-
1
-
-
67449094358
-
The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling
-
Aanstad P., Santos N., Corbit K.C., Scherz P.J., Trinh le A., Salvenmoser W., Huisken J., Reiter J.F., Stainier D.Y. The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Curr. Biol. 2009, 19:1034-1039.
-
(2009)
Curr. Biol.
, vol.19
, pp. 1034-1039
-
-
Aanstad, P.1
Santos, N.2
Corbit, K.C.3
Scherz, P.J.4
Trinh le, A.5
Salvenmoser, W.6
Huisken, J.7
Reiter, J.F.8
Stainier, D.Y.9
-
2
-
-
27144487469
-
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
-
Ahn S., Joyner A.L. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 2005, 437:894-897.
-
(2005)
Nature
, vol.437
, pp. 894-897
-
-
Ahn, S.1
Joyner, A.L.2
-
3
-
-
0030901264
-
Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling
-
Akimaru H., Chen Y., Dai P., Hou D.X., Nonaka M., Smolik S.M., Armstrong S., Goodman R.H., Ishii S. Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 1997, 386:735-738.
-
(1997)
Nature
, vol.386
, pp. 735-738
-
-
Akimaru, H.1
Chen, Y.2
Dai, P.3
Hou, D.X.4
Nonaka, M.5
Smolik, S.M.6
Armstrong, S.7
Goodman, R.H.8
Ishii, S.9
-
4
-
-
0030602796
-
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal
-
Alcedo J., Ayzenzon M., Von Ohlen T., Noll M., Hooper J.E. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell 1996, 86:221-232.
-
(1996)
Cell
, vol.86
, pp. 221-232
-
-
Alcedo, J.1
Ayzenzon, M.2
Von Ohlen, T.3
Noll, M.4
Hooper, J.E.5
-
5
-
-
34249007279
-
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
-
Allen B.L., Tenzen T., McMahon A.P. The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 2007, 21:1244-1257.
-
(2007)
Genes Dev.
, vol.21
, pp. 1244-1257
-
-
Allen, B.L.1
Tenzen, T.2
McMahon, A.P.3
-
6
-
-
38949091712
-
Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression
-
Alvarez-Medina R., Cayuso J., Okubo T., Takada S., Marti E. Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development 2008, 135:237-247.
-
(2008)
Development
, vol.135
, pp. 237-247
-
-
Alvarez-Medina, R.1
Cayuso, J.2
Okubo, T.3
Takada, S.4
Marti, E.5
-
7
-
-
70349895668
-
Hedgehog activation is required upstream of Wnt signalling to control neural progenitor proliferation
-
Alvarez-Medina R., Le Dreau G., Ros M., Marti E. Hedgehog activation is required upstream of Wnt signalling to control neural progenitor proliferation. Development 2009, 136:3301-3309.
-
(2009)
Development
, vol.136
, pp. 3301-3309
-
-
Alvarez-Medina, R.1
Le Dreau, G.2
Ros, M.3
Marti, E.4
-
8
-
-
0031647941
-
Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs
-
Alves G., Limbourg-Bouchon B., Tricoire H., Brissard-Zahraoui J., Lamour-Isnard C., Busson D. Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs. Mech. Dev. 1998, 78:17-31.
-
(1998)
Mech. Dev.
, vol.78
, pp. 17-31
-
-
Alves, G.1
Limbourg-Bouchon, B.2
Tricoire, H.3
Brissard-Zahraoui, J.4
Lamour-Isnard, C.5
Busson, D.6
-
9
-
-
33244485265
-
The interpretation of morphogen gradients
-
Ashe H.L., Briscoe J. The interpretation of morphogen gradients. Development 2006, 133:385-394.
-
(2006)
Development
, vol.133
, pp. 385-394
-
-
Ashe, H.L.1
Briscoe, J.2
-
10
-
-
77952546990
-
Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
-
Ayers K.L., Therond P.P. Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling. Trends Cell Biol. 2010, 20:287-298.
-
(2010)
Trends Cell Biol.
, vol.20
, pp. 287-298
-
-
Ayers, K.L.1
Therond, P.P.2
-
11
-
-
0035691773
-
Gli1 can rescue the in vivo function of Gli2
-
Bai C.B., Joyner A.L. Gli1 can rescue the in vivo function of Gli2. Development 2001, 128:5161-5172.
-
(2001)
Development
, vol.128
, pp. 5161-5172
-
-
Bai, C.B.1
Joyner, A.L.2
-
12
-
-
0036801765
-
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
-
Bai C.B., Auerbach W., Lee J.S., Stephen D., Joyner A.L. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 2002, 129:4753-4761.
-
(2002)
Development
, vol.129
, pp. 4753-4761
-
-
Bai, C.B.1
Auerbach, W.2
Lee, J.S.3
Stephen, D.4
Joyner, A.L.5
-
13
-
-
0347764480
-
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
-
Bai C.B., Stephen D., Joyner A.L. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 2004, 6:103-115.
-
(2004)
Dev. Cell
, vol.6
, pp. 103-115
-
-
Bai, C.B.1
Stephen, D.2
Joyner, A.L.3
-
14
-
-
34249805084
-
Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons
-
Balordi F., Fishell G. Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons. J. Neurosci. 2007, 27:5936-5947.
-
(2007)
J. Neurosci.
, vol.27
, pp. 5936-5947
-
-
Balordi, F.1
Fishell, G.2
-
15
-
-
31744450041
-
Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
-
Barnfield P.C., Zhang X., Thanabalasingham V., Yoshida M., Hui C.C. Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 2005, 73:397-405.
-
(2005)
Differentiation
, vol.73
, pp. 397-405
-
-
Barnfield, P.C.1
Zhang, X.2
Thanabalasingham, V.3
Yoshida, M.4
Hui, C.C.5
-
16
-
-
79953138390
-
Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins
-
Barzi M., Kostrz D., Menendez A., Pons S. Sonic Hedgehog-induced proliferation requires specific Gα inhibitory proteins. J. Biol. Chem. 2011, 286:8067-8074.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 8067-8074
-
-
Barzi, M.1
Kostrz, D.2
Menendez, A.3
Pons, S.4
-
17
-
-
77956814604
-
Interactions between Hedgehog proteins and their binding partners come into view
-
Beachy P.A., Hymowitz S.G., Lazarus R.A., Leahy D.J., Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev. 2011, 24:2001-2012.
-
(2011)
Genes Dev.
, vol.24
, pp. 2001-2012
-
-
Beachy, P.A.1
Hymowitz, S.G.2
Lazarus, R.A.3
Leahy, D.J.4
Siebold, C.5
-
18
-
-
79952733097
-
Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
-
Belgacem Y.H., Borodinsky L.N. Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. Proc. Natl. Acad. Sci. USA 2011, 108(11):4482-4487.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, Issue.11
, pp. 4482-4487
-
-
Belgacem, Y.H.1
Borodinsky, L.N.2
-
19
-
-
33751048034
-
A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling?
-
author reply 3952-3953
-
Bijlsma M.F., Peppelenbosch M.P., Spek C.A. A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling?. Development 2006, 133:3951. author reply 3952-3953.
-
(2006)
Development
, vol.133
, pp. 3951
-
-
Bijlsma, M.F.1
Peppelenbosch, M.P.2
Spek, C.A.3
-
20
-
-
0035252990
-
Specification of neuronal fates in the ventral neural tube
-
Briscoe J., Ericson J. Specification of neuronal fates in the ventral neural tube. Curr. Opin. Neurobiol. 2001, 11:43-49.
-
(2001)
Curr. Opin. Neurobiol.
, vol.11
, pp. 43-49
-
-
Briscoe, J.1
Ericson, J.2
-
21
-
-
0034640087
-
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
-
Briscoe J., Pierani A., Jessell T.M., Ericson J. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 2000, 101:435-445.
-
(2000)
Cell
, vol.101
, pp. 435-445
-
-
Briscoe, J.1
Pierani, A.2
Jessell, T.M.3
Ericson, J.4
-
22
-
-
51949097274
-
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
-
Buglino J.A., Resh M.D. Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J. Biol. Chem. 2008, 283:22076-22088.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 22076-22088
-
-
Buglino, J.A.1
Resh, M.D.2
-
23
-
-
2542555722
-
FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
-
Bulgakov O.V., Eggenschwiler J.T., Hong D.H., Anderson K.V., Li T. FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development 2004, 131:2149-2159.
-
(2004)
Development
, vol.131
, pp. 2149-2159
-
-
Bulgakov, O.V.1
Eggenschwiler, J.T.2
Hong, D.H.3
Anderson, K.V.4
Li, T.5
-
24
-
-
0346888543
-
Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
-
Buttitta L., Mo R., Hui C.C., Fan C.M. Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 2003, 130:6233-6243.
-
(2003)
Development
, vol.130
, pp. 6233-6243
-
-
Buttitta, L.1
Mo, R.2
Hui, C.C.3
Fan, C.M.4
-
25
-
-
43049097898
-
Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding
-
Capurro M.I., Xu P., Shi W., Li F., Jia A., Filmus J. Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev. Cell 2008, 14:700-711.
-
(2008)
Dev. Cell
, vol.14
, pp. 700-711
-
-
Capurro, M.I.1
Xu, P.2
Shi, W.3
Li, F.4
Jia, A.5
Filmus, J.6
-
26
-
-
77952715761
-
Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala
-
Carney R.S., Mangin J.M., Hayes L., Mansfield K., Sousa V.H., Fishell G., Machold R.P., Ahn S., Gallo V., Corbin J.G. Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala. Neural Dev. 2010, 5:14.
-
(2010)
Neural Dev.
, vol.5
, pp. 14
-
-
Carney, R.S.1
Mangin, J.M.2
Hayes, L.3
Mansfield, K.4
Sousa, V.H.5
Fishell, G.6
Machold, R.P.7
Ahn, S.8
Gallo, V.9
Corbin, J.G.10
-
27
-
-
0032506115
-
Characterization of two patched receptors for the vertebrate hedgehog protein family
-
Carpenter D., Stone D.M., Brush J., Ryan A., Armanini M., Frantz G., Rosenthal A., de Sauvage F.J. Characterization of two patched receptors for the vertebrate hedgehog protein family. PNAS 1998, 95:13630-13634.
-
(1998)
PNAS
, vol.95
, pp. 13630-13634
-
-
Carpenter, D.1
Stone, D.M.2
Brush, J.3
Ryan, A.4
Armanini, M.5
Frantz, G.6
Rosenthal, A.7
de Sauvage, F.J.8
-
28
-
-
0037125938
-
Mouse Dispatched homolog1 is required for long-range, but not juxtacrine Hh signaling
-
Caspary T., Garcia-Garcia M.J., Huangfu D., Eggenschwiler J.T., Wyler M.R., Rakeman A.S., Alcorn H.L., Anderson K.V. Mouse Dispatched homolog1 is required for long-range, but not juxtacrine Hh signaling. Curr. Biol. 2002, 12:1628-1632.
-
(2002)
Curr. Biol.
