Balanced Shh signaling is required for proper formation and maintenance of dorsal telencephalic midline structures

BMC Developmental Biology

Volumn 10, Issue , 2010, Pages

  Himmelstein, Diana S ^a   Bi, Chunming ^a   Clark, Brian S ^a,b   Bai, Brian ^c   Kohtz, Jhumku D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; LHX5 PROTEIN, MOUSE; NERVE PROTEIN; SHH PROTEIN, MOUSE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION; TELENCEPHALON; TRANSGENIC MOUSE;

ANIMALS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; SIGNAL TRANSDUCTION; TELENCEPHALON; TRANSCRIPTION FACTORS;

EID: 78649385622     PISSN: None     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/1471-213X-10-118     Document Type: Article

References (53)

1. Roof plate-dependent patterning of the vertebrate dorsal central nervous system. VV Chizhikov KJ Millen, Dev Biol 2005 277 287 95 10.1016/j.ydbio.2004. 10.011 15617675
2. Genetic regulation of arealization of the neocortex. DD O'Leary S Sahara, Curr Opin Neurobiol 2008 18 90 100 10.1016/j.conb.2008.05.011 18524571
3. A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord. KF Liem G Tremml TM Jessell, Cell 1997 91 127 38 10.1016/S0092-8674(01)80015-5 9335341
4. Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. R Awatramani P Soriano C Rodriguez JJ Mai SM Dymecki, Nat Genet 2003 35 70 5 10.1038/ng1228 12923530
5. Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation. DS Currle X Cheng CM Hsu ES Monuki, Development 2005 132 3549 59 10.1242/dev.01915 15975937
6. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. KJ Lee P Dietrich TM Jessell, Nature 2000 403 734 40 10.1038/35001507 10693795
7. Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway. ES Monuki FD Porter CA Walsh, Neuron 2001 32 591 604 10.1016/S0896-6273(01)00504-9 11719201
8. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. EA Grove S Tole J Limon L Yip CW Ragsdale, Development 1998 125 2315 25 9584130
9. Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. VS Mangale KE Hirokawa PR Satyaki N Gokulchandran S Chikbire L Subramanian AS Shetty B Martynoga J Paul MV Mai, et al. Science 2008 319 304 9 10.1126/science.1151695 18202285
10. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. J Galceran EM Miyashita-Lin E Devaney JL Rubenstein R Grosschedl, Development 2000 127 469 82 10631168
11. A local Wnt-3a signal is required for development of the mammalian hippocampus. SM Lee S Tole E Grove AP McMahon, Development 2000 127 457 67 10631167
12. Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex. T Shimogori V Banuchi HY Ng JB Strauss EA Grove, Development 2004 131 5639 47 10.1242/dev.01428 15509764
13. Genetic patterning of the mammalian telencephalon by morphogenetic molecules and transcription factors. H Takahashi FC Liu, Birth Defects Res C Embryo Today 2006 78 256 66 10.1002/bdrc.20077 17061260
14. The mechanisms of dorsoventral patterning in the vertebrate neural tube. L Wilson M Maden, Dev Biol 2005 282 1 13 10.1016/j.ydbio.2005.02.027 15936325
15. Neocortex patterning by the secreted signaling molecule FGF8. T Fukuchi-Shimogori EA Grove, Science 2001 294 1071 4 10.1126/science.1064252 11567107
16. Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. EE Storm S Garel U Borello JM Hebert S Martinez SK McConnell GR Martin JL Rubenstein, Development 2006 133 1831 44 10.1242/dev.02324 16613831
17. Mouse models of holoprosencephaly. M Hayhurst SK McConnell, Curr Opin Neurol 2003 16 135 41 10.1097/00019052-200304000-00003 12644739
18. The morphogen signaling network in forebrain development and holoprosencephaly. ES Monuki, J Neuropathol Exp Neurol 2007 66 566 75 10.1097/nen.0b013e3180986e1b 17620982
19. Genetics of ventral forebrain development and holoprosencephaly. M Muenke PA Beachy, Curr Opin Genet Dev 2000 10 262 9 10.1016/S0959-437X(00)00084-8 10826992
20. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Y Litingtung C Chiang, Nat Neurosci 2000 3 979 85 10.1038/79916 11017169
21. Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. M Rallu R Machold N Gaiano JG Corbin AP McMahon G Fishell, Development 2002 129 4963 74 12397105
22. Patterning the dorsal telencephalon: a role for sonic hedgehog? BG Rash EA Grove, J Neurosci 2007 27 11595 603 10.1523/JNEUROSCI.3204-07.2007 17959802
23. Hedgehog signaling from the ZLI regulates diencephalic regional identity. C Kiecker A Lumsden, Nat Neurosci 2004 7 1242 9 10.1038/nn1338 15494730
24. The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. J Feng C Bi BS Clark R Mady P Shah JD Kohtz, Genes Dev 2006 20 1470 84 10.1101/gad.1416106 16705037
25. Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids. J Feng B White OV Tyurina B Guner T Larson HY Lee RO Karlstrom JD Kohtz, Development 2004 131 4357 70 10.1242/dev.01301 15294867
