Magalhaes JP, Remacle J, Toussaint O (2001) Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem 276: 2531-2537.
    • (2001) J Biol Chem , vol.276 , pp. 2531-2537
    • Frippiat, C.1    Chen, Q.M.2    Zdanov, S.3    Magalhaes, J.P.4    Remacle, J.5    Toussaint, O.6
  • 27
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto S, Finkel T (2002) Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295: 2450-2452.
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 29
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane J, Le HV, Shen L, Anderson SA, Massague J (2004) Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117: 211-223.
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 32
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    • Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D (2002) Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet 32: 245-253.
    • (2002) Nat Genet , vol.32 , pp. 245-253
    • Nakae, J.1    Biggs, W.H.2    Kitamura, T.3    Cavenee, W.K.4    Wright, C.V.5    Arden, K.C.6    Accili, D.7
  • 35
    • 30044452201 scopus 로고    scopus 로고
    • The tangled path to glucose production
    • discussion 34
    • Matsumoto M, Accili D (2006) The tangled path to glucose production. Nat Med 12: 33-34; discussion 34.
    • (2006) Nat Med , vol.12 , pp. 33-34
    • Matsumoto, M.1    Accili, D.2
  • 36
    • 33744515637 scopus 로고    scopus 로고
    • FoxO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipogenic gene expression
    • Zhang W, Patil S, Chauhan B, Guo S, Powell DR, Le J, Klotsas A, Matika R, Xiao X, Franks R, et al. (2006) FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem 281: 10105-10117.
    • (2006) J Biol Chem , vol.281 , pp. 10105-10117
    • Zhang, W.1    Patil, S.2    Chauhan, B.3    Guo, S.4    Powell, D.R.5    Le, J.6    Klotsas, A.7    Matika, R.8    Xiao, X.9    Franks, R.10
  • 38
    • 0042477748 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors
    • Hribal ML, Nakae J, Kitamura T, Shutter JR, Accili D (2003) Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J Cell Biol 162: 535-541.
    • (2003) J Cell Biol , vol.162 , pp. 535-541
    • Hribal, M.L.1    Nakae, J.2    Kitamura, T.3    Shutter, J.R.4    Accili, D.5
  • 39
    • 4544358547 scopus 로고    scopus 로고
    • Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
    • Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, et al. (2004) Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J Biol Chem 279: 41114-41123.
    • (2004) J Biol Chem , vol.279 , pp. 41114-41123
    • Kamei, Y.1    Miura, S.2    Suzuki, M.3    Kai, Y.4    Mizukami, J.5    Taniguchi, T.6    Mochida, K.7    Hata, T.8    Matsuda, J.9    Aburatani, H.10
  • 41
    • 17144428529 scopus 로고    scopus 로고
    • FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms
    • Bastie CC, Nahle Z, McLoughlin T, Esser K, Zhang W, Unterman T, Abumrad NA (2005) FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms. J Biol Chem 280: 14222-14229.
    • (2005) J Biol Chem , vol.280 , pp. 14222-14229
    • Bastie, C.C.1    Nahle, Z.2    McLoughlin, T.3    Esser, K.4    Zhang, W.5    Unterman, T.6    Abumrad, N.A.7
  • 43
    • 22944451474 scopus 로고    scopus 로고
    • Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin
    • Liu ZP, Wang Z, Yanagisawa H, Olson EN (2005) Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Dev Cell 9: 261-270.
    • (2005) Dev Cell , vol.9 , pp. 261-270
    • Liu, Z.P.1    Wang, Z.2    Yanagisawa, H.3    Olson, E.N.4
  • 45
  • 48
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96: 329-339.
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 49
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
    • Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF (1999) Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nature Genet 23: 32-40.
    • (1999) Nature Genet , vol.23 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4    Flint, C.L.5    White, M.F.6
  • 51
    • 0033755408 scopus 로고    scopus 로고
    • Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
    • Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, et al. (2000) Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 49: 1880-1889.
    • (2000) Diabetes , vol.49 , pp. 1880-1889
    • Kubota, N.1    Tobe, K.2    Terauchi, Y.3    Eto, K.4    Yamauchi, T.5    Suzuki, R.6    Tsubamoto, Y.7    Komeda, K.8    Nakano, R.9    Miki, H.10
  • 52
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371: 606-609.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 53
    • 0032525981 scopus 로고    scopus 로고
    • beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell pheno-type and maturity onset diabetes
    • Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H (1998) beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell pheno-type and maturity onset diabetes. Genes Dev 12: 1763-1768.
    • (1998) Genes Dev , vol.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonsson, J.2    Jonsson, L.3    Simu, K.4    Edlund, H.5
  • 55
    • 33644865024 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
    • Kawamori D, Kaneto H, Nakatani Y, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y (2006) The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J Biol Chem 281: 1091-1098.
    • (2006) J Biol Chem , vol.281 , pp. 1091-1098
    • Kawamori, D.1    Kaneto, H.2    Nakatani, Y.3    Matsuoka, T.A.4    Matsuhisa, M.5    Hori, M.6    Yamasaki, Y.7
  • 57
    • 0029950724 scopus 로고    scopus 로고
    • The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    • Ahlgren U, Jonsson J, Edlund H (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122: 1409-1416.
    • (1996) Development , vol.122 , pp. 1409-1416
    • Ahlgren, U.1    Jonsson, J.2    Edlund, H.3
  • 58
    • 0028869514 scopus 로고
    • Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CV, Teitelman G (1995) Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121: 11-18.