, vol.12
, pp. 1628-1632
-
-
Caspary, T.1
Garcia-Garcia, M.J.2
Huangfu, D.3
Eggenschwiler, J.T.4
Wyler, M.R.5
Rakeman, A.S.6
Alcorn, H.L.7
Anderson, K.V.8
-
29
-
-
34247558062
-
The graded response to Sonic Hedgehog depends on cilia architecture
-
Caspary T., Larkins C.E., Anderson K.V. The graded response to Sonic Hedgehog depends on cilia architecture. Dev. Cell 2007, 12:767-778.
-
(2007)
Dev. Cell
, vol.12
, pp. 767-778
-
-
Caspary, T.1
Larkins, C.E.2
Anderson, K.V.3
-
30
-
-
42549109108
-
Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning
-
Chamberlain C.E., Jeong J., Guo C., Allen B.L., McMahon A.P. Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development 2008, 135:1097-1106.
-
(2008)
Development
, vol.135
, pp. 1097-1106
-
-
Chamberlain, C.E.1
Jeong, J.2
Guo, C.3
Allen, B.L.4
McMahon, A.P.5
-
31
-
-
63649136098
-
Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses
-
Chan J.A., Balasubramanian S., Witt R.M., Nazemi K.J., Choi Y., Pazyra-Murphy M.F., Walsh C.O., Thompson M., Segal R.A. Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat. Neurosci. 2009, 12:409-417.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 409-417
-
-
Chan, J.A.1
Balasubramanian, S.2
Witt, R.M.3
Nazemi, K.J.4
Choi, Y.5
Pazyra-Murphy, M.F.6
Walsh, C.O.7
Thompson, M.8
Segal, R.A.9
-
32
-
-
0037418830
-
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance
-
Charron F., Stein E., Jeong J., McMahon A.P., Tessier-Lavigne M. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 2003, 113:11-23.
-
(2003)
Cell
, vol.113
, pp. 11-23
-
-
Charron, F.1
Stein, E.2
Jeong, J.3
McMahon, A.P.4
Tessier-Lavigne, M.5
-
34
-
-
0032478107
-
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
-
Chen Y., Gallaher N., Goodman R.H., Smolik S.M. Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc. Natl. Acad. Sci. USA 1998, 95:2349-2354.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2349-2354
-
-
Chen, Y.1
Gallaher, N.2
Goodman, R.H.3
Smolik, S.M.4
-
35
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
-
Chen J.K., Taipale J., Cooper M.K., Beachy P.A. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 2002, 16:2743-2748.
-
(2002)
Genes Dev.
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
36
-
-
0037195074
-
Small molecule modulation of Smoothened activity
-
Chen J.K., Taipale J., Young K.E., Maiti T., Beachy P.A. Small molecule modulation of Smoothened activity. Proc. Natl. Acad. Sci. USA 2002, 99:14071-14076.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14071-14076
-
-
Chen, J.K.1
Taipale, J.2
Young, K.E.3
Maiti, T.4
Beachy, P.A.5
-
37
-
-
1842853184
-
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
-
Chen M.H., Li Y.J., Kawakami T., Xu S.M., Chuang P.T. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004, 18:641-659.
-
(2004)
Genes Dev.
, vol.18
, pp. 641-659
-
-
Chen, M.H.1
Li, Y.J.2
Kawakami, T.3
Xu, S.M.4
Chuang, P.T.5
-
38
-
-
11144256194
-
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
-
Chen W., Ren X.R., Nelson C.D., Barak L.S., Chen J.K., Beachy P.A., de Sauvage F., Lefkowitz R.J. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 2004, 306:2257-2260.
-
(2004)
Science
, vol.306
, pp. 2257-2260
-
-
Chen, W.1
Ren, X.R.2
Nelson, C.D.3
Barak, L.S.4
Chen, J.K.5
Beachy, P.A.6
de Sauvage, F.7
Lefkowitz, R.J.8
-
39
-
-
23344453462
-
Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development
-
Chen M.H., Gao N., Kawakami T., Chuang P.T. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol. Cell. Biol. 2005, 25:7042-7053.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 7042-7053
-
-
Chen, M.H.1
Gao, N.2
Kawakami, T.3
Chuang, P.T.4
-
40
-
-
69249245332
-
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
-
Chen M.H., Wilson C.W., Li Y.J., Law K.K., Lu C.S., Gacayan R., Zhang X., Hui C.C., Chuang P.T. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009, 23:1910-1928.
-
(2009)
Genes Dev.
, vol.23
, pp. 1910-1928
-
-
Chen, M.H.1
Wilson, C.W.2
Li, Y.J.3
Law, K.K.4
Lu, C.S.5
Gacayan, R.6
Zhang, X.7
Hui, C.C.8
Chuang, P.T.9
-
41
-
-
0037117611
-
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
-
Cheng S.Y., Bishop J.M. Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc. Natl. Acad. Sci. USA 2002, 99:5442-5447.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5442-5447
-
-
Cheng, S.Y.1
Bishop, J.M.2
-
42
-
-
0029777408
-
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
-
Chiang C., Litingtung Y., Lee E., Young K.E., Corden J.L., Westphal H., Beachy P.A. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 1996, 383:407-413.
-
(1996)
Nature
, vol.383
, pp. 407-413
-
-
Chiang, C.1
Litingtung, Y.2
Lee, E.3
Young, K.E.4
Corden, J.L.5
Westphal, H.6
Beachy, P.A.7
-
43
-
-
49049103512
-
FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism
-
Cho A., Ko H.W., Eggenschwiler J.T. FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 2008, 321:27-39.
-
(2008)
Dev. Biol.
, vol.321
, pp. 27-39
-
-
Cho, A.1
Ko, H.W.2
Eggenschwiler, J.T.3
-
44
-
-
72449152214
-
Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala
-
Cocas L.A., Miyoshi G., Carney R.S., Sousa V.H., Hirata T., Jones K.R., Fishell G., Huntsman M.M., Corbin J.G. Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala. J. Neurosci. 2009, 29:15933-15946.
-
(2009)
J. Neurosci.
, vol.29
, pp. 15933-15946
-
-
Cocas, L.A.1
Miyoshi, G.2
Carney, R.S.3
Sousa, V.H.4
Hirata, T.5
Jones, K.R.6
Fishell, G.7
Huntsman, M.M.8
Corbin, J.G.9
-
45
-
-
27644584608
-
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
-
Cooper A.F., Yu K.P., Brueckner M., Brailey L.L., Johnson L., McGrath J.M., Bale A.E. Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 2005, 132:4407-4417.
-
(2005)
Development
, vol.132
, pp. 4407-4417
-
-
Cooper, A.F.1
Yu, K.P.2
Brueckner, M.3
Brailey, L.L.4
Johnson, L.5
McGrath, J.M.6
Bale, A.E.7
-
46
-
-
26644460824
-
Vertebrate Smoothened functions at the primary cilium
-
Corbit K.C., Aanstad P., Singla V., Norman A.R., Stainier D.Y., Reiter J.F. Vertebrate Smoothened functions at the primary cilium. Nature 2005, 437:1018-1021.
-
(2005)
Nature
, vol.437
, pp. 1018-1021
-
-
Corbit, K.C.1
Aanstad, P.2
Singla, V.3
Norman, A.R.4
Stainier, D.Y.5
Reiter, J.F.6
-
47
-
-
33744788672
-
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
-
Corcoran R.B., Scott M.P. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc. Natl. Acad. Sci. USA 2006, 103:8408-8413.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 8408-8413
-
-
Corcoran, R.B.1
Scott, M.P.2
-
48
-
-
0035499392
-
Transcriptional repression: The long and the short of it
-
Courey A.J., Jia S. Transcriptional repression: The long and the short of it. Genes Dev. 2001, 15:2786-2796.
-
(2001)
Genes Dev.
, vol.15
, pp. 2786-2796
-
-
Courey, A.J.1
Jia, S.2
-
49
-
-
0033583035
-
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
-
Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., Ishii S. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 1999, 274:8143-8152.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8143-8152
-
-
Dai, P.1
Akimaru, H.2
Tanaka, Y.3
Maekawa, T.4
Nakafuku, M.5
Ishii, S.6
-
50
-
-
0037112001
-
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
-
Dai P., Shinagawa T., Nomura T., Harada J., Kaul S.C., Wadhwa R., Khan M.M., Akimaru H., Sasaki H., Colmenares C., Ishii S. Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev. 2002, 16:2843-2848.
-
(2002)
Genes Dev.
, vol.16
, pp. 2843-2848
-
-
Dai, P.1
Shinagawa, T.2
Nomura, T.3
Harada, J.4
Kaul, S.C.5
Wadhwa, R.6
Khan, M.M.7
Akimaru, H.8
Sasaki, H.9
Colmenares, C.10
Ishii, S.11
-
51
-
-
33646914937
-
Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: Involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord
-
Danesin C., Agius E., Escalas N., Ai X., Emerson C., Cochard P., Soula C. Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: Involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord. J. Neurosci. 2006, 26:5037-5048.
-
(2006)
J. Neurosci.
, vol.26
, pp. 5037-5048
-
-
Danesin, C.1
Agius, E.2
Escalas, N.3
Ai, X.4
Emerson, C.5
Cochard, P.6
Soula, C.7
-
52
-
-
0034713934
-
Smoothened activates Galphai-mediated signaling in frog melanophores
-
DeCamp D.L., Thompson T.M., de Sauvage F.J., Lerner M.R. Smoothened activates Galphai-mediated signaling in frog melanophores. J. Biol. Chem. 2000, 275:26322-26327.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26322-26327
-
-
DeCamp, D.L.1
Thompson, T.M.2
de Sauvage, F.J.3
Lerner, M.R.4
-
53
-
-
36749092279
-
Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism
-
Dessaud E., Yang L.L., Hill K., Cox B., Ulloa F., Ribeiro A., Mynett A., Novitch B.G., Briscoe J. Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature 2007, 450:717-720.
-
(2007)
Nature
, vol.450
, pp. 717-720
-
-
Dessaud, E.1
Yang, L.L.2
Hill, K.3
Cox, B.4
Ulloa, F.5
Ribeiro, A.6
Mynett, A.7
Novitch, B.G.8
Briscoe, J.9
-
54
-
-
50649088457
-
Pattern formation in the vertebrate neural tube: A sonic hedgehog morphogen-regulated transcriptional network
-
Dessaud E., McMahon A.P., Briscoe J. Pattern formation in the vertebrate neural tube: A sonic hedgehog morphogen-regulated transcriptional network. Development 2008, 135:2489-2503.
-
(2008)
Development
, vol.135
, pp. 2489-2503
-
-
Dessaud, E.1
McMahon, A.P.2
Briscoe, J.3
-
55
-
-
77954746410
-
Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog
-
Dessaud E., Ribes V., Balaskas N., Yang L.L., Pierani A., Kicheva A., Novitch B.G., Briscoe J., Sasai N. Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. PLoS Biol. 2010, 8:e1000382.
-
(2010)
PLoS Biol.
, vol.8
-
-
Dessaud, E.1
Ribes, V.2
Balaskas, N.3
Yang, L.L.4
Pierani, A.5
Kicheva, A.6
Novitch, B.G.7
Briscoe, J.8
Sasai, N.9
-
56
-
-
0031855859
-
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
-
Ding Q., Motoyama J., Gasca S., Mo R., Sasaki H., Rossant J., Hui C.C. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 1998, 125:2533-2543.