26. A method for rapid gain-of-function studies in the mouse embryonic nervous system. N Gaiano JD Kohtz DH Turnbull G Fishell, Nat Neurosci 1999 2 812 9 10.1038/12186 10461220
27. Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog. JD Kohtz DP Baker G Corte G Fishell, Development 1998 125 5079 89 9811591
28. N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons. JD Kohtz HY Lee N Gaiano J Segal E Ng T Larson DP Baker EA Garber KP Williams G Fishell, Development 2001 128 2351 63 11493554
29. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. J Lee KA Platt P Censullo A Ruiz i Altaba, Development 1997 124 2537 52 9216996
30. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. LV Goodrich RL Johnson L Milenkovic JA McMahon MP Scott, Genes Dev 1996 10 301 12 10.1101/gad.10.3.301 8595881
31. Biochemical evidence that patched is the Hedgehog receptor. V Marigo RA Davey Y Zuo JM Cunningham CJ Tabin, Nature 1996 384 176 9 10.1038/384176a0 8906794
32. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. DM Stone M Hynes M Armanini TA Swanson Q Gu RL Johnson MP Scott D Pennica A Goddard H Phillips, et al. Nature 1996 384 129 34 10.1038/384129a0 8906787
33. Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. X Huang Y Litingtung C Chiang, Hum Mol Genet 2007 16 1454 68 10.1093/hmg/ddm096 17468181
34. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. C Chiang Y Litingtung E Lee KE Young JL Corden H Westphal PA Beachy, Nature 1996 383 407 13 10.1038/383407a0 8837770
35. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. CB Bai W Auerbach JS Lee D Stephen AL Joyner, Development 2002 129 4753 61 10.1242/dev.00115 12361967
36. Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. HL Park C Bai KA Platt MP Matise A Beeghly CC Hui M Nakashima AL Joyner, Development 2000 127 1593 605 10725236
37. Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles. Y Ohkubo C Chiang JL Rubenstein, Neuroscience 2002 111 1 17 10.1016/S0306-4522(01)00616-9 11955708
38. The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types. M Hynes W Ye K Wang D Stone M Murone F Sauvage A Rosenthal, Nat Neurosci 2000 3 41 6 10.1038/71114 10607393
39. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Y Echelard DJ Epstein B St-Jacques L Shen J Mohler JA McMahon AP McMahon, Cell 1993 75 1417 30 10.1016/0092-8674(93)90627-3 7916661
40. Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. X Huang Y Litingtung C Chiang, Development 2007 134 2095 105 10.1242/dev.000729 17507410
41. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Y Li H Zhang Y Litingtung C Chiang, Proc Natl Acad Sci USA 2006 103 6548 53 10.1073/pnas.0600124103 16611729
42. Embryogenesis of holoprosencephaly. K Shiota S Yamada M Komada M Ishibashi, Am J Med Genet A 2007 143A 3079 87 10.1002/ajmg.a.32020 17963261
43. Middle interhemispheric fusion: an unusual variant of holoprosencephaly. AJ Barkovich DJ Quint, AJNR Am J Neuroradiol 1993 14 431 40 8456724
44. Central roles of the roof plate in telencephalic development and holoprosencephaly. X Cheng CM Hsu DS Currle JS Hu AJ Barkovich ES Monuki, J Neurosci 2006 26 7640 9 10.1523/JNEUROSCI.0714-06.2006 16855091
45. The middle interhemispheric variant of holoprosencephaly. EM Simon RF Hevner JD Pinter NJ Clegg M Delgado SL Kinsman JS Hahn AJ Barkovich, AJNR Am J Neuroradiol 2002 23 151 6 11827888
46. Shh-dependent formation of the ZLI is opposed by signals from the dorsal diencephalon. LM Zeltser, Development 2005 132 2023 33 10.1242/dev.01783 15788458
47. Sonic hedgehog from the basal plate and the zona limitans intrathalamica exhibits differential activity on diencephalic molecular regionalization and nuclear structure. C Vieira S Martinez, Neuroscience 2006 143 129 40 10.1016/j.neuroscience.2006.08.032 17045408
48. Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. H Tian J Jeong BD Harfe CJ Tabin AP McMahon, Development 2005 132 133 42 10.1242/dev.01563 15576405
49. Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells. A Liu AL Joyner DH Turnbull, Mech Dev 1998 75 107 15 10.1016/S0925-4773(98)00090-2 9739117
50. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. EY Snyder DL Deitcher C Walsh S Arnold-Aldea EA Hartwieg CL Cepko, Cell 1992 68 33 51 10.1016/0092-8674(92)90204-P 1732063
51. Specification of mouse telencephalic and mid-hindbrain progenitors following heterotopic ultrasound-guided embryonic transplantation. M Olsson K Campbell DH Turnbull, Neuron 1997 19 761 72 10.1016/S0896-6273(00)80959-9 9354324
52. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. N Schaeren-Wiemers A Gerfin-Moser, Histochemistry 1993 100 431 40 10.1007/BF00267823 7512949
53. Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. N Tekki-Kessaris R Woodruff AC Hall W Gaffield S Kimura CD Stiles DH Rowitch WD Richardson, Development 2001 128 2545 54 11493571