On the range of Hedgehog signaling

Current Opinion in Genetics and Development

Volumn 10, Issue 5, 2000, Pages 515-522

  Chuang, Pao Tien ^a   Kornberg, Thomas B ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEVELOPMENT; DROSOPHILA; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE;

EID: 0033858381     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00121-0     Document Type: Review

References (107)

1. Mutations affecting segment number and polarity in Drosophila
2. Autoproteolysis in hedgehog protein biogenesis
3. Cholesterol modification of hedgehog signaling proteins in animal development
4. Identification of a palmitic acid-modified form of human Sonic hedgehog
5. Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
6. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
7. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
8. The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate
9. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
10. Biochemical evidence that patched is the Hedgehog receptor
11. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
12. Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family
13. Transducing Hedgehog: The story so far
14. Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened
15. Cyclopamine reversal of abnormal cell growth and hedgehog pathway activation induced by oncogenic mutations in Patched and Smoothened
16. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
17. Hedgehog signal transduction in the posterior compartment of Drosophila imaginal discs
18. Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain
19. Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly
20. Dual roles for patched in sequestering and transducing Hedgehog
21. Control of compartment development by the engrailed gene of Drosophila
22. The engrailed locus of Drosophila: In situ localization of transcripts reveals compartment-specific expression
23. Compartments in the wing of Drosophila: A study of the engrailed gene
24. Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila
25. Control of compartmental affinity boundaries by hedgehog
26. Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
27. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
28. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
29. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
30. Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
31. Sonic hedgehog mediates the polarizing activity of the ZPA
32. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb
33. Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway
34. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
35. Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase
36. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the G LI family of zinc finger DNA-binding proteins
37. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
38. Cytonemes: Cellular processes that project to the principal signaling center in Drosophila imaginal discs
39. Wingless, decapentaplegic and EGF receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila
40. Hedgehog and engrailed: Pattern formation and polarity in the Drosophila abdomen
41. Hedgehog activates the EGF receptor pathway during Drosophila head development
42. Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus
43. Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis
44. Establishing neuroblast-specific gene expression in the Drosophila CNS: Huckebein is activated by Wingless and Hedgehog and repressed by Engrailed and Gooseberry
45. Hedgehog signaling independent of engrailed and wingless required for post-S1 neuroblast formation in Drosophila CNS
46. Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals
47. Differential requirements of the fused kinase for hedgehog signalling in the Drosophila embryo
48. Mutual antagonism between signals secreted by adjacent wingless and engrailed cells leads to specification of complementary regions of the Drosophila parasegment
49. Morphogenetic furrow initiation and progression during eye development in Drosophila: The roles of decapentaplegic, hedgehog and eyes absent
50. Progression of the morphogenetic furrow in the Drosophila eye: The roles of Hedgehog, Decapentaplegic and the Raf pathway
51. Compartments and organising boundaries in the Drosophila eye: The role of the homeodomain Iroquois proteins
52. The genetic control of the distinction between fat body and gonadal mesoderm in Drosophila
53. Decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
54. Developmental genetics of the Drosophila gut: Specification of primordia, subdivision and overt-differentiation
55. Compartmental organization of the Drosophila genital imaginal discs
56. The heterotrimeric protein Go is required for the formation of heart epithelium in Drosophila
57. Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila
58. Ladybird determines cell fate decisions during diversification of Drosophila somatic muscles
59. A retinal axon fascicle uses spitz, an EGF receptor ligand, to construct a synaptic cartridge in the brain of Drosophila
60. Identification of mutations that cause cell migration defects in mosaic clones
61. Hedgehog and wingless induce metameric pattern in the Drosophila visceral mesoderm
62. More surprises in the Hedgehog signaling pathway
63. Ci: A complex transducer of the hedgehog signal
64. New mouse models of congenital anorectal malformations
65. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
66. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
67. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
68. Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
69. Sonic hedgehog regulates the growth and patterning of the cerebellum
70. Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
71. A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve
72. Function for Hedgehog genes in zebrafish retinal development
73. The concentric structure of the developing gut is regulated by sonic hedgehog derived from endodermal epithelium
74. Hedgehog signals regulate multiple aspects of gastrointestinal development
75. Sonic hedgehog signaling is essential for hair development
76. Essential role for Sonic hedgehog during hair follicle morphogenesis
77. Differences in left-right axis pathways in mouse and chick: Functions of FGF8 and SHH
78. Regulation of left-right asymmetries in the zebrafish by Shh and BMP4
79. Multiple left-right asymmetry defects in Shh((-/-)) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1
80. A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling
81. Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity
82. Sonic hedgehog is essential to foregut development
83. Sonic hedgehog regulates branching morphogenesis in the mammalian lung
84. Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1
85. Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb
86. Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death
87. Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling
88. Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths
89. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
90. Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways
91. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
92. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
93. Notochord repression of endodermal Sonic hedgehog permits pancreas development
94. Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium
95. Mediolateral patterning of somites: Multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression
96. In vivo regulation of somite differentiation and proliferation by Sonic Hedgehog
97. Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish
98. Role of sonic hedgehog in branchiomotor neuron induction in zebrafish
99. Sonic hedgehog synergizes with the extracellular matrix protein vitronectin to induce spinal motor neuron differentiation
100. Sertoli cell signaling by Desert hedgehog regulates the male germline
101. Polarizing activity, Sonic hedgehog, and tooth development in embryonic and postnatal mouse
102. The Shh signalling pathway in tooth development: Defects in Gli2 and Gli3 mutants
103. Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube
104. Comparative synteny cloning of zebrafish you-too: Mutations in the Hedgehog target gli2 affect ventral forebrain patterning
105. Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult in vitro
106. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
107. Control of chick tectum territory along dorsoventral axis by Sonic hedgehog