-
(1998)
Development
, vol.125
, pp. 2533-2543
-
-
Ding, Q.1
Motoyama, J.2
Gasca, S.3
Mo, R.4
Sasaki, H.5
Rossant, J.6
Hui, C.C.7
-
57
-
-
0033533714
-
Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1
-
Ding Q., Fukami S., Meng X., Nishizaki Y., Zhang X., Sasaki H., Dlugosz A., Nakafuku M., Hui C. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr. Biol. 1999, 9:1119-1122.
-
(1999)
Curr. Biol.
, vol.9
, pp. 1119-1122
-
-
Ding, Q.1
Fukami, S.2
Meng, X.3
Nishizaki, Y.4
Zhang, X.5
Sasaki, H.6
Dlugosz, A.7
Nakafuku, M.8
Hui, C.9
-
58
-
-
0038813753
-
Characterization of the physical interaction of Gli proteins with SUFU proteins
-
Dunaeva M., Michelson P., Kogerman P., Toftgard R. Characterization of the physical interaction of Gli proteins with SUFU proteins. J. Biol. Chem. 2003, 278:5116-5122.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 5116-5122
-
-
Dunaeva, M.1
Michelson, P.2
Kogerman, P.3
Toftgard, R.4
-
59
-
-
33644766718
-
Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs
-
Dussillol-Godar F., Brissard-Zahraoui J., Limbourg-Bouchon B., Boucher D., Fouix S., Lamour-Isnard C., Plessis A., Busson D. Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs. Dev. Biol. 2006, 291:53-66.
-
(2006)
Dev. Biol.
, vol.291
, pp. 53-66
-
-
Dussillol-Godar, F.1
Brissard-Zahraoui, J.2
Limbourg-Bouchon, B.3
Boucher, D.4
Fouix, S.5
Lamour-Isnard, C.6
Plessis, A.7
Busson, D.8
-
60
-
-
44349159118
-
Multiple roles for lipids in the Hedgehog signalling pathway
-
Eaton S. Multiple roles for lipids in the Hedgehog signalling pathway. Nat. Rev. Mol. Cell Biol. 2008, 9:437-445.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 437-445
-
-
Eaton, S.1
-
61
-
-
0027756145
-
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
-
Echelard Y., Epstein D.J., St-Jacques B., Shen L., Mohler J., McMahon J.A., McMahon A.P. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993, 75:1417-1430.
-
(1993)
Cell
, vol.75
, pp. 1417-1430
-
-
Echelard, Y.1
Epstein, D.J.2
St-Jacques, B.3
Shen, L.4
Mohler, J.5
McMahon, J.A.6
McMahon, A.P.7
-
63
-
-
68149178664
-
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
-
Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J., de Sauvage F.J., Peterson A.S. The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr. Biol. 2009, 19:1320-1326.
-
(2009)
Curr. Biol.
, vol.19
, pp. 1320-1326
-
-
Endoh-Yamagami, S.1
Evangelista, M.2
Wilson, D.3
Wen, X.4
Theunissen, J.W.5
Phamluong, K.6
Davis, M.7
Scales, S.J.8
Solloway, M.J.9
de Sauvage, F.J.10
Peterson, A.S.11
-
64
-
-
34247567111
-
G proteins: More than transducers of receptor-generated signals?
-
Engelhardt S., Rochais F. G proteins: More than transducers of receptor-generated signals?. Circ. Res. 2007, 100:1109-1111.
-
(2007)
Circ. Res.
, vol.100
, pp. 1109-1111
-
-
Engelhardt, S.1
Rochais, F.2
-
65
-
-
0026638915
-
Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1
-
Ericson J., Thor S., Edlund T., Jessell T.M., Yamada T. Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 1992, 256:1555-1560.
-
(1992)
Science
, vol.256
, pp. 1555-1560
-
-
Ericson, J.1
Thor, S.2
Edlund, T.3
Jessell, T.M.4
Yamada, T.5
-
66
-
-
0031433360
-
Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube
-
Ericson J., Briscoe J., Rashbass P., van Heyningen V., Jessell T.M. Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. Cold Spring Harb. Symp. Quant. Biol. 1997, 62:451-466.
-
(1997)
Cold Spring Harb. Symp. Quant. Biol.
, vol.62
, pp. 451-466
-
-
Ericson, J.1
Briscoe, J.2
Rashbass, P.3
van Heyningen, V.4
Jessell, T.M.5
-
67
-
-
0031458813
-
Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
-
Ericson J., Rashbass P., Schedl A., Brenner-Morton S., Kawakami A., van Heynigen V., Jessell T.M., Briscoe J. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 1997, 90:169-180.
-
(1997)
Cell
, vol.90
, pp. 169-180
-
-
Ericson, J.1
Rashbass, P.2
Schedl, A.3
Brenner-Morton, S.4
Kawakami, A.5
van Heynigen, V.6
Jessell, T.M.7
Briscoe, J.8
-
68
-
-
73649106563
-
Evidence for a role of vertebrate Disp1 in long-range Shh signaling
-
Etheridge L.A., Crawford T.Q., Zhang S., Roelink H. Evidence for a role of vertebrate Disp1 in long-range Shh signaling. Development 2010, 137:133-140.
-
(2010)
Development
, vol.137
, pp. 133-140
-
-
Etheridge, L.A.1
Crawford, T.Q.2
Zhang, S.3
Roelink, H.4
-
69
-
-
79953161898
-
Hedgehog morphogen: From secretion to reception
-
Gallet A. Hedgehog morphogen: From secretion to reception. Trends Cell Biol. 2011, 21(4):238-246.
-
(2011)
Trends Cell Biol.
, vol.21
, Issue.4
, pp. 238-246
-
-
Gallet, A.1
-
70
-
-
33645228803
-
A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form
-
Goetz J.A., Singh S., Suber L.M., Kull F.J., Robbins D.J. A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J. Biol. Chem. 2006, 281:4087-4093.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 4087-4093
-
-
Goetz, J.A.1
Singh, S.2
Suber, L.M.3
Kull, F.J.4
Robbins, D.J.5
-
71
-
-
0030866154
-
Altered neural cell fates and medulloblastoma in mouse patched mutants
-
Goodrich L.V., Milenkovic L., Higgins K.M., Scott M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997, 277:1109-1113.
-
(1997)
Science
, vol.277
, pp. 1109-1113
-
-
Goodrich, L.V.1
Milenkovic, L.2
Higgins, K.M.3
Scott, M.P.4
-
72
-
-
0027497981
-
Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord
-
Goulding M.D., Lumsden A., Gruss P. Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. Development 1993, 117:1001-1016.
-
(1993)
Development
, vol.117
, pp. 1001-1016
-
-
Goulding, M.D.1
Lumsden, A.2
Gruss, P.3
-
73
-
-
0035881919
-
The whereabouts of a morphogen: Direct evidence for short- and graded long-range activity of hedgehog signaling peptides
-
Gritli-Linde A., Lewis P., McMahon A.P., Linde A. The whereabouts of a morphogen: Direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev. Biol. 2001, 236:364-386.
-
(2001)
Dev. Biol.
, vol.236
, pp. 364-386
-
-
Gritli-Linde, A.1
Lewis, P.2
McMahon, A.P.3
Linde, A.4
-
74
-
-
33845873602
-
A conserved mechanism of Hedgehog gradient formation by lipid modifications
-
Guerrero I., Chiang C. A conserved mechanism of Hedgehog gradient formation by lipid modifications. Trends Cell Biol. 2007, 17:1-5.
-
(2007)
Trends Cell Biol.
, vol.17
, pp. 1-5
-
-
Guerrero, I.1
Chiang, C.2
-
75
-
-
0035950105
-
Morphogen gradient interpretation
-
Gurdon J.B., Bourillot P.Y. Morphogen gradient interpretation. Nature 2001, 413:797-803.
-
(2001)
Nature
, vol.413
, pp. 797-803
-
-
Gurdon, J.B.1
Bourillot, P.Y.2
-
76
-
-
30344439849
-
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity
-
Hallikas O., Palin K., Sinjushina N., Rautiainen R., Partanen J., Ukkonen E., Taipale J. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell 2006, 124:47-59.
-
(2006)
Cell
, vol.124
, pp. 47-59
-
-
Hallikas, O.1
Palin, K.2
Sinjushina, N.3
Rautiainen, R.4
Partanen, J.5
Ukkonen, E.6
Taipale, J.7
-
77
-
-
39749112475
-
Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
-
Han Y.G., Spassky N., Romaguera-Ros M., Garcia-Verdugo J.M., Aguilar A., Schneider-Maunoury S., Alvarez-Buylla A. Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat. Neurosci. 2008, 11:277-284.
-
(2008)
Nat. Neurosci.
, vol.11
, pp. 277-284
-
-
Han, Y.G.1
Spassky, N.2
Romaguera-Ros, M.3
Garcia-Verdugo, J.M.4
Aguilar, A.5
Schneider-Maunoury, S.6
Alvarez-Buylla, A.7
-
78
-
-
79952249809
-
Development and cancer of the cerebellum
-
Hatten M.E., Roussel M.F. Development and cancer of the cerebellum. Trends Neurosci. 2011, 34:134-142.
-
(2011)
Trends Neurosci.
, vol.34
, pp. 134-142
-
-
Hatten, M.E.1
Roussel, M.F.2
-
79
-
-
38149103016
-
Ongoing sonic hedgehog signaling is required for dorsal midline formation in the developing forebrain
-
Hayhurst M., Gore B.B., Tessier-Lavigne M., McConnell S.K. Ongoing sonic hedgehog signaling is required for dorsal midline formation in the developing forebrain. Dev. Neurobiol. 2008, 68:83-100.
-
(2008)
Dev. Neurobiol.
, vol.68
, pp. 83-100
-
-
Hayhurst, M.1
Gore, B.B.2
Tessier-Lavigne, M.3
McConnell, S.K.4
-
80
-
-
0036478946
-
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis
-
Herron B.J., Lu W., Rao C., Liu S., Peters H., Bronson R.T., Justice M.J., McDonald J.D., Beier D.R. Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat. Genet. 2002, 30:185-189.
-
(2002)
Nat. Genet.
, vol.30
, pp. 185-189
-
-
Herron, B.J.1
Lu, W.2
Rao, C.3
Liu, S.4
Peters, H.5
Bronson, R.T.6
Justice, M.J.7
McDonald, J.D.8
Beier, D.R.9
-
81
-
-
78649385622
-
Balanced Shh signaling is required for proper formation and maintenance of dorsal telencephalic midline structures
-
Himmelstein D.S., Bi C., Clark B.S., Bai B., Kohtz J.D. Balanced Shh signaling is required for proper formation and maintenance of dorsal telencephalic midline structures. BMC Dev. Biol. 2010, 10:118.
-
(2010)
BMC Dev. Biol.
, vol.10
, pp. 118
-
-
Himmelstein, D.S.1
Bi, C.2
Clark, B.S.3
Bai, B.4
Kohtz, J.D.5
-
83
-
-
34447329291
-
Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: Implication for human holoprosencephaly
-
Huang X., Litingtung Y., Chiang C. Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: Implication for human holoprosencephaly. Hum. Mol. Genet. 2007, 16:1454-1468.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 1454-1468
-
-
Huang, X.1
Litingtung, Y.2
Chiang, C.3
-
84
-
-
34250875089
-
Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord
-
Huang X., Litingtung Y., Chiang C. Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. Development 2007, 134:2095-2105.
