Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver

Biochemical and Biophysical Research Communications

Volumn 403, Issue 3-4, 2010, Pages 329-334

  Park, Joo Man ^a   Kim, Tae Hyun ^a   Bae, Jin Sik ^a   Kim, Mi Young ^a   Kim, Kyung Sup ^a   Ahn, Yong Ho ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

FOXO1; Gluconeogenesis; Resveratrol; SIRT1

Indexed keywords

GLUCOSE 6 PHOSPHATASE; INSULIN; MESSENGER RNA; PROTEIN KINASE B; RESVERATROL; SIRTINOL; SIRTUIN 1; TRANSCRIPTION FACTOR FKHR;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL ISOLATION; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOSOL; DEACETYLATION; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE REPRESSION; GLUCONEOGENESIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; LIVER CELL; MALE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; ANTIOXIDANTS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GLUCONEOGENESIS; HUMANS; LIVER; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SIRTUIN 1; STILBENES; UP-REGULATION;

EID: 78650171440     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.11.028     Document Type: Article

References (27)

1. Mokdad A.H., Ford E.S., Bowman B.A., Dietz W.H., Vinicor F., Bales V.S., Marks J.S. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 2003, 289:76-79.
2. Consoli A. Role of liver in pathophysiology of NIDDM. Diabetes Care 1992, 15:430-441.
3. Rodgers J.T., Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc. Natl. Acad. Sci. USA 2007, 104:12861-12866.
4. Lemaigre F.P., Rousseau G.G. Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver. Biochem. J. 1994, 303(Pt. 1):1-14.
5. Liu J.S., Park E.A., Gurney A.L., Roesler W.J., Hanson R.W. Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements. J. Biol. Chem. 1991, 266:19095-19102.
6. O'Brien R.M., Lucas P.C., Forest C.D., Magnuson M.A., Granner D.K. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science 1990, 249:533-537.
7. Barthel A., Schmoll D., Kruger K.D., Bahrenberg G., Walther R., Roth R.A., Joost H.G. Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells. Biochem. Biophys. Res. Commun. 2001, 285:897-902.
8. Nakae J., Kitamura T., Silver D.L., Accili D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 2001, 108:1359-1367.
9. Puigserver P., Rhee J., Donovan J., Walkey C.J., Yoon J.C., Oriente F., Kitamura Y., Altomonte J., Dong H., Accili D., Spiegelman B.M. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003, 423:550-555.
10. Housley M.P., Rodgers J.T., Udeshi N.D., Kelly T.J., Shabanowitz J., Hunt D.F., Puigserver P., Hart G.W. O-GlcNAc regulates FoxO activation in response to glucose. J. Biol. Chem. 2008, 283:16283-16292.
11. Matsuzaki H., Daitoku H., Hatta M., Aoyama H., Yoshimochi K., Fukamizu A. Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc. Natl. Acad. Sci. USA 2005, 102:11278-11283.
12. Zhang X., Gan L., Pan H., Guo S., He X., Olson S.T., Mesecar A., Adam S., Unterman T.G. Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J. Biol. Chem. 2002, 277:45276-45284.
13. Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J. 2003, 17:1975-1985.
14. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., Pistell P.J., Poosala S., Becker K.G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K.W., Spencer R.G., Lakatta E.G., Le Couteur D., Shaw R.J., Navas P., Puigserver P., Ingram D.K., de Cabo R., Sinclair D.A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
15. Zhang J. Resveratrol inhibits insulin responses in a SirT1-independent pathway. Biochem. J. 2006, 397:519-527.
16. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., Sinclair D.A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425:191-196.
17. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127:1109-1122.
18. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005, 434:113-118.
19. Ganjam G.K., Dimova E.Y., Unterman T.G., Kietzmann T. FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol. J. Biol. Chem. 2009, 284:30783-30797.
20. Choi K.C., Jung M.G., Lee Y.H., Yoon J.C., Kwon S.H., Kang H.B., Kim M.J., Cha J.H., Kim Y.J., Jun W.J., Lee J.M., Yoon H.G. Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res. 2009, 69:583-592.
21. Kim J.W., Ahn Y.H. CCAAT/enhancer binding protein regulates the promoter activity of the rat GLUT2 glucose transporter gene in liver cells. Biochem. J. 1998, 336(Pt. 1):83-90.
22. Grozinger C.M., Chao E.D., Blackwell H.E., Moazed D., Schreiber S.L. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J. Biol. Chem. 2001, 276:38837-38843.
23. Rena G., Guo S., Cichy S.C., Unterman T.G., Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 1999, 274:17179-17183.
24. Nakae J., Cao Y., Daitoku H., Fukamizu A., Ogawa W., Yano Y., Hayashi Y. The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J. Clin. Invest. 2006, 116:2473-2483.
25. Perrot V., Rechler M.M. The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription. Mol. Endocrinol. 2005, 19:2283-2298.
26. Erion D.M., Yonemitsu S., Nie Y., Nagai Y., Gillum M.P., Hsiao J.J., Iwasaki T., Stark R., Weismann D., Yu X.X., Murray S.F., Bhanot S., Monia B.P., Horvath T.L., Gao Q., Samuel V.T., Shulman G.I. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc. Natl. Acad. Sci. USA 2009, 106:11288-11293.
27. Frojdo S., Cozzone D., Vidal H., Pirola L. Resveratrol is a class IA phosphoinositide 3-kinase inhibitor. Biochem. J. 2007, 406:511-518.