Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP

Biochemical and Biophysical Research Communications

Volumn 332, Issue 1, 2005, Pages 174-180

  Yellaturu, Chandrahasa R ^a   Deng, Xiong ^a   Cagen, Lauren M ^a   Wilcox, Henry G ^a   Park, Edwards A ^a   Raghow, Rajendra ^a   Elam, Marshall B ^a  

^a NONE

Author keywords

cAMP; Hepatocyte; Insig; Insulin; SREBP 1; Ubiquitin

Indexed keywords

ADENOVIRUS VECTOR; CYCLIC AMP; INSULIN; MESSENGER RNA; PROTEIN; PROTEIN INSIG 2; PROTEIN PRECURSOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HALF LIFE TIME; HORMONE ACTION; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; RNA TRANSLATION; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CYCLIC AMP; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

ADENOVIRIDAE; ANIMALIA;

EID: 19344377132     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.04.112     Document Type: Article

References (24)

1. H. Shimano Sterol-regulatory element binding protein family as global regulators of lipid synthetic genes in energy metabolism Vitam. Horm. 65 2002 167 194
2. D. Eberlé, B. Hegarty, P. Bossard, P. Ferré, and F. Foufelle SREBP transcription factors: master regulators of lipid homeostasis Biochimie 86 2004 839 848
3. X. Hua, J. Wu, J.L. Goldstein, MS. Brown, and H.H. Hobbs Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13 Genomics 25 1995 667 673
4. I. Shimomura, H. Shimano, J.D. Horton, J.L. Goldstein, and M.S. Brown Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells J. Clin. Invest. 99 1997 838 845
5. R.G. Anderson Joe Goldstein and Mike Brown: from cholesterol homeostasis to new paradigms in membrane biology Trends Cell Biol. 13 2003 534 539
6. R.B. Rawson The SREBP pathway-insights from Insigs and insects Nat. Rev. Mol. Cell Biol. 4 2003 631 640
7. M.S. Brown, and J.L. Goldstein A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Proc. Natl. Acad. Sci USA 96 1999 11041 11048
8. P.A. Edwards, D. Tabor, H.R. Kast, and A. Venkateswaran Regulation of gene expression by SREBP and SCAP Biochim. Biophys. Acta 1529 2000 103 113
9. D. Yabe, M.S. Brown, and J.L. Goldstein Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins Proc. Natl. Acad. Sci. USA 99 2002 12753 12758
10. C.M. Adams, J.L. Goldstein, and M.S. Brown Cholesterol-induced conformational, change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles Proc. Natl. Acad. Sci. USA 100 2003 10647 10652
11. P.J. Espenshade, W.-P. Li, and D. Yabe Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER Proc. Natl. Acad. Sci. USA 99 2002 11694 11699
12. D. Yabe, R. Komuro, G. Liang, J.L. Goldstein, and M.S. Brown Liver-specific mRNA for insig-2 down-regulated by insulin: implications for fatty acid biosynthesis Proc. Natl. Acad. Sci. USA 100 2003 3155 3160
13. J.N. Lee, and J. Ye Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of insig-1 J. Biol. Chem. 279 2004 45257 45265
14. T. Yang, P.J. Espenschade, M.E. Wright, D. Yabe, Y. Gong, R. Aebersold, J.L. Goldstein, and M.S. Brown Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in the ER Cell 110 2002 489 500
15. L.J. Engelking, H. Kuriyama, R.E. Hammer, J.D. Horton, M.S. Brown, J.L. Goldstein, and G. Liang Overexpression of insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis J Clin. Invest. 113 2004 1168 1175
16. K. Takaishi, L. Duplomb, M.-Y. Wang, J. Li, and R.H. Unger Hepatic insig1 or insig2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats Proc. Natl. Acad. Sci. USA 101 2004 7106 7111
17. F.E. Thorngate, R. Raghow, H.G. Wilcox, C.S. Werner, and M.B. Elam Insulin promotes the biosynthesis and secretion of apolipoprotein B-48 by dramatically altering apolipoprotein B mRNA editing Proc. Natl. Acad. Sci. USA 91 1994 5392 5396
18. Y. Hirano, Y. Minoru, M. Shimizu, and R. Sato Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway J. Biol. Chem. 276 2001 36341 36437
19. J.D. Dignam, R.M. Lebovitz, and R.G. Roeder Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Res. 11 1983 1475 1489
20. D. Azout-Marniche, D. Bécard, C. Guichard, M. Foretz, P. Ferré, and F. Foufelle Insulin effects on sterol regulatory element binding protein 1c (SREBP-1c) transcriptional activity in rat hepatocytes Biochem. J. 350 2000 389 393
21. X. Deng, L.M. Cagen, H.G. Wilcox, E.A. Park, R. Raghow, and M.B. Elam Regulation of the rat SREBP-1c promoter in primary rat hepatocytes Biochem. Biophys. Res. Commun. 290 2002 256 262
22. B.D. Hegarty, A. Bobard, I. Hainault, P. Ferre, P. Bossard, and F. Foufelle Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c Proc. Natl. Acad. Sci. USA 102 2005 791 796
23. M. Foretz, C. Guichard, P. Ferré, and F. Foufelle Sterol regulatory element binding protein 1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes Proc. Natl. Acad. Sci. USA 96 1999 12737 12742
24. V.S. Rangan, B. Oskouian, and S. Smith Identification of an inverted CCAAT box motif in the fatty acid synthase gene as an essential element for the modification of transcriptional regulation by cAMP J. Biol. Chem. 271 1996 2307 2312