-
(2007)
Development
, vol.134
, pp. 2095-2105
-
-
Huang, X.1
Litingtung, Y.2
Chiang, C.3
-
85
-
-
31644442906
-
Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
-
Huangfu D., Anderson K.V. Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 2006, 133:3-14.
-
(2006)
Development
, vol.133
, pp. 3-14
-
-
Huangfu, D.1
Anderson, K.V.2
-
86
-
-
0242581681
-
Hedgehog signalling in the mouse requires intraflagellar transport proteins
-
Huangfu D., Liu A., Rakeman A.S., Murcia N.S., Niswander L., Anderson K.V. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 2003, 426:83-87.
-
(2003)
Nature
, vol.426
, pp. 83-87
-
-
Huangfu, D.1
Liu, A.2
Rakeman, A.S.3
Murcia, N.S.4
Niswander, L.5
Anderson, K.V.6
-
87
-
-
32044436273
-
Dual degradation signals control Gli protein stability and tumor formation
-
Huntzicker E.G., Estay I.S., Zhen H., Lokteva L.A., Jackson P.K., Oro A.E. Dual degradation signals control Gli protein stability and tumor formation. Genes Dev. 2006, 20:276-281.
-
(2006)
Genes Dev.
, vol.20
, pp. 276-281
-
-
Huntzicker, E.G.1
Estay, I.S.2
Zhen, H.3
Lokteva, L.A.4
Jackson, P.K.5
Oro, A.E.6
-
88
-
-
15744399873
-
Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase
-
Iyer G.H., Moore M.J., Taylor S.S. Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase. J. Biol. Chem. 2005, 280:8800-8807.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 8800-8807
-
-
Iyer, G.H.1
Moore, M.J.2
Taylor, S.S.3
-
89
-
-
64849094028
-
Hedgehog signalling: Emerging evidence for non-canonical pathways
-
Jenkins D. Hedgehog signalling: Emerging evidence for non-canonical pathways. Cell. Signal. 2009, 21:1023-1034.
-
(2009)
Cell. Signal.
, vol.21
, pp. 1023-1034
-
-
Jenkins, D.1
-
90
-
-
0041508221
-
Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node
-
Jeong Y., Epstein D.J. Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node. Development 2003, 130:3891-3902.
-
(2003)
Development
, vol.130
, pp. 3891-3902
-
-
Jeong, Y.1
Epstein, D.J.2
-
91
-
-
13344275921
-
Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1
-
Jeong J., McMahon A.P. Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 2005, 132:143-154.
-
(2005)
Development
, vol.132
, pp. 143-154
-
-
Jeong, J.1
McMahon, A.P.2
-
92
-
-
78751522900
-
Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity
-
Jeong Y., Dolson D.K., Waclaw R.R., Matise M.P., Sussel L., Campbell K., Kaestner K.H., Epstein D.J. Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development 2011, 138:531-541.
-
(2011)
Development
, vol.138
, pp. 531-541
-
-
Jeong, Y.1
Dolson, D.K.2
Waclaw, R.R.3
Matise, M.P.4
Sussel, L.5
Campbell, K.6
Kaestner, K.H.7
Epstein, D.J.8
-
93
-
-
0034303585
-
Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
-
Jessell T.M. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes. Nat. Rev. Genet. 2000, 1:20-29.
-
(2000)
Nat. Rev. Genet.
, vol.1
, pp. 20-29
-
-
Jessell, T.M.1
-
94
-
-
0242361620
-
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
-
Jia J., Tong C., Jiang J. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev. 2003, 17:2709-2720.
-
(2003)
Genes Dev.
, vol.17
, pp. 2709-2720
-
-
Jia, J.1
Tong, C.2
Jiang, J.3
-
95
-
-
11144237279
-
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
-
Jia J., Tong C., Wang B., Luo L., Jiang J. Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 2004, 432:1045-1050.
-
(2004)
Nature
, vol.432
, pp. 1045-1050
-
-
Jia, J.1
Tong, C.2
Wang, B.3
Luo, L.4
Jiang, J.5
-
96
-
-
0033846864
-
Transcriptional activity of GLI1 is negatively regulated by protein kinase A
-
Kaesler S., Luscher B., Ruther U. Transcriptional activity of GLI1 is negatively regulated by protein kinase A. Biol. Chem. 2000, 381:545-551.
-
(2000)
Biol. Chem.
, vol.381
, pp. 545-551
-
-
Kaesler, S.1
Luscher, B.2
Ruther, U.3
-
97
-
-
0025156778
-
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
-
Kinzler K.W., Vogelstein B. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol. Cell. Biol. 1990, 10:634-642.
-
(1990)
Mol. Cell. Biol.
, vol.10
, pp. 634-642
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
98
-
-
0033194243
-
Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1
-
Kogerman P., Grimm T., Kogerman L., Krause D., Unden A.B., Sandstedt B., Toftgard R., Zaphiropoulos P.G. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat. Cell Biol. 1999, 1:312-319.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 312-319
-
-
Kogerman, P.1
Grimm, T.2
Kogerman, L.3
Krause, D.4
Unden, A.B.5
Sandstedt, B.6
Toftgard, R.7
Zaphiropoulos, P.G.8
-
99
-
-
46449127054
-
Beta-arrestin-mediated localization of smoothened to the primary cilium
-
Kovacs J.J., Whalen E.J., Liu R., Xiao K., Kim J., Chen M., Wang J., Chen W., Lefkowitz R.J. Beta-arrestin-mediated localization of smoothened to the primary cilium. Science 2008, 320:1777-1781.
-
(2008)
Science
, vol.320
, pp. 1777-1781
-
-
Kovacs, J.J.1
Whalen, E.J.2
Liu, R.3
Xiao, K.4
Kim, J.5
Chen, M.6
Wang, J.7
Chen, W.8
Lefkowitz, R.J.9
-
100
-
-
0035831529
-
Physical and functional interactions between Zic and Gli proteins
-
Koyabu Y., Nakata K., Mizugishi K., Aruga J., Mikoshiba K. Physical and functional interactions between Zic and Gli proteins. J. Biol. Chem. 2001, 276:6889-6892.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 6889-6892
-
-
Koyabu, Y.1
Nakata, K.2
Mizugishi, K.3
Aruga, J.4
Mikoshiba, K.5
-
101
-
-
0027749249
-
A functionally conserved homolog of the drosophila segment polarity gene hh is expressed in tissues with polarizing activity in Zebrafish embryos
-
Krauss S., Concordet J.P., Ingham P.W. A functionally conserved homolog of the drosophila segment polarity gene hh is expressed in tissues with polarizing activity in Zebrafish embryos. Cell 1993, 75:1431-1444.
-
(1993)
Cell
, vol.75
, pp. 1431-1444
-
-
Krauss, S.1
Concordet, J.P.2
Ingham, P.W.3
-
103
-
-
35848938488
-
Non-canonical activation of GLI transcription factors: Implications for targeted anti-cancer therapy
-
Lauth M., Toftgard R. Non-canonical activation of GLI transcription factors: Implications for targeted anti-cancer therapy. Cell Cycle 2007, 6:2458-2463.
-
(2007)
Cell Cycle
, vol.6
, pp. 2458-2463
-
-
Lauth, M.1
Toftgard, R.2
-
104
-
-
0035513502
-
Transcriptional networks regulating neuronal identity in the developing spinal cord
-
Lee S.-K., Pfaff S.L. Transcriptional networks regulating neuronal identity in the developing spinal cord. Nat. Neurosci. 2001, 4:1183-1191.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 1183-1191
-
-
Lee, S.-K.1
Pfaff, S.L.2
-
105
-
-
0035949695
-
Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite
-
Lee C.S., Buttitta L., Fan C.M. Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc. Natl. Acad. Sci. USA 2001, 98:11347-11352.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 11347-11352
-
-
Lee, C.S.1
Buttitta, L.2
Fan, C.M.3
-
106
-
-
33746879125
-
Patched2 modulates tumorigenesis in patched1 heterozygous mice
-
Lee Y., Miller H.L., Russell H.R., Boyd K., Curran T., McKinnon P.J. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res. 2006, 66:6964-6971.
-
(2006)
Cancer Res.
, vol.66
, pp. 6964-6971
-
-
Lee, Y.1
Miller, H.L.2
Russell, H.R.3
Boyd, K.4
Curran, T.5
McKinnon, P.J.6
-
107
-
-
4444220296
-
Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
-
Lei Q., Zelman A.K., Kuang E., Li S., Matise M.P. Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 2004, 131:3593-3604.
-
(2004)
Development
, vol.131
, pp. 3593-3604
-
-
Lei, Q.1
Zelman, A.K.2
Kuang, E.3
Li, S.4
Matise, M.P.5
-
108
-
-
33747833061
-
Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube
-
Lei Q., Jeong Y., Misra K., Li S., Zelman A.K., Epstein D.J., Matise M.P. Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 2006, 11:325-337.
-
(2006)
Dev. Cell
, vol.11
, pp. 325-337
-
-
Lei, Q.1
Jeong, Y.2
Misra, K.3
Li, S.4
Zelman, A.K.5
Epstein, D.J.6
Matise, M.P.7
-
109
-
-
78649887219
-
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning
-
Lek M., Dias J.M., Marklund U., Uhde C.W., Kurdija S., Lei Q., Sussel L., Rubenstein J.L., Matise M.P., Arnold H.H., Jessell T.M., Ericson J. A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development 2010, 137:4051-4060.
-
(2010)
Development
, vol.137
, pp. 4051-4060
-
-
Lek, M.1
Dias, J.M.2
Marklund, U.3
Uhde, C.W.4
Kurdija, S.5
Lei, Q.6
Sussel, L.7
Rubenstein, J.L.8
Matise, M.P.9
Arnold, H.H.10
Jessell, T.M.11
Ericson, J.12
-
110
-
-
0035368725
-
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
-
Lewis P.M., Dunn M.P., McMahon J.A., Logan M., Martin J.F., St-Jacques B., McMahon A.P. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 2001, 105:599-612.
-
(2001)
Cell
, vol.105
, pp. 599-612
-
-
Lewis, P.M.1
Dunn, M.P.2
McMahon, J.A.3
Logan, M.4
Martin, J.F.5
St-Jacques, B.6
McMahon, A.P.7
-
111
-
-
2942530769
-
Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum
-
Lewis P.M., Gritli-Linde A., Smeyne R., Kottmann A., McMahon A.P. Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev. Biol. 2004, 270:393-410.
-
(2004)
Dev. Biol.
, vol.270
, pp. 393-410
-
-
Lewis, P.M.1
Gritli-Linde, A.2
Smeyne, R.3
Kottmann, A.4
McMahon, A.P.5
-
112
-
-
79952636214
-
Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo
-
Li J., Wang C., Pan Y., Bai Z., Wang B. Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo. Dev. Dyn. 2011, 240(4):766-774.
-
(2011)
Dev. Dyn.
