Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 2 37-2, 1998, Pages

  Diraison, Frederique ^a   Beylot, Michel ^a,b,c  

^a Lab Physiopathol Metabolique R   (France)

^b Ctr de Rech en Nutr Hum de Lyon   (France)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

Indirect calorimetry; Lipids; Mass spectrometry; Oxidation; Stable isotopes

Indexed keywords

DEUTERIUM OXIDE; FATTY ACID; GLYCEROL; PALMITIC ACID; TRIACYLGLYCEROL;

ADULT; ARTICLE; ESTERIFICATION; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; LIPID METABOLISM; LIPID OXIDATION; LIPOGENESIS; MALE; NORMAL HUMAN; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0031887281     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.2.e321     Document Type: Article

References (40)

1. Aarsland, A., D. Chinkes, and R. R. Wolfe. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J. Clin. Invest. 98: 2008-2017, 1996.
2. Barter, P. J., and P. J. Nestel. Precursors of plasma triglyceride fatty acids in obesity. Metabolism 22: 779-785, 1973.
3. Beylot, M., C. Martin, B. Beaufrere, J. P. Riou, and R. Mornex. Determination of steady-state and nonsteady-state glycerol kinetics in humans using deuterium-labeled tracer. J. Lipid Res. 28: 414-422, 1987.
4. Beylot, M., C. Martin, M. Laville, J. P. Riou, R. Cohen, and R. Mornex. Lipolytic and ketogenic flux in hyperthyroidism. J. Clin. Endocrinol. Metab. 73: 42-49, 1991.
5. Beylot, M., J. P. Riou, F. Bienvenu, and R. Mornex. Increased ketonemia in hyperthyroidism; evidence for a β-adernergic mechanism. Diabetologia 19: 505-510, 1983.
6. Binnert, C., M. Laville, C. Pachiaudi, V. Rigalleau, and M. Beylot. Use of gas chromatography isotope ratio mass spectrometry to study triglycerides metabolism in humans. Lipids 30: 869-873, 1995.
7. Budohoski, L., J. Gorski, K. Nazar, H. Kaciuba-Uscilko, and R. L. Terjung. Triacylglycerol synthesis in the different skeletal muscle fiber sections of the rat. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E574-E581, 1996.
8. Dagenais, G. R., R. G. Tancredi, and K. L. Zierler. Free fatty acid oxidation by forearm muscle at rest and evidence for an intramuscular lipid pool in the human forearm. J. Clin. Invest. 58: 421-431, 1976.
9. Dagher, J. F., J. H. Lyons, D. C. Finlayson, J. Shamsai, and F. D. Moore. Blood volume measurement: a critical study. Adv. Surg. 1: 69-109, 1965.
10. Diraison, F., C. Pachiaudi, and M. Beylot. Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatography-mass spectrometry techniques. J. Mass Spectrom. 32: 81-86, 1997.
11. Folch, J., M. Lees, and G. H. Sloane Stanley. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509, 1957.
12. Fontbonne, A., E. Eschwege, and F. Cambien. Hypertriglyceridemia as a risk factor of coronary heart disease in subjects with impaired glucose tolerance or diabetes. The Paris prospective study. Diabetologia 32: 300-304, 1989.
13. Frayn, K. N. Calculation of substrate oxidation rates in vivo from gaseous exchange. J. Appl. Physiol. 55: 628-634, 1983.
14. Groop, L. C., R. C. Bonadonna, M. Shank, A. S. Petrides, and R. A. DeFronzo. Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man. J. Clin. Invest. 87: 83-89, 1991.
15. Grundy, S. M., H. Y. I. Mok, L. Zech, D. Steinberg, and M. Berman. Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia. J. Clin. Invest. 63: 1274-1283, 1979.
16. Guilly, R., E. Billion-Rey, C. Pachiaudi, S. Normand, J. P. Riou, E. S. Jumeau, and J. L. Brazier. On-line purification and carbon 13 isotopic analysis of carbon dioxide in breath: evaluation of on-line gas chromatography isotope ratio mass spectrometry. Anal. Chim. Acta 259: 193-202, 1992.
17. Havel, R. J., J. P. Kane, E. O. Balasse, N. Segel, and L. V. Basso. Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J. Clin. Invest. 49: 2017-2035, 1970.
18. Hellerstein, M. K., M. Christiansen, S. Kaempfer, C Kletke, K. Wu, J. S. Reid, K. Mulligan, N. S. Hellerstein, and C. H. L. Shackleton. Measurement of de novo lipogenesis in humans using stable isotopes. J. Clin. Invest. 87: 1841-1852, 1991.
19. Hellerstein, M. K., R. A. Neese, and J. M. Schwarz. Model for measuring absolute rates of hepatic de novo lipogenesis and reesterification of free fatty acids. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E814-E820, 1993.