    • (1995) Development , vol.121 , pp. 11-18
    • Guz, Y.1    Montminy, M.R.2    Stein, R.3    Leonard, J.4    Gamer, L.W.5    Wright, C.V.6    Teitelman, G.7
  • 59
    • 0028314969 scopus 로고
    • IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
    • Miller CP, McGehee RE Jr, Habener JF (1994) IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. Embo J 13: 1145-1156.
    • (1994) Embo J , vol.13 , pp. 1145-1156
    • Miller, C.P.1    McGehee Jr, R.E.2    Habener, J.F.3
  • 60
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson H, Karlsson K, Edlund T (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. Embo J 12: 4251-4259.
    • (1993) Embo J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 61
    • 0031843386 scopus 로고    scopus 로고
    • Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
    • Sussel L, Kalamaras J, Hartigan OCDJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS (1998) Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 125: 2213-2221.
    • (1998) Development , vol.125 , pp. 2213-2221
    • Sussel, L.1    Kalamaras, J.2    Hartigan, O.C.D.J.3    Meneses, J.J.4    Pedersen, R.A.5    Rubenstein, J.L.6    German, M.S.7
  • 63
    • 0347722280 scopus 로고    scopus 로고
    • The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
    • Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B (2004) The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol 266: 178-189.
    • (2004) Dev Biol , vol.266 , pp. 178-189
    • Wang, J.1    Elghazi, L.2    Parker, S.E.3    Kizilocak, H.4    Asano, M.5    Sussel, L.6    Sosa-Pineda, B.7
  • 66
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129: 2447-2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 67
    • 0034652287 scopus 로고    scopus 로고
    • neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, LeMeur M, Guillemot F (2000) neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97: 1607-1611.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 68
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 69
    • 9644266753 scopus 로고    scopus 로고
    • Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • Georgia S, Bhushan A (2004) Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 114: 963-968.
    • (2004) J Clin Invest , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 70
    • 0027276885 scopus 로고
    • Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice
    • Gu D, Sarvetnick N (1993) Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development 118: 33-46.
    • (1993) Development , vol.118 , pp. 33-46
    • Gu, D.1    Sarvetnick, N.2
  • 71
    • 0028243350 scopus 로고
    • Transitional cells in the regenerating pancreas
    • Gu D, Lee MS, Krahl T, Sarvetnick N (1994) Transitional cells in the regenerating pancreas. Development 120: 1873-1881.
    • (1994) Development , vol.120 , pp. 1873-1881
    • Gu, D.1    Lee, M.S.2    Krahl, T.3    Sarvetnick, N.4
  • 72
    • 0028793314 scopus 로고
    • Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
    • Wang RN, Kloppel G, Bouwens L (1995) Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia 38: 1405-1411.
    • (1995) Diabetologia , vol.38 , pp. 1405-1411
    • Wang, R.N.1    Kloppel, G.2    Bouwens, L.3
  • 74
    • 0036070177 scopus 로고    scopus 로고
    • Pancreatic stem cells
    • Bonner-Weir S, Sharma A (2002) Pancreatic stem cells. J Pathol 197: 519-526.
    • (2002) J Pathol , vol.197 , pp. 519-526
    • Bonner-Weir, S.1    Sharma, A.2
  • 75
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
    • Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE (1993) A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42: 1715-1720.
    • (1993) Diabetes , vol.42 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 76
    • 0026693159 scopus 로고
    • Ultrastructure of the rat pancreas after experimental duct ligation. II. Duct and stromal cell proliferation, differentiation, and deletion
    • Walker NI, Winterford CM, Kerr JF (1992) Ultrastructure of the rat pancreas after experimental duct ligation. II. Duct and stromal cell proliferation, differentiation, and deletion. Pancreas 7: 420-434.
    • (1992) Pancreas , vol.7 , pp. 420-434
    • Walker, N.I.1    Winterford, C.M.2    Kerr, J.F.3
  • 77
    • 0020639481 scopus 로고
    • A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas
    • Rosenberg L, Brown RA, Duguid WP (1983) A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas. J Surg Res 35: 63-72.
    • (1983) J Surg Res , vol.35 , pp. 63-72
    • Rosenberg, L.1    Brown, R.A.2    Duguid, W.P.3
  • 78
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S (1999) Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48: 2270-2276.
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 79
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
    • Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H (2003) Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52: 581-587.
    • (2003) Diabetes , vol.52 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5
  • 80
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S, Drinkgern J, Tiedge M (1996) Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 20: 463-466.
    • (1996) Free Radic Biol Med , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 81
    • 0029401861 scopus 로고
    • Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus
    • Welsh N, Margulis B, Borg LA, Wiklund HJ, Saldeen J, Flodstrom M, Mello MA, Andersson A, Pipeleers DG, Hellerstrom C, et al. (1995) Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus. Mol Med 1: 806-820.
    • (1995) Mol Med , vol.1 , pp. 806-820
    • Welsh, N.1    Margulis, B.2    Borg, L.A.3    Wiklund, H.J.4    Saldeen, J.5    Flodstrom, M.6    Mello, M.A.7    Andersson, A.8    Pipeleers, D.G.9    Hellerstrom, C.10
  • 82
    • 0029893530 scopus 로고    scopus 로고
    • Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells
    • Harbeck MC, Louie DC, Howland J, Wolf BA, Rothenberg PL (1996) Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells. Diabetes 45: 711-717.
    • (1996) Diabetes , vol.45 , pp. 711-717
    • Harbeck, M.C.1    Louie, D.C.2    Howland, J.3    Wolf, B.A.4    Rothenberg, P.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.