, vol.240
, Issue.4
, pp. 766-774
-
-
Li, J.1
Wang, C.2
Pan, Y.3
Bai, Z.4
Wang, B.5
-
113
-
-
69449099121
-
Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
-
Liem K.F., He M., Ocbina P.J., Anderson K.V. Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc. Natl. Acad. Sci. USA 2009, 106:13377-13382.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 13377-13382
-
-
Liem, K.F.1
He, M.2
Ocbina, P.J.3
Anderson, K.V.4
-
114
-
-
0033808256
-
Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
-
Litingtung Y., Chiang C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 2000, 3:979-985.
-
(2000)
Nat. Neurosci.
, vol.3
, pp. 979-985
-
-
Litingtung, Y.1
Chiang, C.2
-
115
-
-
23144466931
-
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
-
Liu A., Wang B., Niswander L.A. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 2005, 132:3103-3111.
-
(2005)
Development
, vol.132
, pp. 3103-3111
-
-
Liu, A.1
Wang, B.2
Niswander, L.A.3
-
116
-
-
49049108307
-
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning
-
Low W.C., Wang C., Pan Y., Huang X.Y., Chen J.K., Wang B. The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Dev. Biol. 2008, 321:188-196.
-
(2008)
Dev. Biol.
, vol.321
, pp. 188-196
-
-
Low, W.C.1
Wang, C.2
Pan, Y.3
Huang, X.Y.4
Chen, J.K.5
Wang, B.6
-
117
-
-
10744233219
-
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
-
Lum L., Zhang C., Oh S., Mann R.K., von Kessler D.P., Taipale J., Weis-Garcia F., Gong R., Wang B., Beachy P.A. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol. Cell 2003, 12:1261-1274.
-
(2003)
Mol. Cell
, vol.12
, pp. 1261-1274
-
-
Lum, L.1
Zhang, C.2
Oh, S.3
Mann, R.K.4
von Kessler, D.P.5
Taipale, J.6
Weis-Garcia, F.7
Gong, R.8
Wang, B.9
Beachy, P.A.10
-
118
-
-
0037020216
-
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
-
Ma Y., Erkner A., Gong R., Yao S., Taipale J., Basler K., Beachy P.A. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell 2002, 111:63-75.
-
(2002)
Cell
, vol.111
, pp. 63-75
-
-
Ma, Y.1
Erkner, A.2
Gong, R.3
Yao, S.4
Taipale, J.5
Basler, K.6
Beachy, P.A.7
-
119
-
-
77449084158
-
Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway
-
Maloverjan A., Piirsoo M., Michelson P., Kogerman P., Osterlund T. Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. Exp. Cell Res. 2010, 316:627-637.
-
(2010)
Exp. Cell Res.
, vol.316
, pp. 627-637
-
-
Maloverjan, A.1
Piirsoo, M.2
Michelson, P.3
Kogerman, P.4
Osterlund, T.5
-
120
-
-
0030601955
-
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development
-
Marigo V., Johnson R.L., Vortkamp A., Tabin C.J. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol. 1996, 180:273-283.
-
(1996)
Dev. Biol.
, vol.180
, pp. 273-283
-
-
Marigo, V.1
Johnson, R.L.2
Vortkamp, A.3
Tabin, C.J.4
-
121
-
-
34548239749
-
Order in the classroom: Graded responses to instructive Hh signaling in the CNS
-
Matise M.P. Order in the classroom: Graded responses to instructive Hh signaling in the CNS. Cell Cycle 2007, 6:1194-1199.
-
(2007)
Cell Cycle
, vol.6
, pp. 1194-1199
-
-
Matise, M.P.1
-
122
-
-
0030774912
-
Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
-
Matise M.P., Joyner A.L. Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons. J. Neurosci. 1997, 17:7805-7816.
-
(1997)
J. Neurosci.
, vol.17
, pp. 7805-7816
-
-
Matise, M.P.1
Joyner, A.L.2
-
123
-
-
0033590144
-
Gli genes in development and cancer
-
Matise M.P., Joyner A.L. Gli genes in development and cancer. Oncogene 1999, 18:7852-7859.
-
(1999)
Oncogene
, vol.18
, pp. 7852-7859
-
-
Matise, M.P.1
Joyner, A.L.2
-
124
-
-
0037444479
-
Megalin and the neurodevelopmental biology of sonic hedgehog and retinol
-
McCarthy R.A., Argraves W.S. Megalin and the neurodevelopmental biology of sonic hedgehog and retinol. J. Cell Sci. 2003, 116:955-960.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 955-960
-
-
McCarthy, R.A.1
Argraves, W.S.2
-
125
-
-
0037067722
-
Megalin functions as an endocytic sonic hedgehog receptor
-
McCarthy R.A., Barth J.L., Chintalapudi M.R., Knaak C., Argraves W.S. Megalin functions as an endocytic sonic hedgehog receptor. J. Biol. Chem. 2002, 277:25660-25667.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25660-25667
-
-
McCarthy, R.A.1
Barth, J.L.2
Chintalapudi, M.R.3
Knaak, C.4
Argraves, W.S.5
-
126
-
-
13944284208
-
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation
-
McDermott A., Gustafsson M., Elsam T., Hui C.C., Emerson C.P., Borycki A.G. Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development 2005, 132:345-357.
-
(2005)
Development
, vol.132
, pp. 345-357
-
-
McDermott, A.1
Gustafsson, M.2
Elsam, T.3
Hui, C.C.4
Emerson, C.P.5
Borycki, A.G.6
-
127
-
-
4544353067
-
Suppressor of fused regulates Gli activity through a dual binding mechanism
-
Merchant M., Vajdos F.F., Ultsch M., Maun H.R., Wendt U., Cannon J., Desmarais W., Lazarus R.A., de Vos A.M., de Sauvage F.J. Suppressor of fused regulates Gli activity through a dual binding mechanism. Mol. Cell. Biol. 2004, 24:8627-8641.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 8627-8641
-
-
Merchant, M.1
Vajdos, F.F.2
Ultsch, M.3
Maun, H.R.4
Wendt, U.5
Cannon, J.6
Desmarais, W.7
Lazarus, R.A.8
de Vos, A.M.9
de Sauvage, F.J.10
-
128
-
-
23344442477
-
Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus
-
Merchant M., Evangelista M., Luoh S.M., Frantz G.D., Chalasani S., Carano R.A., van Hoy M., Ramirez J., Ogasawara A.K., McFarland L.M., Filvaroff E.H., French D.M., et al. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol. Cell. Biol. 2005, 25:7054-7068.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 7054-7068
-
-
Merchant, M.1
Evangelista, M.2
Luoh, S.M.3
Frantz, G.D.4
Chalasani, S.5
Carano, R.A.6
van Hoy, M.7
Ramirez, J.8
Ogasawara, A.K.9
McFarland, L.M.10
Filvaroff, E.H.11
French, D.M.12
-
129
-
-
75549090700
-
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
-
Milenkovic L., Scott M.P., Rohatgi R. Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J. Cell Biol. 2009, 187:365-374.
-
(2009)
J. Cell Biol.
, vol.187
, pp. 365-374
-
-
Milenkovic, L.1
Scott, M.P.2
Rohatgi, R.3
-
130
-
-
0035910569
-
Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins
-
Mizugishi K., Aruga J., Nakata K., Mikoshiba K. Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J. Biol. Chem. 2001, 276:2180-2188.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2180-2188
-
-
Mizugishi, K.1
Aruga, J.2
Nakata, K.3
Mikoshiba, K.4
-
131
-
-
0031647943
-
Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis
-
Motoyama J., Heng H., Crackower M.A., Takabatake T., Takeshima K., Tsui L.C., Hui C. Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis. Mech. Dev. 1998, 78:81-84.
-
(1998)
Mech. Dev.
, vol.78
, pp. 81-84
-
-
Motoyama, J.1
Heng, H.2
Crackower, M.A.3
Takabatake, T.4
Takeshima, K.5
Tsui, L.C.6
Hui, C.7
-
132
-
-
0031989439
-
Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog
-
Motoyama J., Takabatake T., Takeshima K., Hui C. Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat. Genet. 1998, 18:104-106.
-
(1998)
Nat. Genet.
, vol.18
, pp. 104-106
-
-
Motoyama, J.1
Takabatake, T.2
Takeshima, K.3
Hui, C.4
-
133
-
-
0036830449
-
A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development
-
Nakashima M., Tanese N., Ito M., Auerbach W., Bai C., Furukawa T., Toyono T., Akamine A., Joyner A.L. A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development. Mech. Dev. 2002, 119:21-34.
-
(2002)
Mech. Dev.
, vol.119
, pp. 21-34
-
-
Nakashima, M.1
Tanese, N.2
Ito, M.3
Auerbach, W.4
Bai, C.5
Furukawa, T.6
Toyono, T.7
Akamine, A.8
Joyner, A.L.9
-
134
-
-
64249089527
-
Modeling the spatio-temporal network that drives patterning in the vertebrate central nervous system
-
Nishi Y., Ji H., Wong W.H., McMahon A.P., Vokes S.A. Modeling the spatio-temporal network that drives patterning in the vertebrate central nervous system. Biochim. Biophys. Acta 2009, 1789:299-305.
-
(2009)
Biochim. Biophys. Acta
, vol.1789
, pp. 299-305
-
-
Nishi, Y.1
Ji, H.2
Wong, W.H.3
McMahon, A.P.4
Vokes, S.A.5
-
135
-
-
0141862010
-
A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification
-
Novitch B.G., Wichterle H., Jessell T.M., Sockanathan S. A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron 2003, 40:81-95.
-
(2003)
Neuron
, vol.40
, pp. 81-95
-
-
Novitch, B.G.1
Wichterle, H.2
Jessell, T.M.3
Sockanathan, S.4
-
136
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
Nusslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287:795-801.
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
-
137
-
-
0242625184
-
Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2
-
Ogden S.K., Ascano M., Stegman M.A., Suber L.M., Hooper J.E., Robbins D.J. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr. Biol. 2003, 13:1998-2003.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1998-2003
-
-
Ogden, S.K.1
Ascano, M.2
Stegman, M.A.3
Suber, L.M.4
Hooper, J.E.5
Robbins, D.J.6
-
138
-
-
27444433813
-
Specific requirements of sonic hedgehog signaling during oligodendrocyte development
-
Oh S., Huang X., Chiang C. Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Dev. Dyn. 2005, 234:489-496.
-
(2005)
Dev. Dyn.
, vol.234
, pp. 489-496
-
-
Oh, S.1
Huang, X.2
Chiang, C.3
-
139
-
-
67549124647
-
Shh and Gli3 activities are required for timely generation of motor neuron progenitors
-
Oh S., Huang X., Liu J., Litingtung Y., Chiang C. Shh and Gli3 activities are required for timely generation of motor neuron progenitors. Dev. Biol. 2009, 331:261-269.
-
(2009)
Dev. Biol.
, vol.331
, pp. 261-269
-
-
Oh, S.1
Huang, X.2
Liu, J.3
Litingtung, Y.4
Chiang, C.5
-
140
-
-
33751078546
-
Boc is a receptor for sonic hedgehog in the guidance of commissural axons
-
Okada A., Charron F., Morin S., Shin D.S., Wong K., Fabre P.J., Tessier-Lavigne M., McConnell S.K. Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 2006, 444:369-373.