20. Jensen, M. D., P. J. Rogers, M. G. Ellman, and J. M. Miles. Choice of infusion-sampling mode for tracer studies of free fatty acid metabolism. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E562-E565, 1988.
21. Kissebah, A. H., S. Alfarsi, and P. W. Adams. Integrated regulation of very low density lipoprotein triglyceride and apoprotein-B kinetics in man: normolipemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia. Metabolism 30: 856-868, 1981.
22. Klein, S., V. R. Young, L. A. Blackburn, B. R. Bistrian, and R. R. Wolfe. Palmitate and glycerol kinetics during brief starvation in normal weight young adult and elderly subjects. J. Clin. Invest. 78: 928-933, 1986.
23. Landau, B. R., J. Wahren, S. F. Previs, K. Ekberg, V. Chandramouli, and H. Brunengraber. Glycerol production and utilization in humans: sites and quantification. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E1110-E1117, 1996.
24. Laville, M., V. Rigalleau, J. P. Riou, and M. Beylot. Respective role of plasma nonesterified fatty acid oxidation and total lipid oxidation in lipid induced insulin-resistance. Metabolism 44: 639-644, 1995.
25. Lee, W. N. P., S. Bassilian, Z. Guo, D. Schoeller, J. Edmond, E. A. Bergner, and L. O. Byerley. Measurement of fractional lipid synthesis using deuterated water and mass isotopomer analysis. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E372-E383, 1994.
26. Leitch, C. A., and P. H. J. Jones. Measurement of triglycerides synthesis in humans using deuterium oxide and isotope ratio mass spectrometry. Biol. Mass Spectrom. 20: 392-396, 1991.
27. Lewis, G. F., K. D. Uffelman, L. W. Szeto, B. Weller, and G. Steiner. Interaction between free fatty acids and insulin in the acute control of very low density lipoproteins in humans. J. Clin. Invest. 95: 158-166, 1995.
28. Morrison, W. R., and L. M. Smith. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 5: 600-608, 1964.
29. Previs, S. F., C. A. Fernandez, D. Yang, M. V. Soloviev, F. David, and H. Brunengraber. Limitations of mass isotopomer distribution analysis of glucose to study gluconeogenesis: substrate cycling between glycerol and triose-phosphates in liver. J. Biol. Chem. 270: 19806-19815, 1995.
30. Reaven, G. R. The fourth musketeer: from Alexandre Dumas to Claude Bernard. Diabetologia 38: 3-13, 1995.
31. Reaven, G., D. B. Gill, R. C. Gross, and J. W. Farquhar. Kinetics of triglyceride turnover of very low density lipoproteins of human plasma. J. Clin. Invest. 44: 1826-1833, 1965.
32. Sidossis, L. S., A. R. Coggan, A. Gastaldelli, and R. R. Wolfe. Pathway of free fatty acid oxidation in human subjects. Implication for tracer studies. J. Clin. Invest. 95: 278-284, 1995.
33. Sidossis, L. S., A. R. Coggan, A. Gastaldelli, and R. R. Wolfe. A new correction factor for use in tracer estimations of plasma fatty acid oxidation. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E649-E656, 1995.
34. Sidossis, L. S., C. A. Stuart, G. I. Shulman, G. D. Lopaschuk, and R. R. Wolfe. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J. Clin. Invest. 98: 2244-2250, 1996.
35. Taskinen, M. R., W. F. Beltz, and I. Harper. The effect of non-insulin-dependent diabetes on VLDL triglycerides and VLDL apoB metabolism. Studies before and after sulfonylurea therapy. Diabetes 35: 1268-1277, 1986.
36. Wahren, J., S. Efendic, R. Luft, L. Hagenfelt, O. Bjorkman, and P. Felig. Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-h fasted humans. J. Clin. Invest. 59: 299-307, 1977.
37. Wiggins, D., and G. F. Gibbons. Origin of hepatic very low density lipoprotein triacylglycerol: the contribution of cellular phospholipid. Biochem. J. 320: 673-679, 1979.
38. Wolfe, R. R., and M. J. Durkot. Role of very low density lipoproteins in the energy metabolism of the rat. J. Lipid Res. 26: 210-217, 1985.
39. Wolfe, R. R., J. H. F. Shaw, and M. J. Durkot. Effect of sepsis on VLDL kinetics: responses in basal state and during glucose infusion. Am. J. Physiol. 248 (Endocrinol. Metab. 11): E732-E740, 1985.
40. Wong, W. W., L. S. Lee, and P. D. Klein. Deuterium and oxygen-18 measurements on microliter samples of urine, plasma, saliva and human milk. Am. J. Clin. Nutr. 45: 905-913, 1987.