-
(2006)
Nature
, vol.444
, pp. 369-373
-
-
Okada, A.1
Charron, F.2
Morin, S.3
Shin, D.S.4
Wong, K.5
Fabre, P.J.6
Tessier-Lavigne, M.7
McConnell, S.K.8
-
141
-
-
1642370648
-
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins
-
Paces-Fessy M., Boucher D., Petit E., Paute-Briand S., Blanchet-Tournier M.F. The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Biochem. J. 2004, 378:353-362.
-
(2004)
Biochem. J.
, vol.378
, pp. 353-362
-
-
Paces-Fessy, M.1
Boucher, D.2
Petit, E.3
Paute-Briand, S.4
Blanchet-Tournier, M.F.5
-
142
-
-
13344282140
-
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain
-
Palma V., Lim D.A., Dahmane N., Sanchez P., Brionne T.C., Herzberg C.D., Gitton Y., Carleton A., Alvarez-Buylla A., Ruiz i Altaba A. Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 2005, 132:335-344.
-
(2005)
Development
, vol.132
, pp. 335-344
-
-
Palma, V.1
Lim, D.A.2
Dahmane, N.3
Sanchez, P.4
Brionne, T.C.5
Herzberg, C.D.6
Gitton, Y.7
Carleton, A.8
Alvarez-Buylla, A.9
Ruiz i Altaba, A.10
-
143
-
-
34249717798
-
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
-
Pan Y., Wang B. A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome. J. Biol. Chem. 2007, 282:10846-10852.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 10846-10852
-
-
Pan, Y.1
Wang, B.2
-
144
-
-
33646270662
-
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
-
Pan Y., Bai C.B., Joyner A.L., Wang B. Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 2006, 26:3365-3377.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3365-3377
-
-
Pan, Y.1
Bai, C.B.2
Joyner, A.L.3
Wang, B.4
-
145
-
-
58549117286
-
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
-
Pan Y., Wang C., Wang B. Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev. Biol. 2009, 326:177-189.
-
(2009)
Dev. Biol.
, vol.326
, pp. 177-189
-
-
Pan, Y.1
Wang, C.2
Wang, B.3
-
146
-
-
0027423758
-
Crystal structure of a five-finger GLI-DNA complex: New perspectives on zinc fingers
-
Pavletich N.P., Pabo C.O. Crystal structure of a five-finger GLI-DNA complex: New perspectives on zinc fingers. Science 1993, 261:1701-1707.
-
(1993)
Science
, vol.261
, pp. 1701-1707
-
-
Pavletich, N.P.1
Pabo, C.O.2
-
147
-
-
0037111829
-
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
-
Persson M., Stamataki D., te Welscher P., Andersson E., Bose J., Ruther U., Ericson J., Briscoe J. Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 2002, 16:2865-2878.
-
(2002)
Genes Dev.
, vol.16
, pp. 2865-2878
-
-
Persson, M.1
Stamataki, D.2
te Welscher, P.3
Andersson, E.4
Bose, J.5
Ruther, U.6
Ericson, J.7
Briscoe, J.8
-
148
-
-
0028978107
-
The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment
-
Pham A., Therond P., Alves G., Tournier F.B., Busson D., Lamour-Isnard C., Bouchon B.L., Preat T., Tricoire H. The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment. Genetics 1995, 140:587-598.
-
(1995)
Genetics
, vol.140
, pp. 587-598
-
-
Pham, A.1
Therond, P.2
Alves, G.3
Tournier, F.B.4
Busson, D.5
Lamour-Isnard, C.6
Bouchon, B.L.7
Preat, T.8
Tricoire, H.9
-
149
-
-
59349091148
-
Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase
-
Philipp M., Fralish G.B., Meloni A.R., Chen W., MacInnes A.W., Barak L.S., Caron M.G. Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. Mol. Biol. Cell 2008, 19:5478-5489.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 5478-5489
-
-
Philipp, M.1
Fralish, G.B.2
Meloni, A.R.3
Chen, W.4
MacInnes, A.W.5
Barak, L.S.6
Caron, M.G.7
-
150
-
-
0033603209
-
A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
-
Pierani A., Brenner-Morton S., Chiang C., Jessell T. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell 1999, 97:903-915.
-
(1999)
Cell
, vol.97
, pp. 903-915
-
-
Pierani, A.1
Brenner-Morton, S.2
Chiang, C.3
Jessell, T.4
-
151
-
-
14844300927
-
The floor plate: Multiple cells, multiple signals
-
Placzek M., Briscoe J. The floor plate: Multiple cells, multiple signals. Nat. Rev. Neurosci. 2005, 6:230-240.
-
(2005)
Nat. Rev. Neurosci.
, vol.6
, pp. 230-240
-
-
Placzek, M.1
Briscoe, J.2
-
152
-
-
15844386540
-
Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
-
Porter J.A., Ekker S.C., Park W.-J., von Kessler D.P., Young K.E., Chen S.-H., Ma Y., Woods A.S., Cotter R.J., Koonin E.V., Beachy P.A. Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell 1996, 86:21-34.
-
(1996)
Cell
, vol.86
, pp. 21-34
-
-
Porter, J.A.1
Ekker, S.C.2
Park, W.-J.3
von Kessler, D.P.4
Young, K.E.5
Chen, S.-H.6
Ma, Y.7
Woods, A.S.8
Cotter, R.J.9
Koonin, E.V.10
Beachy, P.A.11
-
153
-
-
0026761497
-
Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster
-
Preat T. Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster. Genetics 1992, 132:725-736.
-
(1992)
Genetics
, vol.132
, pp. 725-736
-
-
Preat, T.1
-
154
-
-
0032756914
-
Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by Protein Kinase A
-
Price M.A., Kalderon D. Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by Protein Kinase A. Development 1999, 126:4331-4339.
-
(1999)
Development
, vol.126
, pp. 4331-4339
-
-
Price, M.A.1
Kalderon, D.2
-
155
-
-
79952171642
-
Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components
-
Qin J., Lin Y., Norman R.X., Ko H.W., Eggenschwiler J.T. Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. USA 2011, 108:1456-1461.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 1456-1461
-
-
Qin, J.1
Lin, Y.2
Norman, R.X.3
Ko, H.W.4
Eggenschwiler, J.T.5
-
156
-
-
35548939953
-
Patterning the dorsal telencephalon: A role for sonic hedgehog?
-
Rash B.G., Grove E.A. Patterning the dorsal telencephalon: A role for sonic hedgehog?. J. Neurosci. 2007, 27:11595-11603.
-
(2007)
J. Neurosci.
, vol.27
, pp. 11595-11603
-
-
Rash, B.G.1
Grove, E.A.2
-
157
-
-
29944444497
-
Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition
-
Reiter J.F., Skarnes W.C. Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev. 2006, 20:22-27.
-
(2006)
Genes Dev.
, vol.20
, pp. 22-27
-
-
Reiter, J.F.1
Skarnes, W.C.2
-
158
-
-
77953766440
-
Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: The role of negative feedback
-
Ribes V., Briscoe J. Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: The role of negative feedback. Cold Spring Harb. Perspect. Biol. 2009, 1:a002014.
-
(2009)
Cold Spring Harb. Perspect. Biol.
, vol.1
-
-
Ribes, V.1
Briscoe, J.2
-
159
-
-
77953045687
-
Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube
-
Ribes V., Balaskas N., Sasai N., Cruz C., Dessaud E., Cayuso J., Tozer S., Yang L.L., Novitch B., Marti E., Briscoe J. Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 2010, 24:1186-1200.
-
(2010)
Genes Dev.
, vol.24
, pp. 1186-1200
-
-
Ribes, V.1
Balaskas, N.2
Sasai, N.3
Cruz, C.4
Dessaud, E.5
Cayuso, J.6
Tozer, S.7
Yang, L.L.8
Novitch, B.9
Marti, E.10
Briscoe, J.11
-
160
-
-
0027760995
-
Sonic hedgehog mediates the polarizing activity of the ZPA
-
Riddle R.D., Johnson R.L., Laufer E., Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 1993, 75:1401-1416.
-
(1993)
Cell
, vol.75
, pp. 1401-1416
-
-
Riddle, R.D.1
Johnson, R.L.2
Laufer, E.3
Tabin, C.4
-
161
-
-
33747614580
-
Activation of heterotrimeric G proteins by Smoothened
-
Riobo N.A., Saucy B., Dilizio C., Manning D.R. Activation of heterotrimeric G proteins by Smoothened. Proc. Natl. Acad. Sci. USA 2006, 103:12607-12612.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 12607-12612
-
-
Riobo, N.A.1
Saucy, B.2
Dilizio, C.3
Manning, D.R.4
-
162
-
-
23444440157
-
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
-
Roelink H., Augsburger A., Heemskerk J., Korzh V., Norlin S., Ruiz i Altaba A., Tanabe Y., Placzek M., Edlund T., Jessell T.M., Dodd J. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 1994, 76:761-775.
-
(1994)
Cell
, vol.76
, pp. 761-775
-
-
Roelink, H.1
Augsburger, A.2
Heemskerk, J.3
Korzh, V.4
Norlin, S.5
Ruiz i Altaba, A.6
Tanabe, Y.7
Placzek, M.8
Edlund, T.9
Jessell, T.M.10
Dodd, J.11
-
163
-
-
34547110771
-
Patched1 regulates hedgehog signaling at the primary cilium
-
Rohatgi R., Milenkovic L., Scott M.P. Patched1 regulates hedgehog signaling at the primary cilium. Science 2007, 317:372-376.
-
(2007)
Science
, vol.317
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
164
-
-
62549159642
-
Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
-
Rohatgi R., Milenkovic L., Corcoran R.B., Scott M.P. Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process. Proc. Natl. Acad. Sci. USA 2009, 106:3196-3201.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 3196-3201
-
-
Rohatgi, R.1
Milenkovic, L.2
Corcoran, R.B.3
Scott, M.P.4
-
165
-
-
0036341998
-
Cerebellar proteoglycans regulate sonic hedgehog responses during development
-
Rubin J.B., Choi Y., Segal R.A. Cerebellar proteoglycans regulate sonic hedgehog responses during development. Development 2002, 129:2223-2232.
-
(2002)
Development
, vol.129
, pp. 2223-2232
-
-
Rubin, J.B.1
Choi, Y.2
Segal, R.A.3
-
166
-
-
69249245330
-
Variations in Hedgehog signaling: Divergence and perpetuation in Sufu regulation of Gli
-
Ruel L., Therond P.P. Variations in Hedgehog signaling: Divergence and perpetuation in Sufu regulation of Gli. Genes Dev. 2009, 23:1843-1848.
-
(2009)
Genes Dev.
, vol.23
, pp. 1843-1848
-
-
Ruel, L.1
Therond, P.P.2
-
167
-
-
0141728540
-
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
-
Ruel L., Rodriguez R., Gallet A., Lavenant-Staccini L., Therond P.P. Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat. Cell Biol. 2003, 5:907-913.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 907-913
-
-
Ruel, L.1
Rodriguez, R.2
Gallet, A.3
Lavenant-Staccini, L.4
Therond, P.P.5
-
168
-
-
36148939854
-
Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
-
Ruel L., Gallet A., Raisin S., Truchi A., Staccini-Lavenant L., Cervantes A., Therond P.P. Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling. Development 2007, 134:3677-3689.
-
(2007)
Development
, vol.134
, pp. 3677-3689
-
-
Ruel, L.1
Gallet, A.2
Raisin, S.3
Truchi, A.4
Staccini-Lavenant, L.5
Cervantes, A.6
Therond, P.P.7
-
169
-
-
52449135489
-
CD spectra show the relational style between Zic-, Gli-Glis-zinc finger protein and DNA
-
Sakai-Kato K., Ishiguro A., Mikoshiba K., Aruga J., Utsunomiya-Tate N. CD spectra show the relational style between Zic-, Gli-Glis-zinc finger protein and DNA. Biochim. Biophys. Acta 2008, 1784:1011-1019.
-
(2008)
Biochim. Biophys. Acta
, vol.1784
, pp. 1011-1019
-
-
Sakai-Kato, K.1
Ishiguro, A.2
Mikoshiba, K.3
Aruga, J.4
Utsunomiya-Tate, N.5
-
170
-
-
70349557615
-
Emerging mechanisms in morphogen-mediated axon guidance
-
Sanchez-Camacho C., Bovolenta P. Emerging mechanisms in morphogen-mediated axon guidance. Bioessays 2009, 31:1013-1025.
-
(2009)
Bioessays
, vol.31
, pp. 1013-1025
-
-
Sanchez-Camacho, C.1
Bovolenta, P.2
-
171
-
-
0032848136
-
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling
-
Sasaki H., Nishizaki Y., Hui C., Nakafuku M., Kondoh H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999, 126:3915-3924.
-
(1999)
Development
, vol.126
, pp. 3915-3924
-
-
Sasaki, H.1
Nishizaki, Y.2
Hui, C.3
Nakafuku, M.4
Kondoh, H.5
-
172
-
-
57649243011
-
C2H2 zinc finger genes of the Gli, Zic, KLF, SP, Wilms' tumour, Huckebein, Snail, Ovo, Spalt, Odd, Blimp-1, Fez and related gene families from Branchiostoma floridae
-
Shimeld S.M. C2H2 zinc finger genes of the Gli, Zic, KLF, SP, Wilms' tumour, Huckebein, Snail, Ovo, Spalt, Odd, Blimp-1, Fez and related gene families from Branchiostoma floridae. Dev. Genes Evol. 2008, 218:639-649.
-
(2008)
Dev. Genes Evol.
, vol.218
, pp. 639-649
-
-
Shimeld, S.M.1
-
173
-
-
34848892735
-
Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation
-
Smelkinson M.G., Zhou Q., Kalderon D. Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation. Dev. Cell 2007, 13:481-495.
-
(2007)
Dev. Cell
, vol.13
, pp. 481-495
-
-
Smelkinson, M.G.1
Zhou, Q.2
Kalderon, D.3
-
174
-
-
77954955134
-
Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
-
Sousa V.H., Fishell G. Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain. Curr. Opin. Genet. Dev. 2010, 20:391-399.
-
(2010)
Curr. Opin. Genet. Dev.
, vol.20
, pp. 391-399
-
-
Sousa, V.H.1
Fishell, G.2
-
175
-
-
5444264003
-
Biological control through regulated transcriptional coactivators
-
Spiegelman B.M., Heinrich R. Biological control through regulated transcriptional coactivators. Cell 2004, 119:157-167.
-
(2004)
Cell
, vol.119
, pp. 157-167
-
-
Spiegelman, B.M.1
Heinrich, R.2
-
176
-
-
13944258550
-
LRP2/megalin is required for patterning of the ventral telencephalon
-
Spoelgen R., Hammes A., Anzenberger U., Zechner D., Andersen O.M., Jerchow B., Willnow T.E. LRP2/megalin is required for patterning of the ventral telencephalon. Development 2005, 132:405-414.
-
(2005)
Development
, vol.132
, pp. 405-414
-
-
Spoelgen, R.1
Hammes, A.2
Anzenberger, U.3
Zechner, D.4
Andersen, O.M.5
Jerchow, B.6
Willnow, T.E.7
-
177
-
-
14644401158
-
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
-
Stamataki D., Ulloa F., Tsoni S.V., Mynett A., Briscoe J. A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev. 2005, 19:626-641.
-
(2005)
Genes Dev.
, vol.19
, pp. 626-641
-
-
Stamataki, D.1
Ulloa, F.2
Tsoni, S.V.3
Mynett, A.4
Briscoe, J.5
-
178
-
-
31744451535
-
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
-
Svard J., Heby-Henricson K., Persson-Lek M., Rozell B., Lauth M., Bergstrom A., Ericson J., Toftgard R., Teglund S. Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell 2006, 10:187-197.
-
(2006)
Dev. Cell
, vol.10
, pp. 187-197
-
-
Svard, J.1
Heby-Henricson, K.2
Persson-Lek, M.3
Rozell, B.4
Lauth, M.5
Bergstrom, A.6
Ericson, J.7
Toftgard, R.8
Teglund, S.9
-
179
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
Taipale J., Cooper M.K., Maiti T., Beachy P.A. Patched acts catalytically to suppress the activity of Smoothened. Nature 2002, 418:892-897.
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
Cooper, M.K.2
Maiti, T.3
Beachy, P.A.4
-
180
-
-
31144469120
-
Gli3 mutation rescues the generation, but not the differentiation, of oligodendrocytes in Shh mutants
-
Tan M., Hu X., Qi Y., Park J., Cai J., Qiu M. Gli3 mutation rescues the generation, but not the differentiation, of oligodendrocytes in Shh mutants. Brain Res. 2006, 1067:158-163.
-
(2006)
Brain Res.
, vol.1067
, pp. 158-163
-
-
Tan, M.1
Hu, X.2
Qi, Y.3
Park, J.4
Cai, J.5
Qiu, M.6
-
181
-
-
33646869503
-
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP
-
Tempe D., Casas M., Karaz S., Blanchet-Tournier M.F., Concordet J.P. Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol. Cell. Biol. 2006, 26:4316-4326.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 4316-4326
-
-
Tempe, D.1
Casas, M.2
Karaz, S.3
Blanchet-Tournier, M.F.4
Concordet, J.P.5
-
182
-
-
33646103902
-
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
-
Tenzen T., Allen B.L., Cole F., Kang J.S., Krauss R.S., McMahon A.P. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev. Cell 2006, 10:647-656.
-
(2006)
Dev. Cell
, vol.10
, pp. 647-656
-
-
Tenzen, T.1
Allen, B.L.2
Cole, F.3
Kang, J.S.4
Krauss, R.S.5
McMahon, A.P.6
-
183
-
-
0029866222
-
Functional domains of fused, a serine-threonine kinase required for signaling in Drosophila
-
Therond P., Alves G., Limbourg-Bouchon B., Tricoire H., Guillemet E., Brissard-Zahraoui J., Lamour-Isnard C., Busson D. Functional domains of fused, a serine-threonine kinase required for signaling in Drosophila. Genetics 1996, 142:1181-1198.
-
(1996)
Genetics
, vol.142
, pp. 1181-1198
-
-
Therond, P.1
Alves, G.2
Limbourg-Bouchon, B.3
Tricoire, H.4
Guillemet, E.5
Brissard-Zahraoui, J.6
Lamour-Isnard, C.7
Busson, D.8
-
184
-
-
0041853572
-
Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog
-
Thibert C., Teillet M.A., Lapointe F., Mazelin L., Le Douarin N.M., Mehlen P. Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science 2003, 301:843-846.
-
(2003)
Science
, vol.301
, pp. 843-846
-
-
Thibert, C.1
Teillet, M.A.2
Lapointe, F.3
Mazelin, L.4
Le Douarin, N.M.5
Mehlen, P.6
-
185
-
-
13344284705
-
Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand
-
Tian H., Jeong J., Harfe B.D., Tabin C.J., McMahon A.P. Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development 2005, 132:133-142.
-
(2005)
Development
, vol.132
, pp. 133-142
-
-
Tian, H.1
Jeong, J.2
Harfe, B.D.3
Tabin, C.J.4
McMahon, A.P.5
-
186
-
-
77449105629
-
The full-length unprocessed hedgehog protein is an active signaling molecule
-
Tokhunts R., Singh S., Chu T., D'Angelo G., Baubet V., Goetz J.A., Huang Z., Yuan Z., Ascano M., Zavros Y., Therond P.P., Kunes S., et al. The full-length unprocessed hedgehog protein is an active signaling molecule. J. Biol. Chem. 2010, 285:2562-2568.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 2562-2568
-
-
Tokhunts, R.1
Singh, S.2
Chu, T.3
D'Angelo, G.4
Baubet, V.5
Goetz, J.A.6
Huang, Z.7
Yuan, Z.8
Ascano, M.9
Zavros, Y.10
Therond, P.P.11
Kunes, S.12
-
187
-
-
77950664245
-
Sonic Hedgehog signaling in the mammalian brain
-
Traiffort E., Angot E., Ruat M. Sonic Hedgehog signaling in the mammalian brain. J. Neurochem. 2010, 113:576-590.
-
(2010)
J. Neurochem.
, vol.113
, pp. 576-590
-
-
Traiffort, E.1
Angot, E.2
Ruat, M.3
-
188
-
-
57749199918
-
Identification of the gene transcription repressor domain of Gli3
-
Tsanev R., Tiigimagi P., Michelson P., Metsis M., Osterlund T., Kogerman P. Identification of the gene transcription repressor domain of Gli3. FEBS Lett. 2009, 583:224-228.
-
(2009)
FEBS Lett.
, vol.583
, pp. 224-228
-
-
Tsanev, R.1
Tiigimagi, P.2
Michelson, P.3
Metsis, M.4
Osterlund, T.5
Kogerman, P.6
-
189
-
-
36849036401
-
Morphogens and the control of cell proliferation and patterning in the spinal cord
-
Ulloa F., Briscoe J. Morphogens and the control of cell proliferation and patterning in the spinal cord. Cell Cycle 2007, 6:2640-2649.
-
(2007)
Cell Cycle
, vol.6
, pp. 2640-2649
-
-
Ulloa, F.1
Briscoe, J.2
-
190
-
-
33947114865
-
Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling
-
Ulloa F., Itasaki N., Briscoe J. Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. Curr. Biol. 2007, 17:545-550.
-
(2007)
Curr. Biol.
, vol.17
, pp. 545-550
-
-
Ulloa, F.1
Itasaki, N.2
Briscoe, J.3
-
191
-
-
69549130773
-
SHH pathway and cerebellar development
-
Vaillant C., Monard D. SHH pathway and cerebellar development. Cerebellum 2009, 8:291-301.
-
(2009)
Cerebellum
, vol.8
, pp. 291-301
-
-
Vaillant, C.1
Monard, D.2
-
192
-
-
0026019629
-
Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box
-
van de Wetering M., Oosterwegel M., Dooijes D., Clevers H. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. EMBO J. 1991, 10:123-132.
-
(1991)
EMBO J.
, vol.10
, pp. 123-132
-
-
van de Wetering, M.1
Oosterwegel, M.2
Dooijes, D.3
Clevers, H.4
-
193
-
-
51949085076
-
Hedgehog: Functions and mechanisms
-
Varjosalo M., Taipale J. Hedgehog: Functions and mechanisms. Genes Dev. 2008, 22:2454-2472.
-
(2008)
Genes Dev.
, vol.22
, pp. 2454-2472
-
-
Varjosalo, M.1
Taipale, J.2
-
194
-
-
31744436876
-
Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
-
Varjosalo M., Li S.P., Taipale J. Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev. Cell 2006, 10:177-186.
-
(2006)
Dev. Cell
, vol.10
, pp. 177-186
-
-
Varjosalo, M.1
Li, S.P.2
Taipale, J.3
-
195
-
-
34250612602
-
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
-
Vokes S.A., Ji H., McCuine S., Tenzen T., Giles S., Zhong S., Longabaugh W.J., Davidson E.H., Wong W.H., McMahon A.P. Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 2007, 134:1977-1989.
-
(2007)
Development
, vol.134
, pp. 1977-1989
-
-
Vokes, S.A.1
Ji, H.2
McCuine, S.3
Tenzen, T.4
Giles, S.5
Zhong, S.6
Longabaugh, W.J.7
Davidson, E.H.8
Wong, W.H.9
McMahon, A.P.10
-
196
-
-
30444437000
-
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing
-
Wang B., Li Y. Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc. Natl. Acad. Sci. USA 2006, 103:33-38.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 33-38
-
-
Wang, B.1
Li, Y.2
-
197
-
-
0034681266
-
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
-
Wang B., Fallon J.F., Beachy P.A. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 2000, 100:423-434.
-
(2000)
Cell
, vol.100
, pp. 423-434
-
-
Wang, B.1
Fallon, J.F.2
Beachy, P.A.3
-
198
-
-
0034669178
-
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
-
Wang G., Amanai K., Wang B., Jiang J. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev. 2000, 14:2893-2905.
-
(2000)
Genes Dev.
, vol.14
, pp. 2893-2905
-
-
Wang, G.1
Amanai, K.2
Wang, B.3
Jiang, J.4
-
199
-
-
62449174504
-
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
-
Wang Y., Zhou Z., Walsh C.T., McMahon A.P. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc. Natl. Acad. Sci. USA 2009, 106:2623-2628.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2623-2628
-
-
Wang, Y.1
Zhou, Z.2
Walsh, C.T.3
McMahon, A.P.4
-
200
-
-
77953050811
-
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
-
Wang C., Pan Y., Wang B. Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development 2010, 137:2001-2009.
-
(2010)
Development
, vol.137
, pp. 2001-2009
-
-
Wang, C.1
Pan, Y.2
Wang, B.3
-
201
-
-
78349305842
-
Direct and indirect requirements of Shh/Gli signaling in early pituitary development
-
Wang Y., Martin J.F., Bai C.B. Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev. Biol. 2010, 348:199-209.
-
(2010)
Dev. Biol.
, vol.348
, pp. 199-209
-
-
Wang, Y.1
Martin, J.F.2
Bai, C.B.3
-
202
-
-
0032959871
-
Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog [see comments]
-
Wechsler-Reya R.J., Scott M.P. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog [see comments]. Neuron 1999, 22:103-114.
-
(1999)
Neuron
, vol.22
, pp. 103-114
-
-
Wechsler-Reya, R.J.1
Scott, M.P.2
-
203
-
-
77950671813
-
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
-
Wen X., Lai C.K., Evangelista M., Hongo J.A., de Sauvage F.J., Scales S.J. Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol. Cell. Biol. 2010, 30:1910-1922.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 1910-1922
-
-
Wen, X.1
Lai, C.K.2
Evangelista, M.3
Hongo, J.A.4
de Sauvage, F.J.5
Scales, S.J.6
-
204
-
-
41849151416
-
Megalin deficiency induces critical changes in mouse spinal cord development
-
Wicher G., Aldskogius H. Megalin deficiency induces critical changes in mouse spinal cord development. Neuroreport 2008, 19:559-563.
-
(2008)
Neuroreport
, vol.19
, pp. 559-563
-
-
Wicher, G.1
Aldskogius, H.2
-
205
-
-
26644440897
-
Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord
-
Wicher G., Larsson M., Rask L., Aldskogius H. Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord. J. Comp. Neurol. 2005, 492:123-131.
-
(2005)
J. Comp. Neurol.
, vol.492
, pp. 123-131
-
-
Wicher, G.1
Larsson, M.2
Rask, L.3
Aldskogius, H.4
-
206
-
-
0037111827
-
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
-
Wijgerde M., McMahon J.A., Rule M., McMahon A.P. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 2002, 16:2849-2864.
-
(2002)
Genes Dev.
, vol.16
, pp. 2849-2864
-
-
Wijgerde, M.1
McMahon, J.A.2
Rule, M.3
McMahon, A.P.4
-
207
-
-
77953316514
-
Mechanism and evolution of cytosolic Hedgehog signal transduction
-
Wilson C.W., Chuang P.T. Mechanism and evolution of cytosolic Hedgehog signal transduction. Development 2010, 137:2079-2094.
-
(2010)
Development
, vol.137
, pp. 2079-2094
-
-
Wilson, C.W.1
Chuang, P.T.2
-
208
-
-
65249123996
-
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
-
Wilson C.W., Chen M.H., Chuang P.T. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One 2009, 4:e5182.
-
(2009)
PLoS One
, vol.4
-
-
Wilson, C.W.1
Chen, M.H.2
Chuang, P.T.3
-
209
-
-
65549170297
-
Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis
-
Wilson C.W., Nguyen C.T., Chen M.H., Yang J.H., Gacayan R., Huang J., Chen J.N., Chuang P.T. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature 2009, 459:98-102.
-
(2009)
Nature
, vol.459
, pp. 98-102
-
-
Wilson, C.W.1
Nguyen, C.T.2
Chen, M.H.3
Yang, J.H.4
Gacayan, R.5
Huang, J.6
Chen, J.N.7
Chuang, P.T.8
-
210
-
-
3042740428
-
Iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
-
Wolff C., Roy S., Lewis K.E., Schauerte H., Joerg-Rauch G., Kirn A., Weiler C., Geisler R., Haffter P., Ingham P.W. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev. 2004, 18:1565-1576.
-
(2004)
Genes Dev.
, vol.18
, pp. 1565-1576
-
-
Wolff, C.1
Roy, S.2
Lewis, K.E.3
Schauerte, H.4
Joerg-Rauch, G.5
Kirn, A.6
Weiler, C.7
Geisler, R.8
Haffter, P.9
Ingham, P.W.10
-
211
-
-
58149333235
-
The primary cilium at the crossroads of mammalian hedgehog signaling
-
Wong S.Y., Reiter J.F. The primary cilium at the crossroads of mammalian hedgehog signaling. Curr. Top. Dev. Biol. 2008, 85:225-260.
-
(2008)
Curr. Top. Dev. Biol.
, vol.85
, pp. 225-260
-
-
Wong, S.Y.1
Reiter, J.F.2
-
212
-
-
0031913524
-
Activating Smoothened mutations in sporadic basal-cell carcinoma
-
Xie J., Murone M., Luoh S.M., Ryan A., Gu Q., Zhang C., Bonifas J.M., Lam C.W., Hynes M., Goddard A., Rosenthal A., Epstein E.H., et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998, 391:90-92.
-
(1998)
Nature
, vol.391
, pp. 90-92
-
-
Xie, J.1
Murone, M.2
Luoh, S.M.3
Ryan, A.4
Gu, Q.5
Zhang, C.6
Bonifas, J.M.7
Lam, C.W.8
Hynes, M.9
Goddard, A.10
Rosenthal, A.11
Epstein, E.H.12
-
213
-
-
75949085585
-
Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates
-
Xu Q., Guo L., Moore H., Waclaw R.R., Campbell K., Anderson S.A. Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates. Neuron 2010, 65:328-340.
-
(2010)
Neuron
, vol.65
, pp. 328-340
-
-
Xu, Q.1
Guo, L.2
Moore, H.3
Waclaw, R.R.4
Campbell, K.5
Anderson, S.A.6
-
214
-
-
65549101582
-
Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway
-
Yam P.T., Langlois S.D., Morin S., Charron F. Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway. Neuron 2009, 62:349-362.
-
(2009)
Neuron
, vol.62
, pp. 349-362
-
-
Yam, P.T.1
Langlois, S.D.2
Morin, S.3
Charron, F.4
-
215
-
-
15144354319
-
GLI activates transcription through a Herpes Simplex viral protein 16-like activation domain
-
Yoon J.W., Liu C.Z., Yang J.T., Swart R., Iannaccone P., Walterhouse D. GLI activates transcription through a Herpes Simplex viral protein 16-like activation domain. J. Biol. Chem. 1998, 273:3496-3501.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3496-3501
-
-
Yoon, J.W.1
Liu, C.Z.2
Yang, J.T.3
Swart, R.4
Iannaccone, P.5
Walterhouse, D.6
-
216
-
-
69949138968
-
Patterning of ventral telencephalon requires positive function of Gli transcription factors
-
Yu W., Wang Y., McDonnell K., Stephen D., Bai C.B. Patterning of ventral telencephalon requires positive function of Gli transcription factors. Dev. Biol. 2009, 334:264-275.
-
(2009)
Dev. Biol.
, vol.334
, pp. 264-275
-
-
Yu, W.1
Wang, Y.2
McDonnell, K.3
Stephen, D.4
Bai, C.B.5
-
217
-
-
13344261322
-
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
-
Zhang W., Zhao Y., Tong C., Wang G., Wang B., Jia J., Jiang J. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev. Cell 2005, 8:267-278.
-
(2005)
Dev. Cell
, vol.8
, pp. 267-278
-
-
Zhang, W.1
Zhao, Y.2
Tong, C.3
Wang, G.4
Wang, B.5
Jia, J.6
Jiang, J.7
-
218
-
-
33646120095
-
Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
-
Zhang W., Kang J.S., Cole F., Yi M.J., Krauss R.S. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev. Cell 2006, 10:657-665.
-
(2006)
Dev. Cell
, vol.10
, pp. 657-665
-
-
Zhang, W.1
Kang, J.S.2
Cole, F.3
Yi, M.J.4
Krauss, R.S.5
-
219
-
-
73549083198
-
Genetic and biochemical definition of the Hedgehog receptor
-
Zheng X., Mann R.K., Sever N., Beachy P.A. Genetic and biochemical definition of the Hedgehog receptor. Genes Dev. 2010, 24:57-71.
-
(2010)
Genes Dev.
, vol.24
, pp. 57-71
-
-
Zheng, X.1
Mann, R.K.2
Sever, N.3
Beachy, P.A.4
-
220
-
-
33845219533
-
Mediator modulates Gli3-dependent Sonic hedgehog signaling
-
Zhou H., Kim S., Ishii S., Boyer T.G. Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol. Cell. Biol. 2006, 26:8667-8682.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 8667-8682
-
-
Zhou, H.1
Kim, S.2
Ishii, S.3
Boyer, T.G.4
-
221
-
-
10644292684
-
Incredible journey: How do developmental signals travel through tissue?
-
Zhu A.J., Scott M.P. Incredible journey: How do developmental signals travel through tissue?. Genes Dev. 2004, 18:2985-2997.
-
(2004)
Genes Dev.
, vol.18
, pp. 2985-2997
-
-
Zhu, A.J.1
Scott, M.P.2
|